DEFA6 (defensin alpha 6)

Gene
Gene Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1671
Gene name Gene Name - the full gene name approved by the HGNC.
Defensin alpha 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
DEFA6
Synonyms (NCBI Gene) Gene synonyms aliases
DEF6, HD-6
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8p23.1
Summary Summary of gene provided in NCBI Entrez Gene.
Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract,
Transcription factors
Gene Transcription factors Gene ontology Other IDs Protein Pathways
Show/Hide all(1)
Transcription factor Regulation Reference
TCF4 Unknown 19221600
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Transcription factors Gene ontology Other IDs Protein Pathways
Show/Hide all(15)
GO ID Ontology Definition Evidence Reference
GO:0002227 Process Innate immune response in mucosa IBA 21873635
GO:0005515 Function Protein binding IPI 25416956, 31515488, 32296183
GO:0005576 Component Extracellular region TAS
GO:0005615 Component Extracellular space IBA 21873635
GO:0005796 Component Golgi lumen TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Transcription factors Gene ontology Other IDs Protein Pathways
MIM HGNC e!Ensembl
600471 2765 ENSG00000164822
Protein
Gene Transcription factors Gene ontology Other IDs Protein Pathways
UniProt ID Q01524
Protein name Defensin-6 (Defensin, alpha 6)
Protein function Host-defense peptide that contributes to intestinal innate immunity and mediates homeostasis at mucosal surfaces by forming higher-order oligomers that capture bacteria and prevent microbial invasion of the epithelium (PubMed:15616305, PubMed:17
PDB 1ZMQ , 3QTE
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00879 Defensin_propep 1 → 58 Defensin propeptide Family
PF00323 Defensin_1 72 → 99 Mammalian defensin Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in Paneth cells of the small intestine (at protein level). {ECO:0000269|PubMed:27076903, ECO:0000269|PubMed:8417977, ECO:0000269|PubMed:8626737}.
Sequence
Sequence length 100
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Transcription factors Gene ontology Other IDs Protein Pathways
  KEGG   Reactome
  NOD-like receptor signaling pathway
Staphylococcus aureus infection
Transcriptional misregulation in cancer 		  Defensins
Alpha-defensins