DCLK2 (doublecortin like kinase 2)

Gene
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
166614
Gene name Gene Name - the full gene name approved by the HGNC.
Doublecortin like kinase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
DCLK2
Synonyms (NCBI Gene) Gene synonyms aliases
CL2, CLICK-II, CLICK2, CLIK2, DCAMKL2, DCDC3, DCDC3B, DCK2
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q31.23-q31.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/t
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(18)
miRTarBase ID miRNA Experiments Reference
MIRT518271 hsa-miR-4644 PAR-CLIP 23446348
MIRT518271 hsa-miR-4644 PAR-CLIP 27292025
MIRT518271 hsa-miR-4644 PAR-CLIP 23446348
MIRT926179 hsa-miR-137 CLIP-seq
MIRT926180 hsa-miR-25 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(8)
GO ID Ontology Definition Evidence Reference
GO:0000226 Process Microtubule cytoskeleton organization IBA 21873635
GO:0005524 Function ATP binding IEA
GO:0005737 Component Cytoplasm IEA
GO:0005856 Component Cytoskeleton IEA
GO:0006468 Process Protein phosphorylation IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
613166 19002 ENSG00000170390
Protein
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Q8N568
Protein name Serine/threonine-protein kinase DCLK2 (EC 2.7.11.1) (CaMK-like CREB regulatory kinase 2) (CL2) (CLICK-II) (CLICK2) (Doublecortin domain-containing protein 3B) (Doublecortin-like and CAM kinase-like 2) (Doublecortin-like kinase 2)
Protein function Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactiva
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03607 DCX 90 → 152 Doublecortin Family
PF03607 DCX 215 → 274 Doublecortin Family
PF00069 Pkinase 394 → 651 Protein kinase domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in the brain, heart and eyes. {ECO:0000269|PubMed:18075264}.
Sequence 
MASTRSIELEHFEERDKRPRPGSRRGAPSSSGGSSSSGPKGNGLIPSPAHSAHCSFYRTR
TLQALSSEKKAKKARFYRNGDRYFKGLVFAISSDRFRSFDALLIELTRSLSDNVNLPQGV
RTIYTIDGSRKVTSLDELLEGESYVCASNEPFRKVDYTKNINPNWSVNIKGGTSRALAAA
SSVKSEVKESKDFIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSG
VVKRLCTLDGKQVTCLQDFFGDDDVFIACGPEKFRYAQDDFVLDHSECRVLKSSYSRSSA
VKYSGSKSPGPSRRSKSPASVNGTPSSQLSTPKSTKSSSSSPTSPGSFRGLKQISAHGRS
SSNVNGGPELDRCISPEGVNGNRCSESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEF
ALKIIDKAKCCGKEHLIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDA
ITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGL
ATVVEGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQED
LFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQENN
MQAEVTGKLKQHFNNALPKQNSTTTGVSVIMNTALDKEGQIFCSKHCQDSGRPGMEPISP
VPPSVEEIPVPGEAVPAPTPPESPTPHPPPAAPGGERAGTWRRHRD
Sequence length 766
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Coronary artery disease Coronary Artery Disease rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs1555800701, rs1215189537 26708285
Show/Hide Unknown Diseases (4)
Unknown
Disease term Disease name Evidence References Source
Mental depression Major Depressive Disorder 27622933 ClinVar
Metabolic Syndrome Metabolic Syndrome GWAS
Myocardial Infarction Myocardial Infarction GWAS
Breast Cancer Breast Cancer Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients GWAS, CBGDA
Show/Hide Text Mining Associations (5)
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Renal Cell Associate 38211588
Ectodermal Dysplasia Associate 31578829
Kidney Diseases Associate 38211588
Leukemia Prolymphocytic T Cell Associate 31919093
Microcephaly Associate 31578829