Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	163486
Gene name Gene Name - the full gene name approved by the HGNC.	DENN domain containing 1B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	DENND1B
Synonyms (NCBI Gene) Gene synonyms aliases	C1ORF18, C1orf218, FAM31B
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1q31.3
Summary Summary of gene provided in NCBI Entrez Gene.	Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase

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miRTarBase ID	miRNA	Experiments	Reference
MIRT497954	hsa-miR-365a-3p	PAR-CLIP	22291592
MIRT497953	hsa-miR-365b-3p	PAR-CLIP	22291592
MIRT497952	hsa-miR-802	PAR-CLIP	22291592
MIRT497951	hsa-miR-532-5p	PAR-CLIP	22291592
MIRT497950	hsa-miR-4312	PAR-CLIP	22291592
MIRT497949	hsa-miR-155-5p	PAR-CLIP	22291592
MIRT497948	hsa-miR-6869-5p	PAR-CLIP	22291592
MIRT497954	hsa-miR-365a-3p	PAR-CLIP	22291592
MIRT497953	hsa-miR-365b-3p	PAR-CLIP	22291592
MIRT497952	hsa-miR-802	PAR-CLIP	22291592
MIRT497951	hsa-miR-532-5p	PAR-CLIP	22291592
MIRT497950	hsa-miR-4312	PAR-CLIP	22291592
MIRT497949	hsa-miR-155-5p	PAR-CLIP	22291592
MIRT497948	hsa-miR-6869-5p	PAR-CLIP	22291592
MIRT932190	hsa-miR-101	CLIP-seq
MIRT932191	hsa-miR-103a	CLIP-seq
MIRT932192	hsa-miR-107	CLIP-seq
MIRT932193	hsa-miR-1178	CLIP-seq
MIRT932194	hsa-miR-1184	CLIP-seq
MIRT932195	hsa-miR-1200	CLIP-seq
MIRT932196	hsa-miR-1205	CLIP-seq
MIRT932197	hsa-miR-1206	CLIP-seq
MIRT932198	hsa-miR-1244	CLIP-seq
MIRT932199	hsa-miR-1270	CLIP-seq
MIRT932200	hsa-miR-128	CLIP-seq
MIRT932201	hsa-miR-129-5p	CLIP-seq
MIRT932202	hsa-miR-1297	CLIP-seq
MIRT932203	hsa-miR-132	CLIP-seq
MIRT932204	hsa-miR-1323	CLIP-seq
MIRT932205	hsa-miR-137	CLIP-seq
MIRT932206	hsa-miR-141	CLIP-seq
MIRT932207	hsa-miR-142-5p	CLIP-seq
MIRT932208	hsa-miR-15a	CLIP-seq
MIRT932209	hsa-miR-15b	CLIP-seq
MIRT932210	hsa-miR-16	CLIP-seq
MIRT932211	hsa-miR-182	CLIP-seq
MIRT932212	hsa-miR-195	CLIP-seq
MIRT932213	hsa-miR-200a	CLIP-seq
MIRT932214	hsa-miR-205	CLIP-seq
MIRT932215	hsa-miR-2054	CLIP-seq
MIRT932216	hsa-miR-212	CLIP-seq
MIRT932217	hsa-miR-23a	CLIP-seq
MIRT932218	hsa-miR-23b	CLIP-seq
MIRT932219	hsa-miR-23c	CLIP-seq
MIRT932220	hsa-miR-26a	CLIP-seq
MIRT932221	hsa-miR-26b	CLIP-seq
MIRT932222	hsa-miR-298	CLIP-seq
MIRT932223	hsa-miR-29a	CLIP-seq
MIRT932224	hsa-miR-29b	CLIP-seq
MIRT932225	hsa-miR-29c	CLIP-seq
MIRT932226	hsa-miR-3065-3p	CLIP-seq
MIRT932227	hsa-miR-3074-5p	CLIP-seq
MIRT932228	hsa-miR-30a	CLIP-seq
MIRT932229	hsa-miR-30b	CLIP-seq
