Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	163087
Gene name	Zinc finger protein 383
Gene symbol	ZNF383
Synonyms (NCBI Gene)	HSD17Zfp383
Chromosome	19
Chromosome location	19q13.12
Summary	The protein encoded by this gene is a KRAB-related zinc finger protein that inhibits the transcription of some MAPK signaling pathway genes. The repressor activity resides in the KRAB domain of the encoded protein. [provided by RefSeq, Sep 2016]

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Show/Hide all (204)

miRTarBase ID	miRNA	Experiments	Reference
MIRT042301	hsa-miR-484	CLASH	23622248
MIRT042301	hsa-miR-484	CLASH	23622248
MIRT693772	hsa-miR-4797-5p	HITS-CLIP	23313552
MIRT693771	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT693770	hsa-miR-5586-3p	HITS-CLIP	23313552
MIRT693769	hsa-miR-759	HITS-CLIP	23313552
MIRT693768	hsa-miR-4793-3p	HITS-CLIP	23313552
MIRT681248	hsa-miR-4537	HITS-CLIP	23313552
MIRT693767	hsa-miR-4252	HITS-CLIP	23313552
MIRT693766	hsa-miR-7703	HITS-CLIP	23313552
MIRT693765	hsa-miR-6890-3p	HITS-CLIP	23313552
MIRT693764	hsa-miR-1273g-3p	HITS-CLIP	23313552
MIRT693763	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT693762	hsa-miR-939-3p	HITS-CLIP	23313552
MIRT693761	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT693760	hsa-miR-18a-3p	HITS-CLIP	23313552
MIRT693759	hsa-miR-1285-3p	HITS-CLIP	23313552
MIRT693758	hsa-miR-3187-5p	HITS-CLIP	23313552
MIRT693757	hsa-miR-5189-5p	HITS-CLIP	23313552
MIRT693756	hsa-miR-612	HITS-CLIP	23313552
MIRT693755	hsa-miR-6860	HITS-CLIP	23313552
MIRT693754	hsa-miR-4290	HITS-CLIP	23313552
MIRT693753	hsa-miR-661	HITS-CLIP	23313552
MIRT693752	hsa-miR-196a-3p	HITS-CLIP	23313552
MIRT693750	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT693751	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT693749	hsa-miR-1229-3p	HITS-CLIP	23313552
MIRT681253	hsa-miR-1910-3p	HITS-CLIP	23706177
MIRT681252	hsa-miR-6511a-5p	HITS-CLIP	23706177
MIRT681251	hsa-miR-4257	HITS-CLIP	23706177
MIRT681250	hsa-miR-6746-5p	HITS-CLIP	23706177
MIRT681249	hsa-miR-4680-5p	HITS-CLIP	23706177
MIRT681248	hsa-miR-4537	HITS-CLIP	23706177
MIRT681247	hsa-miR-1827	HITS-CLIP	23706177
MIRT681246	hsa-miR-377-5p	HITS-CLIP	23706177
MIRT681245	hsa-miR-6086	HITS-CLIP	23706177
MIRT681244	hsa-miR-2467-3p	HITS-CLIP	23706177
MIRT681243	hsa-miR-6499-3p	HITS-CLIP	23706177
MIRT681242	hsa-miR-3612	HITS-CLIP	23706177
MIRT681241	hsa-miR-650	HITS-CLIP	23706177
MIRT681240	hsa-miR-6771-5p	HITS-CLIP	23706177
MIRT681239	hsa-miR-7158-3p	HITS-CLIP	23706177
MIRT681238	hsa-miR-203b-3p	HITS-CLIP	23706177
MIRT681237	hsa-miR-455-3p	HITS-CLIP	23706177
MIRT681236	hsa-miR-6516-5p	HITS-CLIP	23706177
MIRT615719	hsa-miR-3137	HITS-CLIP	23824327
MIRT615718	hsa-miR-20b-3p	HITS-CLIP	23824327
MIRT615717	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT615716	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT615715	hsa-miR-4775	HITS-CLIP	23824327
MIRT615714	hsa-miR-3686	HITS-CLIP	23824327
MIRT615713	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT615712	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT637374	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT615719	hsa-miR-3137	HITS-CLIP	23824327
MIRT615718	hsa-miR-20b-3p	HITS-CLIP	23824327
MIRT615717	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT615716	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT615715	hsa-miR-4775	HITS-CLIP	23824327
MIRT615714	hsa-miR-3686	HITS-CLIP	23824327
MIRT615713	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT615712	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT637374	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT615719	hsa-miR-3137	HITS-CLIP	23824327
MIRT615718	hsa-miR-20b-3p	HITS-CLIP	23824327
MIRT615717	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT615716	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT615715	hsa-miR-4775	HITS-CLIP	23824327
MIRT615714	hsa-miR-3686	HITS-CLIP	23824327
MIRT615713	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT615712	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT631630	hsa-miR-5197-5p	HITS-CLIP	23824327
MIRT631629	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT631628	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT615719	hsa-miR-3137	HITS-CLIP	23824327
MIRT615718	hsa-miR-20b-3p	HITS-CLIP	23824327
MIRT615717	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT615716	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT615715	hsa-miR-4775	HITS-CLIP	23824327
MIRT615714	hsa-miR-3686	HITS-CLIP	23824327
MIRT615713	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT615712	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT544550	hsa-miR-3163	PAR-CLIP	21572407
MIRT544551	hsa-miR-369-3p	PAR-CLIP	21572407
MIRT544549	hsa-miR-5692b	PAR-CLIP	21572407
MIRT544548	hsa-miR-5692c	PAR-CLIP	21572407
MIRT544547	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT544546	hsa-miR-374b-5p	PAR-CLIP	21572407
MIRT544550	hsa-miR-3163	PAR-CLIP	21572407
MIRT544551	hsa-miR-369-3p	PAR-CLIP	21572407
MIRT544549	hsa-miR-5692b	PAR-CLIP	21572407
MIRT544548	hsa-miR-5692c	PAR-CLIP	21572407
MIRT544547	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT544546	hsa-miR-374b-5p	PAR-CLIP	21572407
MIRT681247	hsa-miR-1827	PAR-CLIP	27292025
MIRT681253	hsa-miR-1910-3p	PAR-CLIP	27292025
