SPIN3 (spindlin family member 3)

Gene

• Entrez ID: 169981
• Gene name: Spindlin family member 3
• Gene symbol: SPIN3
• Synonyms (NCBI Gene): SPIN-3, TDRD27, bA445O16.1
• Chromosome: X
• Chromosome location: Xp11.21

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT023137	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT645472	hsa-miR-6777-3p	HITS-CLIP	23824327
MIRT645471	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT645470	hsa-miR-4301	HITS-CLIP	23824327
MIRT645469	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT645468	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT645467	hsa-miR-27a-5p	HITS-CLIP	23824327
MIRT645466	hsa-miR-188-3p	HITS-CLIP	23824327
MIRT645464	hsa-miR-1260a	HITS-CLIP	23824327
MIRT645465	hsa-miR-1260b	HITS-CLIP	23824327
MIRT645463	hsa-miR-3156-3p	HITS-CLIP	23824327
MIRT645472	hsa-miR-6777-3p	HITS-CLIP	23824327
MIRT645471	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT645470	hsa-miR-4301	HITS-CLIP	23824327
MIRT645469	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT645468	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT645467	hsa-miR-27a-5p	HITS-CLIP	23824327
MIRT645466	hsa-miR-188-3p	HITS-CLIP	23824327
MIRT645464	hsa-miR-1260a	HITS-CLIP	23824327
MIRT645465	hsa-miR-1260b	HITS-CLIP	23824327
MIRT645463	hsa-miR-3156-3p	HITS-CLIP	23824327
MIRT1384280	hsa-miR-1179	CLIP-seq
MIRT1384281	hsa-miR-1262	CLIP-seq
MIRT1384282	hsa-miR-150	CLIP-seq
MIRT1384283	hsa-miR-2114	CLIP-seq
MIRT1384284	hsa-miR-2355-5p	CLIP-seq
MIRT1384285	hsa-miR-298	CLIP-seq
MIRT1384286	hsa-miR-3136-5p	CLIP-seq
MIRT1384287	hsa-miR-3145-5p	CLIP-seq
MIRT1384288	hsa-miR-3148	CLIP-seq
MIRT1384289	hsa-miR-3616-3p	CLIP-seq
MIRT1384290	hsa-miR-3661	CLIP-seq
MIRT1384291	hsa-miR-378	CLIP-seq
MIRT1384292	hsa-miR-378b	CLIP-seq
MIRT1384293	hsa-miR-378c	CLIP-seq
MIRT1384294	hsa-miR-378d	CLIP-seq
MIRT1384295	hsa-miR-378e	CLIP-seq
MIRT1384296	hsa-miR-378f	CLIP-seq
MIRT1384297	hsa-miR-378h	CLIP-seq
MIRT1384298	hsa-miR-378i	CLIP-seq
MIRT1384299	hsa-miR-422a	CLIP-seq
MIRT1384300	hsa-miR-4436b-3p	CLIP-seq
MIRT1384301	hsa-miR-4439	CLIP-seq
