Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1676
Gene name Gene Name - the full gene name approved by the HGNC.
DNA fragmentation factor subunit alpha
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
DFFA
Synonyms (NCBI Gene) Gene synonyms aliases
DFF-45, DFF1, ICAD
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p36.22
Summary Summary of gene provided in NCBI Entrez Gene.
Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal uni
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT026094 hsa-miR-196a-5p Sequencing 20371350
MIRT052026 hsa-let-7b-5p CLASH 23622248
MIRT633058 hsa-miR-6796-3p HITS-CLIP 23824327
MIRT230668 hsa-miR-216a-5p HITS-CLIP 23824327
MIRT645259 hsa-miR-5693 HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin IDA 19882353
GO:0005515 Function Protein binding IPI 19882353, 22727028, 25277244, 32296183
GO:0005634 Component Nucleus IDA 15572351
GO:0005654 Component Nucleoplasm TAS
GO:0005829 Component Cytosol IDA 9108473, 22253444
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
601882 2772 ENSG00000160049
Protein
UniProt ID O00273
Protein name DNA fragmentation factor subunit alpha (DNA fragmentation factor 45 kDa subunit) (DFF-45) (Inhibitor of CAD) (ICAD)
Protein function Inhibitor of the caspase-activated DNase (DFF40).
PDB 1IBX , 1IYR , 1KOY
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02017 CIDE-N 18 95 CIDE-N domain Domain
PF09033 DFF-C 100 264 DNA Fragmentation factor 45kDa, C terminal domain Domain
Sequence
Sequence length 331
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Apoptosis   Apoptosis induced DNA fragmentation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Mental depression Major Depressive Disorder 30219690 ClinVar
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Stimulate 23625600
Brain Neoplasms Associate 11473733, 29110584
Carcinogenesis Associate 23625600
Carcinoma Hepatocellular Associate 32955083
Cardiomyopathies Associate 12181128
Cardiomyopathy Dilated Associate 12181128
Cholecystitis Associate 23625600
Colorectal Neoplasms Associate 20687965
Corneal Dystrophy Crystalline of Schnyder Associate 16163269
Esophageal Neoplasms Inhibit 12467059