MIRT681238	hsa-miR-203b-3p	PAR-CLIP	27292025
MIRT681244	hsa-miR-2467-3p	PAR-CLIP	27292025
MIRT681242	hsa-miR-3612	PAR-CLIP	27292025
MIRT681246	hsa-miR-377-5p	PAR-CLIP	27292025
MIRT681251	hsa-miR-4257	PAR-CLIP	27292025
MIRT681248	hsa-miR-4537	PAR-CLIP	27292025
MIRT681237	hsa-miR-455-3p	PAR-CLIP	27292025
MIRT681249	hsa-miR-4680-5p	PAR-CLIP	27292025
MIRT681245	hsa-miR-6086	PAR-CLIP	27292025
MIRT681243	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT681241	hsa-miR-650	PAR-CLIP	27292025
MIRT681252	hsa-miR-6511a-5p	PAR-CLIP	27292025
MIRT681236	hsa-miR-6516-5p	PAR-CLIP	27292025
MIRT681250	hsa-miR-6746-5p	PAR-CLIP	27292025
MIRT681240	hsa-miR-6771-5p	PAR-CLIP	27292025
MIRT681239	hsa-miR-7158-3p	PAR-CLIP	27292025
MIRT693772	hsa-miR-4797-5p	HITS-CLIP	23313552
MIRT693771	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT693770	hsa-miR-5586-3p	HITS-CLIP	23313552
MIRT693769	hsa-miR-759	HITS-CLIP	23313552
MIRT693768	hsa-miR-4793-3p	HITS-CLIP	23313552
MIRT681248	hsa-miR-4537	HITS-CLIP	23313552
MIRT693767	hsa-miR-4252	HITS-CLIP	23313552
MIRT693766	hsa-miR-7703	HITS-CLIP	23313552
MIRT693765	hsa-miR-6890-3p	HITS-CLIP	23313552
MIRT693764	hsa-miR-1273g-3p	HITS-CLIP	23313552
MIRT693763	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT693762	hsa-miR-939-3p	HITS-CLIP	23313552
MIRT693761	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT693760	hsa-miR-18a-3p	HITS-CLIP	23313552
MIRT693759	hsa-miR-1285-3p	HITS-CLIP	23313552
MIRT693758	hsa-miR-3187-5p	HITS-CLIP	23313552
MIRT693757	hsa-miR-5189-5p	HITS-CLIP	23313552
MIRT693756	hsa-miR-612	HITS-CLIP	23313552
MIRT693755	hsa-miR-6860	HITS-CLIP	23313552
MIRT693754	hsa-miR-4290	HITS-CLIP	23313552
MIRT693753	hsa-miR-661	HITS-CLIP	23313552
MIRT693752	hsa-miR-196a-3p	HITS-CLIP	23313552
MIRT693750	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT693751	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT693749	hsa-miR-1229-3p	HITS-CLIP	23313552
MIRT681253	hsa-miR-1910-3p	HITS-CLIP	23706177
MIRT681252	hsa-miR-6511a-5p	HITS-CLIP	23706177
MIRT681251	hsa-miR-4257	HITS-CLIP	23706177
MIRT681250	hsa-miR-6746-5p	HITS-CLIP	23706177
MIRT681249	hsa-miR-4680-5p	HITS-CLIP	23706177
MIRT681248	hsa-miR-4537	HITS-CLIP	23706177
MIRT681247	hsa-miR-1827	HITS-CLIP	23706177
MIRT681246	hsa-miR-377-5p	HITS-CLIP	23706177
MIRT681245	hsa-miR-6086	HITS-CLIP	23706177
MIRT681244	hsa-miR-2467-3p	HITS-CLIP	23706177
MIRT681243	hsa-miR-6499-3p	HITS-CLIP	23706177
MIRT681242	hsa-miR-3612	HITS-CLIP	23706177
MIRT681241	hsa-miR-650	HITS-CLIP	23706177
MIRT681240	hsa-miR-6771-5p	HITS-CLIP	23706177
MIRT681239	hsa-miR-7158-3p	HITS-CLIP	23706177
MIRT681238	hsa-miR-203b-3p	HITS-CLIP	23706177
MIRT681237	hsa-miR-455-3p	HITS-CLIP	23706177
MIRT681236	hsa-miR-6516-5p	HITS-CLIP	23706177
MIRT615719	hsa-miR-3137	HITS-CLIP	23824327
MIRT615718	hsa-miR-20b-3p	HITS-CLIP	23824327
MIRT615717	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT615716	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT615715	hsa-miR-4775	HITS-CLIP	23824327
MIRT615714	hsa-miR-3686	HITS-CLIP	23824327
MIRT615713	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT615712	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT637374	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT615719	hsa-miR-3137	HITS-CLIP	23824327
MIRT615718	hsa-miR-20b-3p	HITS-CLIP	23824327
MIRT615717	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT615716	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT615715	hsa-miR-4775	HITS-CLIP	23824327
MIRT615714	hsa-miR-3686	HITS-CLIP	23824327
MIRT615713	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT615712	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT637374	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT615719	hsa-miR-3137	HITS-CLIP	23824327
MIRT615718	hsa-miR-20b-3p	HITS-CLIP	23824327
MIRT615717	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT615716	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT615715	hsa-miR-4775	HITS-CLIP	23824327
MIRT615714	hsa-miR-3686	HITS-CLIP	23824327
MIRT615713	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT615712	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT631630	hsa-miR-5197-5p	HITS-CLIP	23824327
MIRT631629	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT631628	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT615719	hsa-miR-3137	HITS-CLIP	23824327
MIRT615718	hsa-miR-20b-3p	HITS-CLIP	23824327
MIRT615717	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT615716	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT615715	hsa-miR-4775	HITS-CLIP	23824327
MIRT615714	hsa-miR-3686	HITS-CLIP	23824327
MIRT615713	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT615712	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT544550	hsa-miR-3163	PAR-CLIP	21572407
MIRT544551	hsa-miR-369-3p	PAR-CLIP	21572407
MIRT544549	hsa-miR-5692b	PAR-CLIP	21572407
MIRT544548	hsa-miR-5692c	PAR-CLIP	21572407
MIRT544547	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT544546	hsa-miR-374b-5p	PAR-CLIP	21572407
MIRT544550	hsa-miR-3163	PAR-CLIP	21572407
MIRT544551	hsa-miR-369-3p	PAR-CLIP	21572407
MIRT544549	hsa-miR-5692b	PAR-CLIP	21572407
MIRT544548	hsa-miR-5692c	PAR-CLIP	21572407
MIRT544547	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT544546	hsa-miR-374b-5p	PAR-CLIP	21572407

Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IBA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0031965	Component	Nuclear membrane	IDA
GO:0031965	Component	Nuclear membrane	IEA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
619499	18609	ENSG00000188283

Q8NA42

Protein name

Zinc finger protein 383

Protein function

May function as a transcriptional repressor, suppressing transcriptional activities mediated by MAPK signaling pathways.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01352	KRAB	5 → 46	KRAB box	Family
PF00096	zf-C2H2	170 → 192	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	226 → 248	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	254 → 276	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	282 → 304	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	310 → 332	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	338 → 360	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	366 → 388	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	394 → 416	Zinc finger, C2H2 type	Domain
PF13465	zf-H2C2_2	436 → 461		Domain
PF00096	zf-C2H2	450 → 472	Zinc finger, C2H2 type	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in heart, placenta, liver, pancreas and with a higher level in skeletal muscle. {ECO:0000269|PubMed:15964543}.

Sequence

MAEGSVMFSDVSIDFSQEEWDCLDPVQRDLYRDVMLENYGNLVSMGLYTPKPQVISLLEQ
GKEPWMVGRELTRGLCSDLESMCETKLLSLKKEVYEIELCQREIMGLTKHGLEYSSFGDV
LEYRSHLAKQLGYPNGHFSQEIFTPEYMPTFIQQTFLTLHQIINNEDRPYECKKCGKAFS
QNSQFIQHQRIHIGEKSYECKECGKFFSCGSHVTRHLKIHTGEKPFECKECGKAFSCSSY
LSQHQRIHTGKKPYECKECGKAFSYCSNLIDHQRIHTGEKPYECKVCGKAFTKSSQLFQH
ARIHTGEKPYECKECGKAFTQSSKLVQHQRIHTGEKPYECKECGKAFSSGSALTNHQRIH
TGEKPYDCKECGKAFTQSSQLRQHQRIHAGEKPFECLECGKAFTQNSQLFQHQRIHTDEK
PYECNECGKAFNKCSNLTRHLRIHTGEKPYNCKECGKAFSSGSDLIRHQGIHTNK

Sequence length

475

Interactions

View interactions

	Reactome
			Generic Transcription Pathway

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	rs1351580126	RCV004558068

ZNF383 (zinc finger protein 383)