ZNF519 (zinc finger protein 519)

Gene

• Entrez ID: 162655
• Gene name: Zinc finger protein 519
• Gene symbol: ZNF519
• Synonyms (NCBI Gene): HsT2362
• Chromosome: 18
• Chromosome location: 18p11.21

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024798	hsa-miR-215-5p	Microarray	19074876
MIRT026721	hsa-miR-192-5p	Microarray	19074876
MIRT677950	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT677949	hsa-miR-764	HITS-CLIP	23824327
MIRT677948	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT677947	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT677944	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT677943	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT677942	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT677941	hsa-miR-8086	HITS-CLIP	23824327
MIRT677939	hsa-miR-4474-5p	HITS-CLIP	23824327
MIRT677938	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT677937	hsa-miR-640	HITS-CLIP	23824327
MIRT677952	hsa-miR-7851-3p	HITS-CLIP	23824327
MIRT677951	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT677950	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT677949	hsa-miR-764	HITS-CLIP	23824327
MIRT677948	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT677947	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT677946	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT677945	hsa-miR-645	HITS-CLIP	23824327
MIRT677944	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT677943	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT677942	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT677941	hsa-miR-8086	HITS-CLIP	23824327
MIRT677940	hsa-miR-6069	HITS-CLIP	23824327
MIRT677939	hsa-miR-4474-5p	HITS-CLIP	23824327
MIRT677938	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT677937	hsa-miR-640	HITS-CLIP	23824327
MIRT514275	hsa-miR-590-3p	PAR-CLIP	23446348
MIRT514274	hsa-miR-6758-5p	PAR-CLIP	23446348
MIRT514273	hsa-miR-6856-5p	PAR-CLIP	23446348
MIRT514272	hsa-miR-4735-5p	PAR-CLIP	23446348
MIRT514271	hsa-miR-4650-3p	PAR-CLIP	23446348
MIRT514270	hsa-miR-3529-5p	PAR-CLIP	23446348
MIRT514269	hsa-miR-379-5p	PAR-CLIP	23446348
MIRT514268	hsa-miR-4451	PAR-CLIP	23446348
MIRT514266	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT514267	hsa-miR-4775	PAR-CLIP	23446348
MIRT514265	hsa-miR-3149	PAR-CLIP	23446348
MIRT514264	hsa-miR-129-5p	PAR-CLIP	23446348
MIRT677950	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT677949	hsa-miR-764	HITS-CLIP	23824327
MIRT677948	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT677947	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT677944	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT677943	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT677942	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT677941	hsa-miR-8086	HITS-CLIP	23824327
MIRT677939	hsa-miR-4474-5p	HITS-CLIP	23824327
MIRT677938	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT677937	hsa-miR-640	HITS-CLIP	23824327
MIRT677952	hsa-miR-7851-3p	HITS-CLIP	23824327