MIRT932230	hsa-miR-30c	CLIP-seq
MIRT932231	hsa-miR-30d	CLIP-seq
MIRT932232	hsa-miR-30e	CLIP-seq
MIRT932233	hsa-miR-3120-5p	CLIP-seq
MIRT932234	hsa-miR-3121-5p	CLIP-seq
MIRT932235	hsa-miR-3132	CLIP-seq
MIRT932236	hsa-miR-3140-3p	CLIP-seq
MIRT932237	hsa-miR-3140-5p	CLIP-seq
MIRT932238	hsa-miR-3153	CLIP-seq
MIRT932239	hsa-miR-3158-5p	CLIP-seq
MIRT932240	hsa-miR-3182	CLIP-seq
MIRT932241	hsa-miR-3194-3p	CLIP-seq
MIRT932242	hsa-miR-3200-3p	CLIP-seq
MIRT932243	hsa-miR-324-5p	CLIP-seq
MIRT932244	hsa-miR-337-3p	CLIP-seq
MIRT932245	hsa-miR-340	CLIP-seq
MIRT932246	hsa-miR-3613-3p	CLIP-seq
MIRT932247	hsa-miR-362-5p	CLIP-seq
MIRT932248	hsa-miR-3647-3p	CLIP-seq
MIRT932249	hsa-miR-365	CLIP-seq
MIRT932250	hsa-miR-3668	CLIP-seq
MIRT932251	hsa-miR-3692	CLIP-seq
MIRT932252	hsa-miR-369-3p	CLIP-seq
MIRT932253	hsa-miR-371b-5p	CLIP-seq
MIRT932254	hsa-miR-374a	CLIP-seq
MIRT932255	hsa-miR-374b	CLIP-seq
MIRT932256	hsa-miR-375	CLIP-seq
MIRT932257	hsa-miR-383	CLIP-seq
MIRT932258	hsa-miR-3910	CLIP-seq
MIRT932259	hsa-miR-424	CLIP-seq
MIRT932260	hsa-miR-4260	CLIP-seq
MIRT932261	hsa-miR-4277	CLIP-seq
MIRT932262	hsa-miR-4291	CLIP-seq
MIRT932263	hsa-miR-4326	CLIP-seq
MIRT932264	hsa-miR-4420	CLIP-seq
MIRT932265	hsa-miR-4422	CLIP-seq
MIRT932266	hsa-miR-4426	CLIP-seq
MIRT932267	hsa-miR-4460	CLIP-seq
MIRT932268	hsa-miR-4464	CLIP-seq
MIRT932269	hsa-miR-4465	CLIP-seq
MIRT932270	hsa-miR-4480	CLIP-seq
MIRT932271	hsa-miR-4503	CLIP-seq
MIRT932272	hsa-miR-4524	CLIP-seq
MIRT932273	hsa-miR-4531	CLIP-seq
MIRT932274	hsa-miR-455-5p	CLIP-seq
MIRT932275	hsa-miR-4645-3p	CLIP-seq
MIRT932276	hsa-miR-4645-5p	CLIP-seq
MIRT932277	hsa-miR-4646-5p	CLIP-seq
MIRT932278	hsa-miR-4647	CLIP-seq
MIRT932279	hsa-miR-4659a-3p	CLIP-seq
MIRT932280	hsa-miR-4659b-3p	CLIP-seq
MIRT932281	hsa-miR-4662b	CLIP-seq
MIRT932282	hsa-miR-4668-3p	CLIP-seq
MIRT932283	hsa-miR-4668-5p	CLIP-seq
MIRT932284	hsa-miR-4673	CLIP-seq
MIRT932285	hsa-miR-4683	CLIP-seq
MIRT932286	hsa-miR-4686	CLIP-seq
MIRT932287	hsa-miR-4694-3p	CLIP-seq
MIRT932288	hsa-miR-4718	CLIP-seq
MIRT932289	hsa-miR-4719	CLIP-seq
MIRT932290	hsa-miR-4727-3p	CLIP-seq
MIRT932291	hsa-miR-4727-5p	CLIP-seq
MIRT932292	hsa-miR-4742-5p	CLIP-seq
MIRT932293	hsa-miR-4748	CLIP-seq
MIRT932294	hsa-miR-4760-3p	CLIP-seq
MIRT932295	hsa-miR-4772-5p	CLIP-seq
MIRT932296	hsa-miR-4776-3p	CLIP-seq
MIRT932297	hsa-miR-4789-5p	CLIP-seq
MIRT932298	hsa-miR-4795-3p	CLIP-seq
MIRT932299	hsa-miR-4799-5p	CLIP-seq
MIRT932300	hsa-miR-486-3p	CLIP-seq
