PHOSPHO1 (phosphoethanolamine/phosphocholine phosphatase 1)

Gene

• Entrez ID: 162466
• Gene name: Phosphoethanolamine/phosphocholine phosphatase 1
• Gene symbol: PHOSPHO1
• Synonyms (NCBI Gene): -
• Chromosome: 17
• Chromosome location: 17q21.32

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1232340	hsa-miR-3184	CLIP-seq
MIRT1232341	hsa-miR-3940-5p	CLIP-seq
MIRT1232342	hsa-miR-423-5p	CLIP-seq
MIRT1232343	hsa-miR-4507	CLIP-seq
MIRT1232344	hsa-miR-4779	CLIP-seq
MIRT1232345	hsa-miR-629	CLIP-seq
MIRT1232346	hsa-miR-639	CLIP-seq
MIRT2295568	hsa-miR-4313	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001958	Process	Endochondral ossification	IEA
GO:0005515	Function	Protein binding	IPI	32296183, 33961781
GO:0005829	Component	Cytosol	TAS
GO:0016462	Function	Pyrophosphatase activity	IDA	19874193
GO:0016787	Function	Hydrolase activity	IEA
GO:0016791	Function	Phosphatase activity	IBA
GO:0016791	Function	Phosphatase activity	IEA
GO:0030282	Process	Bone mineralization	IEA
GO:0030282	Process	Bone mineralization	ISS
GO:0030500	Process	Regulation of bone mineralization	IEA
GO:0031012	Component	Extracellular matrix	IEA
GO:0035630	Process	Bone mineralization involved in bone maturation	IBA
GO:0035630	Process	Bone mineralization involved in bone maturation	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0052731	Function	Phosphocholine phosphatase activity	IDA	15175005
GO:0052731	Function	Phosphocholine phosphatase activity	IEA
GO:0052732	Function	Phosphoethanolamine phosphatase activity	IDA	15175005
GO:0052732	Function	Phosphoethanolamine phosphatase activity	IEA
GO:0065010	Component	Extracellular membrane-bounded organelle	IEA
GO:0065010	Component	Extracellular membrane-bounded organelle	ISS

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q8TCT1
• Protein name: Phosphoethanolamine/phosphocholine phosphatase (EC 3.1.3.75)
• Protein function: Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho) (PubMed:15175005). Involved in the generation of inorganic phosphate for bone mineralization (By similarity). Acts in a non-redundant manner with PHO
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF06888	Put_Phosphatase	27 → 264	Putative Phosphatase	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed at sites of mineralization in bone and cartilage. Highly expressed in osteoblast cell line SaOS-2 which produces a mineralized matrix, but not in MG-63 cell line, which do not mineralize. {ECO:0000269|PubMed:15050893}.
• Sequence:

  MSGCFPVSGLRCLSRDGRMAAQGAPRFLLTFDFDETIVDENSDDSIVRAAPGQRLPESLR
  ATYREGFYNEYMQRVFKYLGEQGVRPRDLSAIYEAIPLSPGMSDLLQFVAKQGACFEVIL
  ISDANTFGVESSLRAAGHHSLFRRILSNPSGPDARGLLALRPFHTHSCARCPANMCKHKV
  LSDYLRERAHDGVHFERLFYVGDGANDFCPMGLLAGGDVAFPRRGYPMHRLIQEAQKAEP
  SSFRASVVPWETAADVRLHLQQVLKSC

• Sequence length: 267

Pathways

KEGG:

Glycerophospholipid metabolism
Metabolic pathways

Reactome:

Synthesis of PC
Synthesis of PE