MIRT677951	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT677950	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT677949	hsa-miR-764	HITS-CLIP	23824327
MIRT677948	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT677947	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT677946	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT677945	hsa-miR-645	HITS-CLIP	23824327
MIRT677944	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT677943	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT677942	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT677941	hsa-miR-8086	HITS-CLIP	23824327
MIRT677940	hsa-miR-6069	HITS-CLIP	23824327
MIRT677939	hsa-miR-4474-5p	HITS-CLIP	23824327
MIRT677938	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT677937	hsa-miR-640	HITS-CLIP	23824327
MIRT514275	hsa-miR-590-3p	PAR-CLIP	23446348
MIRT514274	hsa-miR-6758-5p	PAR-CLIP	23446348
MIRT514273	hsa-miR-6856-5p	PAR-CLIP	23446348
MIRT514272	hsa-miR-4735-5p	PAR-CLIP	23446348
MIRT514271	hsa-miR-4650-3p	PAR-CLIP	23446348
MIRT514270	hsa-miR-3529-5p	PAR-CLIP	23446348
MIRT514269	hsa-miR-379-5p	PAR-CLIP	23446348
MIRT514268	hsa-miR-4451	PAR-CLIP	23446348
MIRT514266	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT514267	hsa-miR-4775	PAR-CLIP	23446348
MIRT514265	hsa-miR-3149	PAR-CLIP	23446348
MIRT514264	hsa-miR-129-5p	PAR-CLIP	23446348
MIRT1528012	hsa-miR-1273g	CLIP-seq
MIRT1528013	hsa-miR-1276	CLIP-seq
MIRT1528014	hsa-miR-1323	CLIP-seq
MIRT1528015	hsa-miR-135a	CLIP-seq
MIRT1528016	hsa-miR-135b	CLIP-seq
MIRT1528017	hsa-miR-136	CLIP-seq
MIRT1528018	hsa-miR-142-5p	CLIP-seq
MIRT1528019	hsa-miR-144	CLIP-seq
MIRT1528020	hsa-miR-150	CLIP-seq
MIRT1528021	hsa-miR-1909	CLIP-seq
MIRT1528022	hsa-miR-200b	CLIP-seq
MIRT1528023	hsa-miR-200c	CLIP-seq
MIRT1528024	hsa-miR-3074-3p	CLIP-seq
MIRT1528025	hsa-miR-3074-5p	CLIP-seq
MIRT1528026	hsa-miR-3120-3p	CLIP-seq
MIRT1528027	hsa-miR-3125	CLIP-seq
MIRT1528028	hsa-miR-3132	CLIP-seq
MIRT1528029	hsa-miR-3150a-3p	CLIP-seq
MIRT1528030	hsa-miR-3154	CLIP-seq
MIRT1528031	hsa-miR-3166	CLIP-seq
MIRT1528032	hsa-miR-3175	CLIP-seq
MIRT1528033	hsa-miR-3179	CLIP-seq
MIRT1528034	hsa-miR-329	CLIP-seq
MIRT1528035	hsa-miR-340	CLIP-seq
MIRT1528036	hsa-miR-3613-3p	CLIP-seq
MIRT1528037	hsa-miR-362-3p	CLIP-seq
MIRT1528038	hsa-miR-3673	CLIP-seq
MIRT1528039	hsa-miR-3688-3p	CLIP-seq
MIRT1528040	hsa-miR-369-3p	CLIP-seq
MIRT1528041	hsa-miR-371-5p	CLIP-seq
MIRT1528042	hsa-miR-371b-5p	CLIP-seq
MIRT1528043	hsa-miR-3916	CLIP-seq
MIRT1528044	hsa-miR-3941	CLIP-seq
MIRT1528045	hsa-miR-3942-5p	CLIP-seq
MIRT1528046	hsa-miR-3978	CLIP-seq
MIRT1528047	hsa-miR-410	CLIP-seq
MIRT1528048	hsa-miR-4259	CLIP-seq
MIRT1528049	hsa-miR-429	CLIP-seq
MIRT1528050	hsa-miR-4421	CLIP-seq
MIRT1528051	hsa-miR-4424	CLIP-seq
MIRT1528052	hsa-miR-4434	CLIP-seq
MIRT1528053	hsa-miR-4452	CLIP-seq
MIRT1528054	hsa-miR-4481	CLIP-seq
MIRT1528055	hsa-miR-4506	CLIP-seq
MIRT1528056	hsa-miR-4516	CLIP-seq
MIRT1528057	hsa-miR-466	CLIP-seq
MIRT1528058	hsa-miR-4666-3p	CLIP-seq
MIRT1528059	hsa-miR-4672	CLIP-seq
MIRT1528060	hsa-miR-4680-5p	CLIP-seq
MIRT1528061	hsa-miR-4696	CLIP-seq