MIRT932301	hsa-miR-497	CLIP-seq
MIRT932302	hsa-miR-500b	CLIP-seq
MIRT932303	hsa-miR-501-5p	CLIP-seq
MIRT932304	hsa-miR-503	CLIP-seq
MIRT932305	hsa-miR-513b	CLIP-seq
MIRT932306	hsa-miR-520a-5p	CLIP-seq
MIRT932307	hsa-miR-520f	CLIP-seq
MIRT932308	hsa-miR-525-5p	CLIP-seq
MIRT932309	hsa-miR-544	CLIP-seq
MIRT932310	hsa-miR-545	CLIP-seq
MIRT932311	hsa-miR-548a-5p	CLIP-seq
MIRT932312	hsa-miR-548aa	CLIP-seq
MIRT932313	hsa-miR-548ab	CLIP-seq
MIRT932314	hsa-miR-548ac	CLIP-seq
MIRT932315	hsa-miR-548ae	CLIP-seq
MIRT932316	hsa-miR-548aj	CLIP-seq
MIRT932317	hsa-miR-548ak	CLIP-seq
MIRT932318	hsa-miR-548am	CLIP-seq
MIRT932319	hsa-miR-548an	CLIP-seq
MIRT932320	hsa-miR-548b-5p	CLIP-seq
MIRT932321	hsa-miR-548c-5p	CLIP-seq
MIRT932322	hsa-miR-548d-3p	CLIP-seq
MIRT932323	hsa-miR-548d-5p	CLIP-seq
MIRT932324	hsa-miR-548h	CLIP-seq
MIRT932325	hsa-miR-548i	CLIP-seq
MIRT932326	hsa-miR-548j	CLIP-seq
MIRT932327	hsa-miR-548k	CLIP-seq
MIRT932328	hsa-miR-548l	CLIP-seq
MIRT932329	hsa-miR-548n	CLIP-seq
MIRT932330	hsa-miR-548o	CLIP-seq
MIRT932331	hsa-miR-548v	CLIP-seq
MIRT932332	hsa-miR-548w	CLIP-seq
MIRT932333	hsa-miR-548x	CLIP-seq
MIRT932334	hsa-miR-548y	CLIP-seq
MIRT932335	hsa-miR-548z	CLIP-seq
MIRT932336	hsa-miR-553	CLIP-seq
MIRT932337	hsa-miR-559	CLIP-seq
MIRT932338	hsa-miR-579	CLIP-seq
MIRT932339	hsa-miR-620	CLIP-seq
MIRT932340	hsa-miR-622	CLIP-seq
MIRT932341	hsa-miR-646	CLIP-seq
MIRT932342	hsa-miR-938	CLIP-seq
MIRT932191	hsa-miR-103a	CLIP-seq
MIRT932192	hsa-miR-107	CLIP-seq
MIRT1976011	hsa-miR-1237	CLIP-seq
MIRT1976012	hsa-miR-1245b-3p	CLIP-seq
MIRT1976013	hsa-miR-1248	CLIP-seq
MIRT1976014	hsa-miR-1283	CLIP-seq
MIRT932201	hsa-miR-129-5p	CLIP-seq
MIRT1976015	hsa-miR-154	CLIP-seq
MIRT932208	hsa-miR-15a	CLIP-seq
MIRT932209	hsa-miR-15b	CLIP-seq
MIRT932210	hsa-miR-16	CLIP-seq
MIRT932212	hsa-miR-195	CLIP-seq
MIRT1976016	hsa-miR-2052	CLIP-seq
MIRT1976017	hsa-miR-219-1-3p	CLIP-seq
MIRT1976018	hsa-miR-31	CLIP-seq
MIRT932236	hsa-miR-3140-3p	CLIP-seq
MIRT1976019	hsa-miR-3155	CLIP-seq
MIRT1976020	hsa-miR-3155b	CLIP-seq
MIRT1976021	hsa-miR-3157-5p	CLIP-seq
MIRT1976022	hsa-miR-3161	CLIP-seq
MIRT1976023	hsa-miR-3173-3p	CLIP-seq
MIRT1976024	hsa-miR-320a	CLIP-seq
MIRT1976025	hsa-miR-320b	CLIP-seq
MIRT1976026	hsa-miR-320c	CLIP-seq
MIRT1976027	hsa-miR-320d	CLIP-seq
MIRT1976028	hsa-miR-323b-3p	CLIP-seq
MIRT1976029	hsa-miR-338-5p	CLIP-seq
MIRT1976030	hsa-miR-339-5p	CLIP-seq
MIRT932248	hsa-miR-3647-3p	CLIP-seq
MIRT1976031	hsa-miR-3685	CLIP-seq
MIRT932257	hsa-miR-383	CLIP-seq
