Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	163087
Gene name Gene Name - the full gene name approved by the HGNC.	Zinc finger protein 383
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ZNF383
Synonyms (NCBI Gene) Gene synonyms aliases	HSD17, Zfp383
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19q13.12
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a KRAB-related zinc finger protein that inhibits the transcription of some MAPK signaling pathway genes. The repressor activity resides in the KRAB domain of the encoded protein. [provided by RefSeq, Sep 2016]

Show/Hide all(204)

miRTarBase ID	miRNA	Experiments	Reference
MIRT042301	hsa-miR-484	CLASH	23622248
MIRT042301	hsa-miR-484	CLASH	23622248
MIRT693772	hsa-miR-4797-5p	HITS-CLIP	23313552
MIRT693771	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT693770	hsa-miR-5586-3p	HITS-CLIP	23313552
MIRT693769	hsa-miR-759	HITS-CLIP	23313552
MIRT693768	hsa-miR-4793-3p	HITS-CLIP	23313552
MIRT681248	hsa-miR-4537	HITS-CLIP	23313552
MIRT693767	hsa-miR-4252	HITS-CLIP	23313552
MIRT693766	hsa-miR-7703	HITS-CLIP	23313552
MIRT693765	hsa-miR-6890-3p	HITS-CLIP	23313552
MIRT693764	hsa-miR-1273g-3p	HITS-CLIP	23313552
MIRT693763	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT693762	hsa-miR-939-3p	HITS-CLIP	23313552
MIRT693761	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT693760	hsa-miR-18a-3p	HITS-CLIP	23313552
MIRT693759	hsa-miR-1285-3p	HITS-CLIP	23313552
MIRT693758	hsa-miR-3187-5p	HITS-CLIP	23313552
MIRT693757	hsa-miR-5189-5p	HITS-CLIP	23313552
MIRT693756	hsa-miR-612	HITS-CLIP	23313552
MIRT693755	hsa-miR-6860	HITS-CLIP	23313552
MIRT693754	hsa-miR-4290	HITS-CLIP	23313552
MIRT693753	hsa-miR-661	HITS-CLIP	23313552
MIRT693752	hsa-miR-196a-3p	HITS-CLIP	23313552
MIRT693750	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT693751	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT693749	hsa-miR-1229-3p	HITS-CLIP	23313552
MIRT681253	hsa-miR-1910-3p	HITS-CLIP	23706177
MIRT681252	hsa-miR-6511a-5p	HITS-CLIP	23706177
MIRT681251	hsa-miR-4257	HITS-CLIP	23706177
MIRT681250	hsa-miR-6746-5p	HITS-CLIP	23706177
MIRT681249	hsa-miR-4680-5p	HITS-CLIP	23706177
MIRT681248	hsa-miR-4537	HITS-CLIP	23706177
MIRT681247	hsa-miR-1827	HITS-CLIP	23706177
MIRT681246	hsa-miR-377-5p	HITS-CLIP	23706177
MIRT681245	hsa-miR-6086	HITS-CLIP	23706177
MIRT681244	hsa-miR-2467-3p	HITS-CLIP	23706177
MIRT681243	hsa-miR-6499-3p	HITS-CLIP	23706177
MIRT681242	hsa-miR-3612	HITS-CLIP	23706177
MIRT681241	hsa-miR-650	HITS-CLIP	23706177
MIRT681240	hsa-miR-6771-5p	HITS-CLIP	23706177
MIRT681239	hsa-miR-7158-3p	HITS-CLIP	23706177
MIRT681238	hsa-miR-203b-3p	HITS-CLIP	23706177
MIRT681237	hsa-miR-455-3p	HITS-CLIP	23706177
MIRT681236	hsa-miR-6516-5p	HITS-CLIP	23706177
MIRT615719	hsa-miR-3137	HITS-CLIP	23824327
MIRT615718	hsa-miR-20b-3p	HITS-CLIP	23824327
MIRT615717	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT615716	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT615715	hsa-miR-4775	HITS-CLIP	23824327
MIRT615714	hsa-miR-3686	HITS-CLIP	23824327
MIRT615713	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT615712	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT637374	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT615719	hsa-miR-3137	HITS-CLIP	23824327
MIRT615718	hsa-miR-20b-3p	HITS-CLIP	23824327
MIRT615717	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT615716	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT615715	hsa-miR-4775	HITS-CLIP	23824327
MIRT615714	hsa-miR-3686	HITS-CLIP	23824327
MIRT615713	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT615712	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT637374	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT615719	hsa-miR-3137	HITS-CLIP	23824327
MIRT615718	hsa-miR-20b-3p	HITS-CLIP	23824327
MIRT615717	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT615716	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT615715	hsa-miR-4775	HITS-CLIP	23824327
MIRT615714	hsa-miR-3686	HITS-CLIP	23824327
MIRT615713	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT615712	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT631630	hsa-miR-5197-5p	HITS-CLIP	23824327
MIRT631629	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT631628	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT615719	hsa-miR-3137	HITS-CLIP	23824327
MIRT615718	hsa-miR-20b-3p	HITS-CLIP	23824327
MIRT615717	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT615716	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT615715	hsa-miR-4775	HITS-CLIP	23824327
MIRT615714	hsa-miR-3686	HITS-CLIP	23824327
MIRT615713	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT615712	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT544550	hsa-miR-3163	PAR-CLIP	21572407
MIRT544551	hsa-miR-369-3p	PAR-CLIP	21572407
MIRT544549	hsa-miR-5692b	PAR-CLIP	21572407
MIRT544548	hsa-miR-5692c	PAR-CLIP	21572407
MIRT544547	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT544546	hsa-miR-374b-5p	PAR-CLIP	21572407
MIRT544550	hsa-miR-3163	PAR-CLIP	21572407
MIRT544551	hsa-miR-369-3p	PAR-CLIP	21572407
MIRT544549	hsa-miR-5692b	PAR-CLIP	21572407
MIRT544548	hsa-miR-5692c	PAR-CLIP	21572407
MIRT544547	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT544546	hsa-miR-374b-5p	PAR-CLIP	21572407
MIRT681247	hsa-miR-1827	PAR-CLIP	27292025