MIRT1528062	hsa-miR-4700-3p	CLIP-seq
MIRT1528063	hsa-miR-4703-3p	CLIP-seq
MIRT1528064	hsa-miR-4703-5p	CLIP-seq
MIRT1528065	hsa-miR-4704-3p	CLIP-seq
MIRT1528066	hsa-miR-4705	CLIP-seq
MIRT1528067	hsa-miR-4715-5p	CLIP-seq
MIRT1528068	hsa-miR-4745-5p	CLIP-seq
MIRT1528069	hsa-miR-4764-5p	CLIP-seq
MIRT1528070	hsa-miR-4771	CLIP-seq
MIRT1528071	hsa-miR-491-5p	CLIP-seq
MIRT1528072	hsa-miR-495	CLIP-seq
MIRT1528073	hsa-miR-499-3p	CLIP-seq
MIRT1528074	hsa-miR-499a-3p	CLIP-seq
MIRT1528075	hsa-miR-5095	CLIP-seq
MIRT1528076	hsa-miR-513c	CLIP-seq
MIRT1528077	hsa-miR-514b-5p	CLIP-seq
MIRT1528078	hsa-miR-541	CLIP-seq
MIRT1528079	hsa-miR-548a-3p	CLIP-seq
MIRT1528080	hsa-miR-548a-5p	CLIP-seq
MIRT1528081	hsa-miR-548ab	CLIP-seq
MIRT1528082	hsa-miR-548ad	CLIP-seq
MIRT1528083	hsa-miR-548ak	CLIP-seq
MIRT1528084	hsa-miR-548b-5p	CLIP-seq
MIRT1528085	hsa-miR-548c-5p	CLIP-seq
MIRT1528086	hsa-miR-548d-5p	CLIP-seq
MIRT1528087	hsa-miR-548e	CLIP-seq
MIRT1528088	hsa-miR-548f	CLIP-seq
MIRT1528089	hsa-miR-548h	CLIP-seq
MIRT1528090	hsa-miR-548i	CLIP-seq
MIRT1528091	hsa-miR-548j	CLIP-seq
MIRT1528092	hsa-miR-548o	CLIP-seq
MIRT1528093	hsa-miR-548w	CLIP-seq
MIRT1528094	hsa-miR-548y	CLIP-seq
MIRT1528095	hsa-miR-559	CLIP-seq
MIRT1528096	hsa-miR-562	CLIP-seq
MIRT1528097	hsa-miR-570	CLIP-seq
MIRT1528098	hsa-miR-603	CLIP-seq
MIRT1528099	hsa-miR-654-5p	CLIP-seq
MIRT1528100	hsa-miR-889	CLIP-seq
MIRT1528101	hsa-miR-939	CLIP-seq
MIRT2159677	hsa-miR-1266	CLIP-seq
MIRT1528013	hsa-miR-1276	CLIP-seq
MIRT2159678	hsa-miR-1913	CLIP-seq
MIRT2159679	hsa-miR-214	CLIP-seq
MIRT2159680	hsa-miR-224	CLIP-seq
MIRT2159681	hsa-miR-3198	CLIP-seq
MIRT2159682	hsa-miR-323-3p	CLIP-seq
MIRT2159683	hsa-miR-324-3p	CLIP-seq
MIRT2159684	hsa-miR-3619-5p	CLIP-seq
MIRT2159685	hsa-miR-3664-3p	CLIP-seq
MIRT2159686	hsa-miR-3665	CLIP-seq
MIRT2159687	hsa-miR-3925-3p	CLIP-seq
MIRT2159688	hsa-miR-421	CLIP-seq
MIRT2159689	hsa-miR-4309	CLIP-seq
MIRT2159690	hsa-miR-4311	CLIP-seq
MIRT1528050	hsa-miR-4421	CLIP-seq
MIRT2159691	hsa-miR-4438	CLIP-seq
MIRT2159692	hsa-miR-4518	CLIP-seq
MIRT2159693	hsa-miR-4699-5p	CLIP-seq
MIRT1528075	hsa-miR-5095	CLIP-seq
MIRT2159694	hsa-miR-511	CLIP-seq
MIRT2159695	hsa-miR-515-5p	CLIP-seq
MIRT2159696	hsa-miR-583	CLIP-seq
MIRT2159697	hsa-miR-657	CLIP-seq
MIRT2159698	hsa-miR-665	CLIP-seq
MIRT2159699	hsa-miR-761	CLIP-seq
MIRT2159700	hsa-miR-766	CLIP-seq
MIRT2378963	hsa-miR-1	CLIP-seq
MIRT2378964	hsa-miR-1252	CLIP-seq
MIRT2378965	hsa-miR-1257	CLIP-seq
MIRT2378966	hsa-miR-1273f	CLIP-seq
MIRT2378967	hsa-miR-128	CLIP-seq
MIRT2378968	hsa-miR-1289	CLIP-seq
MIRT2378969	hsa-miR-1296	CLIP-seq
MIRT2378970	hsa-miR-1303	CLIP-seq
MIRT2378971	hsa-miR-137	CLIP-seq
MIRT1528020	hsa-miR-150	CLIP-seq
MIRT2378972	hsa-miR-206	CLIP-seq
MIRT2378973	hsa-miR-2355-5p	CLIP-seq
MIRT2378974	hsa-miR-2909	CLIP-seq
MIRT1528024	hsa-miR-3074-3p	CLIP-seq
MIRT1528025	hsa-miR-3074-5p	CLIP-seq
MIRT2378975	hsa-miR-3124-3p	CLIP-seq
MIRT2378976	hsa-miR-3143	CLIP-seq
MIRT2378977	hsa-miR-3146	CLIP-seq
MIRT2378978	hsa-miR-3148	CLIP-seq
MIRT2378979	hsa-miR-3151	CLIP-seq
