Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	171425
Gene name Gene Name - the full gene name approved by the HGNC.	Citramalyl-CoA lyase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CLYBL
Synonyms (NCBI Gene) Gene synonyms aliases	CLB
Chromosome Chromosome number	13
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	13q32.3

Show/Hide all(197)

miRTarBase ID	miRNA	Experiments	Reference
MIRT039139	hsa-miR-769-5p	CLASH	23622248
MIRT898310	hsa-miR-1185	CLIP-seq
MIRT898311	hsa-miR-1224-3p	CLIP-seq
MIRT898312	hsa-miR-1260	CLIP-seq
MIRT898313	hsa-miR-1260b	CLIP-seq
MIRT898314	hsa-miR-1280	CLIP-seq
MIRT898315	hsa-miR-1299	CLIP-seq
MIRT898316	hsa-miR-150	CLIP-seq
MIRT898317	hsa-miR-1915	CLIP-seq
MIRT898318	hsa-miR-200b	CLIP-seq
MIRT898319	hsa-miR-200c	CLIP-seq
MIRT898320	hsa-miR-216a	CLIP-seq
MIRT898321	hsa-miR-27a	CLIP-seq
MIRT898322	hsa-miR-27b	CLIP-seq
MIRT898323	hsa-miR-3126-5p	CLIP-seq
MIRT898324	hsa-miR-3141	CLIP-seq
MIRT898325	hsa-miR-3150b-3p	CLIP-seq
MIRT898326	hsa-miR-3151	CLIP-seq
MIRT898327	hsa-miR-3169	CLIP-seq
MIRT898328	hsa-miR-3185	CLIP-seq
MIRT898329	hsa-miR-342-5p	CLIP-seq
MIRT898330	hsa-miR-3605-5p	CLIP-seq
MIRT898331	hsa-miR-3671	CLIP-seq
MIRT898332	hsa-miR-3677-5p	CLIP-seq
MIRT898333	hsa-miR-3679-5p	CLIP-seq
MIRT898334	hsa-miR-3915	CLIP-seq
MIRT898335	hsa-miR-3918	CLIP-seq
MIRT898336	hsa-miR-3928	CLIP-seq
MIRT898337	hsa-miR-412	CLIP-seq
MIRT898338	hsa-miR-4254	CLIP-seq
MIRT898339	hsa-miR-4283	CLIP-seq
MIRT898340	hsa-miR-429	CLIP-seq
MIRT898341	hsa-miR-4292	CLIP-seq
MIRT898342	hsa-miR-4302	CLIP-seq
MIRT898343	hsa-miR-4308	CLIP-seq
MIRT898344	hsa-miR-4318	CLIP-seq
MIRT898345	hsa-miR-433	CLIP-seq
MIRT898346	hsa-miR-4419a	CLIP-seq
MIRT898347	hsa-miR-4444	CLIP-seq
MIRT898348	hsa-miR-4446-5p	CLIP-seq
MIRT898349	hsa-miR-4447	CLIP-seq
MIRT898350	hsa-miR-4472	CLIP-seq
MIRT898351	hsa-miR-4474-3p	CLIP-seq
MIRT898352	hsa-miR-4489	CLIP-seq
MIRT898353	hsa-miR-4492	CLIP-seq
MIRT898354	hsa-miR-4498	CLIP-seq
MIRT898355	hsa-miR-4505	CLIP-seq
MIRT898356	hsa-miR-4510	CLIP-seq
MIRT898357	hsa-miR-4519	CLIP-seq
MIRT898358	hsa-miR-452	CLIP-seq
MIRT898359	hsa-miR-4533	CLIP-seq
MIRT898360	hsa-miR-4632	CLIP-seq
MIRT898361	hsa-miR-4651	CLIP-seq
MIRT898362	hsa-miR-4653-3p	CLIP-seq
MIRT898363	hsa-miR-4661-3p	CLIP-seq
MIRT898364	hsa-miR-4664-5p	CLIP-seq
MIRT898365	hsa-miR-4667-5p	CLIP-seq
MIRT898366	hsa-miR-4676-3p	CLIP-seq
