Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	1665
Gene name Gene Name - the full gene name approved by the HGNC.	DEAH-box helicase 15
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	DHX15
Synonyms (NCBI Gene) Gene synonyms aliases	DBP1, DDX15, PRP43, PRPF43, PrPp43p, hPrp43
Chromosome Chromosome number	4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	4p15.2
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a putative ATP-dependent RNA helicase implicated in pre-mRNA splicing. [provided by RefSeq, Jul 2008]

Show/Hide all(183)

miRTarBase ID	miRNA	Experiments	Reference
MIRT002740	hsa-miR-1-3p	pSILAC	18668040
MIRT002740	hsa-miR-1-3p	Microarray	15685193
MIRT002740	hsa-miR-1-3p	Microarray;Other	15685193
MIRT002740	hsa-miR-1-3p	Proteomics	18668040
MIRT051549	hsa-let-7e-5p	CLASH	23622248
MIRT051549	hsa-let-7e-5p	CLASH	23622248
MIRT050083	hsa-miR-26a-5p	CLASH	23622248
MIRT046931	hsa-miR-221-3p	CLASH	23622248
MIRT043871	hsa-miR-378a-3p	CLASH	23622248
MIRT041781	hsa-miR-484	CLASH	23622248
MIRT935266	hsa-miR-1	CLIP-seq
MIRT935267	hsa-miR-1183	CLIP-seq
MIRT935268	hsa-miR-1298	CLIP-seq
MIRT935269	hsa-miR-1305	CLIP-seq
MIRT935270	hsa-miR-139-5p	CLIP-seq
MIRT935271	hsa-miR-145	CLIP-seq
MIRT935272	hsa-miR-186	CLIP-seq
MIRT935273	hsa-miR-206	CLIP-seq
MIRT935274	hsa-miR-3065-5p	CLIP-seq
MIRT935275	hsa-miR-3133	CLIP-seq
MIRT935276	hsa-miR-3143	CLIP-seq
MIRT935277	hsa-miR-3180-5p	CLIP-seq
MIRT935278	hsa-miR-3183	CLIP-seq
MIRT935279	hsa-miR-320a	CLIP-seq
MIRT935280	hsa-miR-320b	CLIP-seq
MIRT935281	hsa-miR-320c	CLIP-seq
MIRT935282	hsa-miR-320d	CLIP-seq
MIRT935283	hsa-miR-3607-3p	CLIP-seq
MIRT935284	hsa-miR-3618	CLIP-seq
MIRT935285	hsa-miR-382	CLIP-seq
MIRT935286	hsa-miR-3909	CLIP-seq
MIRT935287	hsa-miR-4263	CLIP-seq
MIRT935288	hsa-miR-4275	CLIP-seq
MIRT935289	hsa-miR-4429	CLIP-seq
MIRT935290	hsa-miR-4484	CLIP-seq
MIRT935291	hsa-miR-4509	CLIP-seq
MIRT935292	hsa-miR-4693-5p	CLIP-seq
MIRT935293	hsa-miR-4699-3p	CLIP-seq
MIRT935294	hsa-miR-4709-3p	CLIP-seq
MIRT935295	hsa-miR-4711-3p	CLIP-seq
MIRT935296	hsa-miR-4712-5p	CLIP-seq
MIRT935297	hsa-miR-4723-3p	CLIP-seq
MIRT935298	hsa-miR-4744	CLIP-seq
MIRT935299	hsa-miR-4753-5p	CLIP-seq
MIRT935300	hsa-miR-4775	CLIP-seq
MIRT935301	hsa-miR-4799-5p	CLIP-seq
MIRT935302	hsa-miR-505	CLIP-seq
MIRT935303	hsa-miR-543	CLIP-seq
MIRT935304	hsa-miR-548an	CLIP-seq
MIRT935305	hsa-miR-548v	CLIP-seq
MIRT935306	hsa-miR-556-5p	CLIP-seq
MIRT935307	hsa-miR-576-5p	CLIP-seq
MIRT935308	hsa-miR-592	CLIP-seq
MIRT935309	hsa-miR-599	CLIP-seq
MIRT935310	hsa-miR-610	CLIP-seq
MIRT935311	hsa-miR-613	CLIP-seq
MIRT935312	hsa-miR-770-5p	CLIP-seq
MIRT935313	hsa-miR-934	CLIP-seq
MIRT935266	hsa-miR-1	CLIP-seq
MIRT935268	hsa-miR-1298	CLIP-seq
MIRT935270	hsa-miR-139-5p	CLIP-seq
MIRT935271	hsa-miR-145	CLIP-seq
MIRT935273	hsa-miR-206	CLIP-seq
MIRT935274	hsa-miR-3065-5p	CLIP-seq
MIRT935277	hsa-miR-3180-5p	CLIP-seq
MIRT935279	hsa-miR-320a	CLIP-seq
MIRT935280	hsa-miR-320b	CLIP-seq
MIRT935281	hsa-miR-320c	CLIP-seq
MIRT935282	hsa-miR-320d	CLIP-seq
MIRT935288	hsa-miR-4275	CLIP-seq
MIRT1976915	hsa-miR-4329	CLIP-seq
MIRT935289	hsa-miR-4429	CLIP-seq
MIRT1976916	hsa-miR-4699-5p	CLIP-seq
MIRT935294	hsa-miR-4709-3p	CLIP-seq
MIRT935296	hsa-miR-4712-5p	CLIP-seq
MIRT935302	hsa-miR-505	CLIP-seq
MIRT935305	hsa-miR-548v	CLIP-seq
MIRT935306	hsa-miR-556-5p	CLIP-seq
MIRT935310	hsa-miR-610	CLIP-seq
MIRT935311	hsa-miR-613	CLIP-seq
MIRT935312	hsa-miR-770-5p	CLIP-seq
