Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	1665
Gene name	DEAH-box helicase 15
Gene symbol	DHX15
Synonyms (NCBI Gene)	DBP1DDX15PRP43PRPF43PrPp43phPrp43
Chromosome	4
Chromosome location	4p15.2
Summary	The protein encoded by this gene is a putative ATP-dependent RNA helicase implicated in pre-mRNA splicing. [provided by RefSeq, Jul 2008]

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miRTarBase ID	miRNA	Experiments	Reference
MIRT002740	hsa-miR-1-3p	pSILAC	18668040
MIRT002740	hsa-miR-1-3p	Microarray	15685193
MIRT002740	hsa-miR-1-3p	Microarray;Other	15685193
MIRT002740	hsa-miR-1-3p	Proteomics	18668040
MIRT051549	hsa-let-7e-5p	CLASH	23622248
MIRT051549	hsa-let-7e-5p	CLASH	23622248
MIRT050083	hsa-miR-26a-5p	CLASH	23622248
MIRT046931	hsa-miR-221-3p	CLASH	23622248
MIRT043871	hsa-miR-378a-3p	CLASH	23622248
MIRT041781	hsa-miR-484	CLASH	23622248
MIRT935266	hsa-miR-1	CLIP-seq
MIRT935267	hsa-miR-1183	CLIP-seq
MIRT935268	hsa-miR-1298	CLIP-seq
MIRT935269	hsa-miR-1305	CLIP-seq
MIRT935270	hsa-miR-139-5p	CLIP-seq
MIRT935271	hsa-miR-145	CLIP-seq
MIRT935272	hsa-miR-186	CLIP-seq
MIRT935273	hsa-miR-206	CLIP-seq
MIRT935274	hsa-miR-3065-5p	CLIP-seq
MIRT935275	hsa-miR-3133	CLIP-seq
MIRT935276	hsa-miR-3143	CLIP-seq
MIRT935277	hsa-miR-3180-5p	CLIP-seq
MIRT935278	hsa-miR-3183	CLIP-seq
MIRT935279	hsa-miR-320a	CLIP-seq
MIRT935280	hsa-miR-320b	CLIP-seq
MIRT935281	hsa-miR-320c	CLIP-seq
MIRT935282	hsa-miR-320d	CLIP-seq
MIRT935283	hsa-miR-3607-3p	CLIP-seq
MIRT935284	hsa-miR-3618	CLIP-seq
MIRT935285	hsa-miR-382	CLIP-seq
MIRT935286	hsa-miR-3909	CLIP-seq
MIRT935287	hsa-miR-4263	CLIP-seq
MIRT935288	hsa-miR-4275	CLIP-seq
MIRT935289	hsa-miR-4429	CLIP-seq
MIRT935290	hsa-miR-4484	CLIP-seq
MIRT935291	hsa-miR-4509	CLIP-seq
MIRT935292	hsa-miR-4693-5p	CLIP-seq
MIRT935293	hsa-miR-4699-3p	CLIP-seq
MIRT935294	hsa-miR-4709-3p	CLIP-seq
MIRT935295	hsa-miR-4711-3p	CLIP-seq
MIRT935296	hsa-miR-4712-5p	CLIP-seq
MIRT935297	hsa-miR-4723-3p	CLIP-seq
MIRT935298	hsa-miR-4744	CLIP-seq
MIRT935299	hsa-miR-4753-5p	CLIP-seq
MIRT935300	hsa-miR-4775	CLIP-seq
MIRT935301	hsa-miR-4799-5p	CLIP-seq
MIRT935302	hsa-miR-505	CLIP-seq
MIRT935303	hsa-miR-543	CLIP-seq
MIRT935304	hsa-miR-548an	CLIP-seq
MIRT935305	hsa-miR-548v	CLIP-seq
MIRT935306	hsa-miR-556-5p	CLIP-seq
MIRT935307	hsa-miR-576-5p	CLIP-seq
MIRT935308	hsa-miR-592	CLIP-seq
MIRT935309	hsa-miR-599	CLIP-seq
MIRT935310	hsa-miR-610	CLIP-seq
MIRT935311	hsa-miR-613	CLIP-seq
MIRT935312	hsa-miR-770-5p	CLIP-seq
MIRT935313	hsa-miR-934	CLIP-seq
MIRT935266	hsa-miR-1	CLIP-seq
MIRT935268	hsa-miR-1298	CLIP-seq
MIRT935270	hsa-miR-139-5p	CLIP-seq
MIRT935271	hsa-miR-145	CLIP-seq
MIRT935273	hsa-miR-206	CLIP-seq
MIRT935274	hsa-miR-3065-5p	CLIP-seq
MIRT935277	hsa-miR-3180-5p	CLIP-seq
MIRT935279	hsa-miR-320a	CLIP-seq
MIRT935280	hsa-miR-320b	CLIP-seq
MIRT935281	hsa-miR-320c	CLIP-seq
MIRT935282	hsa-miR-320d	CLIP-seq
MIRT935288	hsa-miR-4275	CLIP-seq
MIRT1976915	hsa-miR-4329	CLIP-seq
MIRT935289	hsa-miR-4429	CLIP-seq
MIRT1976916	hsa-miR-4699-5p	CLIP-seq
MIRT935294	hsa-miR-4709-3p	CLIP-seq
MIRT935296	hsa-miR-4712-5p	CLIP-seq
MIRT935302	hsa-miR-505	CLIP-seq
MIRT935305	hsa-miR-548v	CLIP-seq
MIRT935306	hsa-miR-556-5p	CLIP-seq
MIRT935310	hsa-miR-610	CLIP-seq
MIRT935311	hsa-miR-613	CLIP-seq
MIRT935312	hsa-miR-770-5p	CLIP-seq
MIRT935266	hsa-miR-1	CLIP-seq
MIRT935268	hsa-miR-1298	CLIP-seq