MIRT898367	hsa-miR-4679	CLIP-seq
MIRT898368	hsa-miR-4685-5p	CLIP-seq
MIRT898369	hsa-miR-4693-5p	CLIP-seq
MIRT898370	hsa-miR-4700-5p	CLIP-seq
MIRT898371	hsa-miR-4711-3p	CLIP-seq
MIRT898372	hsa-miR-4713-5p	CLIP-seq
MIRT898373	hsa-miR-4726-3p	CLIP-seq
MIRT898374	hsa-miR-4728-5p	CLIP-seq
MIRT898375	hsa-miR-4731-5p	CLIP-seq
MIRT898376	hsa-miR-4740-5p	CLIP-seq
MIRT898377	hsa-miR-4779	CLIP-seq
MIRT898378	hsa-miR-4784	CLIP-seq
MIRT898379	hsa-miR-483-3p	CLIP-seq
MIRT898380	hsa-miR-491-5p	CLIP-seq
MIRT898381	hsa-miR-513a-5p	CLIP-seq
MIRT898382	hsa-miR-532-3p	CLIP-seq
MIRT898383	hsa-miR-548p	CLIP-seq
MIRT898384	hsa-miR-579	CLIP-seq
MIRT898385	hsa-miR-607	CLIP-seq
MIRT898386	hsa-miR-608	CLIP-seq
MIRT898387	hsa-miR-615-5p	CLIP-seq
MIRT898388	hsa-miR-637	CLIP-seq
MIRT898389	hsa-miR-644	CLIP-seq
MIRT898390	hsa-miR-671-5p	CLIP-seq
MIRT898391	hsa-miR-762	CLIP-seq
MIRT898392	hsa-miR-765	CLIP-seq
MIRT898393	hsa-miR-875-3p	CLIP-seq
MIRT898394	hsa-miR-892a	CLIP-seq
MIRT1546524	hsa-miR-4746-3p	CLIP-seq
MIRT1546525	hsa-miR-938	CLIP-seq
MIRT1556185	hsa-miR-4269	CLIP-seq
MIRT1556186	hsa-miR-4514	CLIP-seq
MIRT1556187	hsa-miR-4692	CLIP-seq
MIRT1556188	hsa-miR-4742-5p	CLIP-seq
MIRT1966366	hsa-miR-1296	CLIP-seq
MIRT1966367	hsa-miR-183	CLIP-seq
MIRT1966368	hsa-miR-1913	CLIP-seq
MIRT1966369	hsa-miR-2909	CLIP-seq
MIRT1966370	hsa-miR-3194-3p	CLIP-seq
MIRT1966371	hsa-miR-324-3p	CLIP-seq
MIRT898332	hsa-miR-3677-5p	CLIP-seq
MIRT1966372	hsa-miR-375	CLIP-seq
MIRT1966373	hsa-miR-4267	CLIP-seq
MIRT1556185	hsa-miR-4269	CLIP-seq
MIRT1966374	hsa-miR-4273	CLIP-seq
MIRT1966375	hsa-miR-4278	CLIP-seq
MIRT898339	hsa-miR-4283	CLIP-seq
MIRT898347	hsa-miR-4444	CLIP-seq
MIRT1966376	hsa-miR-4461	CLIP-seq
MIRT898352	hsa-miR-4489	CLIP-seq
MIRT1966377	hsa-miR-4512	CLIP-seq
MIRT1556186	hsa-miR-4514	CLIP-seq
MIRT898360	hsa-miR-4632	CLIP-seq
MIRT1966378	hsa-miR-4640-5p	CLIP-seq
MIRT1966379	hsa-miR-4677-5p	CLIP-seq
MIRT1966380	hsa-miR-4678	CLIP-seq
MIRT1966381	hsa-miR-4688	CLIP-seq
MIRT1556187	hsa-miR-4692	CLIP-seq
MIRT1966382	hsa-miR-4726-5p	CLIP-seq
MIRT1556188	hsa-miR-4742-5p	CLIP-seq
MIRT898310	hsa-miR-1185	CLIP-seq
MIRT898321	hsa-miR-27a	CLIP-seq
MIRT898322	hsa-miR-27b	CLIP-seq
MIRT898329	hsa-miR-342-5p	CLIP-seq
MIRT898330	hsa-miR-3605-5p	CLIP-seq
MIRT898332	hsa-miR-3677-5p	CLIP-seq
MIRT898333	hsa-miR-3679-5p	CLIP-seq
MIRT898337	hsa-miR-412	CLIP-seq
MIRT1556185	hsa-miR-4269	CLIP-seq
MIRT2202240	hsa-miR-4282	CLIP-seq
