Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	171568
Gene name Gene Name - the full gene name approved by the HGNC.	RNA polymerase III subunit H
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	POLR3H
Synonyms (NCBI Gene) Gene synonyms aliases	C25, RPC22.9, RPC8
Chromosome Chromosome number	22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	22q13.2

Show/Hide all(165)

miRTarBase ID	miRNA	Experiments	Reference
MIRT047813	hsa-miR-30d-5p	CLASH	23622248
MIRT043433	hsa-miR-331-3p	CLASH	23622248
MIRT043160	hsa-miR-324-5p	CLASH	23622248
MIRT042471	hsa-miR-423-3p	CLASH	23622248
MIRT042331	hsa-miR-484	CLASH	23622248
MIRT039879	hsa-miR-615-3p	CLASH	23622248
MIRT038118	hsa-miR-423-5p	CLASH	23622248
MIRT035985	hsa-miR-1301-3p	CLASH	23622248
MIRT1249367	hsa-miR-1273g	CLIP-seq
MIRT1249368	hsa-miR-2116	CLIP-seq
MIRT1249369	hsa-miR-3179	CLIP-seq
MIRT1249370	hsa-miR-323b-5p	CLIP-seq
MIRT1249371	hsa-miR-4447	CLIP-seq
MIRT1249372	hsa-miR-4472	CLIP-seq
MIRT1249373	hsa-miR-4649-3p	CLIP-seq
MIRT1249374	hsa-miR-4792	CLIP-seq
MIRT1249375	hsa-miR-541	CLIP-seq
MIRT1249376	hsa-miR-654-5p	CLIP-seq
MIRT1249377	hsa-miR-1182	CLIP-seq
MIRT1249378	hsa-miR-193a-5p	CLIP-seq
MIRT1249379	hsa-miR-3136-3p	CLIP-seq
MIRT1249369	hsa-miR-3179	CLIP-seq
MIRT1249380	hsa-miR-3202	CLIP-seq
MIRT1249381	hsa-miR-3612	CLIP-seq
MIRT1249382	hsa-miR-3974	CLIP-seq
MIRT1249383	hsa-miR-4443	CLIP-seq
MIRT1249384	hsa-miR-4476	CLIP-seq
MIRT1249373	hsa-miR-4649-3p	CLIP-seq
MIRT1249385	hsa-miR-4697-3p	CLIP-seq
MIRT1249386	hsa-miR-4704-3p	CLIP-seq
MIRT1249387	hsa-miR-4761-5p	CLIP-seq
MIRT1249374	hsa-miR-4792	CLIP-seq
MIRT1249388	hsa-miR-650	CLIP-seq
MIRT1249389	hsa-miR-665	CLIP-seq
MIRT2073653	hsa-miR-1227	CLIP-seq
MIRT1249378	hsa-miR-193a-5p	CLIP-seq
MIRT2073654	hsa-miR-1976	CLIP-seq
MIRT2073655	hsa-miR-2682	CLIP-seq
MIRT2073656	hsa-miR-29a	CLIP-seq
MIRT2073657	hsa-miR-29b	CLIP-seq
MIRT2073658	hsa-miR-29c	CLIP-seq
MIRT2073659	hsa-miR-3157-3p	CLIP-seq
MIRT2073660	hsa-miR-3190	CLIP-seq
MIRT2073661	hsa-miR-3606	CLIP-seq
MIRT2073662	hsa-miR-3614-5p	CLIP-seq
MIRT1249382	hsa-miR-3974	CLIP-seq
MIRT2073663	hsa-miR-4256	CLIP-seq
MIRT2073664	hsa-miR-4279	CLIP-seq
MIRT2073665	hsa-miR-4423-3p	CLIP-seq
MIRT2073666	hsa-miR-4432	CLIP-seq
MIRT2073667	hsa-miR-4468	CLIP-seq
MIRT2073668	hsa-miR-449c	CLIP-seq
MIRT2073669	hsa-miR-4509	CLIP-seq
MIRT2073670	hsa-miR-4512	CLIP-seq
MIRT2073671	hsa-miR-4640-5p	CLIP-seq
MIRT2073672	hsa-miR-4660	CLIP-seq
MIRT2073673	hsa-miR-4688	CLIP-seq
MIRT1249386	hsa-miR-4704-3p	CLIP-seq
MIRT2073674	hsa-miR-4710	CLIP-seq
MIRT2073675	hsa-miR-4715-3p	CLIP-seq
MIRT2073676	hsa-miR-4722-3p	CLIP-seq
MIRT2073677	hsa-miR-4726-5p	CLIP-seq
MIRT2073678	hsa-miR-4733-3p	CLIP-seq
MIRT2073679	hsa-miR-4742-3p	CLIP-seq
MIRT2073680	hsa-miR-4744	CLIP-seq
MIRT1249387	hsa-miR-4761-5p	CLIP-seq
MIRT2073681	hsa-miR-488	CLIP-seq
MIRT2073682	hsa-miR-561	CLIP-seq
MIRT2073683	hsa-miR-646	CLIP-seq
MIRT2073684	hsa-miR-663b	CLIP-seq
MIRT2073685	hsa-miR-671-5p	CLIP-seq
MIRT2073686	hsa-miR-874	CLIP-seq
MIRT2073687	hsa-miR-891b	CLIP-seq
MIRT2073688	hsa-miR-938	CLIP-seq
MIRT2073689	hsa-miR-940	CLIP-seq
MIRT2432220	hsa-miR-1972	CLIP-seq
