Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	170689
Gene name	ADAM metallopeptidase with thrombospondin type 1 motif 15
Gene symbol	ADAMTS15
Synonyms (NCBI Gene)	DA12
Chromosome	11
Chromosome location	11q24.3
Summary	This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegri

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Show/Hide all (117)

miRTarBase ID	miRNA	Experiments	Reference
MIRT723925	hsa-miR-6858-3p	HITS-CLIP	19536157
MIRT723924	hsa-miR-208a-5p	HITS-CLIP	19536157
MIRT723923	hsa-miR-208b-5p	HITS-CLIP	19536157
MIRT723922	hsa-miR-6723-5p	HITS-CLIP	19536157
MIRT723921	hsa-miR-4540	HITS-CLIP	19536157
MIRT723920	hsa-miR-137	HITS-CLIP	19536157
MIRT723925	hsa-miR-6858-3p	HITS-CLIP	19536157
MIRT723924	hsa-miR-208a-5p	HITS-CLIP	19536157
MIRT723923	hsa-miR-208b-5p	HITS-CLIP	19536157
MIRT723922	hsa-miR-6723-5p	HITS-CLIP	19536157
MIRT723921	hsa-miR-4540	HITS-CLIP	19536157
MIRT723920	hsa-miR-137	HITS-CLIP	19536157
MIRT766397	hsa-miR-1204	CLIP-seq
MIRT766398	hsa-miR-122	CLIP-seq
MIRT766399	hsa-miR-1243	CLIP-seq
MIRT766400	hsa-miR-1262	CLIP-seq
MIRT766401	hsa-miR-1273	CLIP-seq
MIRT766402	hsa-miR-299-3p	CLIP-seq
MIRT766403	hsa-miR-3155	CLIP-seq
MIRT766404	hsa-miR-3155b	CLIP-seq
MIRT766405	hsa-miR-3180-5p	CLIP-seq
MIRT766406	hsa-miR-3197	CLIP-seq
MIRT766407	hsa-miR-320a	CLIP-seq
MIRT766408	hsa-miR-320b	CLIP-seq
MIRT766409	hsa-miR-320c	CLIP-seq
MIRT766410	hsa-miR-320d	CLIP-seq
MIRT766411	hsa-miR-3607-3p	CLIP-seq
MIRT766412	hsa-miR-3612	CLIP-seq
MIRT766413	hsa-miR-3654	CLIP-seq
MIRT766414	hsa-miR-3686	CLIP-seq
MIRT766415	hsa-miR-3913-3p	CLIP-seq
MIRT766416	hsa-miR-4279	CLIP-seq
MIRT766417	hsa-miR-4429	CLIP-seq
MIRT766418	hsa-miR-4443	CLIP-seq
MIRT766419	hsa-miR-4470	CLIP-seq
MIRT766420	hsa-miR-4649-3p	CLIP-seq
MIRT766421	hsa-miR-4652-3p	CLIP-seq
MIRT766422	hsa-miR-4685-5p	CLIP-seq
MIRT766423	hsa-miR-4690-3p	CLIP-seq
MIRT766424	hsa-miR-4701-3p	CLIP-seq
MIRT766425	hsa-miR-4707-5p	CLIP-seq
MIRT766426	hsa-miR-4755-3p	CLIP-seq
MIRT766427	hsa-miR-4764-5p	CLIP-seq
MIRT766428	hsa-miR-484	CLIP-seq
MIRT766429	hsa-miR-489	CLIP-seq
MIRT766430	hsa-miR-505	CLIP-seq
MIRT766431	hsa-miR-650	CLIP-seq
MIRT1925792	hsa-miR-1225-3p	CLIP-seq
MIRT1925793	hsa-miR-1233	CLIP-seq
MIRT1925794	hsa-miR-1913	CLIP-seq
MIRT1925795	hsa-miR-3157-5p	CLIP-seq