MIRT681253	hsa-miR-1910-3p	PAR-CLIP	27292025
MIRT681238	hsa-miR-203b-3p	PAR-CLIP	27292025
MIRT681244	hsa-miR-2467-3p	PAR-CLIP	27292025
MIRT681242	hsa-miR-3612	PAR-CLIP	27292025
MIRT681246	hsa-miR-377-5p	PAR-CLIP	27292025
MIRT681251	hsa-miR-4257	PAR-CLIP	27292025
MIRT681248	hsa-miR-4537	PAR-CLIP	27292025
MIRT681237	hsa-miR-455-3p	PAR-CLIP	27292025
MIRT681249	hsa-miR-4680-5p	PAR-CLIP	27292025
MIRT681245	hsa-miR-6086	PAR-CLIP	27292025
MIRT681243	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT681241	hsa-miR-650	PAR-CLIP	27292025
MIRT681252	hsa-miR-6511a-5p	PAR-CLIP	27292025
MIRT681236	hsa-miR-6516-5p	PAR-CLIP	27292025
MIRT681250	hsa-miR-6746-5p	PAR-CLIP	27292025
MIRT681240	hsa-miR-6771-5p	PAR-CLIP	27292025
MIRT681239	hsa-miR-7158-3p	PAR-CLIP	27292025
MIRT693772	hsa-miR-4797-5p	HITS-CLIP	23313552
MIRT693771	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT693770	hsa-miR-5586-3p	HITS-CLIP	23313552
MIRT693769	hsa-miR-759	HITS-CLIP	23313552
MIRT693768	hsa-miR-4793-3p	HITS-CLIP	23313552
MIRT681248	hsa-miR-4537	HITS-CLIP	23313552
MIRT693767	hsa-miR-4252	HITS-CLIP	23313552
MIRT693766	hsa-miR-7703	HITS-CLIP	23313552
MIRT693765	hsa-miR-6890-3p	HITS-CLIP	23313552
MIRT693764	hsa-miR-1273g-3p	HITS-CLIP	23313552
MIRT693763	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT693762	hsa-miR-939-3p	HITS-CLIP	23313552
MIRT693761	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT693760	hsa-miR-18a-3p	HITS-CLIP	23313552
MIRT693759	hsa-miR-1285-3p	HITS-CLIP	23313552
MIRT693758	hsa-miR-3187-5p	HITS-CLIP	23313552
MIRT693757	hsa-miR-5189-5p	HITS-CLIP	23313552
MIRT693756	hsa-miR-612	HITS-CLIP	23313552
MIRT693755	hsa-miR-6860	HITS-CLIP	23313552
MIRT693754	hsa-miR-4290	HITS-CLIP	23313552
MIRT693753	hsa-miR-661	HITS-CLIP	23313552
MIRT693752	hsa-miR-196a-3p	HITS-CLIP	23313552
MIRT693750	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT693751	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT693749	hsa-miR-1229-3p	HITS-CLIP	23313552
MIRT681253	hsa-miR-1910-3p	HITS-CLIP	23706177
MIRT681252	hsa-miR-6511a-5p	HITS-CLIP	23706177
MIRT681251	hsa-miR-4257	HITS-CLIP	23706177
MIRT681250	hsa-miR-6746-5p	HITS-CLIP	23706177
MIRT681249	hsa-miR-4680-5p	HITS-CLIP	23706177
MIRT681248	hsa-miR-4537	HITS-CLIP	23706177
MIRT681247	hsa-miR-1827	HITS-CLIP	23706177
MIRT681246	hsa-miR-377-5p	HITS-CLIP	23706177
MIRT681245	hsa-miR-6086	HITS-CLIP	23706177
MIRT681244	hsa-miR-2467-3p	HITS-CLIP	23706177
MIRT681243	hsa-miR-6499-3p	HITS-CLIP	23706177
MIRT681242	hsa-miR-3612	HITS-CLIP	23706177
MIRT681241	hsa-miR-650	HITS-CLIP	23706177
MIRT681240	hsa-miR-6771-5p	HITS-CLIP	23706177
MIRT681239	hsa-miR-7158-3p	HITS-CLIP	23706177
MIRT681238	hsa-miR-203b-3p	HITS-CLIP	23706177
MIRT681237	hsa-miR-455-3p	HITS-CLIP	23706177
MIRT681236	hsa-miR-6516-5p	HITS-CLIP	23706177
MIRT615719	hsa-miR-3137	HITS-CLIP	23824327
MIRT615718	hsa-miR-20b-3p	HITS-CLIP	23824327
MIRT615717	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT615716	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT615715	hsa-miR-4775	HITS-CLIP	23824327
MIRT615714	hsa-miR-3686	HITS-CLIP	23824327
MIRT615713	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT615712	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT637374	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT615719	hsa-miR-3137	HITS-CLIP	23824327
MIRT615718	hsa-miR-20b-3p	HITS-CLIP	23824327
MIRT615717	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT615716	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT615715	hsa-miR-4775	HITS-CLIP	23824327
MIRT615714	hsa-miR-3686	HITS-CLIP	23824327
MIRT615713	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT615712	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT637374	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT615719	hsa-miR-3137	HITS-CLIP	23824327
MIRT615718	hsa-miR-20b-3p	HITS-CLIP	23824327
MIRT615717	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT615716	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT615715	hsa-miR-4775	HITS-CLIP	23824327
MIRT615714	hsa-miR-3686	HITS-CLIP	23824327
MIRT615713	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT615712	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT631630	hsa-miR-5197-5p	HITS-CLIP	23824327
MIRT631629	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT631628	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT615719	hsa-miR-3137	HITS-CLIP	23824327
MIRT615718	hsa-miR-20b-3p	HITS-CLIP	23824327
MIRT615717	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT615716	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT615715	hsa-miR-4775	HITS-CLIP	23824327
MIRT615714	hsa-miR-3686	HITS-CLIP	23824327
MIRT615713	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT615712	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT544550	hsa-miR-3163	PAR-CLIP	21572407
MIRT544551	hsa-miR-369-3p	PAR-CLIP	21572407
MIRT544549	hsa-miR-5692b	PAR-CLIP	21572407
MIRT544548	hsa-miR-5692c	PAR-CLIP	21572407
MIRT544547	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT544546	hsa-miR-374b-5p	PAR-CLIP	21572407
MIRT544550	hsa-miR-3163	PAR-CLIP	21572407
MIRT544551	hsa-miR-369-3p	PAR-CLIP	21572407
MIRT544549	hsa-miR-5692b	PAR-CLIP	21572407
MIRT544548	hsa-miR-5692c	PAR-CLIP	21572407
MIRT544547	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT544546	hsa-miR-374b-5p	PAR-CLIP	21572407