MIRT935270	hsa-miR-139-5p	CLIP-seq
MIRT935271	hsa-miR-145	CLIP-seq
MIRT935273	hsa-miR-206	CLIP-seq
MIRT2212235	hsa-miR-23a	CLIP-seq
MIRT2212236	hsa-miR-23b	CLIP-seq
MIRT2212237	hsa-miR-23c	CLIP-seq
MIRT935274	hsa-miR-3065-5p	CLIP-seq
MIRT935276	hsa-miR-3143	CLIP-seq
MIRT2212238	hsa-miR-3168	CLIP-seq
MIRT935277	hsa-miR-3180-5p	CLIP-seq
MIRT935278	hsa-miR-3183	CLIP-seq
MIRT935279	hsa-miR-320a	CLIP-seq
MIRT935280	hsa-miR-320b	CLIP-seq
MIRT935281	hsa-miR-320c	CLIP-seq
MIRT935282	hsa-miR-320d	CLIP-seq
MIRT2212239	hsa-miR-34b	CLIP-seq
MIRT935284	hsa-miR-3618	CLIP-seq
MIRT935286	hsa-miR-3909	CLIP-seq
MIRT935287	hsa-miR-4263	CLIP-seq
MIRT935288	hsa-miR-4275	CLIP-seq
MIRT2212240	hsa-miR-4277	CLIP-seq
MIRT1976915	hsa-miR-4329	CLIP-seq
MIRT935289	hsa-miR-4429	CLIP-seq
MIRT1976916	hsa-miR-4699-5p	CLIP-seq
MIRT935294	hsa-miR-4709-3p	CLIP-seq
MIRT935295	hsa-miR-4711-3p	CLIP-seq
MIRT935296	hsa-miR-4712-5p	CLIP-seq
MIRT935297	hsa-miR-4723-3p	CLIP-seq
MIRT935301	hsa-miR-4799-5p	CLIP-seq
MIRT935302	hsa-miR-505	CLIP-seq
MIRT2212241	hsa-miR-513b	CLIP-seq
MIRT935303	hsa-miR-543	CLIP-seq
MIRT935305	hsa-miR-548v	CLIP-seq
MIRT935306	hsa-miR-556-5p	CLIP-seq
MIRT935308	hsa-miR-592	CLIP-seq
MIRT935309	hsa-miR-599	CLIP-seq
MIRT935310	hsa-miR-610	CLIP-seq
MIRT935311	hsa-miR-613	CLIP-seq
MIRT935312	hsa-miR-770-5p	CLIP-seq
MIRT935313	hsa-miR-934	CLIP-seq
MIRT935288	hsa-miR-4275	CLIP-seq
MIRT935302	hsa-miR-505	CLIP-seq
MIRT935266	hsa-miR-1	CLIP-seq
MIRT935269	hsa-miR-1305	CLIP-seq
MIRT935272	hsa-miR-186	CLIP-seq
MIRT2515945	hsa-miR-194	CLIP-seq
MIRT935273	hsa-miR-206	CLIP-seq
MIRT2212235	hsa-miR-23a	CLIP-seq
MIRT2212236	hsa-miR-23b	CLIP-seq
MIRT2212237	hsa-miR-23c	CLIP-seq
MIRT935274	hsa-miR-3065-5p	CLIP-seq
MIRT935275	hsa-miR-3133	CLIP-seq
MIRT935276	hsa-miR-3143	CLIP-seq
MIRT2212239	hsa-miR-34b	CLIP-seq
MIRT935284	hsa-miR-3618	CLIP-seq
MIRT935285	hsa-miR-382	CLIP-seq
MIRT935287	hsa-miR-4263	CLIP-seq
MIRT935288	hsa-miR-4275	CLIP-seq
MIRT935291	hsa-miR-4509	CLIP-seq
MIRT1976916	hsa-miR-4699-5p	CLIP-seq
MIRT935295	hsa-miR-4711-3p	CLIP-seq
MIRT935298	hsa-miR-4744	CLIP-seq
MIRT935301	hsa-miR-4799-5p	CLIP-seq
MIRT935302	hsa-miR-505	CLIP-seq
MIRT2212241	hsa-miR-513b	CLIP-seq
MIRT935303	hsa-miR-543	CLIP-seq
MIRT935307	hsa-miR-576-5p	CLIP-seq
MIRT935308	hsa-miR-592	CLIP-seq
MIRT935309	hsa-miR-599	CLIP-seq
MIRT935311	hsa-miR-613	CLIP-seq
MIRT935313	hsa-miR-934	CLIP-seq
MIRT935266	hsa-miR-1	CLIP-seq
MIRT935269	hsa-miR-1305	CLIP-seq
MIRT935272	hsa-miR-186	CLIP-seq
MIRT2515945	hsa-miR-194	CLIP-seq
MIRT935273	hsa-miR-206	CLIP-seq
MIRT2212235	hsa-miR-23a	CLIP-seq
MIRT2212236	hsa-miR-23b	CLIP-seq
MIRT2212237	hsa-miR-23c	CLIP-seq
MIRT935274	hsa-miR-3065-5p	CLIP-seq
MIRT935275	hsa-miR-3133	CLIP-seq
MIRT935276	hsa-miR-3143	CLIP-seq
MIRT2212239	hsa-miR-34b	CLIP-seq
MIRT935284	hsa-miR-3618	CLIP-seq
MIRT935285	hsa-miR-382	CLIP-seq
MIRT935287	hsa-miR-4263	CLIP-seq
MIRT935288	hsa-miR-4275	CLIP-seq
MIRT935291	hsa-miR-4509	CLIP-seq
MIRT1976916	hsa-miR-4699-5p	CLIP-seq
MIRT935295	hsa-miR-4711-3p	CLIP-seq
MIRT935298	hsa-miR-4744	CLIP-seq
MIRT935301	hsa-miR-4799-5p	CLIP-seq
MIRT935302	hsa-miR-505	CLIP-seq
MIRT2212241	hsa-miR-513b	CLIP-seq
MIRT935303	hsa-miR-543	CLIP-seq
MIRT935307	hsa-miR-576-5p	CLIP-seq
MIRT935308	hsa-miR-592	CLIP-seq
MIRT935309	hsa-miR-599	CLIP-seq
MIRT935311	hsa-miR-613	CLIP-seq
MIRT935313	hsa-miR-934	CLIP-seq