MIRT1925796	hsa-miR-324-3p	CLIP-seq
MIRT1925797	hsa-miR-331-3p	CLIP-seq
MIRT766411	hsa-miR-3607-3p	CLIP-seq
MIRT766414	hsa-miR-3686	CLIP-seq
MIRT1925798	hsa-miR-3909	CLIP-seq
MIRT1925799	hsa-miR-4505	CLIP-seq
MIRT1925800	hsa-miR-455-3p	CLIP-seq
MIRT766421	hsa-miR-4652-3p	CLIP-seq
MIRT1925801	hsa-miR-4672	CLIP-seq
MIRT1925802	hsa-miR-4691-3p	CLIP-seq
MIRT1925803	hsa-miR-4701-5p	CLIP-seq
MIRT1925804	hsa-miR-4711-5p	CLIP-seq
MIRT1925805	hsa-miR-4728-5p	CLIP-seq
MIRT1925806	hsa-miR-4789-5p	CLIP-seq
MIRT766430	hsa-miR-505	CLIP-seq
MIRT1925807	hsa-miR-588	CLIP-seq
MIRT2167133	hsa-miR-1226	CLIP-seq
MIRT2167134	hsa-miR-1324	CLIP-seq
MIRT2167135	hsa-miR-1915	CLIP-seq
MIRT2167136	hsa-miR-3175	CLIP-seq
MIRT2167137	hsa-miR-3184	CLIP-seq
MIRT766411	hsa-miR-3607-3p	CLIP-seq
MIRT2167138	hsa-miR-3617	CLIP-seq
MIRT766414	hsa-miR-3686	CLIP-seq
MIRT2167139	hsa-miR-423-5p	CLIP-seq
MIRT2167140	hsa-miR-4428	CLIP-seq
MIRT2167141	hsa-miR-4463	CLIP-seq
MIRT2167142	hsa-miR-4476	CLIP-seq
MIRT2167143	hsa-miR-4533	CLIP-seq
MIRT766421	hsa-miR-4652-3p	CLIP-seq
MIRT1925801	hsa-miR-4672	CLIP-seq
MIRT766423	hsa-miR-4690-3p	CLIP-seq
MIRT2167144	hsa-miR-4716-3p	CLIP-seq
MIRT2167145	hsa-miR-4723-5p	CLIP-seq
MIRT2167146	hsa-miR-4733-3p	CLIP-seq
MIRT2167147	hsa-miR-4796-5p	CLIP-seq
MIRT766430	hsa-miR-505	CLIP-seq
MIRT2167148	hsa-miR-641	CLIP-seq
MIRT766399	hsa-miR-1243	CLIP-seq
MIRT2383898	hsa-miR-128	CLIP-seq
MIRT2383899	hsa-miR-134	CLIP-seq
MIRT2383900	hsa-miR-3118	CLIP-seq
MIRT2383901	hsa-miR-3194-5p	CLIP-seq
MIRT766412	hsa-miR-3612	CLIP-seq
MIRT766413	hsa-miR-3654	CLIP-seq
MIRT766416	hsa-miR-4279	CLIP-seq
MIRT766418	hsa-miR-4443	CLIP-seq
MIRT2383902	hsa-miR-4727-5p	CLIP-seq
MIRT766431	hsa-miR-650	CLIP-seq
MIRT2435201	hsa-miR-193a-3p	CLIP-seq
MIRT2435202	hsa-miR-193b	CLIP-seq
MIRT2435203	hsa-miR-3158-5p	CLIP-seq
MIRT2435204	hsa-miR-892b	CLIP-seq
MIRT2469810	hsa-miR-1254	CLIP-seq
MIRT2469811	hsa-miR-3116	CLIP-seq
MIRT2469812	hsa-miR-4686	CLIP-seq
MIRT2383902	hsa-miR-4727-5p	CLIP-seq
MIRT2469813	hsa-miR-661	CLIP-seq
MIRT2469810	hsa-miR-1254	CLIP-seq
MIRT2469811	hsa-miR-3116	CLIP-seq
MIRT2674436	hsa-miR-4643	CLIP-seq
MIRT2469812	hsa-miR-4686	CLIP-seq
MIRT2383902	hsa-miR-4727-5p	CLIP-seq
MIRT2674437	hsa-miR-642b	CLIP-seq
MIRT2469813	hsa-miR-661	CLIP-seq
MIRT2674438	hsa-miR-7	CLIP-seq