MIRT2378980	hsa-miR-3158-3p	CLIP-seq
MIRT2159681	hsa-miR-3198	CLIP-seq
MIRT2378981	hsa-miR-3617	CLIP-seq
MIRT2378982	hsa-miR-3618	CLIP-seq
MIRT2378983	hsa-miR-3646	CLIP-seq
MIRT2378984	hsa-miR-3662	CLIP-seq
MIRT2159687	hsa-miR-3925-3p	CLIP-seq
MIRT2378985	hsa-miR-4269	CLIP-seq
MIRT2378986	hsa-miR-4272	CLIP-seq
MIRT2378987	hsa-miR-4283	CLIP-seq
MIRT2378988	hsa-miR-4294	CLIP-seq
MIRT2159689	hsa-miR-4309	CLIP-seq
MIRT1528050	hsa-miR-4421	CLIP-seq
MIRT2378989	hsa-miR-4446-3p	CLIP-seq
MIRT2378990	hsa-miR-4489	CLIP-seq
MIRT2378991	hsa-miR-4501	CLIP-seq
MIRT2378992	hsa-miR-4514	CLIP-seq
MIRT2378993	hsa-miR-4534	CLIP-seq
MIRT2378994	hsa-miR-4656	CLIP-seq
MIRT2378995	hsa-miR-4692	CLIP-seq
MIRT1528062	hsa-miR-4700-3p	CLIP-seq
MIRT2378996	hsa-miR-4709-5p	CLIP-seq
MIRT2378997	hsa-miR-4728-3p	CLIP-seq
MIRT2378998	hsa-miR-4742-5p	CLIP-seq
MIRT2378999	hsa-miR-4774-3p	CLIP-seq
MIRT1528075	hsa-miR-5095	CLIP-seq
MIRT2159695	hsa-miR-515-5p	CLIP-seq
MIRT2379000	hsa-miR-520d-5p	CLIP-seq
MIRT2379001	hsa-miR-522	CLIP-seq
MIRT2379002	hsa-miR-524-5p	CLIP-seq
MIRT1528078	hsa-miR-541	CLIP-seq
MIRT2379003	hsa-miR-543	CLIP-seq
MIRT2379004	hsa-miR-548ae	CLIP-seq
MIRT2379005	hsa-miR-548aj	CLIP-seq
MIRT2379006	hsa-miR-548am	CLIP-seq
MIRT2379007	hsa-miR-548x	CLIP-seq
MIRT1528096	hsa-miR-562	CLIP-seq
MIRT1528097	hsa-miR-570	CLIP-seq
MIRT2379008	hsa-miR-587	CLIP-seq
MIRT2379009	hsa-miR-613	CLIP-seq
MIRT2379010	hsa-miR-641	CLIP-seq
MIRT2379011	hsa-miR-654-3p	CLIP-seq
MIRT1528099	hsa-miR-654-5p	CLIP-seq
MIRT2159698	hsa-miR-665	CLIP-seq
MIRT2159700	hsa-miR-766	CLIP-seq
MIRT2379012	hsa-miR-802	CLIP-seq
MIRT2379013	hsa-miR-924	CLIP-seq
MIRT2379014	hsa-miR-944	CLIP-seq
MIRT2671151	hsa-miR-3529	CLIP-seq
MIRT2671152	hsa-miR-379	CLIP-seq
MIRT2671153	hsa-miR-4760-3p	CLIP-seq
MIRT2671154	hsa-miR-664	CLIP-seq
MIRT2378963	hsa-miR-1	CLIP-seq
MIRT2378972	hsa-miR-206	CLIP-seq
MIRT2696065	hsa-miR-298	CLIP-seq
MIRT2696066	hsa-miR-3121-3p	CLIP-seq
MIRT1528038	hsa-miR-3673	CLIP-seq
MIRT2696067	hsa-miR-3678-3p	CLIP-seq
MIRT2671153	hsa-miR-4760-3p	CLIP-seq
MIRT2379009	hsa-miR-613	CLIP-seq
MIRT2671154	hsa-miR-664	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0003677	Function	DNA binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IBA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q8TB69
• Protein name: Zinc finger protein 519
• Protein function: May be involved in transcriptional regulation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01352	KRAB	3 → 43	KRAB box	Family
  PF00096	zf-C2H2	292 → 314	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	320 → 342	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	348 → 370	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	376 → 398	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	404 → 426	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	432 → 454	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	460 → 482	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	488 → 510	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	516 → 538	Zinc finger, C2H2 type	Domain

