Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	161829
Gene name Gene Name - the full gene name approved by the HGNC.	Exonuclease 3'-5' domain containing 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	EXD1
Synonyms (NCBI Gene) Gene synonyms aliases	EXDL1
Chromosome Chromosome number	15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	15q15.1

Show/Hide all(147)

miRTarBase ID	miRNA	Experiments
MIRT972379	hsa-miR-1185	CLIP-seq
MIRT972380	hsa-miR-1273e	CLIP-seq
MIRT972381	hsa-miR-1297	CLIP-seq
MIRT972382	hsa-miR-1324	CLIP-seq
MIRT972383	hsa-miR-1827	CLIP-seq
MIRT972384	hsa-miR-26a	CLIP-seq
MIRT972385	hsa-miR-26b	CLIP-seq
MIRT972386	hsa-miR-2964a-3p	CLIP-seq
MIRT972387	hsa-miR-302f	CLIP-seq
MIRT972388	hsa-miR-3679-5p	CLIP-seq
MIRT972389	hsa-miR-410	CLIP-seq
MIRT972390	hsa-miR-4433	CLIP-seq
MIRT972391	hsa-miR-4465	CLIP-seq
MIRT972392	hsa-miR-4468	CLIP-seq
MIRT972393	hsa-miR-451b	CLIP-seq
MIRT972394	hsa-miR-4722-5p	CLIP-seq
MIRT972395	hsa-miR-4756-3p	CLIP-seq
MIRT972396	hsa-miR-4768-3p	CLIP-seq
MIRT972397	hsa-miR-4775	CLIP-seq
MIRT972398	hsa-miR-4786-3p	CLIP-seq
MIRT972399	hsa-miR-590-3p	CLIP-seq
MIRT972400	hsa-miR-658	CLIP-seq
MIRT972401	hsa-miR-671-5p	CLIP-seq
MIRT972402	hsa-miR-940	CLIP-seq
MIRT972380	hsa-miR-1273e	CLIP-seq
MIRT972383	hsa-miR-1827	CLIP-seq
MIRT972386	hsa-miR-2964a-3p	CLIP-seq
MIRT972387	hsa-miR-302f	CLIP-seq
MIRT1988091	hsa-miR-3664-3p	CLIP-seq
MIRT1988092	hsa-miR-3929	CLIP-seq
MIRT1988093	hsa-miR-4419b	CLIP-seq
MIRT972390	hsa-miR-4433	CLIP-seq
MIRT1988094	hsa-miR-4459	CLIP-seq
MIRT972392	hsa-miR-4468	CLIP-seq
MIRT1988095	hsa-miR-4478	CLIP-seq
MIRT1988096	hsa-miR-4649-3p	CLIP-seq
MIRT1988097	hsa-miR-4695-5p	CLIP-seq
MIRT972394	hsa-miR-4722-5p	CLIP-seq
MIRT972395	hsa-miR-4756-3p	CLIP-seq
MIRT972396	hsa-miR-4768-3p	CLIP-seq
MIRT1988098	hsa-miR-485-5p	CLIP-seq
MIRT1988099	hsa-miR-510	CLIP-seq
MIRT1988100	hsa-miR-512-5p	CLIP-seq
MIRT1988101	hsa-miR-564	CLIP-seq
MIRT972400	hsa-miR-658	CLIP-seq
MIRT972402	hsa-miR-940	CLIP-seq
MIRT2222564	hsa-miR-1228	CLIP-seq
MIRT2222565	hsa-miR-1262	CLIP-seq
MIRT972380	hsa-miR-1273e	CLIP-seq
MIRT972383	hsa-miR-1827	CLIP-seq
MIRT2222566	hsa-miR-1915	CLIP-seq
MIRT972386	hsa-miR-2964a-3p	CLIP-seq
MIRT972387	hsa-miR-302f	CLIP-seq
MIRT1988091	hsa-miR-3664-3p	CLIP-seq
MIRT2222567	hsa-miR-3926	CLIP-seq
MIRT1988092	hsa-miR-3929	CLIP-seq
MIRT2222568	hsa-miR-3974	CLIP-seq
MIRT1988093	hsa-miR-4419b	CLIP-seq
MIRT972390	hsa-miR-4433	CLIP-seq
MIRT1988094	hsa-miR-4459	CLIP-seq
MIRT1988095	hsa-miR-4478	CLIP-seq
MIRT1988096	hsa-miR-4649-3p	CLIP-seq
MIRT1988097	hsa-miR-4695-5p	CLIP-seq
MIRT2222569	hsa-miR-4701-3p	CLIP-seq
MIRT2222570	hsa-miR-4704-3p	CLIP-seq
MIRT972394	hsa-miR-4722-5p	CLIP-seq
MIRT972396	hsa-miR-4768-3p	CLIP-seq
MIRT972398	hsa-miR-4786-3p	CLIP-seq