MIRT1384302	hsa-miR-4638-3p	CLIP-seq
MIRT1384303	hsa-miR-4662a-3p	CLIP-seq
MIRT1384304	hsa-miR-4668-5p	CLIP-seq
MIRT1384305	hsa-miR-4687-3p	CLIP-seq
MIRT1384306	hsa-miR-4701-3p	CLIP-seq
MIRT1384307	hsa-miR-4704-5p	CLIP-seq
MIRT1384308	hsa-miR-4712-3p	CLIP-seq
MIRT1384309	hsa-miR-508-5p	CLIP-seq
MIRT1384310	hsa-miR-554	CLIP-seq
MIRT1384311	hsa-miR-626	CLIP-seq
MIRT1384312	hsa-miR-631	CLIP-seq
MIRT1384313	hsa-miR-647	CLIP-seq
MIRT1384314	hsa-miR-943	CLIP-seq
MIRT2115060	hsa-miR-1202	CLIP-seq
MIRT1384283	hsa-miR-2114	CLIP-seq
MIRT2115061	hsa-miR-3194-5p	CLIP-seq
MIRT2115062	hsa-miR-361-5p	CLIP-seq
MIRT2115063	hsa-miR-3972	CLIP-seq
MIRT2115064	hsa-miR-4328	CLIP-seq
MIRT2115065	hsa-miR-450b-5p	CLIP-seq
MIRT2115066	hsa-miR-4691-3p	CLIP-seq
MIRT2115067	hsa-miR-4708-3p	CLIP-seq
MIRT2115068	hsa-miR-507	CLIP-seq
MIRT2115069	hsa-miR-557	CLIP-seq
MIRT2337702	hsa-miR-144	CLIP-seq
MIRT1384285	hsa-miR-298	CLIP-seq
MIRT2337703	hsa-miR-3127-3p	CLIP-seq
MIRT2337704	hsa-miR-3944-5p	CLIP-seq
MIRT2337705	hsa-miR-4270	CLIP-seq
MIRT2337706	hsa-miR-4323	CLIP-seq
MIRT2337707	hsa-miR-4441	CLIP-seq
MIRT2337708	hsa-miR-4676-5p	CLIP-seq
MIRT2337709	hsa-miR-4685-5p	CLIP-seq
MIRT2337710	hsa-miR-4704-3p	CLIP-seq
MIRT2337711	hsa-miR-4709-5p	CLIP-seq
MIRT2337712	hsa-miR-4717-3p	CLIP-seq
MIRT2337713	hsa-miR-4773	CLIP-seq
MIRT2337714	hsa-miR-4786-5p	CLIP-seq
MIRT2337715	hsa-miR-575	CLIP-seq
MIRT2337716	hsa-miR-627	CLIP-seq
MIRT2631255	hsa-miR-132	CLIP-seq
MIRT2631256	hsa-miR-194	CLIP-seq
MIRT2631257	hsa-miR-212	CLIP-seq
MIRT2631258	hsa-miR-3647-3p	CLIP-seq
MIRT2631259	hsa-miR-4490	CLIP-seq
MIRT2631260	hsa-miR-499-3p	CLIP-seq
MIRT2631261	hsa-miR-499a-3p	CLIP-seq
MIRT2631262	hsa-miR-582-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	29061846
GO:0005654	Component	Nucleoplasm	IBA	21873635
GO:0005829	Component	Cytosol	IBA	21873635
GO:0006355	Process	Regulation of transcription, DNA-templated	IBA	21873635
GO:0007276	Process	Gamete generation	IEA
GO:0035064	Function	Methylated histone binding	IBA	21873635
GO:0035064	Function	Methylated histone binding	IDA	29061846