Show/Hide all (40)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000398	Process	MRNA splicing, via spliceosome	TAS
GO:0002376	Process	Immune system process	IEA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	IDA	32179686
GO:0003723	Function	RNA binding	IEA
GO:0003724	Function	RNA helicase activity	IDA	32179686
GO:0003724	Function	RNA helicase activity	IEA
GO:0003724	Function	RNA helicase activity	TAS	7935475
GO:0003725	Function	Double-stranded RNA binding	IDA	21266579, 24990078
GO:0004386	Function	Helicase activity	IBA
GO:0004386	Function	Helicase activity	IEA
GO:0005515	Function	Protein binding	IPI	17332742, 19644445, 22365833, 22569250, 24304693, 24965446, 24990078, 25416956, 26494172, 26871637, 28514442, 29021621, 32296183, 35271311
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	9388478
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IBA
GO:0005689	Component	U12-type spliceosomal complex	IDA	15146077
GO:0005730	Component	Nucleolus	IEA
GO:0006397	Process	MRNA processing	IEA
GO:0006397	Process	MRNA processing	TAS	7935475
GO:0008186	Function	ATP-dependent activity, acting on RNA	TAS
GO:0008380	Process	RNA splicing	IC	15146077
GO:0008380	Process	RNA splicing	IEA
GO:0009636	Process	Response to toxic substance	IEA
GO:0016607	Component	Nuclear speck	IDA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0042742	Process	Defense response to bacterium	IEA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IDA	24990078
GO:0043279	Process	Response to alkaloid	IEA
GO:0045087	Process	Innate immune response	IEA
GO:0051607	Process	Defense response to virus	IDA	24990078
GO:0051607	Process	Defense response to virus	IEA
GO:0071008	Component	U2-type post-mRNA release spliceosomal complex	IDA	19103666
GO:0140374	Process	Antiviral innate immune response	IDA	24990078
GO:0140374	Process	Antiviral innate immune response	IEA

