FAM171B (family with sequence similarity 171 member B)

Gene

• Entrez ID: 165215
• Gene name: Family with sequence similarity 171 member B
• Gene symbol: FAM171B
• Synonyms (NCBI Gene): KIAA1946
• Chromosome: 2
• Chromosome location: 2q32.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022182	hsa-miR-124-3p	Microarray	18668037
MIRT024632	hsa-miR-215-5p	Microarray	19074876
MIRT026167	hsa-miR-192-5p	Microarray	19074876
MIRT048646	hsa-miR-99a-5p	CLASH	23622248
MIRT981958	hsa-miR-1183	CLIP-seq
MIRT981959	hsa-miR-338-5p	CLIP-seq
MIRT981960	hsa-miR-3607-3p	CLIP-seq
MIRT981961	hsa-miR-3682-3p	CLIP-seq
MIRT981962	hsa-miR-3689a-5p	CLIP-seq
MIRT981963	hsa-miR-3689b	CLIP-seq
MIRT981964	hsa-miR-3689e	CLIP-seq
MIRT981965	hsa-miR-3689f	CLIP-seq
MIRT981966	hsa-miR-450b-3p	CLIP-seq
MIRT981967	hsa-miR-4643	CLIP-seq
MIRT981968	hsa-miR-466	CLIP-seq
MIRT981969	hsa-miR-4666-3p	CLIP-seq
MIRT981970	hsa-miR-4760-3p	CLIP-seq
MIRT981971	hsa-miR-4764-3p	CLIP-seq
MIRT981972	hsa-miR-4789-3p	CLIP-seq
MIRT981973	hsa-miR-758	CLIP-seq
MIRT981974	hsa-miR-769-3p	CLIP-seq
MIRT1991064	hsa-miR-3064-5p	CLIP-seq
MIRT1991065	hsa-miR-3652	CLIP-seq
MIRT1991066	hsa-miR-3977	CLIP-seq
MIRT1991067	hsa-miR-4289	CLIP-seq
MIRT1991068	hsa-miR-4430	CLIP-seq
MIRT1991069	hsa-miR-4505	CLIP-seq
MIRT1991070	hsa-miR-892b	CLIP-seq
MIRT2225171	hsa-miR-1224-5p	CLIP-seq
MIRT2225172	hsa-miR-3150b-3p	CLIP-seq
MIRT2225173	hsa-miR-3612	CLIP-seq
MIRT2225174	hsa-miR-3915	CLIP-seq
MIRT2225175	hsa-miR-4443	CLIP-seq
MIRT2225176	hsa-miR-4689	CLIP-seq
MIRT2225177	hsa-miR-4784	CLIP-seq
MIRT2225178	hsa-miR-650	CLIP-seq
MIRT2225179	hsa-miR-891b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0016021	Component	Integral component of membrane	IEA

Other IDs

• MIM: 620309
• HGNC: 29412
• e!Ensembl: ENSG00000144369

Protein

• UniProt ID: Q6P995
• Protein name: Protein FAM171B
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF10577	UPF0560	82 → 612	Uncharacterised protein family UPF0560	Family
  PF10577	UPF0560	592 → 826	Uncharacterised protein family UPF0560	Family

• Sequence:

  MARLCRRVPCTLLLGLAVVLLKARLVPAAARAELSRSDLSLIQQQQQQQQQQQQQQKQLE
  EAEEERTEVPGATSTLTVPVSVFMLKVQVNDIISRQYLSQAVVEVFVNYTKTNSTVTKSN
  GAVLIKVPYKLGLSLTIIAYKDGYVLTPLPWKTRRMPIYSSVTLSLFPQSQANIWLFEDT
  VLITGKLADAKSQPSVQFSKALIKLPDNHHISNVTGYLTVLQQFLKVDNFLHTTGITLNK
  PGFENIELTPLAAICVKIYSGGKELKVNGSIQVSLPLLRLNDISAGDRIPAWTFDMNTGA
  WVNHGRGMVKEHNNHLIWTYDAPHLGYWIAAPLPGTRGSGINEDSKDITAYHTVFLTAIL
  GGTIVIVIGFFAVLLCYCRDKCGTPQKRERNITKLEVLKRDQTTSTTHINHISTVKVALK
  AEDKSQLFNAKNSSYSPQKKEPSKAETEERVSMVKTRDDFKIYNEDVSFLSVNQNNYSRN
  PTQSLEPNVGSKQPKHINNNLSSSLGDAQDEKRYLTGNEEAYGRSHIPEQLMHIYSQPIA
  ILQTSDLFSTPEQLHTAKSATLPRKGQLVYGQLMEPVNRENFTQTLPKMPIHSHAQPPDA
  REEDIILEGQQSLPSQASDWSRYSSSLLESVSVPGTLNEAVVMTPFSSELQGISEQTLLE
  LSKGKPSPHPRAWFVSLDGKPVAQVRHSFIDLKKGKRTQSNDTSLDSGVDMNELHSSRKL
  EREKTFIKSMHQPKILYLEDLDLSSSESGTTVCSPEDPALRHILDGGSGVIMEHPGEESP
  GRKSTVEDFEANTSPTKRRGRPPLAKRDSKTNIWKKREERPLIPIN

• Sequence length: 826

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Inflammatory bowel disease	Inflammatory Bowel Diseases	rs137853579, rs137853580, rs121909601, rs149491038, rs368287711, rs387907326, rs587777338, rs758439420, rs1329427406, rs1264862631, rs1192830343, rs1373354533, rs1419560997, rs1591263883, rs1989014468	28067908

Unknown
Disease term	Disease name	Evidence	References	Source
Crohn disease	Crohn Disease		28067908	ClinVar

Associations from Text Mining
Disease Name	Relationship Type	References
Colorectal Neoplasms	Associate	30861353
Pulmonary Arterial Hypertension	Associate	36248192