DCLK2 (doublecortin like kinase 2)

Gene

• Entrez ID: 166614
• Gene name: Doublecortin like kinase 2
• Gene symbol: DCLK2
• Synonyms (NCBI Gene): CL2, CLICK-II, CLICK2, CLIK2, DCAMKL2, DCDC3, DCDC3B, DCK2
• Chromosome: 4
• Chromosome location: 4q31.23-q31.3
• Summary: This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/t

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT518271	hsa-miR-4644	PAR-CLIP	23446348
MIRT518271	hsa-miR-4644	PAR-CLIP	27292025
MIRT518271	hsa-miR-4644	PAR-CLIP	23446348
MIRT926179	hsa-miR-137	CLIP-seq
MIRT926180	hsa-miR-25	CLIP-seq
MIRT926181	hsa-miR-32	CLIP-seq
MIRT926182	hsa-miR-363	CLIP-seq
MIRT926183	hsa-miR-3665	CLIP-seq
MIRT926184	hsa-miR-367	CLIP-seq
MIRT926185	hsa-miR-561	CLIP-seq
MIRT926186	hsa-miR-657	CLIP-seq
MIRT926187	hsa-miR-92a	CLIP-seq
MIRT926188	hsa-miR-92b	CLIP-seq
MIRT1974380	hsa-miR-127-5p	CLIP-seq
MIRT1974381	hsa-miR-3065-5p	CLIP-seq
MIRT1974382	hsa-miR-3607-3p	CLIP-seq
MIRT1974383	hsa-miR-3662	CLIP-seq
MIRT1974384	hsa-miR-495	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000226	Process	Microtubule cytoskeleton organization	IBA
GO:0000226	Process	Microtubule cytoskeleton organization	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	32707033, 33199366, 36931259
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0007417	Process	Central nervous system development	IEA
GO:0008017	Function	Microtubule binding	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0021766	Process	Hippocampus development	IEA
GO:0021860	Process	Pyramidal neuron development	IEA
GO:0034504	Process	Protein localization to nucleus	IBA
GO:0034504	Process	Protein localization to nucleus	IEA
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0106310	Function	Protein serine kinase activity	IEA
GO:1900181	Process	Negative regulation of protein localization to nucleus	IEA

Other IDs

• MIM: 613166
• HGNC: 19002
• e!Ensembl: ENSG00000170390

Protein

• UniProt ID: Q8N568
• Protein name: Serine/threonine-protein kinase DCLK2 (EC 2.7.11.1) (CaMK-like CREB regulatory kinase 2) (CL2) (CLICK-II) (CLICK2) (Doublecortin domain-containing protein 3B) (Doublecortin-like and CAM kinase-like 2) (Doublecortin-like kinase 2)
• Protein function: Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactiva
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03607	DCX	90 → 152	Doublecortin	Family
  PF03607	DCX	215 → 274	Doublecortin	Family
  PF00069	Pkinase	394 → 651	Protein kinase domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in the brain, heart and eyes. {ECO:0000269|PubMed:18075264}.
• Sequence:

  MASTRSIELEHFEERDKRPRPGSRRGAPSSSGGSSSSGPKGNGLIPSPAHSAHCSFYRTR
  TLQALSSEKKAKKARFYRNGDRYFKGLVFAISSDRFRSFDALLIELTRSLSDNVNLPQGV
  RTIYTIDGSRKVTSLDELLEGESYVCASNEPFRKVDYTKNINPNWSVNIKGGTSRALAAA
  SSVKSEVKESKDFIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSG
  VVKRLCTLDGKQVTCLQDFFGDDDVFIACGPEKFRYAQDDFVLDHSECRVLKSSYSRSSA
  VKYSGSKSPGPSRRSKSPASVNGTPSSQLSTPKSTKSSSSSPTSPGSFRGLKQISAHGRS
  SSNVNGGPELDRCISPEGVNGNRCSESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEF
  ALKIIDKAKCCGKEHLIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDA
  ITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGL
  ATVVEGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQED
  LFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQENN
  MQAEVTGKLKQHFNNALPKQNSTTTGVSVIMNTALDKEGQIFCSKHCQDSGRPGMEPISP
  VPPSVEEIPVPGEAVPAPTPPESPTPHPPPAAPGGERAGTWRRHRD

• Sequence length: 766