MIRT2432221	hsa-miR-4650-5p	CLIP-seq
MIRT2073653	hsa-miR-1227	CLIP-seq
MIRT2456876	hsa-miR-1252	CLIP-seq
MIRT2456877	hsa-miR-138	CLIP-seq
MIRT2073654	hsa-miR-1976	CLIP-seq
MIRT1249368	hsa-miR-2116	CLIP-seq
MIRT2456878	hsa-miR-3123	CLIP-seq
MIRT2456879	hsa-miR-320e	CLIP-seq
MIRT2456880	hsa-miR-337-3p	CLIP-seq
MIRT2456881	hsa-miR-375	CLIP-seq
MIRT2456882	hsa-miR-3925-5p	CLIP-seq
MIRT2456883	hsa-miR-4273	CLIP-seq
MIRT2073664	hsa-miR-4279	CLIP-seq
MIRT2456884	hsa-miR-4320	CLIP-seq
MIRT2073666	hsa-miR-4432	CLIP-seq
MIRT2456885	hsa-miR-4456	CLIP-seq
MIRT2073669	hsa-miR-4509	CLIP-seq
MIRT2456886	hsa-miR-4677-5p	CLIP-seq
MIRT2456887	hsa-miR-4708-3p	CLIP-seq
MIRT2073676	hsa-miR-4722-3p	CLIP-seq
MIRT2073680	hsa-miR-4744	CLIP-seq
MIRT2456888	hsa-miR-4777-5p	CLIP-seq
MIRT2456889	hsa-miR-4781-5p	CLIP-seq
MIRT2456890	hsa-miR-516a-3p	CLIP-seq
MIRT2456891	hsa-miR-518d-5p	CLIP-seq
MIRT2456892	hsa-miR-519b-5p	CLIP-seq
MIRT2456893	hsa-miR-519c-5p	CLIP-seq
MIRT2456894	hsa-miR-520c-5p	CLIP-seq
MIRT2456895	hsa-miR-526a	CLIP-seq
MIRT1249375	hsa-miR-541	CLIP-seq
MIRT2073682	hsa-miR-561	CLIP-seq
MIRT2456896	hsa-miR-589	CLIP-seq
MIRT1249376	hsa-miR-654-5p	CLIP-seq
MIRT2456897	hsa-miR-744	CLIP-seq
MIRT2456898	hsa-miR-765	CLIP-seq
MIRT2456876	hsa-miR-1252	CLIP-seq
MIRT2597476	hsa-miR-1291	CLIP-seq
MIRT2073654	hsa-miR-1976	CLIP-seq
MIRT1249368	hsa-miR-2116	CLIP-seq
MIRT2456878	hsa-miR-3123	CLIP-seq
MIRT2597477	hsa-miR-3173-3p	CLIP-seq
MIRT2597478	hsa-miR-3173-5p	CLIP-seq
MIRT2456881	hsa-miR-375	CLIP-seq
MIRT2597479	hsa-miR-3918	CLIP-seq
MIRT2456882	hsa-miR-3925-5p	CLIP-seq
MIRT2456883	hsa-miR-4273	CLIP-seq
MIRT2073664	hsa-miR-4279	CLIP-seq
MIRT2456884	hsa-miR-4320	CLIP-seq
MIRT2073666	hsa-miR-4432	CLIP-seq
MIRT2073669	hsa-miR-4509	CLIP-seq
MIRT2073670	hsa-miR-4512	CLIP-seq
MIRT2456886	hsa-miR-4677-5p	CLIP-seq
MIRT2456887	hsa-miR-4708-3p	CLIP-seq
MIRT2073676	hsa-miR-4722-3p	CLIP-seq
MIRT2073680	hsa-miR-4744	CLIP-seq
MIRT2456888	hsa-miR-4777-5p	CLIP-seq
MIRT2456891	hsa-miR-518d-5p	CLIP-seq
MIRT2456892	hsa-miR-519b-5p	CLIP-seq
MIRT2456893	hsa-miR-519c-5p	CLIP-seq
MIRT2456894	hsa-miR-520c-5p	CLIP-seq
MIRT2456895	hsa-miR-526a	CLIP-seq
MIRT2073682	hsa-miR-561	CLIP-seq
MIRT2597480	hsa-miR-570	CLIP-seq
MIRT2456896	hsa-miR-589	CLIP-seq
MIRT2456898	hsa-miR-765	CLIP-seq
MIRT2456876	hsa-miR-1252	CLIP-seq
MIRT2073654	hsa-miR-1976	CLIP-seq
MIRT1249368	hsa-miR-2116	CLIP-seq
MIRT2456878	hsa-miR-3123	CLIP-seq
MIRT2456881	hsa-miR-375	CLIP-seq
MIRT2456882	hsa-miR-3925-5p	CLIP-seq
MIRT2456883	hsa-miR-4273	CLIP-seq
MIRT2073664	hsa-miR-4279	CLIP-seq
MIRT2456884	hsa-miR-4320	CLIP-seq
MIRT2073666	hsa-miR-4432	CLIP-seq
MIRT2073669	hsa-miR-4509	CLIP-seq
MIRT2456886	hsa-miR-4677-5p	CLIP-seq
MIRT2456887	hsa-miR-4708-3p	CLIP-seq
MIRT2073676	hsa-miR-4722-3p	CLIP-seq
MIRT2073680	hsa-miR-4744	CLIP-seq
MIRT2456888	hsa-miR-4777-5p	CLIP-seq
MIRT2456891	hsa-miR-518d-5p	CLIP-seq
MIRT2456892	hsa-miR-519b-5p	CLIP-seq
MIRT2456893	hsa-miR-519c-5p	CLIP-seq
MIRT2456894	hsa-miR-520c-5p	CLIP-seq
MIRT2456895	hsa-miR-526a	CLIP-seq
MIRT2073682	hsa-miR-561	CLIP-seq
MIRT2597480	hsa-miR-570	CLIP-seq
MIRT2456896	hsa-miR-589	CLIP-seq

