Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1642
Gene name Gene Name - the full gene name approved by the HGNC.
Damage specific DNA binding protein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
DDB1
Synonyms (NCBI Gene) Gene synonyms aliases
DDBA, UV-DDB1, WHIKERS, XAP1, XPCE, XPE, XPE-BF
Disease Acronyms (UniProt) Disease acronyms from UniProt database
WHIKERS
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11q12.2
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT016411 hsa-miR-193b-3p Proteomics 21512034
MIRT050184 hsa-miR-26a-5p CLASH 23622248
MIRT047942 hsa-miR-30c-5p CLASH 23622248
MIRT045485 hsa-miR-149-5p CLASH 23622248
MIRT045270 hsa-miR-186-5p CLASH 23622248
Transcription factors
Transcription factor Regulation Reference
MYCN Unknown 12527763
NF1 Unknown 12527763
SP1 Unknown 12527763
TP53 Activation 16357511
TP53 Repression 19382146
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000715 Process Nucleotide-excision repair, DNA damage recognition TAS
GO:0000717 Process Nucleotide-excision repair, DNA duplex unwinding TAS
GO:0000781 Component Chromosome, telomeric region HDA 19135898
GO:0003677 Function DNA binding TAS 8798680
GO:0003684 Function Damaged DNA binding IDA 22334663
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
600045 2717 ENSG00000167986
Protein
UniProt ID Q16531
Protein name DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding f
Protein function Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively (PubMed:14739464, PubMed:15448697, PubMed:16260596, PubMed:16407242, PubMed:16407252, PubMe
PDB 2B5L , 2B5M , 2B5N , 2HYE , 3E0C , 3EI1 , 3EI2 , 3EI3 , 3EI4 , 3I7H , 3I7K , 3I7L , 3I7N , 3I7O , 3I7P , 3I89 , 3I8C , 3I8E , 4A08 , 4A09 , 4A0A , 4A0B , 4A0K , 4A0L , 4A11 , 4CI1 , 4CI2 , 4CI3 , 4E54 , 4E5Z , 4TZ4 , 5FQD , 5HXB , 5JK7 , 5V3O , 6BN7 , 6BN8 , 6BN9 , 6BNB , 6BOY , 6DSZ , 6FCV , 6H0F , 6H0G , 6PAI , 6Q0R , 6Q0V , 6Q0W , 6R8Y , 6R8Z , 6R90
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF10433 MMS1_N 75 543 Domain
PF03178 CPSF_A 788 1099 CPSF A subunit region Family
Sequence
MSYNYVVTAQKPTAVNGCVTGHFTSAEDLNLLIAKNTRLEIYVVTAEGLRPVKEVGMYGK
IAVMELFRPKGESKDLLFILTAKYNACILEYKQSGESIDIITRAHGNVQDRIGRPSETGI
IGIIDPECRMIGLRLYDGLFKVIPLDRDNKELKAFNIRLEELHVIDVKFLYGCQAPTICF
VYQDPQGRHVKTYEVSLREKEFNKGPWKQENVEAEASMVIAVPEPFGGAIIIGQESITYH
NGDKYLAIAPPIIKQSTIVCHNRVDPNGSRYLLGDMEGRLFMLLLEKEEQMDGTVTLKDL
RVELLGETSIAECLTYLDNGVVFVGSRLGDSQLVKLNVDSNEQGSYVVAMETFTNLGPIV
DMCVVDLERQGQGQLVTCSGAFKEGSLRIIRNGIGIHEHASIDLPGIKGLWPLRSDPNRE
TDDTLVLSFVGQTRVLMLNGEEVEETELMGFVDDQQTFFCGNVAHQQLIQITSASVRLVS
QEPKALVSEWKEPQAKNISVASCNSSQVVVAVGRALYYLQIHPQELRQISHTEMEHEVAC
LDI
TPLGDSNGLSPLCAIGLWTDISARILKLPSFELLHKEMLGGEIIPRSILMTTFESSH
YLLCALGDGALFYFGLNIETGLLSDRKKVTLGTQPTVLRTFRSLSTTNVFACSDRPTVIY
SSNHKLVFSNVNLKEVNYMCPLNSDGYPDSLALANNSTLTIGTIDEIQKLHIRTVPLYES
PRKICYQEVSQCFGVLSSRIEVQDTSGGTTALRPSASTQALSSSVSSSKLFSSSTAPHET
SFGEEVEVHNLLIIDQHTFEVLHAHQFLQNEYALSLVSCKLGKDPNTYFIVGTAMVYPEE
AEPKQGRIVVFQYSDGKLQTVAEKEVKGAVYSMVEFNGKLLASINSTVRLYEWTTEKELR
TECNHYNNIMALYLKTKGDFILVGDLMRSVLLLAYKPMEGNFEEIARDFNPNWMSAVEIL
DDDNFLGAENAFNLFVCQKDSAATTDEERQHLQEVGLFHLGEFVNVFCHGSLVMQNLGET
STPTQGSVLFGTVNGMIGLVTSLSESWYNLLLDMQNRLNKVIKSVGKIEHSFWRSFHTER
KTEPATGFIDGDLIESFLD
ISRPKMQEVVANLQYDDGSGMKREATADDLIKVVEELTRIH
Sequence length 1140
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Nucleotide excision repair
Ubiquitin mediated proteolysis
Hepatitis B
Human immunodeficiency virus 1 infection
Viral carcinogenesis
  Recognition of DNA damage by PCNA-containing replication complex
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Neddylation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Gastric cancer Hereditary Diffuse Gastric Cancer rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802
View all (244 more)
21364753
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 28336923
Adrenocortical Carcinoma Associate 20231622
Brachydactyly Associate 33743206
Carcinoma Non Small Cell Lung Associate 24082123
Carcinoma Ovarian Epithelial Associate 36934683
Carcinoma Renal Cell Associate 36934683
Colorectal Neoplasms Associate 34720086
Coronary Restenosis Associate 35968900
Death Associate 23407396
DNA Repair Deficiency Disorders Associate 33743206