Gene Gene information from NCBI Gene database.
Entrez ID 171392
Gene name Zinc finger protein 675
Gene symbol ZNF675
Synonyms (NCBI Gene)
TBZFTIZ
Chromosome 19
Chromosome location 19p12
miRNA miRNA information provided by mirtarbase database.
243
miRTarBase ID miRNA Experiments Reference
MIRT516693 hsa-miR-6758-5p HITS-CLIP 21572407
MIRT516692 hsa-miR-6856-5p HITS-CLIP 21572407
MIRT516691 hsa-miR-3976 HITS-CLIP 21572407
MIRT516690 hsa-miR-5011-5p HITS-CLIP 21572407
MIRT516689 hsa-miR-190a-3p HITS-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
23
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 11751921
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA
GO:0001960 Process Negative regulation of cytokine-mediated signaling pathway IDA 11751921
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
620090 30768 ENSG00000197372
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8TD23
Protein name Zinc finger protein 675 (TRAF6-binding zinc finger protein) (TRAF6-inhibitory zinc finger protein)
Protein function May be involved in transcriptional regulation. May play a role during osteoclast differentiation by modulating TRAF6 signaling activity.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01352 KRAB 3 44 KRAB box Family
PF00096 zf-C2H2 172 193 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 256 278 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 284 306 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 312 334 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 340 362 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 368 390 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 396 418 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 424 446 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 452 474 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 480 502 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 508 530 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 536 558 Zinc finger, C2H2 type Domain
Sequence
MGLLTFRDVAIEFSLEEWQCLDTAQRNLYKNVILENYRNLVFLGIAVSKQDLITCLEQEK
EPLTVKRHEMVNEPPVMCSHFAQEFWPEQNIKDSFEKVTLRRYEKCGNDNFQLKGCKSVD
ECKLHKGGYNGLNQCLPTMQSKMFQCDKYVKVFNKFSHSDRHKIKHMENKPFKCKECGRS
FCMLSHLTRHERN
YTKVNFCKCEECEKAVNQSSKLTKHKRIYTCEKLYKCQECDRTFNQF
SNLTEYKKDYAREKPYKCEECGKAFNQSSHLTTHKIIHTGEKPYKCEECGKAFNQFSNLT
THKKIH
TGEQPYICEECGKAFTQSSTLTTHKRIHTGEKPYKCEECGKAFNRSSKLTEHKN
IH
TGEQPYKCEECGKAFNRSSNLTEHRKIHTEEKPYKCKECGKAFKHSSALTTHKRIHTG
EKPYKCEECGKAFNRSSKLTEHKKLHTGKKPYKCEECGKAFIQSSKLTEHKKIHSGEIPY
KCEECGKAFKHSSSLTTHKRIH
TGEKPYKCEECGKAFSRSSKLTEHKIIHTGEKPYKCER
CDKAFNQSANLTKHKKIH
TGEKLQNWNV
Sequence length 568
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Generic Transcription Pathway
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
AMBLYOPIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
TESTICULAR CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
VASCULAR DEMENTIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Chronic Periodontitis Associate 25056994
★☆☆☆☆
Found in Text Mining only