TTLL9 (tubulin tyrosine ligase like 9)

Gene

• Entrez ID: 164395
• Gene name: Tubulin tyrosine ligase like 9
• Gene symbol: TTLL9
• Synonyms (NCBI Gene): C20orf125
• Chromosome: 20
• Chromosome location: 20q11.21

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT455327	hsa-miR-4428	PAR-CLIP	23592263
MIRT455326	hsa-miR-552-3p	PAR-CLIP	23592263
MIRT455325	hsa-miR-6888-5p	PAR-CLIP	23592263
MIRT455324	hsa-miR-9500	PAR-CLIP	23592263
MIRT455323	hsa-miR-4533	PAR-CLIP	23592263
MIRT455322	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT455321	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT455320	hsa-miR-6722-5p	PAR-CLIP	23592263
MIRT455319	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT455318	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT455317	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT455316	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT455314	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT455315	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT455313	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT455312	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT455311	hsa-miR-1273h-5p	PAR-CLIP	23592263
MIRT455310	hsa-miR-30b-3p	PAR-CLIP	23592263
MIRT455309	hsa-miR-3689a-3p	PAR-CLIP	23592263
MIRT455308	hsa-miR-3689b-3p	PAR-CLIP	23592263
MIRT455307	hsa-miR-3689c	PAR-CLIP	23592263
MIRT455306	hsa-miR-6779-5p	PAR-CLIP	23592263
MIRT455305	hsa-miR-6780a-5p	PAR-CLIP	23592263
MIRT455327	hsa-miR-4428	PAR-CLIP	23592263
MIRT455326	hsa-miR-552-3p	PAR-CLIP	23592263
MIRT455325	hsa-miR-6888-5p	PAR-CLIP	23592263
MIRT455324	hsa-miR-9500	PAR-CLIP	23592263
MIRT455323	hsa-miR-4533	PAR-CLIP	23592263
MIRT455322	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT455321	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT455320	hsa-miR-6722-5p	PAR-CLIP	23592263
MIRT455319	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT455318	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT455317	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT455316	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT455314	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT455315	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT455313	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT455312	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT455311	hsa-miR-1273h-5p	PAR-CLIP	23592263
MIRT455310	hsa-miR-30b-3p	PAR-CLIP	23592263
MIRT455309	hsa-miR-3689a-3p	PAR-CLIP	23592263
MIRT455308	hsa-miR-3689b-3p	PAR-CLIP	23592263
MIRT455307	hsa-miR-3689c	PAR-CLIP	23592263
MIRT455306	hsa-miR-6779-5p	PAR-CLIP	23592263
MIRT455305	hsa-miR-6780a-5p	PAR-CLIP	23592263

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000226	Process	Microtubule cytoskeleton organization	IBA
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IEA
GO:0005929	Component	Cilium	IEA
GO:0015631	Function	Tubulin binding	IBA
GO:0016874	Function	Ligase activity	IEA
GO:0030317	Process	Flagellated sperm motility	IBA
GO:0030317	Process	Flagellated sperm motility	IEA
GO:0031514	Component	Motile cilium	IEA
GO:0036064	Component	Ciliary basal body	IBA
GO:0036064	Component	Ciliary basal body	IEA
GO:0042995	Component	Cell projection	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0070740	Function	Tubulin-glutamic acid ligase activity	IBA
GO:0070740	Function	Tubulin-glutamic acid ligase activity	IEA
GO:0070740	Function	Tubulin-glutamic acid ligase activity	ISS
GO:0106438	Function	Protein-glutamic acid ligase activity, elongating	IEA

Other IDs

• MIM: 619838
• HGNC: 16118
• e!Ensembl: ENSG00000131044

Protein

• UniProt ID: Q3SXZ7
• Protein name: Probable tubulin polyglutamylase TTLL9 (EC 6.3.2.-) (Tubulin--tyrosine ligase-like protein 9)
• Protein function: Probable tubulin polyglutamylase that generates side chains of glutamate on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of target proteins. Similar to TTLL1, may acquire enzymatic activity only in complex w
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03133	TTL	87 → 375	Tubulin-tyrosine ligase family	Family

• Sequence:

  MVPSREALLGPGTTAIRCPKKLQNQNYKGHGLSKGKEREQRASIRFKTTLMNTLMDVLRH
  RPGWVEVKDEGEWDFYWCDVSWLRENFDHTYMDEHVRISHFRNHYELTRKNYMVKNLKRF
  RKQLEREAGKLEAAKCDFFPKTFEMPCEYHLFVEEFRKNPGITWIMKPVARSQGKGIFLF
  RRLKDIVDWRKDTRSSDDQKDDIPVENYVAQRYIENPYLIGGRKFDLRVYVLVMSVFAEC
  LLWSGHRRQDVHLTNVAVQKTSPDYHPKKGCKWTLQRFRQYLASKHGPEAVETLFRDIDN
  IFVKSLQSVQKVIISDKHCFELYGYDILIDQDLKPWLLEVNASPSLTASSQEDYELKTCL
  LEDTLHVVDMEARLTGREKRVGGFDLMWNDGPVSREEGAPDLSGMGNFVTNTHLGCVNDR
  KKQLRQLFCSLQVQKKASS

• Sequence length: 439

Pathways

Reactome:

Carboxyterminal post-translational modifications of tubulin