SPTSSB (serine palmitoyltransferase small subunit B)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
165679
Gene name Gene Name - the full gene name approved by the HGNC.
Serine palmitoyltransferase small subunit B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SPTSSB
Synonyms (NCBI Gene) Gene synonyms aliases
ADMP, C3orf57, SSSPTB
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q26.1
Summary Summary of gene provided in NCBI Entrez Gene.
Serine palmitoyltransferase (SPT; EC 2.3.1.50) catalyzes the first committed and rate-limiting step in sphingolipid biosynthesis. SSSPTB is a small SPT subunit that stimulates SPT activity and confers acyl-CoA preference to the SPT catalytic heterodimer o
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(8)
miRTarBase ID miRNA Experiments Reference
MIRT500961 hsa-miR-1252-5p PAR-CLIP 24398324
MIRT500960 hsa-miR-7-5p PAR-CLIP 24398324
MIRT500959 hsa-miR-6801-5p PAR-CLIP 24398324
MIRT500958 hsa-miR-3606-5p PAR-CLIP 24398324
MIRT500961 hsa-miR-1252-5p PAR-CLIP 24398324
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(25)
GO ID Ontology Definition Evidence Reference
GO:0004758 Function Serine C-palmitoyltransferase activity IBA
GO:0004758 Function Serine C-palmitoyltransferase activity IDA 19416851
GO:0004758 Function Serine C-palmitoyltransferase activity IEA
GO:0005515 Function Protein binding IPI 19416851
GO:0005783 Component Endoplasmic reticulum IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
610412 24045 ENSG00000196542
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q8NFR3
Protein name Serine palmitoyltransferase small subunit B (Protein ADMP) (Small subunit of serine palmitoyltransferase B) (ssSPTb)
Protein function Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF11779 SPT_ssu-like 7 → 60 Small subunit of serine palmitoyltransferase-like Family
Tissue specificity TISSUE SPECIFICITY: Expression is seen predominantly in the prostate epithelium with weaker expression in the fibroblasts and endothelial cells. {ECO:0000269|PubMed:15777716}.
Sequence
Sequence length 76
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Sphingolipid signaling pathway   Sphingolipid de novo biosynthesis
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Parkinson Disease Parkinson's disease N/A N/A GWAS
Show/Hide Text Mining Associations (1)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Intervertebral Disc Degeneration Associate 35409356