IFNLR1 (interferon lambda receptor 1)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 163702
Gene name Interferon lambda receptor 1
Gene symbol IFNLR1
Synonyms (NCBI Gene)
CRF2/12IFNLRIL-28R1IL28RALICR2
Chromosome 1
Chromosome location 1p36.11
Summary The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, in
miRNA miRNA information provided by mirtarbase database.
255
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (255)
miRTarBase ID miRNA Experiments Reference
MIRT024759 hsa-miR-215-5p Microarray 19074876
MIRT026809 hsa-miR-192-5p Microarray 19074876
MIRT710804 hsa-miR-519a-3p HITS-CLIP 19536157
MIRT710803 hsa-miR-519b-3p HITS-CLIP 19536157
MIRT710802 hsa-miR-519c-3p HITS-CLIP 19536157
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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Transcription factor Regulation Reference
STAT1 Unknown 20372826
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0002385 Process Mucosal immune response IEA
GO:0002385 Process Mucosal immune response ISS
GO:0004896 Function Cytokine receptor activity IBA
GO:0004896 Function Cytokine receptor activity NAS 12483210
GO:0005515 Function Protein binding IPI 12469119, 12483210, 32296183
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
607404 18584 ENSG00000185436
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8IU57
Protein name Interferon lambda receptor 1 (IFN-lambda receptor 1) (IFN-lambda-R1) (Cytokine receptor class-II member 12) (Cytokine receptor family 2 member 12) (CRF2-12) (Interleukin-28 receptor subunit alpha) (IL-28 receptor subunit alpha) (IL-28R-alpha) (IL-28RA) (L
Protein function The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimula
PDB 3OG4 , 3OG6 , 5IXD , 5IXI , 5L04 , 5T5W , 9BPU , 9BPV
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01108 Tissue_fac 8 → 111 Tissue factor Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:12469119, ECO:0000269|PubMed:12483210}.
Sequence 
MAGPERWGPLLLCLLQAAPGRPRLAPPQNVTLLSQNFSVYLTWLPGLGNPQDVTYFVAYQ
SSPTRRRWREVEECAGTKELLCSMMCLKKQDLYNKFKGRVRTVSPSSKSPWVESEYLDYL
FEVEPAPPVLVLTQTEEILSANATYQLPPCMPPLDLKYEVAFWKEGAGNKTLFPVTPHGQ
PVQITLQPAASEHHCLSARTIYTFSVPKYSKFSKPTCFLLEVPEANWAFLVLPSLLILLL
VIAAGGVIWKTLMGNPWFQRAKMPRALDFSGHTHPVATFQPSRPESVNDLFLCPQKELTR
GVRPTPRVRAPATQQTRWKKDLAEDEEEEDEEDTEDGVSFQPYIEPPSFLGQEHQAPGHS
EAGGVDSGRPRAPLVPSEGSSAWDSSDRSWASTVDSSWDRAGSSGYLAEKGPGQGPGGDG
HQESLPPPEFSKDSGFLEELPEDNLSSWATWGTLPPEPNLVPGGPPVSLQTLTFCWESSP
EEEEEARESEIEDSDAGSWGAESTQRTEDRGRTLGHYMAR
Sequence length 520
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Cytokine-cytokine receptor interaction
JAK-STAT signaling pathway 		  Other interleukin signaling
Interleukin-20 family signaling
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
IFNLR1-related disorder Uncertain significance; Likely benign; Benign rs200996459, rs575575280, rs74399859, rs750327742, rs116722436, rs59631801, rs2523170421, rs141659592, rs763613375, rs115773768, rs200988201, rs141989044, rs78627520, rs35682685, rs74060530 RCV003405963
RCV003421027
RCV003923912
RCV003924088
RCV003912128
RCV003973920
RCV003969244
RCV003936833
RCV003947043
RCV003979212
RCV003954828
RCV003962304
RCV003905956
RCV003905912
RCV003955951
Show/Hide Text Mining Associations (14)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Arthritis Rheumatoid Stimulate 23078630
Arthritis Rheumatoid Associate 24286242
Carcinoma Non Small Cell Lung Associate 37146414
COVID 19 Stimulate 34723226
Dementia Associate 36421848
Infections Associate 36379255
Inflammation Associate 34723226
Influenza Human Associate 36379255
Lung Diseases Associate 28777004
Melanoma Associate 20103601