Show/Hide all (23)

GO ID	Ontology	Definition	Evidence
GO:0004175	Function	Endopeptidase activity	IEA
GO:0004175	Function	Endopeptidase activity	ISS
GO:0004222	Function	Metalloendopeptidase activity	IBA
GO:0004222	Function	Metalloendopeptidase activity	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IEA
GO:0006508	Process	Proteolysis	IBA
GO:0006508	Process	Proteolysis	IEA
GO:0007520	Process	Myoblast fusion	IEA
GO:0007520	Process	Myoblast fusion	ISS
GO:0008201	Function	Heparin binding	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0009986	Component	Cell surface	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0022617	Process	Extracellular matrix disassembly	IEA
GO:0022617	Process	Extracellular matrix disassembly	ISS
GO:0030198	Process	Extracellular matrix organization	IBA
GO:0030198	Process	Extracellular matrix organization	IEA
GO:0031012	Component	Extracellular matrix	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0050840	Function	Extracellular matrix binding	IEA

MIM	HGNC	e!Ensembl
607509	16305	ENSG00000166106

Q8TE58

Protein name

A disintegrin and metalloproteinase with thrombospondin motifs 15 (ADAM-TS 15) (ADAM-TS15) (ADAMTS-15) (EC 3.4.24.-)

Protein function

Metalloprotease which has proteolytic activity against the proteoglycan VCAN, cleaving it at the 'Glu-1428-|-1429-Ala' site. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is require

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01562	Pep_M12B_propep	24 → 157	Reprolysin family propeptide	Family
PF01421	Reprolysin	218 → 427	Reprolysin (M12B) family zinc metalloprotease	Domain
PF17771	ADAM_CR_2	438 → 505	ADAM cysteine-rich domain	Domain
PF00090	TSP_1	520 → 570	Thrombospondin type 1 domain	Domain
PF05986	ADAM_spacer1	683 → 801	ADAM-TS Spacer 1	Family
PF19030	TSP1_ADAMTS	843 → 894		Domain
PF19030	TSP1_ADAMTS	897 → 950		Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in fetal liver and kidney, but not in any of the adult tissues examined. {ECO:0000269|PubMed:11867212}.

Sequence

MLLLGILTLAFAGRTAGGSEPEREVVVPIRLDPDINGRRYYWRGPEDSGDQGLIFQITAF
QEDFYLHLTPDAQFLAPAFSTEHLGVPLQGLTGGSSDLRRCFYSGDVNAEPDSFAAVSLC
GGLRGAFGYRGAEYVISPLPNASAPAAQRNSQGAHLLQRRGVPGGPSGDPTSRCGVASGW
NPAILRALDPYKPRRAGFGESRSRRRSGRAKRFVSIPRYVETLVVADESMVKFHGADLEH
YLLTLLATAARLYRHPSILNPINIVVVKVLLLRDRDSGPKVTGNAALTLRNFCAWQKKLN
KVSDKHPEYWDTAILFTRQDLCGATTCDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTA
HELGHVFNMPHDNVKVCEEVFGKLRANHMMSPTLIQIDRANPWSACSAAIITDFLDSGHG
DCLLDQPSKPISLPEDLPGASYTLSQQCELAFGVGSKPCPYMQYCTKLWCTGKAKGQMVC
QTRHFPWADGTSCGEGKLCLKGACVERHNLNKHRVDGSWAKWDPYGPCSRTCGGGVQLAR
RQCTNPTPANGGKYCEGVRVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLA
VAWVPKYSGVSPRDKCKLICRANGTGYFYVLAPKVVDGTLCSPDSTSVCVQGKCIKAGCD
GNLGSKKRFDKCGVCGGDNKSCKKVTGLFTKPMHGYNFVVAIPAGASSIDIRQRGYKGLI
GDDNYLALKNSQGKYLLNGHFVVSAVERDLVVKGSLLRYSGTGTAVESLQASRPILEPLT
VEVLSVGKMTPPRVRYSFYLPKEPREDKSSHPKDPRGPSVLHNSVLSLSNQVEQPDDRPP
ARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACGEPCPTWELS
AWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC

Sequence length

950

Interactions

View interactions

	Reactome
			Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Arthrogryposis, distal, type 12	Pathogenic; Likely pathogenic	rs2541520331, rs900442449, rs754451064, rs2541545118	RCV003337697 RCV003337698 RCV003337699 RCV003337700

Show/Hide Text Mining Associations (14)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Asthma	Inhibit	17088949
Axial Spondyloarthritis	Associate	25142923
Burkitt Lymphoma	Associate	36354023
Cartilage Diseases	Associate	18671975
Colitis Ulcerative	Associate	37798683
Diabetes Mellitus Type 2	Associate	36339449
Heart Failure	Associate	37073135
Intervertebral Disc Degeneration	Associate	19180493
Laryngeal Neoplasms	Associate	37875354
Lung Neoplasms	Associate	37073135
Neoplasms Adipose Tissue	Associate	37676424
Osteoarthritis	Inhibit	14730609
Spondylitis Ankylosing	Associate	25142923
Stomach Neoplasms	Associate	31151932

ADAMTS15 (ADAM metallopeptidase with thrombospondin type 1 motif 15)