MIM	HGNC	e!Ensembl
603403	2738	ENSG00000109606

O43143

Protein name

ATP-dependent RNA helicase DHX15 (EC 3.6.4.13) (ATP-dependent RNA helicase #46) (DEAH box protein 15) (Splicing factor Prp43) (hPrp43)

Protein function

RNA helicase involved in mRNA processing and antiviral innate immunity (PubMed:19103666, PubMed:19432882, PubMed:24782566, PubMed:24990078, PubMed:32179686, PubMed:34161762). Pre-mRNA processing factor involved in disassembly of spliceosomes aft

PDB

5XDR , 6ID1 , 6SH6 , 6SH7 , 8EJM , 8RO2

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00270	DEAD	141 → 301	DEAD/DEAH box helicase	Domain
PF00271	Helicase_C	334 → 477	Helicase conserved C-terminal domain	Family
PF04408	HA2	539 → 627	Helicase associated domain (HA2)	Domain
PF07717	OB_NTP_bind	689 → 765	Oligonucleotide/oligosaccharide-binding (OB)-fold	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:9388478}.

Sequence

MSKRHRLDLGEDYPSGKKRAGTDGKDRDRDRDREDRSKDRDRERDRGDREREREKEKEKE
LRASTNAMLISAGLPPLKASHSAHSTHSAHSTHSTHSAHSTHAGHAGHTSLPQCINPFTN
LPHTPRYYDILKKRLQLPVWEYKDRFTDILVRHQSFVLVGETGSGKTTQIPQWCVEYMRS
LPGPKRGVACTQPRRVAAMSVAQRVADEMDVMLGQEVGYSIRFEDCSSAKTILKYMTDGM
LLREAMNDPLLERYGVIILDEAHERTLATDILMGVLKEVVRQRSDLKVIVMSATLDAGKF
QIYFDNCPLLTIPGRTHPVEIFYTPEPERDYLEAAIRTVIQIHMCEEEEGDLLLFLTGQE
EIDEACKRIKREVDDLGPEVGDIKIIPLYSTLPPQQQQRIFEPPPPKKQNGAIGRKVVVS
TNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVTAISKASAQQRAGRAGRTRPGK
CFRLYTEKAYKTEMQDNTYPEILRSNLGSVVLQLKKLGIDDLVHFDFMDPPAPETLMRAL
ELLNYLAALNDDGDLTELGSMMAEFPLDPQLAKMVIASCDYNCSNEVLSITAMLSVPQCF
VRPTEAKKAADEAKMRFAHIDGDHLTLLNVYHAFKQNHESVQWCYDNFINYRSLMSADNV
RQQLSRIMDRFNLPRRSTDFTSRDYYINIRKALVTGYFMQVAHLERTGHYLTVKDNQVVQ
LHPSTVLDHKPEWVLYNEFVLTTKNYIRTCTDIKPEWLVKIAPQYYDMSNFPQCEAKRQL
DRIIAKLQSKEYSQY

Sequence length

795

Interactions

View interactions

	KEGG		Reactome
	Spliceosome		mRNA Splicing - Major Pathway

DHX15 (DEAH-box helicase 15)