Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	162466
Gene name Gene Name - the full gene name approved by the HGNC.	Phosphoethanolamine/phosphocholine phosphatase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PHOSPHO1
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17q21.32

Show/Hide all(8)

miRTarBase ID	miRNA	Experiments
MIRT1232340	hsa-miR-3184	CLIP-seq
MIRT1232341	hsa-miR-3940-5p	CLIP-seq
MIRT1232342	hsa-miR-423-5p	CLIP-seq
MIRT1232343	hsa-miR-4507	CLIP-seq
MIRT1232344	hsa-miR-4779	CLIP-seq
MIRT1232345	hsa-miR-629	CLIP-seq
MIRT1232346	hsa-miR-639	CLIP-seq
MIRT2295568	hsa-miR-4313	CLIP-seq

Show/Hide all(15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001958	Process	Endochondral ossification	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005829	Component	Cytosol	TAS
GO:0006646	Process	Phosphatidylethanolamine biosynthetic process	TAS
GO:0006656	Process	Phosphatidylcholine biosynthetic process	TAS
GO:0016311	Process	Dephosphorylation	IEA
GO:0016462	Function	Pyrophosphatase activity	IDA	19874193
GO:0016791	Function	Phosphatase activity	IBA	21873635
GO:0030500	Process	Regulation of bone mineralization	IEA
GO:0031012	Component	Extracellular matrix	IEA
GO:0035630	Process	Bone mineralization involved in bone maturation	IBA	21873635
GO:0046872	Function	Metal ion binding	IEA
GO:0052731	Function	Phosphocholine phosphatase activity	IEA
GO:0052732	Function	Phosphoethanolamine phosphatase activity	IEA
GO:0065010	Component	Extracellular membrane-bounded organelle	IEA

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Protein

UniProt ID

Q8TCT1

Protein name

Phosphoethanolamine/phosphocholine phosphatase (EC 3.1.3.75)

Protein function

Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho) (PubMed:15175005). Involved in the generation of inorganic phosphate for bone mineralization (By similarity). Acts in a non-redundant manner with PHO

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF06888	Put_Phosphatase	27 → 264	Putative Phosphatase	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed at sites of mineralization in bone and cartilage. Highly expressed in osteoblast cell line SaOS-2 which produces a mineralized matrix, but not in MG-63 cell line, which do not mineralize. {ECO:0000269|PubMed:15050893}.

Sequence

MSGCFPVSGLRCLSRDGRMAAQGAPRFLLTFDFDETIVDENSDDSIVRAAPGQRLPESLR
ATYREGFYNEYMQRVFKYLGEQGVRPRDLSAIYEAIPLSPGMSDLLQFVAKQGACFEVIL
ISDANTFGVESSLRAAGHHSLFRRILSNPSGPDARGLLALRPFHTHSCARCPANMCKHKV
LSDYLRERAHDGVHFERLFYVGDGANDFCPMGLLAGGDVAFPRRGYPMHRLIQEAQKAEP
SSFRASVVPWETAADVRLHLQQVLKSC

Sequence length

267

Interactions

View interactions

	KEGG		Reactome
	Glycerophospholipid metabolism Metabolic pathways		Synthesis of PC Synthesis of PE

PHOSPHO1 (phosphoethanolamine/phosphocholine phosphatase 1)