DACT2 (dishevelled binding antagonist of beta catenin 2)

Gene

• Entrez ID: 168002
• Gene name: Dishevelled binding antagonist of beta catenin 2
• Gene symbol: DACT2
• Synonyms (NCBI Gene): C6orf116, DAPPER2, DPR2, bA503C24.7
• Chromosome: 6
• Chromosome location: 6q27

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022027	hsa-miR-128-3p	Microarray	17612493
MIRT041542	hsa-miR-193b-3p	CLASH	23622248
MIRT922674	hsa-miR-103a	CLIP-seq
MIRT922675	hsa-miR-107	CLIP-seq
MIRT922676	hsa-miR-214	CLIP-seq
MIRT922677	hsa-miR-3619-5p	CLIP-seq
MIRT922678	hsa-miR-3944-5p	CLIP-seq
MIRT922679	hsa-miR-4690-5p	CLIP-seq
MIRT922680	hsa-miR-4753-3p	CLIP-seq
MIRT922681	hsa-miR-761	CLIP-seq
MIRT922682	hsa-miR-942	CLIP-seq
MIRT2386695	hsa-miR-4271	CLIP-seq
MIRT2386696	hsa-miR-4725-3p	CLIP-seq
MIRT2386697	hsa-miR-4786-3p	CLIP-seq
MIRT2386698	hsa-miR-671-5p	CLIP-seq
MIRT2465171	hsa-miR-3180-5p	CLIP-seq
MIRT2465172	hsa-miR-4267	CLIP-seq
MIRT2465173	hsa-miR-888	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
NKX2-5	Repression	19479054

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003382	Process	Epithelial cell morphogenesis	ISS
GO:0005080	Function	Protein kinase C binding	ISS
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0007162	Process	Negative regulation of cell adhesion	ISS
GO:0008013	Function	Beta-catenin binding	ISS
GO:0008134	Function	Transcription factor binding	ISS
GO:0043588	Process	Skin development	ISS
GO:0051018	Function	Protein kinase A binding	ISS
GO:0070097	Function	Delta-catenin binding	ISS
GO:0072061	Process	Inner medullary collecting duct development	ISS
GO:1900108	Process	Negative regulation of nodal signaling pathway	IBA	21873635
GO:1900108	Process	Negative regulation of nodal signaling pathway	ISS

Other IDs

• MIM: 608966
• HGNC: 21231
• e!Ensembl: ENSG00000164488

Protein

• UniProt ID: Q5SW24
• Protein name: Dapper homolog 2 (Dapper antagonist of catenin 2)
• Protein function: Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved in control of th
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15268	Dapper	20 → 774	Dapper	Family

• Sequence:

  MWTPGGPPGSAGWDRRRLGARLRAAFAGLQELQGLRATQQERVRGALALQPPPAPAAPCG
  PHGLHGPEQQLEAALAALQEQLSRLRQQDIGLKTHLDQLDLQISKLQLDVGTASGEALDS
  DSRPSSGFYEMSDGGSCSLSTSCASVCSDHISPSLGSLLPVAQAHKARPSMGDWRPRSVD
  ETTVPAWRPQATEEGARPPGSVEDAGQPWGTFWPRPVSTGDLDRALPADTGLQKASADAE
  LLGLLCQGVDIPLHVPDPKYRQDLVSQGGREVYPYPSPLHAVALQSPLFVLTKETPQRGG
  PSFPRESPRGPAGLNTIQTGPVLEAGPARARAYIDRLLHLWGRETPAKGSEGEQGPLRHA
  ASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRGAGRGGPQQQGYMPLEGPQQSGSL
  PEEGSKPSNSCVLRETMVQASPSSKAQQTPSAQDYGRGNIISPSRMLDKSPSPASGHFAH
  PSFAASLKMGPPKSKAEKIKRSPMDKVLRFARQPLLLLDRPEGAHAAPQPSLEWDPAHWP
  TGRGGLQRRPALAWEAPGRSCSESTLYPMPVLVPLAVAPQESHRTSAQALFPFEASLLTS
  VARRKHRRWQSTVEISARARLASCPESNLGPPRPVARRAGGPLARGRPSLVRQDAYTRSD
  SEPSKHSAECDPRFPSVIPETSEGESSDHTTNRFGDRESSSSDEEGGAQSRDCDLALGYV
  AAGHAELAWTQEAPVSSGPLLSPVPKLCRIKASKALKKKIRRFQPTALKVMTMV

• Sequence length: 774