MIRT1976032	hsa-miR-3907	CLIP-seq
MIRT1976033	hsa-miR-3923	CLIP-seq
MIRT932259	hsa-miR-424	CLIP-seq
MIRT1976034	hsa-miR-4263	CLIP-seq
MIRT1976035	hsa-miR-4282	CLIP-seq
MIRT1976036	hsa-miR-4307	CLIP-seq
MIRT1976037	hsa-miR-4330	CLIP-seq
MIRT1976038	hsa-miR-4428	CLIP-seq
MIRT1976039	hsa-miR-4429	CLIP-seq
MIRT1976040	hsa-miR-4452	CLIP-seq
MIRT932270	hsa-miR-4480	CLIP-seq
MIRT1976041	hsa-miR-4521	CLIP-seq
MIRT932272	hsa-miR-4524	CLIP-seq
MIRT1976042	hsa-miR-4659a-5p	CLIP-seq
MIRT1976043	hsa-miR-4659b-5p	CLIP-seq
MIRT932282	hsa-miR-4668-3p	CLIP-seq
MIRT1976044	hsa-miR-4691-3p	CLIP-seq
MIRT1976045	hsa-miR-4704-5p	CLIP-seq
MIRT1976046	hsa-miR-4738-3p	CLIP-seq
MIRT932292	hsa-miR-4742-5p	CLIP-seq
MIRT1976047	hsa-miR-4761-5p	CLIP-seq
MIRT932295	hsa-miR-4772-5p	CLIP-seq
MIRT1976048	hsa-miR-4775	CLIP-seq
MIRT932296	hsa-miR-4776-3p	CLIP-seq
MIRT1976049	hsa-miR-4777-3p	CLIP-seq
MIRT932298	hsa-miR-4795-3p	CLIP-seq
MIRT932299	hsa-miR-4799-5p	CLIP-seq
MIRT1976050	hsa-miR-484	CLIP-seq
MIRT932301	hsa-miR-497	CLIP-seq
MIRT932304	hsa-miR-503	CLIP-seq
MIRT1976051	hsa-miR-513a-5p	CLIP-seq
MIRT1976052	hsa-miR-539	CLIP-seq
MIRT932311	hsa-miR-548a-5p	CLIP-seq
MIRT932313	hsa-miR-548ab	CLIP-seq
MIRT932317	hsa-miR-548ak	CLIP-seq
MIRT932320	hsa-miR-548b-5p	CLIP-seq
MIRT932321	hsa-miR-548c-5p	CLIP-seq
MIRT932323	hsa-miR-548d-5p	CLIP-seq
MIRT1976053	hsa-miR-548g	CLIP-seq
MIRT932324	hsa-miR-548h	CLIP-seq
MIRT932325	hsa-miR-548i	CLIP-seq
MIRT932326	hsa-miR-548j	CLIP-seq
MIRT932328	hsa-miR-548l	CLIP-seq
MIRT932332	hsa-miR-548w	CLIP-seq
MIRT932334	hsa-miR-548y	CLIP-seq
MIRT932337	hsa-miR-559	CLIP-seq
MIRT1976054	hsa-miR-571	CLIP-seq
MIRT1976055	hsa-miR-576-5p	CLIP-seq
MIRT932341	hsa-miR-646	CLIP-seq
MIRT932191	hsa-miR-103a	CLIP-seq
MIRT2211415	hsa-miR-105	CLIP-seq
MIRT932192	hsa-miR-107	CLIP-seq
MIRT2211416	hsa-miR-1182	CLIP-seq
MIRT2211417	hsa-miR-1183	CLIP-seq
MIRT932197	hsa-miR-1206	CLIP-seq
MIRT932198	hsa-miR-1244	CLIP-seq
MIRT932200	hsa-miR-128	CLIP-seq
MIRT1976014	hsa-miR-1283	CLIP-seq
MIRT932201	hsa-miR-129-5p	CLIP-seq
MIRT932203	hsa-miR-132	CLIP-seq
MIRT2211418	hsa-miR-136	CLIP-seq
MIRT932206	hsa-miR-141	CLIP-seq
MIRT2211419	hsa-miR-143	CLIP-seq
MIRT2211420	hsa-miR-144	CLIP-seq
MIRT2211421	hsa-miR-147	CLIP-seq
MIRT932208	hsa-miR-15a	CLIP-seq
MIRT932209	hsa-miR-15b	CLIP-seq
MIRT932210	hsa-miR-16	CLIP-seq
MIRT932211	hsa-miR-182	CLIP-seq
MIRT2211422	hsa-miR-193a-5p	CLIP-seq
MIRT2211423	hsa-miR-194	CLIP-seq
MIRT932212	hsa-miR-195	CLIP-seq
