ZNF596 (zinc finger protein 596)

Gene

• Entrez ID: 169270
• Gene name: Zinc finger protein 596
• Gene symbol: ZNF596
• Synonyms (NCBI Gene): -
• Chromosome: 8
• Chromosome location: 8p23.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1531365	hsa-miR-544	CLIP-seq
MIRT1531366	hsa-miR-600	CLIP-seq
MIRT1531367	hsa-miR-329	CLIP-seq
MIRT1531368	hsa-miR-362-3p	CLIP-seq
MIRT1531369	hsa-miR-377	CLIP-seq
MIRT1531370	hsa-miR-3910	CLIP-seq
MIRT1531371	hsa-miR-4269	CLIP-seq
MIRT1531372	hsa-miR-5096	CLIP-seq
MIRT1531373	hsa-miR-515-5p	CLIP-seq
MIRT1531374	hsa-miR-545	CLIP-seq
MIRT1531375	hsa-miR-548an	CLIP-seq
MIRT1531376	hsa-miR-578	CLIP-seq
MIRT1531377	hsa-miR-654-3p	CLIP-seq
MIRT2464417	hsa-miR-150	CLIP-seq
MIRT2464418	hsa-miR-4713-5p	CLIP-seq
MIRT2464419	hsa-miR-4729	CLIP-seq
MIRT2464420	hsa-miR-532-3p	CLIP-seq
MIRT2464417	hsa-miR-150	CLIP-seq
MIRT2464418	hsa-miR-4713-5p	CLIP-seq
MIRT2464419	hsa-miR-4729	CLIP-seq
MIRT2464420	hsa-miR-532-3p	CLIP-seq
MIRT2464417	hsa-miR-150	CLIP-seq
MIRT2464418	hsa-miR-4713-5p	CLIP-seq
MIRT2464419	hsa-miR-4729	CLIP-seq
MIRT2464420	hsa-miR-532-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q8TC21
• Protein name: Zinc finger protein 596
• Protein function: May be involved in transcriptional regulation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01352	KRAB	6 → 47	KRAB box	Family
  PF00096	zf-C2H2	195 → 217	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	225 → 245	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	251 → 273	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	280 → 301	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	307 → 329	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	335 → 357	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	365 → 385	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	391 → 413	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	419 → 441	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	447 → 469	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	475 → 497	Zinc finger, C2H2 type	Domain

• Sequence:

  MPSPDSMTFEDIIVDFTQEEWALLDTSQRKLFQDVMLENISHLVSIGKQLCKSVVLSQLE
  QVEKLSTQRISLLQGREVGIKHQEIPFIQHIYQKGTSTISTMRSHTQEDPFLCNDLGEDF
  TQHIALTQNVITYMRTKHFVSKKFGKIFSDWLSFNQHKEIHTKCKSYGSHLFDYAFIQNS
  ALRPHSVTHTREITLECRVCGKTFSKNSNLRRHEMIHTGEKPHGCHLCGKAFTHCSDLRK
  HERTHTGEKPYGCHLCGKAFSKSSNLRRHEMIHTREKAQICHLCGKAFTHCSDLRKHERT
  HLGDKPYGCLLCGKAFSKCSYLRQHERTHNGEKPYECHLCGKAFSHCSHLRQHERSHNGE
  KPHGCHLCGKAFTESSVLKRHERIHTGEKPYECHVCGKAFTESSDLRRHERTHTGEKPYE
  CHLCGKAFNHSSVLRRHERTHTGEKPYECNICGKAFNRSYNFRLHRRVHTGEKPYVCPLC
  GKAFSKFFNLRQHERTHTKKAMNM

• Sequence length: 504

Pathways

Reactome:

Generic Transcription Pathway

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
BREAST CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESTROGEN-RECEPTOR NEGATIVE BREAST CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Obesity	Associate	27421018	★☆☆☆☆ Found in Text Mining only