Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	171019
Gene name Gene Name - the full gene name approved by the HGNC.	ADAM metallopeptidase with thrombospondin type 1 motif 19
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ADAMTS19
Synonyms (NCBI Gene) Gene synonyms aliases	CVDP2
Chromosome Chromosome number	5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	5q23.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin

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miRTarBase ID	miRNA	Experiments
MIRT766516	hsa-miR-103a	CLIP-seq
MIRT766517	hsa-miR-107	CLIP-seq
MIRT766518	hsa-miR-1184	CLIP-seq
MIRT766519	hsa-miR-1197	CLIP-seq
MIRT766520	hsa-miR-1205	CLIP-seq
MIRT766521	hsa-miR-1206	CLIP-seq
MIRT766522	hsa-miR-1244	CLIP-seq
MIRT766523	hsa-miR-125a-3p	CLIP-seq
MIRT766524	hsa-miR-1261	CLIP-seq
MIRT766525	hsa-miR-1286	CLIP-seq
MIRT766526	hsa-miR-129-3p	CLIP-seq
MIRT766527	hsa-miR-1297	CLIP-seq
MIRT766528	hsa-miR-1299	CLIP-seq
MIRT766529	hsa-miR-1303	CLIP-seq
MIRT766530	hsa-miR-154	CLIP-seq
MIRT766531	hsa-miR-181a	CLIP-seq
MIRT766532	hsa-miR-181b	CLIP-seq
MIRT766533	hsa-miR-181c	CLIP-seq
MIRT766534	hsa-miR-181d	CLIP-seq
MIRT766535	hsa-miR-185	CLIP-seq
MIRT766536	hsa-miR-1976	CLIP-seq
MIRT766537	hsa-miR-214	CLIP-seq
MIRT766538	hsa-miR-224	CLIP-seq
MIRT766539	hsa-miR-26a	CLIP-seq
MIRT766540	hsa-miR-26b	CLIP-seq
MIRT766541	hsa-miR-29a	CLIP-seq
MIRT766542	hsa-miR-29b	CLIP-seq
MIRT766543	hsa-miR-29c	CLIP-seq
MIRT766544	hsa-miR-3120-3p	CLIP-seq
MIRT766545	hsa-miR-3146	CLIP-seq
MIRT766546	hsa-miR-3150a-3p	CLIP-seq
MIRT766547	hsa-miR-3158-5p	CLIP-seq
MIRT766548	hsa-miR-3160-5p	CLIP-seq
MIRT766549	hsa-miR-3175	CLIP-seq
MIRT766550	hsa-miR-3613-3p	CLIP-seq
MIRT766551	hsa-miR-3619-5p	CLIP-seq
MIRT766552	hsa-miR-3651	CLIP-seq
MIRT766553	hsa-miR-3665	CLIP-seq
MIRT766554	hsa-miR-374a	CLIP-seq
MIRT766555	hsa-miR-374b	CLIP-seq
MIRT766556	hsa-miR-384	CLIP-seq
MIRT766557	hsa-miR-3929	CLIP-seq
MIRT766558	hsa-miR-3941	CLIP-seq
MIRT766559	hsa-miR-4251	CLIP-seq
MIRT766560	hsa-miR-4262	CLIP-seq
MIRT766561	hsa-miR-4306	CLIP-seq
MIRT766562	hsa-miR-4326	CLIP-seq
MIRT766563	hsa-miR-433	CLIP-seq
MIRT766564	hsa-miR-4419b	CLIP-seq
MIRT766565	hsa-miR-4436a	CLIP-seq
MIRT766566	hsa-miR-4465	CLIP-seq
MIRT766567	hsa-miR-4478	CLIP-seq
MIRT766568	hsa-miR-4639-5p	CLIP-seq
MIRT766569	hsa-miR-4643	CLIP-seq
MIRT766570	hsa-miR-4644	CLIP-seq
MIRT766571	hsa-miR-4652-3p	CLIP-seq
MIRT766572	hsa-miR-466	CLIP-seq
MIRT766573	hsa-miR-4666-5p	CLIP-seq
MIRT766574	hsa-miR-4668-5p	CLIP-seq
MIRT766575	hsa-miR-4672	CLIP-seq
MIRT766576	hsa-miR-4676-5p	CLIP-seq
MIRT766577	hsa-miR-4687-5p	CLIP-seq
MIRT766578	hsa-miR-4760-3p	CLIP-seq
MIRT766579	hsa-miR-4782-5p	CLIP-seq
MIRT766580	hsa-miR-4789-3p	CLIP-seq
MIRT766581	hsa-miR-491-5p	CLIP-seq
MIRT766582	hsa-miR-502-5p	CLIP-seq
MIRT766583	hsa-miR-516b	CLIP-seq
MIRT766584	hsa-miR-539	CLIP-seq
MIRT766585	hsa-miR-541	CLIP-seq
MIRT766586	hsa-miR-542-3p	CLIP-seq
MIRT766587	hsa-miR-544	CLIP-seq
MIRT766588	hsa-miR-575	CLIP-seq
MIRT766589	hsa-miR-654-5p	CLIP-seq
MIRT766590	hsa-miR-657	CLIP-seq
MIRT766591	hsa-miR-761	CLIP-seq
MIRT766592	hsa-miR-922	CLIP-seq
MIRT766593	hsa-miR-939	CLIP-seq
MIRT766522	hsa-miR-1244	CLIP-seq
MIRT766524	hsa-miR-1261	CLIP-seq
MIRT766528	hsa-miR-1299	CLIP-seq
MIRT766529	hsa-miR-1303	CLIP-seq
MIRT766531	hsa-miR-181a	CLIP-seq
MIRT766532	hsa-miR-181b	CLIP-seq
MIRT766533	hsa-miR-181c	CLIP-seq
