Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
163486
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
DENN domain containing 1B |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
DENND1B |
Synonyms (NCBI Gene)
Gene synonyms aliases
|
C1ORF18, C1orf218, FAM31B |
Chromosome
Chromosome number
|
1 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
1q31.3 |
Summary
Summary of gene provided in NCBI Entrez Gene.
|
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase |
Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Inflammatory bowel disease |
Inflammatory Bowel Diseases |
rs137853579, rs137853580, rs121909601, rs149491038, rs368287711, rs387907326, rs587777338, rs758439420, rs1329427406, rs1264862631, rs1192830343, rs1373354533, rs1419560997, rs1591263883, rs1989014468 |
26192919, 23128233, 28067908 |
Psoriasis |
Psoriasis |
rs281875215, rs587777763, rs281875213, rs281875212 |
26974007 |
|
Unknown |
Disease term |
Disease name |
Evidence |
References |
Source |
Asthma |
Asthma |
|
21907864 |
ClinVar |
Crohn disease |
Crohn Disease, Regional enteritis |
|
21102463, 26974007, 28067908, 26192919 |
ClinVar |
Mental depression |
Major Depressive Disorder |
|
30718901, 29662059, 27479909 |
ClinVar |
Neuroticism |
Neuroticism |
|
|
GWAS |
Biliary Cholangitis |
Biliary Cholangitis |
|
|
GWAS |
Crohn Disease |
Crohn Disease |
|
|
GWAS |
Biliary Cirrhosis |
Biliary Cirrhosis |
|
|
GWAS |
Inflammatory Bowel Disease |
Inflammatory Bowel Disease |
|
|
GWAS |
Metabolic Syndrome |
Metabolic Syndrome |
|
|
GWAS |
Mental Depression |
Mental Depression |
|
|
GWAS |
Anxiety Disorder |
Anxiety Disorder |
|
|
GWAS |
Ulcerative colitis |
Ulcerative colitis |
|
|
GWAS |
Coronary artery disease |
Coronary artery disease |
|
|
GWAS |
Insomnia |
Insomnia |
|
|
GWAS |
Myocardial Infarction |
Myocardial Infarction |
|
|
GWAS |
|
Associations from Text Mining |
Disease Name |
Relationship Type |
References |
Asthma |
Associate
|
20032318, 23517042 |
Dementia Vascular |
Associate
|
39909351 |
Diabetes Mellitus Type 2 |
Associate
|
24455749 |
Invasive Pulmonary Aspergillosis |
Associate
|
24712925 |
Narcolepsy |
Associate
|
37188663 |
Obesity |
Associate
|
24455749 |
Pancreatic Neoplasms |
Associate
|
25945796 |
Status Asthmaticus |
Associate
|
23517042 |
|