• Sequence:

  MELLTFRDVAIEFSPEEWKCLDPAQQNLYRDVMLENYRNLVSLAVYSYYNQGILPEQGIQ
  DSFKKATLGRYGSCGLENICLWKNWESIGEGEGQKECYNLCSQYLTTSHNKHLTVKGDKE
  YRIFQKKPQFLSAAPTEPCIPMNKYQHKFLKSVFCNKNQINFNHDSNISKHHSTHFLENY
  YNCNECEKVFYQSSKLIFPENIHIQKKPYNSNECGETSDPFSKLTQHQRIYIGESSQRCN
  KKCIIVFSQSHLKGHKIINTGEKSVKYKERGKAFTRGLHLGHQKIHTGEKPYKCKKCDKA
  FNKSSHLAQHQRIHTGEKPFKCKECGKAFNRGSYLTQHQRIHTGERAFKCEECGKAFNRG
  SYLTQHQRIHTGEKPFRCKECGKAFNRSSYVTQHQRMHTGEKPFKCKECGKAFNRASHLT
  QHQRIHTGEKHFKCKECGKAFNRGSHLTRHQRIHTGEKSFKCEECGKAFIWGSHLTQHQR
  VHTGEKFFKCKECGKAFTRSSHLTQHQRIHTGEKPFKCKECGKAFNRRSTLTQHQIIHTR
  

• Sequence length: 540

Pathways

Reactome:

Generic Transcription Pathway

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
COLORECTAL CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations