ADAD2 (adenosine deaminase domain containing 2)

Gene

• Entrez ID: 161931
• Gene name: Adenosine deaminase domain containing 2
• Gene symbol: ADAD2
• Synonyms (NCBI Gene): TENRL
• Chromosome: 16
• Chromosome location: 16q24.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT051152	hsa-miR-16-5p	CLASH	23622248
MIRT040814	hsa-miR-18a-3p	CLASH	23622248

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	IEA
GO:0003725	Function	Double-stranded RNA binding	IBA
GO:0003726	Function	Double-stranded RNA adenosine deaminase activity	IBA
GO:0004000	Function	Adenosine deaminase activity	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005730	Component	Nucleolus	IBA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0006382	Process	Adenosine to inosine editing	IBA
GO:0006396	Process	RNA processing	IBA
GO:0006396	Process	RNA processing	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0007286	Process	Spermatid development	IEA
GO:0007286	Process	Spermatid development	ISS
GO:0008251	Function	TRNA-specific adenosine deaminase activity	IBA
GO:0030154	Process	Cell differentiation	IEA

Other IDs

• MIM: 619532
• HGNC: 30714
• e!Ensembl: ENSG00000140955

Protein

• UniProt ID: Q8NCV1
• Protein name: Adenosine deaminase domain-containing protein 2 (Testis nuclear RNA-binding protein-like)
• Protein function: Required for male fertility and normal male germ cell differentiation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00035	dsrm	116 → 179	Double-stranded RNA binding motif	Domain
  PF02137	A_deamin	261 → 576	Adenosine-deaminase (editase) domain	Family

• Sequence:

  MASASQGADDDGSRRKPRLAASLQISPQPRPWRPLPAQAQSAWGPAPAPATYRAEGGWPQ
  VSVLRDSGPGAGAGVGELGAARAWENLGEQMGKAPRVPVPPAGLSLPLKDPPASQAVSLL
  TEYAASLGIFLLFREDQPPGPCFPFSVSAELDGVVCPAGTANSKTEAKQQAALSALCYIR
  SQLENPESPQTSSRPPLAPLSVENILTHEQRCAALVSAGFDLLLDERSPYWACKGTVAGV
  ILEREIPRARGHVKEIYKLVALGTGSSCCAGWLEFSGQQLHDCHGLVIARRALLRFLFRQ
  LLLATQGGPKGKEQSVLAPQPGPGPPFTLKPRVFLHLYISNTPKGAARDIYLPPTSEGGL
  PHSPPMRLQAHVLGQLKPVCYVAPSLCDTHVGCLSASDKLARWAVLGLGGALLAHLVSPL
  YSTSLILADSCHDPPTLSRAIHTRPCLDSVLGPCLPPPYVRTALHLFAGPPVAPSEPTPD
  TCRGLSLNWSLGDPGIEVVDVATGRVKANAALGPPSRLCKASFLRAFHQAARAVGKPYLL
  ALKTYEAAKAGPYQEARRQLSLLLDQQGLGAWPSKPLVGKFRN

• Sequence length: 583

Associated diseases

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Non-obstructive azoospermia	Pathogenic	rs2151327314	RCV001648493