Show/Hide all(8)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0003700	Function	DNA-binding transcription factor activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0031965	Component	Nuclear membrane	IDA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
619499	18609	ENSG00000188283

Protein

UniProt ID

Q8NA42

Protein name

Zinc finger protein 383

Protein function

May function as a transcriptional repressor, suppressing transcriptional activities mediated by MAPK signaling pathways.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01352	KRAB	5 → 46	KRAB box	Family
PF00096	zf-C2H2	170 → 192	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	226 → 248	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	254 → 276	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	282 → 304	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	310 → 332	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	338 → 360	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	366 → 388	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	394 → 416	Zinc finger, C2H2 type	Domain
PF13465	zf-H2C2_2	436 → 461		Domain
PF00096	zf-C2H2	450 → 472	Zinc finger, C2H2 type	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in heart, placenta, liver, pancreas and with a higher level in skeletal muscle. {ECO:0000269|PubMed:15964543}.

Sequence

MAEGSVMFSDVSIDFSQEEWDCLDPVQRDLYRDVMLENYGNLVSMGLYTPKPQVISLLEQ
GKEPWMVGRELTRGLCSDLESMCETKLLSLKKEVYEIELCQREIMGLTKHGLEYSSFGDV
LEYRSHLAKQLGYPNGHFSQEIFTPEYMPTFIQQTFLTLHQIINNEDRPYECKKCGKAFS
QNSQFIQHQRIHIGEKSYECKECGKFFSCGSHVTRHLKIHTGEKPFECKECGKAFSCSSY
LSQHQRIHTGKKPYECKECGKAFSYCSNLIDHQRIHTGEKPYECKVCGKAFTKSSQLFQH
ARIHTGEKPYECKECGKAFTQSSKLVQHQRIHTGEKPYECKECGKAFSSGSALTNHQRIH
TGEKPYDCKECGKAFTQSSQLRQHQRIHAGEKPFECLECGKAFTQNSQLFQHQRIHTDEK
PYECNECGKAFNKCSNLTRHLRIHTGEKPYNCKECGKAFSSGSDLIRHQGIHTNK

Sequence length

475

Interactions

View interactions

	Reactome
			Generic Transcription Pathway

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297	27903959

ZNF383 (zinc finger protein 383)