MIRT935266	hsa-miR-1	CLIP-seq
MIRT935268	hsa-miR-1298	CLIP-seq
MIRT935270	hsa-miR-139-5p	CLIP-seq
MIRT935271	hsa-miR-145	CLIP-seq
MIRT935273	hsa-miR-206	CLIP-seq
MIRT2212235	hsa-miR-23a	CLIP-seq
MIRT2212236	hsa-miR-23b	CLIP-seq
MIRT2212237	hsa-miR-23c	CLIP-seq
MIRT935274	hsa-miR-3065-5p	CLIP-seq
MIRT935276	hsa-miR-3143	CLIP-seq
MIRT2212238	hsa-miR-3168	CLIP-seq
MIRT935277	hsa-miR-3180-5p	CLIP-seq
MIRT935278	hsa-miR-3183	CLIP-seq
MIRT935279	hsa-miR-320a	CLIP-seq
MIRT935280	hsa-miR-320b	CLIP-seq
MIRT935281	hsa-miR-320c	CLIP-seq
MIRT935282	hsa-miR-320d	CLIP-seq
MIRT2212239	hsa-miR-34b	CLIP-seq
MIRT935284	hsa-miR-3618	CLIP-seq
MIRT935286	hsa-miR-3909	CLIP-seq
MIRT935287	hsa-miR-4263	CLIP-seq
MIRT935288	hsa-miR-4275	CLIP-seq
MIRT2212240	hsa-miR-4277	CLIP-seq
MIRT1976915	hsa-miR-4329	CLIP-seq
MIRT935289	hsa-miR-4429	CLIP-seq
MIRT1976916	hsa-miR-4699-5p	CLIP-seq
MIRT935294	hsa-miR-4709-3p	CLIP-seq
MIRT935295	hsa-miR-4711-3p	CLIP-seq
MIRT935296	hsa-miR-4712-5p	CLIP-seq
MIRT935297	hsa-miR-4723-3p	CLIP-seq
MIRT935301	hsa-miR-4799-5p	CLIP-seq
MIRT935302	hsa-miR-505	CLIP-seq
MIRT2212241	hsa-miR-513b	CLIP-seq
MIRT935303	hsa-miR-543	CLIP-seq
MIRT935305	hsa-miR-548v	CLIP-seq
MIRT935306	hsa-miR-556-5p	CLIP-seq
MIRT935308	hsa-miR-592	CLIP-seq
MIRT935309	hsa-miR-599	CLIP-seq
MIRT935310	hsa-miR-610	CLIP-seq
MIRT935311	hsa-miR-613	CLIP-seq
MIRT935312	hsa-miR-770-5p	CLIP-seq
MIRT935313	hsa-miR-934	CLIP-seq
MIRT935288	hsa-miR-4275	CLIP-seq
MIRT935302	hsa-miR-505	CLIP-seq
MIRT935266	hsa-miR-1	CLIP-seq
MIRT935269	hsa-miR-1305	CLIP-seq
MIRT935272	hsa-miR-186	CLIP-seq
MIRT2515945	hsa-miR-194	CLIP-seq
MIRT935273	hsa-miR-206	CLIP-seq
MIRT2212235	hsa-miR-23a	CLIP-seq
MIRT2212236	hsa-miR-23b	CLIP-seq
MIRT2212237	hsa-miR-23c	CLIP-seq
MIRT935274	hsa-miR-3065-5p	CLIP-seq
MIRT935275	hsa-miR-3133	CLIP-seq
MIRT935276	hsa-miR-3143	CLIP-seq
MIRT2212239	hsa-miR-34b	CLIP-seq
MIRT935284	hsa-miR-3618	CLIP-seq
MIRT935285	hsa-miR-382	CLIP-seq
MIRT935287	hsa-miR-4263	CLIP-seq
MIRT935288	hsa-miR-4275	CLIP-seq
MIRT935291	hsa-miR-4509	CLIP-seq
MIRT1976916	hsa-miR-4699-5p	CLIP-seq
MIRT935295	hsa-miR-4711-3p	CLIP-seq
MIRT935298	hsa-miR-4744	CLIP-seq
MIRT935301	hsa-miR-4799-5p	CLIP-seq
MIRT935302	hsa-miR-505	CLIP-seq
MIRT2212241	hsa-miR-513b	CLIP-seq
MIRT935303	hsa-miR-543	CLIP-seq
MIRT935307	hsa-miR-576-5p	CLIP-seq
MIRT935308	hsa-miR-592	CLIP-seq
MIRT935309	hsa-miR-599	CLIP-seq
MIRT935311	hsa-miR-613	CLIP-seq
MIRT935313	hsa-miR-934	CLIP-seq
MIRT935266	hsa-miR-1	CLIP-seq
MIRT935269	hsa-miR-1305	CLIP-seq
MIRT935272	hsa-miR-186	CLIP-seq
MIRT2515945	hsa-miR-194	CLIP-seq
MIRT935273	hsa-miR-206	CLIP-seq
MIRT2212235	hsa-miR-23a	CLIP-seq
MIRT2212236	hsa-miR-23b	CLIP-seq
MIRT2212237	hsa-miR-23c	CLIP-seq
MIRT935274	hsa-miR-3065-5p	CLIP-seq
MIRT935275	hsa-miR-3133	CLIP-seq
MIRT935276	hsa-miR-3143	CLIP-seq
MIRT2212239	hsa-miR-34b	CLIP-seq
MIRT935284	hsa-miR-3618	CLIP-seq
MIRT935285	hsa-miR-382	CLIP-seq
MIRT935287	hsa-miR-4263	CLIP-seq
MIRT935288	hsa-miR-4275	CLIP-seq
MIRT935291	hsa-miR-4509	CLIP-seq
MIRT1976916	hsa-miR-4699-5p	CLIP-seq
MIRT935295	hsa-miR-4711-3p	CLIP-seq
MIRT935298	hsa-miR-4744	CLIP-seq
MIRT935301	hsa-miR-4799-5p	CLIP-seq
MIRT935302	hsa-miR-505	CLIP-seq
MIRT2212241	hsa-miR-513b	CLIP-seq
MIRT935303	hsa-miR-543	CLIP-seq
MIRT935307	hsa-miR-576-5p	CLIP-seq
MIRT935308	hsa-miR-592	CLIP-seq
MIRT935309	hsa-miR-599	CLIP-seq
MIRT935311	hsa-miR-613	CLIP-seq
MIRT935313	hsa-miR-934	CLIP-seq