MIRT932213	hsa-miR-200a	CLIP-seq
MIRT1976016	hsa-miR-2052	CLIP-seq
MIRT2211424	hsa-miR-2113	CLIP-seq
MIRT932216	hsa-miR-212	CLIP-seq
MIRT2211425	hsa-miR-216a	CLIP-seq
MIRT1976017	hsa-miR-219-1-3p	CLIP-seq
MIRT2211426	hsa-miR-2277-3p	CLIP-seq
MIRT2211427	hsa-miR-2682	CLIP-seq
MIRT932222	hsa-miR-298	CLIP-seq
MIRT932223	hsa-miR-29a	CLIP-seq
MIRT932224	hsa-miR-29b	CLIP-seq
MIRT932225	hsa-miR-29c	CLIP-seq
MIRT2211428	hsa-miR-3065-5p	CLIP-seq
MIRT1976018	hsa-miR-31	CLIP-seq
MIRT2211429	hsa-miR-3121-3p	CLIP-seq
MIRT2211430	hsa-miR-3127-5p	CLIP-seq
MIRT932236	hsa-miR-3140-3p	CLIP-seq
MIRT2211431	hsa-miR-3143	CLIP-seq
MIRT2211432	hsa-miR-3152-3p	CLIP-seq
MIRT932238	hsa-miR-3153	CLIP-seq
MIRT1976019	hsa-miR-3155	CLIP-seq
MIRT1976020	hsa-miR-3155b	CLIP-seq
MIRT1976022	hsa-miR-3161	CLIP-seq
MIRT2211433	hsa-miR-3170	CLIP-seq
MIRT1976023	hsa-miR-3173-3p	CLIP-seq
MIRT932242	hsa-miR-3200-3p	CLIP-seq
MIRT932245	hsa-miR-340	CLIP-seq
MIRT2211434	hsa-miR-3545-3p	CLIP-seq
MIRT932246	hsa-miR-3613-3p	CLIP-seq
MIRT2211435	hsa-miR-3613-5p	CLIP-seq
MIRT2211436	hsa-miR-3622a-5p	CLIP-seq
MIRT2211437	hsa-miR-3646	CLIP-seq
MIRT932249	hsa-miR-365	CLIP-seq
MIRT2211438	hsa-miR-3662	CLIP-seq
MIRT932250	hsa-miR-3668	CLIP-seq
MIRT2211439	hsa-miR-3671	CLIP-seq
MIRT1976031	hsa-miR-3685	CLIP-seq
MIRT2211440	hsa-miR-3688-3p	CLIP-seq
MIRT2211441	hsa-miR-371-5p	CLIP-seq
MIRT932253	hsa-miR-371b-5p	CLIP-seq
MIRT932257	hsa-miR-383	CLIP-seq
MIRT932258	hsa-miR-3910	CLIP-seq
MIRT2211442	hsa-miR-3935	CLIP-seq
MIRT2211443	hsa-miR-3941	CLIP-seq
MIRT932259	hsa-miR-424	CLIP-seq
MIRT2211444	hsa-miR-4273	CLIP-seq
MIRT932261	hsa-miR-4277	CLIP-seq
MIRT2211445	hsa-miR-4294	CLIP-seq
MIRT2211446	hsa-miR-4310	CLIP-seq
MIRT2211447	hsa-miR-4328	CLIP-seq
MIRT932265	hsa-miR-4422	CLIP-seq
MIRT2211448	hsa-miR-4423-3p	CLIP-seq
MIRT1976038	hsa-miR-4428	CLIP-seq
MIRT2211449	hsa-miR-4433	CLIP-seq
MIRT2211450	hsa-miR-4459	CLIP-seq
MIRT2211451	hsa-miR-449c	CLIP-seq
MIRT932271	hsa-miR-4503	CLIP-seq
MIRT1976041	hsa-miR-4521	CLIP-seq
MIRT932272	hsa-miR-4524	CLIP-seq
MIRT2211452	hsa-miR-4528	CLIP-seq
MIRT932274	hsa-miR-455-5p	CLIP-seq
MIRT2211453	hsa-miR-4643	CLIP-seq
MIRT932277	hsa-miR-4646-5p	CLIP-seq
MIRT2211454	hsa-miR-4652-3p	CLIP-seq
MIRT1976042	hsa-miR-4659a-5p	CLIP-seq
MIRT1976043	hsa-miR-4659b-5p	CLIP-seq
MIRT2211455	hsa-miR-466	CLIP-seq
MIRT932283	hsa-miR-4668-5p	CLIP-seq
MIRT2211456	hsa-miR-4672	CLIP-seq
MIRT932287	hsa-miR-4694-3p	CLIP-seq
MIRT2211457	hsa-miR-4698	CLIP-seq
MIRT932290	hsa-miR-4727-3p	CLIP-seq
MIRT932292	hsa-miR-4742-5p	CLIP-seq
MIRT2211458	hsa-miR-4768-3p	CLIP-seq
MIRT2211459	hsa-miR-4770	CLIP-seq
MIRT932295	hsa-miR-4772-5p	CLIP-seq
MIRT932296	hsa-miR-4776-3p	CLIP-seq
MIRT2211460	hsa-miR-4778-5p	CLIP-seq
MIRT2211461	hsa-miR-4781-3p	CLIP-seq
MIRT2211462	hsa-miR-4789-3p	CLIP-seq
MIRT932297	hsa-miR-4789-5p	CLIP-seq
MIRT932298	hsa-miR-4795-3p	CLIP-seq
MIRT932299	hsa-miR-4799-5p	CLIP-seq
MIRT1976050	hsa-miR-484	CLIP-seq
MIRT2211463	hsa-miR-496	CLIP-seq
MIRT932301	hsa-miR-497	CLIP-seq
MIRT932304	hsa-miR-503	CLIP-seq
MIRT1976051	hsa-miR-513a-5p	CLIP-seq
MIRT1976052	hsa-miR-539	CLIP-seq
MIRT2211464	hsa-miR-543	CLIP-seq
MIRT932311	hsa-miR-548a-5p	CLIP-seq
MIRT932313	hsa-miR-548ab	CLIP-seq
MIRT932314	hsa-miR-548ac	CLIP-seq
MIRT932315	hsa-miR-548ae	CLIP-seq
MIRT932316	hsa-miR-548aj	CLIP-seq
MIRT932317	hsa-miR-548ak	CLIP-seq
MIRT932318	hsa-miR-548am	CLIP-seq
MIRT932320	hsa-miR-548b-5p	CLIP-seq
MIRT932321	hsa-miR-548c-5p	CLIP-seq
MIRT932322	hsa-miR-548d-3p	CLIP-seq
MIRT932323	hsa-miR-548d-5p	CLIP-seq
MIRT932324	hsa-miR-548h	CLIP-seq
MIRT932325	hsa-miR-548i	CLIP-seq
MIRT932326	hsa-miR-548j	CLIP-seq
MIRT932327	hsa-miR-548k	CLIP-seq
MIRT932328	hsa-miR-548l	CLIP-seq
MIRT932329	hsa-miR-548n	CLIP-seq
MIRT932332	hsa-miR-548w	CLIP-seq
MIRT932333	hsa-miR-548x	CLIP-seq
MIRT932334	hsa-miR-548y	CLIP-seq
MIRT932335	hsa-miR-548z	CLIP-seq
MIRT932336	hsa-miR-553	CLIP-seq
MIRT932337	hsa-miR-559	CLIP-seq
MIRT1976054	hsa-miR-571	CLIP-seq
MIRT2211465	hsa-miR-586	CLIP-seq
MIRT2211466	hsa-miR-599	CLIP-seq
MIRT932341	hsa-miR-646	CLIP-seq
MIRT2211467	hsa-miR-885-5p	CLIP-seq
MIRT2211468	hsa-miR-934	CLIP-seq
MIRT932201	hsa-miR-129-5p	CLIP-seq
MIRT932206	hsa-miR-141	CLIP-seq
MIRT932213	hsa-miR-200a	CLIP-seq
MIRT932223	hsa-miR-29a	CLIP-seq
MIRT932224	hsa-miR-29b	CLIP-seq
MIRT932225	hsa-miR-29c	CLIP-seq
MIRT932271	hsa-miR-4503	CLIP-seq
MIRT932277	hsa-miR-4646-5p	CLIP-seq
MIRT932217	hsa-miR-23a	CLIP-seq
MIRT932218	hsa-miR-23b	CLIP-seq
MIRT932219	hsa-miR-23c	CLIP-seq
MIRT932228	hsa-miR-30a	CLIP-seq
MIRT932229	hsa-miR-30b	CLIP-seq
MIRT932230	hsa-miR-30c	CLIP-seq
MIRT932231	hsa-miR-30d	CLIP-seq
MIRT932232	hsa-miR-30e	CLIP-seq
MIRT2515198	hsa-miR-570	CLIP-seq
MIRT932338	hsa-miR-579	CLIP-seq
MIRT932222	hsa-miR-298	CLIP-seq
MIRT2211457	hsa-miR-4698	CLIP-seq
MIRT2679155	hsa-miR-548a-3p	CLIP-seq
MIRT2679156	hsa-miR-548e	CLIP-seq
MIRT2679157	hsa-miR-548f	CLIP-seq
MIRT1976053	hsa-miR-548g	CLIP-seq