MIRT766534	hsa-miR-181d	CLIP-seq
MIRT766535	hsa-miR-185	CLIP-seq
MIRT766538	hsa-miR-224	CLIP-seq
MIRT766541	hsa-miR-29a	CLIP-seq
MIRT766542	hsa-miR-29b	CLIP-seq
MIRT766543	hsa-miR-29c	CLIP-seq
MIRT1925815	hsa-miR-302f	CLIP-seq
MIRT1925816	hsa-miR-3119	CLIP-seq
MIRT1925817	hsa-miR-3140-3p	CLIP-seq
MIRT766545	hsa-miR-3146	CLIP-seq
MIRT766546	hsa-miR-3150a-3p	CLIP-seq
MIRT766549	hsa-miR-3175	CLIP-seq
MIRT1925818	hsa-miR-320e	CLIP-seq
MIRT1925819	hsa-miR-335	CLIP-seq
MIRT1925820	hsa-miR-369-3p	CLIP-seq
MIRT1925821	hsa-miR-421	CLIP-seq
MIRT766560	hsa-miR-4262	CLIP-seq
MIRT1925822	hsa-miR-4282	CLIP-seq
MIRT766561	hsa-miR-4306	CLIP-seq
MIRT1925823	hsa-miR-4480	CLIP-seq
MIRT1925824	hsa-miR-4503	CLIP-seq
MIRT766568	hsa-miR-4639-5p	CLIP-seq
MIRT766570	hsa-miR-4644	CLIP-seq
MIRT766572	hsa-miR-466	CLIP-seq
MIRT766576	hsa-miR-4676-5p	CLIP-seq
MIRT1925825	hsa-miR-4679	CLIP-seq
MIRT1925826	hsa-miR-4698	CLIP-seq
MIRT1925827	hsa-miR-4709-5p	CLIP-seq
MIRT766578	hsa-miR-4760-3p	CLIP-seq
MIRT1925828	hsa-miR-4764-5p	CLIP-seq
MIRT1925829	hsa-miR-4768-5p	CLIP-seq
MIRT766579	hsa-miR-4782-5p	CLIP-seq
MIRT766581	hsa-miR-491-5p	CLIP-seq
MIRT766583	hsa-miR-516b	CLIP-seq
MIRT766585	hsa-miR-541	CLIP-seq
MIRT1925830	hsa-miR-548ac	CLIP-seq
MIRT1925831	hsa-miR-548ae	CLIP-seq
MIRT1925832	hsa-miR-548aj	CLIP-seq
MIRT1925833	hsa-miR-548am	CLIP-seq
MIRT1925834	hsa-miR-548d-3p	CLIP-seq
MIRT1925835	hsa-miR-548x	CLIP-seq
MIRT1925836	hsa-miR-548z	CLIP-seq
MIRT766588	hsa-miR-575	CLIP-seq
MIRT1925837	hsa-miR-590-3p	CLIP-seq
MIRT1925838	hsa-miR-640	CLIP-seq
MIRT1925839	hsa-miR-649	CLIP-seq
MIRT766589	hsa-miR-654-5p	CLIP-seq
MIRT766593	hsa-miR-939	CLIP-seq
MIRT766521	hsa-miR-1206	CLIP-seq
MIRT766522	hsa-miR-1244	CLIP-seq
MIRT766524	hsa-miR-1261	CLIP-seq
MIRT766528	hsa-miR-1299	CLIP-seq
MIRT766531	hsa-miR-181a	CLIP-seq
MIRT766532	hsa-miR-181b	CLIP-seq
MIRT766533	hsa-miR-181c	CLIP-seq
MIRT766534	hsa-miR-181d	CLIP-seq
MIRT766538	hsa-miR-224	CLIP-seq
MIRT2167197	hsa-miR-3680	CLIP-seq
MIRT2167198	hsa-miR-3973	CLIP-seq
MIRT766560	hsa-miR-4262	CLIP-seq
MIRT766563	hsa-miR-433	CLIP-seq
MIRT2167199	hsa-miR-4426	CLIP-seq
MIRT2167200	hsa-miR-4647	CLIP-seq
MIRT2167201	hsa-miR-4662b	CLIP-seq
MIRT766576	hsa-miR-4676-5p	CLIP-seq
MIRT1925826	hsa-miR-4698	CLIP-seq
MIRT766579	hsa-miR-4782-5p	CLIP-seq
MIRT2167202	hsa-miR-4798-3p	CLIP-seq
MIRT766583	hsa-miR-516b	CLIP-seq
MIRT2167203	hsa-miR-520g	CLIP-seq
MIRT2167204	hsa-miR-520h	CLIP-seq
MIRT766588	hsa-miR-575	CLIP-seq
MIRT2167205	hsa-miR-599	CLIP-seq
MIRT766521	hsa-miR-1206	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0003180	Process	Aortic valve morphogenesis	IMP	31844321, 32323311
GO:0003183	Process	Mitral valve morphogenesis	IMP	31844321
GO:0003184	Process	Pulmonary valve morphogenesis	IMP	32323311
GO:0003186	Process	Tricuspid valve morphogenesis	IMP	32323311
GO:0004222	Function	Metalloendopeptidase activity	IBA
GO:0004222	Function	Metalloendopeptidase activity	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0006508	Process	Proteolysis	IBA
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0030198	Process	Extracellular matrix organization	IBA
GO:0030198	Process	Extracellular matrix organization	IEA
GO:0030199	Process	Collagen fibril organization	ISS	31844321
GO:0031012	Component	Extracellular matrix	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0060412	Process	Ventricular septum morphogenesis	IMP	32323311

MIM	HGNC	e!Ensembl
607513	17111	ENSG00000145808

Protein

UniProt ID

Q8TE59

Protein name

A disintegrin and metalloproteinase with thrombospondin motifs 19 (ADAM-TS 19) (ADAM-TS19) (ADAMTS-19) (EC 3.4.24.-)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01562	Pep_M12B_propep	146 → 273	Reprolysin family propeptide	Family
PF01421	Reprolysin	325 → 546	Reprolysin (M12B) family zinc metalloprotease	Domain
PF17771	ADAM_CR_2	559 → 626	ADAM cysteine-rich domain	Domain
PF00090	TSP_1	637 → 685	Thrombospondin type 1 domain	Domain
PF05986	ADAM_spacer1	790 → 900	ADAM-TS Spacer 1	Family
PF19030	TSP1_ADAMTS	919 → 976		Domain
PF19030	TSP1_ADAMTS	980 → 1036		Domain
PF19030	TSP1_ADAMTS	1040 → 1088		Domain
PF19030	TSP1_ADAMTS	1091 → 1143		Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in fetal lung, but not in any adult tissues examined. Expression was detected in an osteosarcoma cDNA library.

Sequence

MRLTHICCCCLLYQLGFLSNGIVSELQFAPDREEWEVVFPALWRREPVDPAGGSGGSADP
GWVRGVGGGGSARAQAAGSSREVRSVAPVPLEEPVEGRSESRLRPPPPSEGEEDEELESQ
ELPRGSSGAAALSPGAPASWQPPPPPQPPPSPPPAQHAEPDGDEVLLRIPAFSRDLYLLL
RRDGRFLAPRFAVEQRPNPGPGPTGAASAPQPPAPPDAGCFYTGAVLRHPGSLASFSTCG
GGLMGFIQLNEDFIFIEPLNDTMAITGHPHRVYRQKRSMEEKVTEKSALHSHYCGIISDK
GRPRSRKIAESGRGKRYSYKLPQEYNIETVVVADPAMVSYHGADAARRFILTILNMVFNL
FQHKSLSVQVNLRVIKLILLHETPPELYIGHHGEKMLESFCKWQHEEFGKKNDIHLEMST
NWGEDMTSVDAAILITRKDFCVHKDEPCDTVGIAYLSGMCSEKRKCIIAEDNGLNLAFTI
AHEMGHNMGINHDNDHPSCADGLHIMSGEWIKGQNLGDVSWSRCSKEDLERFLRSKASNC
LLQTNPQSVNSVMVPSKLPGMTYTADEQCQILFGPLASFCQEMQHVICTGLWCKVEGEKE
CRTKLDPPMDGTDCDLGKWCKAGECTSRTSAPEHLAGEWSLWSPCSRTCSAGISSRERKC
PGLDSEARDCNGPRKQYRICENPPCPAGLPGFRDWQCQAYSVRTSSPKHILQWQAVLDEE
KPCALFCSPVGKEQPILLSEKVMDGTSCGYQGLDICANGRCQKVGCDGLLGSLAREDHCG
VCNGNGKSCKIIKGDFNHTRGAGYVEVLVIPAGARRIKVVEEKPAHSYLALRDAGKQSIN
SDWKIEHSGAFNLAGTTVHYVRRGLWEKISAKGPTTAPLHLLVLLFQDQNYGLHYEYTIP
SDPLPENQSSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKY
LTKPEPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDC
IGPKPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRCTNPRKKCVLSTRPREAE
DCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHL
QPCNEKINVNTITSPRLAALTFKCLGDQWPVYCRVIREKNLCQDMRWYQRCCETCRDFYA
QKLQQKS

Sequence length

1207

Interactions

View interactions

	Reactome
			Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins

ADAMTS19 (ADAM metallopeptidase with thrombospondin type 1 motif 19)