MIRT2222571	hsa-miR-4786-5p	CLIP-seq
MIRT2222572	hsa-miR-4797-5p	CLIP-seq
MIRT1988098	hsa-miR-485-5p	CLIP-seq
MIRT2222573	hsa-miR-508-5p	CLIP-seq
MIRT1988099	hsa-miR-510	CLIP-seq
MIRT1988100	hsa-miR-512-5p	CLIP-seq
MIRT2222574	hsa-miR-542-3p	CLIP-seq
MIRT2222575	hsa-miR-548s	CLIP-seq
MIRT972400	hsa-miR-658	CLIP-seq
MIRT2222576	hsa-miR-661	CLIP-seq
MIRT972401	hsa-miR-671-5p	CLIP-seq
MIRT2222577	hsa-miR-766	CLIP-seq
MIRT972402	hsa-miR-940	CLIP-seq
MIRT972392	hsa-miR-4468	CLIP-seq
MIRT972395	hsa-miR-4756-3p	CLIP-seq
MIRT972400	hsa-miR-658	CLIP-seq
MIRT2448992	hsa-miR-1268	CLIP-seq
MIRT2448993	hsa-miR-1268b	CLIP-seq
MIRT972380	hsa-miR-1273e	CLIP-seq
MIRT972383	hsa-miR-1827	CLIP-seq
MIRT972386	hsa-miR-2964a-3p	CLIP-seq
MIRT972387	hsa-miR-302f	CLIP-seq
MIRT2448994	hsa-miR-3675-3p	CLIP-seq
MIRT2448995	hsa-miR-4684-5p	CLIP-seq
MIRT972394	hsa-miR-4722-5p	CLIP-seq
MIRT972396	hsa-miR-4768-3p	CLIP-seq
MIRT2448996	hsa-miR-548c-3p	CLIP-seq
MIRT1988101	hsa-miR-564	CLIP-seq
MIRT972400	hsa-miR-658	CLIP-seq
MIRT972402	hsa-miR-940	CLIP-seq
MIRT972380	hsa-miR-1273e	CLIP-seq
MIRT972383	hsa-miR-1827	CLIP-seq
MIRT972386	hsa-miR-2964a-3p	CLIP-seq
MIRT972387	hsa-miR-302f	CLIP-seq
MIRT972394	hsa-miR-4722-5p	CLIP-seq
MIRT972396	hsa-miR-4768-3p	CLIP-seq
MIRT1988101	hsa-miR-564	CLIP-seq
MIRT972400	hsa-miR-658	CLIP-seq
MIRT972402	hsa-miR-940	CLIP-seq
MIRT2448992	hsa-miR-1268	CLIP-seq
MIRT2448993	hsa-miR-1268b	CLIP-seq
MIRT972380	hsa-miR-1273e	CLIP-seq
MIRT972383	hsa-miR-1827	CLIP-seq
MIRT972386	hsa-miR-2964a-3p	CLIP-seq
MIRT972387	hsa-miR-302f	CLIP-seq
MIRT2448994	hsa-miR-3675-3p	CLIP-seq
MIRT972392	hsa-miR-4468	CLIP-seq
MIRT2448995	hsa-miR-4684-5p	CLIP-seq
MIRT972394	hsa-miR-4722-5p	CLIP-seq
MIRT972396	hsa-miR-4768-3p	CLIP-seq
MIRT2448996	hsa-miR-548c-3p	CLIP-seq
MIRT1988101	hsa-miR-564	CLIP-seq
MIRT972400	hsa-miR-658	CLIP-seq
MIRT972402	hsa-miR-940	CLIP-seq
MIRT2448992	hsa-miR-1268	CLIP-seq
MIRT2448993	hsa-miR-1268b	CLIP-seq
MIRT972380	hsa-miR-1273e	CLIP-seq
MIRT972383	hsa-miR-1827	CLIP-seq
MIRT972386	hsa-miR-2964a-3p	CLIP-seq
MIRT972387	hsa-miR-302f	CLIP-seq
MIRT1988091	hsa-miR-3664-3p	CLIP-seq
MIRT2448994	hsa-miR-3675-3p	CLIP-seq
MIRT1988092	hsa-miR-3929	CLIP-seq
MIRT1988093	hsa-miR-4419b	CLIP-seq
MIRT972390	hsa-miR-4433	CLIP-seq
MIRT1988094	hsa-miR-4459	CLIP-seq
MIRT1988095	hsa-miR-4478	CLIP-seq
MIRT1988096	hsa-miR-4649-3p	CLIP-seq
MIRT2448995	hsa-miR-4684-5p	CLIP-seq
MIRT1988097	hsa-miR-4695-5p	CLIP-seq
MIRT972394	hsa-miR-4722-5p	CLIP-seq
MIRT972396	hsa-miR-4768-3p	CLIP-seq
MIRT1988098	hsa-miR-485-5p	CLIP-seq
MIRT1988099	hsa-miR-510	CLIP-seq
MIRT1988100	hsa-miR-512-5p	CLIP-seq
MIRT2448996	hsa-miR-548c-3p	CLIP-seq
MIRT1988101	hsa-miR-564	CLIP-seq
MIRT972400	hsa-miR-658	CLIP-seq
MIRT972402	hsa-miR-940	CLIP-seq

Show/Hide all(10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	ISS
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0008408	Function	3'-5' exonuclease activity	ISS
GO:0031047	Process	Gene silencing by RNA	ISS
GO:0034587	Process	PiRNA metabolic process	ISS
GO:0042803	Function	Protein homodimerization activity	ISS
GO:0043186	Component	P granule	ISS
GO:0051321	Process	Meiotic cell cycle	IEA
GO:0090305	Process	Nucleic acid phosphodiester bond hydrolysis	IEA
GO:1990923	Component	PET complex	ISS

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Protein

UniProt ID

Q8NHP7

Protein name

piRNA biogenesis protein EXD1 (Exonuclease 3'-5' domain-containing protein 1) (Exonuclease 3'-5' domain-like-containing protein 1) (Inactive exonuclease EXD1)

Protein function

RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes compo

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01612	DNA_pol_A_exo1	80 → 280		Domain

Sequence

MEDSEFLAYVELLDEVEQGSVRAKASSVSLHAERTWMEKMKVEDLNVCEPASPAPEAPAT
SLLNDLKYSPSEEEEVTYTVINQFQQKFGAAILHIKKQNVLSVAAEGANVCRHGKLCWLQ
VATNCRVYLFDIFLLGSRAFHNGLQMILEDKRILKVIHDCRWLSDCLSHQYGILLNNVFD
TQVADVLQFSMETGGYLPNCITTLQESLIKHLQVAPKYLSFLEKRQKLIQENPEVWFIRP
VSPSLLKILALEATYLLPLRLALLDEMMSDLTTLVDGYLNTYREGSADRLGGTEPTCMEL
PEELLQLKDFQKQRREKAAREYRVNAQGLLIRTVLQPKKLVTETAGKEEKVKGFLFGKNF
RIDKAPSFTSQDFHGDVNLLKEESLNKQATNPQHLPPTEEGETSEDSSNKLICTKSKGSE
DQRITQKEHFMTPKHEFQASLSLKEETEQLLMVENKEDLKCTKQAVSMSSFPQETRVSPS
DTFYPIRKTVVSTLPPCPALEKIDSWISPFLNLP

Sequence length

514

Interactions

View interactions

Show/Hide Unknown Diseases (2)

Disease term	Disease name	References	Source
Unknown
Asthma	Asthma	29785011	ClinVar, GWAS
Hypertension	Hypertension		GWAS

EXD1 (exonuclease 3'-5' domain containing 1)