Show/Hide all(19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000398	Process	MRNA splicing, via spliceosome	TAS
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IBA	21873635
GO:0003724	Function	RNA helicase activity	IEA
GO:0003725	Function	Double-stranded RNA binding	IDA	21266579
GO:0005515	Function	Protein binding	IPI	17332742, 19644445, 22365833, 22569250, 24304693, 24965446, 25416956, 26494172, 26871637, 28514442, 29021621, 32296183
GO:0005524	Function	ATP binding	IEA
GO:0005622	Component	Intracellular anatomical structure	IBA	21873635
GO:0005634	Component	Nucleus	TAS	9388478
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IBA	21873635
GO:0005689	Component	U12-type spliceosomal complex	IDA	15146077
GO:0005730	Component	Nucleolus	IEA
GO:0006397	Process	MRNA processing	TAS	7935475
GO:0008380	Process	RNA splicing	IC	15146077
GO:0009636	Process	Response to toxic substance	IEA
GO:0016607	Component	Nuclear speck	IDA
GO:0043279	Process	Response to alkaloid	IEA
GO:0071008	Component	U2-type post-mRNA release spliceosomal complex	IDA	19103666

MIM	HGNC	e!Ensembl
603403	2738	ENSG00000109606

Protein

UniProt ID

O43143

Protein name

ATP-dependent RNA helicase DHX15 (EC 3.6.4.13) (ATP-dependent RNA helicase #46) (DEAH box protein 15) (Splicing factor Prp43) (hPrp43)