Show/Hide all(27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IDA	20937701
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006897	Process	Endocytosis	IBA
GO:0015031	Process	Protein transport	IEA
GO:0016607	Component	Nuclear speck	IBA
GO:0016607	Component	Nuclear speck	IDA
GO:0030136	Component	Clathrin-coated vesicle	IEA
GO:0031267	Function	Small GTPase binding	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0032456	Process	Endocytic recycling	IBA
GO:0032456	Process	Endocytic recycling	IEA
GO:0032456	Process	Endocytic recycling	ISS
GO:0043231	Component	Intracellular membrane-bounded organelle	IBA
GO:0050776	Process	Regulation of immune response	IEA
GO:0050776	Process	Regulation of immune response	ISS
GO:0050852	Process	T cell receptor signaling pathway	IBA
GO:0050852	Process	T cell receptor signaling pathway	IEA
GO:0050852	Process	T cell receptor signaling pathway	IMP	26774822
GO:1901981	Function	Phosphatidylinositol phosphate binding	IBA
GO:2000553	Process	Positive regulation of T-helper 2 cell cytokine production	IEA
GO:2000553	Process	Positive regulation of T-helper 2 cell cytokine production	IMP	26774822

MIM	HGNC	e!Ensembl
613292	28404	ENSG00000213047

Protein

UniProt ID

Q6P3S1

Protein name

DENN domain-containing protein 1B (Connecdenn 2) (Protein FAM31B)