MIRT898347	hsa-miR-4444	CLIP-seq
MIRT2202241	hsa-miR-4448	CLIP-seq
MIRT1556186	hsa-miR-4514	CLIP-seq
MIRT898360	hsa-miR-4632	CLIP-seq
MIRT898363	hsa-miR-4661-3p	CLIP-seq
MIRT898364	hsa-miR-4664-5p	CLIP-seq
MIRT1556187	hsa-miR-4692	CLIP-seq
MIRT898371	hsa-miR-4711-3p	CLIP-seq
MIRT898375	hsa-miR-4731-5p	CLIP-seq
MIRT1556188	hsa-miR-4742-5p	CLIP-seq
MIRT1546524	hsa-miR-4746-3p	CLIP-seq
MIRT2202242	hsa-miR-513a-3p	CLIP-seq
MIRT898381	hsa-miR-513a-5p	CLIP-seq
MIRT2202243	hsa-miR-545	CLIP-seq
MIRT898383	hsa-miR-548p	CLIP-seq
MIRT1546525	hsa-miR-938	CLIP-seq
MIRT898332	hsa-miR-3677-5p	CLIP-seq
MIRT898347	hsa-miR-4444	CLIP-seq
MIRT898360	hsa-miR-4632	CLIP-seq
MIRT898312	hsa-miR-1260	CLIP-seq
MIRT898313	hsa-miR-1260b	CLIP-seq
MIRT2447274	hsa-miR-188-3p	CLIP-seq
MIRT898325	hsa-miR-3150b-3p	CLIP-seq
MIRT2447275	hsa-miR-3152-5p	CLIP-seq
MIRT2447276	hsa-miR-3156-3p	CLIP-seq
MIRT898338	hsa-miR-4254	CLIP-seq
MIRT898341	hsa-miR-4292	CLIP-seq
MIRT2447277	hsa-miR-4297	CLIP-seq
MIRT2447278	hsa-miR-4301	CLIP-seq
MIRT898343	hsa-miR-4308	CLIP-seq
MIRT2447279	hsa-miR-4480	CLIP-seq
MIRT898374	hsa-miR-4728-5p	CLIP-seq
MIRT2447280	hsa-miR-4774-3p	CLIP-seq
MIRT898377	hsa-miR-4779	CLIP-seq
MIRT898378	hsa-miR-4784	CLIP-seq
MIRT898392	hsa-miR-765	CLIP-seq
MIRT2465096	hsa-miR-22	CLIP-seq
MIRT898325	hsa-miR-3150b-3p	CLIP-seq
MIRT898338	hsa-miR-4254	CLIP-seq
MIRT898341	hsa-miR-4292	CLIP-seq
MIRT898343	hsa-miR-4308	CLIP-seq
MIRT898374	hsa-miR-4728-5p	CLIP-seq
MIRT898377	hsa-miR-4779	CLIP-seq
MIRT898378	hsa-miR-4784	CLIP-seq
MIRT898392	hsa-miR-765	CLIP-seq
MIRT898325	hsa-miR-3150b-3p	CLIP-seq
MIRT898338	hsa-miR-4254	CLIP-seq
MIRT1556185	hsa-miR-4269	CLIP-seq
MIRT898341	hsa-miR-4292	CLIP-seq
MIRT898343	hsa-miR-4308	CLIP-seq
MIRT1556186	hsa-miR-4514	CLIP-seq
MIRT1556187	hsa-miR-4692	CLIP-seq
MIRT898374	hsa-miR-4728-5p	CLIP-seq
MIRT1556188	hsa-miR-4742-5p	CLIP-seq
MIRT898377	hsa-miR-4779	CLIP-seq
MIRT898378	hsa-miR-4784	CLIP-seq
MIRT898392	hsa-miR-765	CLIP-seq
MIRT898325	hsa-miR-3150b-3p	CLIP-seq
MIRT898338	hsa-miR-4254	CLIP-seq
MIRT1556185	hsa-miR-4269	CLIP-seq
MIRT898341	hsa-miR-4292	CLIP-seq
MIRT898343	hsa-miR-4308	CLIP-seq
MIRT1556186	hsa-miR-4514	CLIP-seq
MIRT1556187	hsa-miR-4692	CLIP-seq
MIRT898374	hsa-miR-4728-5p	CLIP-seq
MIRT1556188	hsa-miR-4742-5p	CLIP-seq
MIRT898377	hsa-miR-4779	CLIP-seq
MIRT898378	hsa-miR-4784	CLIP-seq
MIRT898392	hsa-miR-765	CLIP-seq