Protein function

RNA helicase involved in mRNA processing and antiviral innate immunity (PubMed:19103666, PubMed:19432882, PubMed:24782566, PubMed:24990078, PubMed:32179686, PubMed:34161762). Pre-mRNA processing factor involved in disassembly of spliceosomes aft

PDB

5XDR , 6ID1 , 6SH6 , 6SH7 , 8EJM , 8RO2

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00270	DEAD	141 → 301	DEAD/DEAH box helicase	Domain
PF00271	Helicase_C	334 → 477	Helicase conserved C-terminal domain	Family
PF04408	HA2	539 → 627	Helicase associated domain (HA2)	Domain
PF07717	OB_NTP_bind	689 → 765	Oligonucleotide/oligosaccharide-binding (OB)-fold	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:9388478}.

Sequence

MSKRHRLDLGEDYPSGKKRAGTDGKDRDRDRDREDRSKDRDRERDRGDREREREKEKEKE
LRASTNAMLISAGLPPLKASHSAHSTHSAHSTHSTHSAHSTHAGHAGHTSLPQCINPFTN
LPHTPRYYDILKKRLQLPVWEYKDRFTDILVRHQSFVLVGETGSGKTTQIPQWCVEYMRS
LPGPKRGVACTQPRRVAAMSVAQRVADEMDVMLGQEVGYSIRFEDCSSAKTILKYMTDGM
LLREAMNDPLLERYGVIILDEAHERTLATDILMGVLKEVVRQRSDLKVIVMSATLDAGKF
QIYFDNCPLLTIPGRTHPVEIFYTPEPERDYLEAAIRTVIQIHMCEEEEGDLLLFLTGQE
EIDEACKRIKREVDDLGPEVGDIKIIPLYSTLPPQQQQRIFEPPPPKKQNGAIGRKVVVS
TNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVTAISKASAQQRAGRAGRTRPGK
CFRLYTEKAYKTEMQDNTYPEILRSNLGSVVLQLKKLGIDDLVHFDFMDPPAPETLMRAL
ELLNYLAALNDDGDLTELGSMMAEFPLDPQLAKMVIASCDYNCSNEVLSITAMLSVPQCF
VRPTEAKKAADEAKMRFAHIDGDHLTLLNVYHAFKQNHESVQWCYDNFINYRSLMSADNV
RQQLSRIMDRFNLPRRSTDFTSRDYYINIRKALVTGYFMQVAHLERTGHYLTVKDNQVVQ
LHPSTVLDHKPEWVLYNEFVLTTKNYIRTCTDIKPEWLVKIAPQYYDMSNFPQCEAKRQL
DRIIAKLQSKEYSQY

Sequence length

795

Interactions

View interactions

	KEGG		Reactome
	Spliceosome		mRNA Splicing - Major Pathway

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Leukemia	Leukemia, Myelocytic, Acute, Acute Myeloid Leukemia (AML-M2)	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297	27798625, 29163777
Myopia	Myopia, Degenerative	rs387907109, rs146936371, rs587776903, rs786205127, rs398122836, rs199624584, rs587777625, rs786205216, rs758872875, rs764211125, rs1135402746, rs765658563, rs1555941129, rs1555941116, rs199923805 View all (6 more)	23049088

Show/Hide Unknown Diseases (7)

Disease term	Disease name	Evidence	Source
Unknown
Schizophrenia	Schizophrenia		GWAS
Gout	Gout		GWAS
Pulmonary Emphysema	Pulmonary Emphysema		GWAS
Neuroticism	Neuroticism		GWAS
Tremor	Tremor		GWAS
Glioblastoma	Glioblastoma	CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587	GWAS, CBGDA
Colorectal Cancer	Colorectal Cancer	In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1.	GWAS, CBGDA

Show/Hide Text Mining Associations (13)

Disease Name	Relationship Type	References
Associations from Text Mining
Alzheimer Disease	Associate	36776048
Amyotrophic Lateral Sclerosis	Associate	38056214
Breast Neoplasms	Associate	37101128
Colorectal Neoplasms	Associate	36177832
Leukemia Myeloid Acute	Associate	31896782, 36459648
Leukemia T Cell	Associate	29512921
Lupus Erythematosus Systemic	Associate	39743791
Lymphatic Metastasis	Associate	36177832
Neoplasms	Associate	22569250, 36459648
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	29512921
Prostatic Neoplasms	Associate	30714180
Urinary Bladder Neoplasms	Associate	29739919
Wolf Hirschhorn Syndrome	Associate	36980907

DHX15 (DEAH-box helicase 15)