Protein function

Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells (PubMed:20154091, PubMed:20937701, PubMed:24520163, PubMed:26774822). Acts by promoting the exchange of GDP to GTP,

PDB

3TW8

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03456	uDENN	29 → 88	uDENN domain	Domain
PF02141	DENN	92 → 291	DENN (AEX-3) domain	Family
PF03455	dDENN	355 → 405	dDENN domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in dendritic and natural killer cells and at lower levels in other myeloid lineage cells and in pituitary. Significantly up-regulated in effector memory T-cells as compared with naive T-cells. {ECO:0000269|PubMed:20032

Sequence

MDCRTKANPDRTFDLVLKVKCHASENEDPVVLWKFPEDFGDQEILQSVPKFCFPFDVERV
SQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADYLAK
ELENDLNETLRSLYNHPVPKANTPVNLSVNQEIFIACEQVLKDQPALVPHSYFIAPDVTG
LPTIPESRNLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMY
WQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFSDL
NNLPSDVVSALKNKLKKQSTATGDGVARAFLRAQAALFGSYRDALRYKPGEPITFCEESF
VKHRSSVMKQFLETAINLQLFKQFIDGRLAKLNAGRGFSDVFEEEITSGGFCGGNPRSYQ
QWVHTVKKGGALFNTAMTKATPAVRTAYKFAKNHAKLGLKEVKSKLKHKENEEDYGTCSS
SVQYTPVYKLHNEKGGNSEKRKLAQARLKRPLKSLDGALYDDEDDDDIERASKLSSEDGE
EASAYLYESDDSVETRVKTPYSGEMDLLGEILDTLSTHSSDQGKLAAAKSLDFFRSMDDI
DYKPTNKSNAPSENNLAFLCGGSGDQAEWNLGQDDSALHGKHLPPSPRKRVSSSGLTDSL
FILKEENSNKHLGADNVSDPTSGLDFQLTSPEVSQTDKGKTEKRETLSQISDDLLIPGLG
RHSSTFVPWEKEGKEAKETSEDIGLLHEVVSLCHMTSDFQQSLNISDKNTNGNQT

Sequence length

775

Interactions

View interactions

	Reactome
			RAB GEFs exchange GTP for GDP on RABs

Show/Hide Unknown Diseases (13)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Anxiety Disorder	Anxiety	N/A	N/A	GWAS
Biliary Cholangitis	Primary biliary cholangitis	N/A	N/A	GWAS
Biliary Cirrhosis	Primary biliary cirrhosis	N/A	N/A	GWAS
Coronary artery disease	Coronary artery disease	N/A	N/A	GWAS
Crohn Disease	Crohn's disease	N/A	N/A	GWAS
Inflammatory Bowel Disease	Inflammatory bowel disease	N/A	N/A	GWAS
Insomnia	Insomnia	N/A	N/A	GWAS
Mental Depression	Major depressive disorder	N/A	N/A	GWAS
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS
Myocardial Infarction	Myocardial infarction	N/A	N/A	GWAS
Neuroticism	Neuroticism	N/A	N/A	GWAS
Psoriasis	Psoriasis	N/A	N/A	GWAS
Ulcerative colitis	Ulcerative colitis	N/A	N/A	GWAS

Show/Hide Text Mining Associations (8)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Asthma	Associate	20032318, 23517042
Dementia Vascular	Associate	39909351
Diabetes Mellitus Type 2	Associate	24455749
Invasive Pulmonary Aspergillosis	Associate	24712925
Narcolepsy	Associate	37188663
Obesity	Associate	24455749
Pancreatic Neoplasms	Associate	25945796
Status Asthmaticus	Associate	23517042

DENND1B (DENN domain containing 1B)