DEFA3 (defensin alpha 3)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1668
Gene name Gene Name - the full gene name approved by the HGNC.
Defensin alpha 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
DEFA3
Synonyms (NCBI Gene) Gene synonyms aliases
DEF3, HNP-3, HNP3, HP-3, HP3
Disease Acronyms (UniProt) Disease acronyms from UniProt database
HP3
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8p23.1
Summary Summary of gene provided in NCBI Entrez Gene.
Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract,
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Show/Hide all(1)
miRTarBase ID miRNA Experiments Reference
MIRT028746 hsa-miR-26b-5p Microarray 19088304
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Show/Hide all(1)
Transcription factor Regulation Reference
CEBPA Unknown 10706719
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Show/Hide all(26)
GO ID Ontology Definition Evidence Reference
GO:0002227 Process Innate immune response in mucosa IBA 21873635
GO:0002227 Process Innate immune response in mucosa IDA 12860195
GO:0003674 Function Molecular_function ND
GO:0005576 Component Extracellular region TAS
GO:0005615 Component Extracellular space HDA 16502470
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
MIM HGNC e!Ensembl
604522 2762 ENSG00000239839
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
UniProt ID P59666
Protein name Neutrophil defensin 3 (Defensin, alpha 3) (HNP-3) (HP-3) (HP3) [Cleaved into: HP 3-56; Neutrophil defensin 2 (HNP-2) (HP-2) (HP2)]
Protein function Effector molecule of the innate immune system that acts via antibiotic-like properties against a broad array of infectious agents including bacteria, fungi, and viruses (PubMed:15616305, PubMed:15772169, PubMed:17142766). Possesses the ability t
PDB 1DFN , 1ZMH , 1ZMI , 1ZMK , 2PM4 , 2PM5
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00879 Defensin_propep 1 → 52 Defensin propeptide Family
PF00323 Defensin_1 66 → 94 Mammalian defensin Domain
Sequence
Sequence length 94
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
  KEGG   Reactome
  NOD-like receptor signaling pathway
Staphylococcus aureus infection
Transcriptional misregulation in cancer 		  Defensins
Alpha-defensins