Show/Hide all(18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000287	Function	Magnesium ion binding	IDA	24334609, 29056341
GO:0003824	Function	Catalytic activity	IEA
GO:0004474	Function	Malate synthase activity	IDA	24334609, 29056341
GO:0004474	Function	Malate synthase activity	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016829	Function	Lyase activity	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0047777	Function	(S)-citramalyl-CoA lyase activity	IBA
GO:0047777	Function	(S)-citramalyl-CoA lyase activity	IDA	29056341
GO:0047777	Function	(S)-citramalyl-CoA lyase activity	IEA
GO:0070207	Process	Protein homotrimerization	IDA	29056341
GO:0106064	Process	Regulation of cobalamin metabolic process	IBA
GO:0106064	Process	Regulation of cobalamin metabolic process	IDA	29056341
GO:0106064	Process	Regulation of cobalamin metabolic process	IEA
GO:0106121	Process	Positive regulation of cobalamin metabolic process	IEA

MIM	HGNC	e!Ensembl
609686	18355	ENSG00000125246

Protein

UniProt ID

Q8N0X4

Protein name

Citramalyl-CoA lyase, mitochondrial (EC 4.1.3.25) ((3S)-malyl-CoA thioesterase) (EC 3.1.2.30) (Beta-methylmalate synthase) (EC 2.3.3.-) (Citrate lyase subunit beta-like protein) (Citrate lyase beta-like) (Malate synthase) (EC 2.3.3.9)

Protein function

Mitochondrial citramalyl-CoA lyase indirectly involved in the vitamin B12 metabolism (PubMed:29056341). Converts citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway (PubMed:29056341). The C5-dicarboxylate catab

PDB

5VXC , 5VXO , 5VXS

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03328	HpcH_HpaI	46 → 274	HpcH/HpaI aldolase/citrate lyase family	Family

Sequence

MALRLLRRAARGAAAAALLRLKASLAADIPRLGYSSSSHHKYIPRRAVLYVPGNDEKKIK
KIPSLNVDCAVLDCEDGVAANKKNEARLRIVKTLEDIDLGPTEKCVRVNSVSSGLAEEDL
ETLLQSRVLPSSLMLPKVESPEEIQWFADKFSFHLKGRKLEQPMNLIPFVETAMGLLNFK
AVCEETLKVGPQVGLFLDAVVFGGEDFRASIGATSSKETLDILYARQKIVVIAKAFGLQA
IDLVYIDFRDGAGLLRQSREGAAMGFTGKQVIHPNQIAVVQEQFSPSPEKIKWAEELIAA
FKEHQQLGKGAFTFQGSMIDMPLLKQAQNTVTLATSIKEK

Sequence length

340

Interactions

View interactions

Show/Hide Unknown Diseases (3)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Alzheimer disease	Alzheimer's disease or family history of Alzheimer's disease	N/A	N/A	GWAS
Attention Deficit Hyperactivity Disorder	Attention deficit hyperactivity disorder	N/A	N/A	GWAS
Uterine Fibroids	Uterine fibroids	N/A	N/A	GWAS

Show/Hide Text Mining Associations (9)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Carcinogenesis	Associate	32475872
COVID 19	Stimulate	35290573
Infections	Associate	30391630
Inflammation	Associate	35290573
Melanoma	Associate	2070066
Neoplasms	Associate	32475872
Parkinson Disease	Associate	23351342
Tuberculosis	Associate	15699433
Urinary Tract Infections	Associate	30391630

CLYBL (citramalyl-CoA lyase)