CLYBL (citramalyl-CoA lyase)

Gene

• Entrez ID: 171425
• Gene name: Citramalyl-CoA lyase
• Gene symbol: CLYBL
• Synonyms (NCBI Gene): CLB
• Chromosome: 13
• Chromosome location: 13q32.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT039139	hsa-miR-769-5p	CLASH	23622248
MIRT898310	hsa-miR-1185	CLIP-seq
MIRT898311	hsa-miR-1224-3p	CLIP-seq
MIRT898312	hsa-miR-1260	CLIP-seq
MIRT898313	hsa-miR-1260b	CLIP-seq
MIRT898314	hsa-miR-1280	CLIP-seq
MIRT898315	hsa-miR-1299	CLIP-seq
MIRT898316	hsa-miR-150	CLIP-seq
MIRT898317	hsa-miR-1915	CLIP-seq
MIRT898318	hsa-miR-200b	CLIP-seq
MIRT898319	hsa-miR-200c	CLIP-seq
MIRT898320	hsa-miR-216a	CLIP-seq
MIRT898321	hsa-miR-27a	CLIP-seq
MIRT898322	hsa-miR-27b	CLIP-seq
MIRT898323	hsa-miR-3126-5p	CLIP-seq
MIRT898324	hsa-miR-3141	CLIP-seq
MIRT898325	hsa-miR-3150b-3p	CLIP-seq
MIRT898326	hsa-miR-3151	CLIP-seq
MIRT898327	hsa-miR-3169	CLIP-seq
MIRT898328	hsa-miR-3185	CLIP-seq
MIRT898329	hsa-miR-342-5p	CLIP-seq
MIRT898330	hsa-miR-3605-5p	CLIP-seq
MIRT898331	hsa-miR-3671	CLIP-seq
MIRT898332	hsa-miR-3677-5p	CLIP-seq
MIRT898333	hsa-miR-3679-5p	CLIP-seq
MIRT898334	hsa-miR-3915	CLIP-seq
MIRT898335	hsa-miR-3918	CLIP-seq
MIRT898336	hsa-miR-3928	CLIP-seq
MIRT898337	hsa-miR-412	CLIP-seq
MIRT898338	hsa-miR-4254	CLIP-seq
MIRT898339	hsa-miR-4283	CLIP-seq
MIRT898340	hsa-miR-429	CLIP-seq
MIRT898341	hsa-miR-4292	CLIP-seq
MIRT898342	hsa-miR-4302	CLIP-seq
MIRT898343	hsa-miR-4308	CLIP-seq
MIRT898344	hsa-miR-4318	CLIP-seq
MIRT898345	hsa-miR-433	CLIP-seq
MIRT898346	hsa-miR-4419a	CLIP-seq
MIRT898347	hsa-miR-4444	CLIP-seq
MIRT898348	hsa-miR-4446-5p	CLIP-seq
MIRT898349	hsa-miR-4447	CLIP-seq
MIRT898350	hsa-miR-4472	CLIP-seq
MIRT898351	hsa-miR-4474-3p	CLIP-seq
MIRT898352	hsa-miR-4489	CLIP-seq
MIRT898353	hsa-miR-4492	CLIP-seq
MIRT898354	hsa-miR-4498	CLIP-seq
MIRT898355	hsa-miR-4505	CLIP-seq
MIRT898356	hsa-miR-4510	CLIP-seq
MIRT898357	hsa-miR-4519	CLIP-seq
MIRT898358	hsa-miR-452	CLIP-seq
MIRT898359	hsa-miR-4533	CLIP-seq
MIRT898360	hsa-miR-4632	CLIP-seq
MIRT898361	hsa-miR-4651	CLIP-seq
MIRT898362	hsa-miR-4653-3p	CLIP-seq
MIRT898363	hsa-miR-4661-3p	CLIP-seq
MIRT898364	hsa-miR-4664-5p	CLIP-seq
MIRT898365	hsa-miR-4667-5p	CLIP-seq
MIRT898366	hsa-miR-4676-3p	CLIP-seq
MIRT898367	hsa-miR-4679	CLIP-seq
MIRT898368	hsa-miR-4685-5p	CLIP-seq
MIRT898369	hsa-miR-4693-5p	CLIP-seq
MIRT898370	hsa-miR-4700-5p	CLIP-seq
MIRT898371	hsa-miR-4711-3p	CLIP-seq
MIRT898372	hsa-miR-4713-5p	CLIP-seq
MIRT898373	hsa-miR-4726-3p	CLIP-seq
MIRT898374	hsa-miR-4728-5p	CLIP-seq
MIRT898375	hsa-miR-4731-5p	CLIP-seq
MIRT898376	hsa-miR-4740-5p	CLIP-seq
MIRT898377	hsa-miR-4779	CLIP-seq
MIRT898378	hsa-miR-4784	CLIP-seq
MIRT898379	hsa-miR-483-3p	CLIP-seq
MIRT898380	hsa-miR-491-5p	CLIP-seq
MIRT898381	hsa-miR-513a-5p	CLIP-seq
MIRT898382	hsa-miR-532-3p	CLIP-seq
MIRT898383	hsa-miR-548p	CLIP-seq
MIRT898384	hsa-miR-579	CLIP-seq
MIRT898385	hsa-miR-607	CLIP-seq
MIRT898386	hsa-miR-608	CLIP-seq
MIRT898387	hsa-miR-615-5p	CLIP-seq
MIRT898388	hsa-miR-637	CLIP-seq
MIRT898389	hsa-miR-644	CLIP-seq
MIRT898390	hsa-miR-671-5p	CLIP-seq
MIRT898391	hsa-miR-762	CLIP-seq
MIRT898392	hsa-miR-765	CLIP-seq
MIRT898393	hsa-miR-875-3p	CLIP-seq
MIRT898394	hsa-miR-892a	CLIP-seq
MIRT1546524	hsa-miR-4746-3p	CLIP-seq
MIRT1546525	hsa-miR-938	CLIP-seq
MIRT1556185	hsa-miR-4269	CLIP-seq
MIRT1556186	hsa-miR-4514	CLIP-seq
MIRT1556187	hsa-miR-4692	CLIP-seq
MIRT1556188	hsa-miR-4742-5p	CLIP-seq
MIRT1966366	hsa-miR-1296	CLIP-seq
MIRT1966367	hsa-miR-183	CLIP-seq
MIRT1966368	hsa-miR-1913	CLIP-seq
MIRT1966369	hsa-miR-2909	CLIP-seq
MIRT1966370	hsa-miR-3194-3p	CLIP-seq
MIRT1966371	hsa-miR-324-3p	CLIP-seq
MIRT898332	hsa-miR-3677-5p	CLIP-seq
MIRT1966372	hsa-miR-375	CLIP-seq
MIRT1966373	hsa-miR-4267	CLIP-seq
MIRT1556185	hsa-miR-4269	CLIP-seq
MIRT1966374	hsa-miR-4273	CLIP-seq
MIRT1966375	hsa-miR-4278	CLIP-seq
MIRT898339	hsa-miR-4283	CLIP-seq
MIRT898347	hsa-miR-4444	CLIP-seq
MIRT1966376	hsa-miR-4461	CLIP-seq
MIRT898352	hsa-miR-4489	CLIP-seq
MIRT1966377	hsa-miR-4512	CLIP-seq
MIRT1556186	hsa-miR-4514	CLIP-seq
MIRT898360	hsa-miR-4632	CLIP-seq
MIRT1966378	hsa-miR-4640-5p	CLIP-seq
MIRT1966379	hsa-miR-4677-5p	CLIP-seq
MIRT1966380	hsa-miR-4678	CLIP-seq
MIRT1966381	hsa-miR-4688	CLIP-seq
MIRT1556187	hsa-miR-4692	CLIP-seq
MIRT1966382	hsa-miR-4726-5p	CLIP-seq
MIRT1556188	hsa-miR-4742-5p	CLIP-seq
MIRT898310	hsa-miR-1185	CLIP-seq
MIRT898321	hsa-miR-27a	CLIP-seq
MIRT898322	hsa-miR-27b	CLIP-seq
MIRT898329	hsa-miR-342-5p	CLIP-seq
MIRT898330	hsa-miR-3605-5p	CLIP-seq
MIRT898332	hsa-miR-3677-5p	CLIP-seq
MIRT898333	hsa-miR-3679-5p	CLIP-seq
MIRT898337	hsa-miR-412	CLIP-seq
MIRT1556185	hsa-miR-4269	CLIP-seq
MIRT2202240	hsa-miR-4282	CLIP-seq
MIRT898347	hsa-miR-4444	CLIP-seq
MIRT2202241	hsa-miR-4448	CLIP-seq
MIRT1556186	hsa-miR-4514	CLIP-seq
MIRT898360	hsa-miR-4632	CLIP-seq
MIRT898363	hsa-miR-4661-3p	CLIP-seq
MIRT898364	hsa-miR-4664-5p	CLIP-seq
MIRT1556187	hsa-miR-4692	CLIP-seq
MIRT898371	hsa-miR-4711-3p	CLIP-seq
MIRT898375	hsa-miR-4731-5p	CLIP-seq
MIRT1556188	hsa-miR-4742-5p	CLIP-seq
MIRT1546524	hsa-miR-4746-3p	CLIP-seq
MIRT2202242	hsa-miR-513a-3p	CLIP-seq
MIRT898381	hsa-miR-513a-5p	CLIP-seq
MIRT2202243	hsa-miR-545	CLIP-seq
MIRT898383	hsa-miR-548p	CLIP-seq
MIRT1546525	hsa-miR-938	CLIP-seq
MIRT898332	hsa-miR-3677-5p	CLIP-seq
MIRT898347	hsa-miR-4444	CLIP-seq
MIRT898360	hsa-miR-4632	CLIP-seq