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q5JUX0
• Protein name: Spindlin-3 (Spindlin-like protein 3) (SPIN-3)
• Protein function: Exhibits H3K4me3-binding activity.
• PDB: 5A1H
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02513	Spin-Ssty	50 → 99	Spin/Ssty Family	Repeat
  PF02513	Spin-Ssty	129 → 178	Spin/Ssty Family	Repeat
  PF02513	Spin-Ssty	210 → 255	Spin/Ssty Family	Repeat

• Sequence:

  MKTPFGKAAAGQRSRTGAGHGSVSVTMIKRKAAHKKHRSRPTSQPRGNIVGCRIQHGWKD
  GDEPLTQWKGTVLDQVPVNPSLYLIKYDGFDCVYGLELHRDERVSSLEVLPNRVASSRIS
  DTHLAEIMVGKAVEHIFETEEGSKNEWRGMVLAQAPVMNTWFYITYEKDPVLYMYQLLDD
  YKDGDLRILQDSNDSPLAEREPGEVIDSLVGKQVEYAKDDGSKRTGMVIHQVEAKPSVYF
  IKFDDDFHIYVYDLVKTS

• Sequence length: 258

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Colorectal cancer	Colorectal Carcinoma	rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800, rs63750198, rs63751109, rs863223312, rs63750710, rs63751615, rs63750206, rs63750781, rs63750899, rs63750691, rs63750217, rs121912965, rs63749939, rs63751194, rs63750693, rs63750540, rs63751221, rs193922370, rs80359596, rs397514632, rs483352909, rs200495564, rs397514684, rs397516436, rs398122386, rs79512956, rs74953290, rs587779001, rs63750677, rs63749837, rs267607816, rs63751715, rs267607819, rs267607815, rs267607822, rs63749906, rs587778883, rs63750472, rs63751012, rs63750715, rs63750580, rs267607706, rs267607709, rs267607710, rs587778894, rs63750749, rs63750483, rs63751015, rs63751153, rs63751094, rs63751118, rs63750316, rs63749981, rs587778906, rs267607821, rs587778908, rs63750020, rs587778909, rs63750713, rs267607825, rs63751592, rs281864936, rs587778913, rs587778914, rs63749795, rs63750855, rs63749916, rs63749923, rs63751472, rs63751689, rs267607832, rs267607837, rs267607836, rs587778923, rs63750028, rs587778928, rs587778929, rs587778930, rs63751277, rs587778933, rs267607842, rs267607843, rs63750192, rs587778934, rs63750193, rs587778937, rs587778938, rs267607845, rs63751244, rs63751393, rs63751460, rs267607849, rs267607853, rs267607856, rs267607850, rs63751657, rs267607854, rs267607852, rs587778942, rs63750309, rs63750587, rs63749863, rs63751486, rs63750016, rs63749868, rs63750375, rs63750035, rs63750604, rs63750386, rs63750150, rs63750486, rs63751428, rs267607866, rs63749986, rs63751594, rs63750152, rs63750850, rs267607867, rs267607868, rs63751632, rs267607871, rs63751892, rs587778956, rs63750469, rs587778958, rs63749792, rs267607875, rs63751255, rs281864938, rs63751202, rs63750726, rs63751310, rs63749900, rs587778964, rs267607879, rs267607878, rs587778966, rs267607883, rs267607887, rs63750061, rs63750663, rs587778968, rs587778971, rs63750809, rs63749867, rs63750864, rs587778972, rs63751275, rs267607718, rs267607722, rs63750769, rs267607717, rs587778973, rs267607716, rs267607720, rs63749995, rs63750859, rs587778975, rs63750114, rs587778976, rs63750603, rs267607889, rs267607723, rs63750561, rs63750499, rs63751642, rs63751022, rs587778981, rs63750971, rs267607898, rs267607906, rs267607903, rs587778989, rs587778992, rs267607894, rs267607901, rs267607892, rs63750437, rs587778997, rs587778998, rs63750005, rs63750641, rs63751421, rs11541859, rs63750266, rs111052004, rs267607726, rs267607727, rs63750453, rs267607734, rs267607735, rs63751665, rs267607736, rs267607732, rs63749816, rs63750539, rs267607739, rs587779006, rs587779008, rs267607745, rs267607742, rs63751595, rs267607743, rs587779010, rs587779012, rs63750057, rs63749818, rs63751124, rs587779014, rs587779015, rs63749820, rs63751302, rs267607750, rs267607751, rs267607749, rs63750891, rs63749959, rs63749804, rs267607765, rs267607760, rs587779021, rs267607759, rs63750515, rs587779023, rs63751021, rs63751480, rs267607772, rs267607773, rs587779024, rs63751653, rs587779027, rs267607767, rs587779029, rs63750706, rs63750385, rs267607774, rs267607778, rs267607780, rs587779034, rs63751711, rs267607784, rs587779035, rs63750823, rs63750822, rs267607787, rs63750303, rs63749839, rs63749827, rs267607789, rs267607790, rs267607791, rs267607786, rs267607771, rs267607795, rs267607794, rs267607788, rs267607799, rs267607801, rs587779045, rs63750034, rs587779047, rs63750216, rs63751707, rs63751598, rs267607803, rs267607777, rs63750144, rs267607805, rs63750547, rs63750489, rs63750993, rs587779054, rs63751259, rs63749926, rs63750796, rs587779058, rs63750745, rs63750582, rs180177084, rs587779866, rs200389141, rs587779950, rs587780104, rs587780183, rs587778536, rs587780683, rs587781554, rs267607712, rs587777627, rs587783057, rs730881734, rs41542214, rs730881273, rs786203456, rs786201990, rs786202767, rs748005072, rs786204317, rs786204318, rs797045117, rs63750549, rs863225383, rs863225384, rs863225373, rs863225376, rs863225377, rs863225378, rs863225379, rs863225380, rs863225381, rs63750059, rs267607823, rs864622457, rs869312767, rs869312753, rs876661059, rs876658915, rs876658923, rs876660860, rs876660822, rs876660458, rs876660214, rs876658657, rs876658247, rs876659226, rs876658821, rs876660589, rs876659068, rs876659681, rs876659608, rs878853794, rs878853778, rs878853780, rs878853785, rs886039423, rs886039424, rs1057517543, rs1057517541, rs756843954, rs1057517617, rs1057517558, rs1057519256, rs1060500689, rs764085979, rs1060500707, rs1060500699, rs1060500706, rs1060500703, rs1064795341, rs1064793607, rs1064794348, rs1064795441, rs1064794373, rs1064793172, rs1064794122, rs1064795515, rs1064794331, rs63750978, rs1114167435, rs1553641362, rs63751448, rs1553648029, rs1553648058, rs587778903, rs1553653237, rs1553664353, rs267607744, rs1553647995, rs1553648047, rs1553653084, rs1553663750, rs1553664436, rs1553488015, rs1553637293, rs63750310, rs63750443, rs63751596, rs1553646681, rs550890395, rs1064796057, rs1553642079, rs1553648023, rs587782087, rs746536721, rs1553653037, rs1248251121, rs1553646602, rs1434898623, rs1553665683, rs1553648068, rs1553645331, rs1553644123, rs1553658246, rs1553651299, rs1553648149, rs1553663159, rs1302248679, rs1553664119, rs1553658009, rs1553665977, rs1416171624, rs1553663834, rs1553664617, rs1553664702, rs1553647969, rs1553648040, rs1437454428, rs1553641273, rs63751101, rs1553646764, rs1553648225, rs1554082118, rs1553648201, rs1553638868, rs1553665866, rs376736188, rs1553642707, rs1553645226, rs1553652883, rs63751435, rs1553653115, rs1553653195, rs63750300, rs1553662622, rs1553658104, rs1553648220, rs1559544064, rs63750584, rs267608083, rs1559551570, rs1559575107, rs1559553501, rs1565986506, rs1559524405, rs1559553492, rs1559554339, rs1559588540, rs1559558071, rs761329565, rs1559521039, rs1559574795, rs1567221417, rs1559578422, rs1481129490, rs1570714352, rs779783209, rs1575376830, rs1575469070, rs1575537843, rs1575620443, rs1575621506, rs587779022, rs1575414904, rs1575449093, rs1575469505, rs1575536254, rs1575537933, rs1575632112, rs1575639851, rs1575441094, rs1575449402, rs267607831, rs2081922847, rs2083403132, rs2085415927, rs2085469647, rs2043913790, rs147542208	22532847

Unknown
Disease term	Disease name	Evidence	References	Source
Neuroticism	Neuroticism			GWAS
Systemic lupus erythematosus	Systemic lupus erythematosus			GWAS
Hypogonadism	Hypogonadism			GWAS