SPTSSB (serine palmitoyltransferase small subunit B)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 165679
Gene name Serine palmitoyltransferase small subunit B
Gene symbol SPTSSB
Synonyms (NCBI Gene)
ADMPC3orf57SSSPTB
Chromosome 3
Chromosome location 3q26.1
Summary Serine palmitoyltransferase (SPT; EC 2.3.1.50) catalyzes the first committed and rate-limiting step in sphingolipid biosynthesis. SSSPTB is a small SPT subunit that stimulates SPT activity and confers acyl-CoA preference to the SPT catalytic heterodimer o
miRNA miRNA information provided by mirtarbase database.
8
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (8)
miRTarBase ID miRNA Experiments Reference
MIRT500961 hsa-miR-1252-5p PAR-CLIP 24398324
MIRT500960 hsa-miR-7-5p PAR-CLIP 24398324
MIRT500959 hsa-miR-6801-5p PAR-CLIP 24398324
MIRT500958 hsa-miR-3606-5p PAR-CLIP 24398324
MIRT500961 hsa-miR-1252-5p PAR-CLIP 24398324
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
25
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (25)
GO ID Ontology Definition Evidence Reference
GO:0004758 Function Serine C-palmitoyltransferase activity IBA
GO:0004758 Function Serine C-palmitoyltransferase activity IDA 19416851
GO:0004758 Function Serine C-palmitoyltransferase activity IEA
GO:0005515 Function Protein binding IPI 19416851
GO:0005783 Component Endoplasmic reticulum IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
610412 24045 ENSG00000196542
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8NFR3
Protein name Serine palmitoyltransferase small subunit B (Protein ADMP) (Small subunit of serine palmitoyltransferase B) (ssSPTb)
Protein function Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF11779 SPT_ssu-like 7 → 60 Small subunit of serine palmitoyltransferase-like Family
Tissue specificity TISSUE SPECIFICITY: Expression is seen predominantly in the prostate epithelium with weaker expression in the fibroblasts and endothelial cells. {ECO:0000269|PubMed:15777716}.
Sequence
Sequence length 76
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Sphingolipid signaling pathway   Sphingolipid de novo biosynthesis
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (1)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
PARKINSON DISEASE — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (1)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Intervertebral Disc Degeneration Associate 35409356
★★★★★
★☆☆☆☆
Found in Text Mining only