DDX10 (DEAD-box helicase 10)

Gene

• Entrez ID: 1662
• Gene name: DEAD-box helicase 10
• Gene symbol: DDX10
• Synonyms (NCBI Gene): Dbp4, HRH-J8
• Chromosome: 11
• Chromosome location: 11q22.3
• Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and m

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020829	hsa-miR-155-5p	Proteomics	18668040
MIRT025474	hsa-miR-34a-5p	Proteomics	21566225
MIRT027606	hsa-miR-98-5p	Microarray	19088304
MIRT028567	hsa-miR-30a-5p	Proteomics	18668040
MIRT032410	hsa-let-7b-5p	Proteomics	18668040
MIRT929633	hsa-miR-101	CLIP-seq
MIRT929634	hsa-miR-1261	CLIP-seq
MIRT929635	hsa-miR-1273d	CLIP-seq
MIRT929636	hsa-miR-144	CLIP-seq
MIRT929637	hsa-miR-3182	CLIP-seq
MIRT929638	hsa-miR-3647-3p	CLIP-seq
MIRT929639	hsa-miR-3686	CLIP-seq
MIRT929640	hsa-miR-3914	CLIP-seq
MIRT929641	hsa-miR-4474-5p	CLIP-seq
MIRT929642	hsa-miR-451b	CLIP-seq
MIRT929643	hsa-miR-4753-3p	CLIP-seq
MIRT929644	hsa-miR-490-5p	CLIP-seq
MIRT929645	hsa-miR-548c-3p	CLIP-seq
MIRT1975238	hsa-miR-2682	CLIP-seq
MIRT1975239	hsa-miR-3167	CLIP-seq
MIRT1975240	hsa-miR-34a	CLIP-seq
MIRT1975241	hsa-miR-34c-5p	CLIP-seq
MIRT1975242	hsa-miR-3613-3p	CLIP-seq
MIRT1975243	hsa-miR-3617	CLIP-seq
MIRT1975244	hsa-miR-3714	CLIP-seq
MIRT1975245	hsa-miR-4263	CLIP-seq
MIRT1975246	hsa-miR-449a	CLIP-seq
MIRT1975247	hsa-miR-449b	CLIP-seq
MIRT1975248	hsa-miR-449c	CLIP-seq
MIRT929642	hsa-miR-451b	CLIP-seq
MIRT1975249	hsa-miR-4696	CLIP-seq
MIRT1975250	hsa-miR-548an	CLIP-seq
MIRT1975251	hsa-miR-576-5p	CLIP-seq
MIRT1975252	hsa-miR-641	CLIP-seq
MIRT1975253	hsa-miR-876-5p	CLIP-seq
MIRT2210634	hsa-miR-335	CLIP-seq
MIRT1975249	hsa-miR-4696	CLIP-seq
MIRT2210635	hsa-miR-4731-3p	CLIP-seq
MIRT2210636	hsa-miR-4801	CLIP-seq
MIRT2210637	hsa-miR-642b	CLIP-seq
MIRT2514556	hsa-miR-1202	CLIP-seq
MIRT929634	hsa-miR-1261	CLIP-seq
MIRT929635	hsa-miR-1273d	CLIP-seq
MIRT1975238	hsa-miR-2682	CLIP-seq
MIRT2210634	hsa-miR-335	CLIP-seq
MIRT1975240	hsa-miR-34a	CLIP-seq
MIRT1975241	hsa-miR-34c-5p	CLIP-seq
MIRT1975243	hsa-miR-3617	CLIP-seq
MIRT1975244	hsa-miR-3714	CLIP-seq
MIRT929640	hsa-miR-3914	CLIP-seq
MIRT2514557	hsa-miR-3972	CLIP-seq
MIRT1975246	hsa-miR-449a	CLIP-seq
MIRT1975247	hsa-miR-449b	CLIP-seq
MIRT1975248	hsa-miR-449c	CLIP-seq
MIRT2210635	hsa-miR-4731-3p	CLIP-seq
MIRT2210636	hsa-miR-4801	CLIP-seq
MIRT929644	hsa-miR-490-5p	CLIP-seq
MIRT1975250	hsa-miR-548an	CLIP-seq
MIRT929645	hsa-miR-548c-3p	CLIP-seq
MIRT1975252	hsa-miR-641	CLIP-seq
MIRT2210637	hsa-miR-642b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0003724	Function	RNA helicase activity	IEA
GO:0003724	Function	RNA helicase activity	TAS	8660968
GO:0004386	Function	Helicase activity	IEA
GO:0005515	Function	Protein binding	IPI	30021884, 33961781
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0006364	Process	RRNA processing	IBA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0097065	Process	Anterior head development	IEA