MIRT898312	hsa-miR-1260	CLIP-seq
MIRT898313	hsa-miR-1260b	CLIP-seq
MIRT2447274	hsa-miR-188-3p	CLIP-seq
MIRT898325	hsa-miR-3150b-3p	CLIP-seq
MIRT2447275	hsa-miR-3152-5p	CLIP-seq
MIRT2447276	hsa-miR-3156-3p	CLIP-seq
MIRT898338	hsa-miR-4254	CLIP-seq
MIRT898341	hsa-miR-4292	CLIP-seq
MIRT2447277	hsa-miR-4297	CLIP-seq
MIRT2447278	hsa-miR-4301	CLIP-seq
MIRT898343	hsa-miR-4308	CLIP-seq
MIRT2447279	hsa-miR-4480	CLIP-seq
MIRT898374	hsa-miR-4728-5p	CLIP-seq
MIRT2447280	hsa-miR-4774-3p	CLIP-seq
MIRT898377	hsa-miR-4779	CLIP-seq
MIRT898378	hsa-miR-4784	CLIP-seq
MIRT898392	hsa-miR-765	CLIP-seq
MIRT2465096	hsa-miR-22	CLIP-seq
MIRT898325	hsa-miR-3150b-3p	CLIP-seq
MIRT898338	hsa-miR-4254	CLIP-seq
MIRT898341	hsa-miR-4292	CLIP-seq
MIRT898343	hsa-miR-4308	CLIP-seq
MIRT898374	hsa-miR-4728-5p	CLIP-seq
MIRT898377	hsa-miR-4779	CLIP-seq
MIRT898378	hsa-miR-4784	CLIP-seq
MIRT898392	hsa-miR-765	CLIP-seq
MIRT898325	hsa-miR-3150b-3p	CLIP-seq
MIRT898338	hsa-miR-4254	CLIP-seq
MIRT1556185	hsa-miR-4269	CLIP-seq
MIRT898341	hsa-miR-4292	CLIP-seq
MIRT898343	hsa-miR-4308	CLIP-seq
MIRT1556186	hsa-miR-4514	CLIP-seq
MIRT1556187	hsa-miR-4692	CLIP-seq
MIRT898374	hsa-miR-4728-5p	CLIP-seq
MIRT1556188	hsa-miR-4742-5p	CLIP-seq
MIRT898377	hsa-miR-4779	CLIP-seq
MIRT898378	hsa-miR-4784	CLIP-seq
MIRT898392	hsa-miR-765	CLIP-seq
MIRT898325	hsa-miR-3150b-3p	CLIP-seq
MIRT898338	hsa-miR-4254	CLIP-seq
MIRT1556185	hsa-miR-4269	CLIP-seq
MIRT898341	hsa-miR-4292	CLIP-seq
MIRT898343	hsa-miR-4308	CLIP-seq
MIRT1556186	hsa-miR-4514	CLIP-seq
MIRT1556187	hsa-miR-4692	CLIP-seq
MIRT898374	hsa-miR-4728-5p	CLIP-seq
MIRT1556188	hsa-miR-4742-5p	CLIP-seq
MIRT898377	hsa-miR-4779	CLIP-seq
MIRT898378	hsa-miR-4784	CLIP-seq
MIRT898392	hsa-miR-765	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000287	Function	Magnesium ion binding	IDA	24334609, 29056341
GO:0003824	Function	Catalytic activity	IEA
GO:0004474	Function	Malate synthase activity	IDA	24334609, 29056341
GO:0004474	Function	Malate synthase activity	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016829	Function	Lyase activity	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0047777	Function	(S)-citramalyl-CoA lyase activity	IBA
GO:0047777	Function	(S)-citramalyl-CoA lyase activity	IDA	29056341
GO:0047777	Function	(S)-citramalyl-CoA lyase activity	IEA
GO:0070207	Process	Protein homotrimerization	IDA	29056341
GO:0106064	Process	Regulation of cobalamin metabolic process	IBA
GO:0106064	Process	Regulation of cobalamin metabolic process	IDA	29056341
GO:0106064	Process	Regulation of cobalamin metabolic process	IEA
GO:0106121	Process	Positive regulation of cobalamin metabolic process	IEA