Show/Hide all(20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000428	Component	DNA-directed RNA polymerase complex	IEA
GO:0002376	Process	Immune system process	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003899	Function	DNA-directed RNA polymerase activity	IDA	12391170
GO:0003899	Function	DNA-directed RNA polymerase activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA	12391170
GO:0005654	Component	Nucleoplasm	TAS
GO:0005666	Component	RNA polymerase III complex	IBA
GO:0005666	Component	RNA polymerase III complex	IDA	12391170, 33335104, 34675218
GO:0005813	Component	Centrosome	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006139	Process	Nucleobase-containing compound metabolic process	IDA	12391170
GO:0006351	Process	DNA-templated transcription	IEA
GO:0006352	Process	DNA-templated transcription initiation	IEA
GO:0006383	Process	Transcription by RNA polymerase III	IDA	12391170
GO:0006384	Process	Transcription initiation at RNA polymerase III promoter	IBA
GO:0045087	Process	Innate immune response	IEA
GO:0051607	Process	Defense response to virus	IEA

MIM	HGNC	e!Ensembl
619801	30349	ENSG00000100413

Protein

UniProt ID

Q9Y535

Protein name

DNA-directed RNA polymerase III subunit RPC8 (RNA polymerase III subunit C8) (DNA-directed RNA polymerase III subunit H) (RNA polymerase III subunit 22.9 kDa subunit) (RPC22.9)

Protein function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:20413673, PubMed:33558764, PubMed:34675218). Specific peripheric component of RNA polymerase III (Pol III)

PDB

7A6H , 7AE1 , 7AE3 , 7AEA , 7AST , 7D58 , 7D59 , 7DN3 , 7DU2 , 7FJI , 7FJJ , 8ITY , 8IUE , 8IUH , 9FSO , 9FSP , 9FSQ , 9FSR , 9FSS

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03876	SHS2_Rpb7-N	8 → 64	SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397	Domain
PF08292	RNA_pol_Rbc25	83 → 201	RNA polymerase III subunit Rpc25	Domain

Sequence

MFVLVEMVDTVRIPPWQFERKLNDSIAEELNKKLANKVVYNVGLCICLFDITKLEDAYVF
PGDGASHTKVHFRCVVFHPFLDEILIGKIKGCSPEGVHVSLGFFDDILIPPESLQQPAKF
DEAEQVWVWEYETEEGAHDLYMDTGEEIRFRVVDESFVDTSPTGPSSADATTSSEELPKK
EAPYTLVGSISEPGLGLLSWWTSN

Sequence length

204

Interactions

View interactions

	KEGG		Reactome
	RNA polymerase Cytosolic DNA-sensing pathway		Cytosolic sensors of pathogen-associated DNA RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Gonadal Dysgenesis	46 XX gonadal dysgenesis	N/A	N/A	GenCC

POLR3H (RNA polymerase III subunit H)