Other IDs

• MIM: 601235
• HGNC: 2735
• e!Ensembl: ENSG00000178105

Protein

• UniProt ID: Q13206
• Protein name: Probable ATP-dependent RNA helicase DDX10 (EC 3.6.4.13) (DEAD box protein 10)
• Protein function: Putative ATP-dependent RNA helicase that plays various role in innate immunity or inflammation. Plays a role in the enhancement of AIM2-induced inflammasome activation by interacting with AIM2 and stabilizing its protein level (PubMed:32519665).
• PDB: 2PL3
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00270	DEAD	93 → 263	DEAD/DEAH box helicase	Domain
  PF00271	Helicase_C	299 → 410	Helicase conserved C-terminal domain	Family
  PF13959	DUF4217	450 → 510	Domain of unknown function (DUF4217)	Domain

• Tissue specificity: TISSUE SPECIFICITY: High in testis but widely expressed.
• Sequence:

  MGKTANSPGSGARPDPVRSFNRWKKKHSHRQNKKKQLRKQLKKPEWQVERESISRLMQNY
  EKINVNEITRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKT
  LAFLVPVLEALYRLQWTSTDGLGVLIISPTRELAYQTFEVLRKVGKNHDFSAGLIIGGKD
  LKHEAERINNINILVCTPGRLLQHMDETVSFHATDLQMLVLDEADRILDMGFADTMNAVI
  ENLPKKRQTLLFSATQTKSVKDLARLSLKNPEYVWVHEKAKYSTPATLEQNYIVCELQQK
  ISVLYSFLRSHLKKKSIVFFSSCKEVQYLYRVFCRLRPGVSILALHGRQQQMRRMEVYNE
  FVRKRAAVLFATDIAARGLDFPAVNWVLQFDCPEDANTYIHRAGRTARYKEDGEALLILL
  PSEKAMVQQLLQKKVPVKEIKINPEKLIDVQKKLESILAQDQDLKERAQRCFVSYVRSVY
  LMKDKEVFDVSKLPIPEYALSLGLAVAPRVRFLQKMQKQPTKELVRSQADKVIEPRAPSL
  TNDEVEEFRAYFNEKMSILQKGGKRLEGTEHRQDNDTGNEEQEEEEDDEEEMEEKLAKAK
  GSQAPSLPNTSEAQKIKEVPTQFLDRDEEEEDADFLKVKRHNVFGLDLKDEKTLQKKEPS
  KSSIKKKMTKVAEAKKVMKRNFKVNKKITFTDEGELVQQWPQMQKSAIKDAEEDDDTGGI
  NLHKAKERLQEEDKFDKEEYRKKIKAKHREKRLKEREARREANKRQAKAKDEEEAFLDWS
  DDDDDDDDGFDPSTLPDPDKYRSSEDSDSEDMENKISDTKKKQGMKKRSNSEVEDVGPTS
  HNRKKARWDTLEPLDTGLSLAEDEELVLHLLRSQS

• Sequence length: 875

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Associated diseases

Unknown
Disease merge term	Disease name	Evidence	References	Source
Prostate cancer	Prostate cancer	N/A	N/A	GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Breast Neoplasms	Associate	23496902
Carcinogenesis	Associate	9166830
Chondrosarcoma	Associate	34797290
Drug Related Side Effects and Adverse Reactions	Associate	33657088
Glioma	Associate	34797290
Hematologic Neoplasms	Associate	10830185
Myelodysplastic Syndromes	Associate	10830185, 40269371
Neoplasms	Associate	23496902, 34797290, 9166830
Osteosarcoma	Associate	30738579