Other IDs

• MIM: 609686
• HGNC: 18355
• e!Ensembl: ENSG00000125246

Protein

• UniProt ID: Q8N0X4
• Protein name: Citramalyl-CoA lyase, mitochondrial (EC 4.1.3.25) ((3S)-malyl-CoA thioesterase) (EC 3.1.2.30) (Beta-methylmalate synthase) (EC 2.3.3.-) (Citrate lyase subunit beta-like protein) (Citrate lyase beta-like) (Malate synthase) (EC 2.3.3.9)
• Protein function: Mitochondrial citramalyl-CoA lyase indirectly involved in the vitamin B12 metabolism (PubMed:29056341). Converts citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway (PubMed:29056341). The C5-dicarboxylate catab
• PDB: 5VXC, 5VXO, 5VXS
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03328	HpcH_HpaI	46 → 274	HpcH/HpaI aldolase/citrate lyase family	Family

• Sequence:

  MALRLLRRAARGAAAAALLRLKASLAADIPRLGYSSSSHHKYIPRRAVLYVPGNDEKKIK
  KIPSLNVDCAVLDCEDGVAANKKNEARLRIVKTLEDIDLGPTEKCVRVNSVSSGLAEEDL
  ETLLQSRVLPSSLMLPKVESPEEIQWFADKFSFHLKGRKLEQPMNLIPFVETAMGLLNFK
  AVCEETLKVGPQVGLFLDAVVFGGEDFRASIGATSSKETLDILYARQKIVVIAKAFGLQA
  IDLVYIDFRDGAGLLRQSREGAAMGFTGKQVIHPNQIAVVQEQFSPSPEKIKWAEELIAA
  FKEHQQLGKGAFTFQGSMIDMPLLKQAQNTVTLATSIKEK

• Sequence length: 340