Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	161514
Gene name Gene Name - the full gene name approved by the HGNC.	TBC1 domain family member 21
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TBC1D21
Synonyms (NCBI Gene) Gene synonyms aliases	MgcRabGAP
Chromosome Chromosome number	15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	15q24.1

Show/Hide all(64)

miRTarBase ID	miRNA	Experiments	Reference
MIRT711111	hsa-miR-508-5p	HITS-CLIP	19536157
MIRT711110	hsa-miR-371b-3p	HITS-CLIP	19536157
MIRT711109	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT711108	hsa-miR-1825	HITS-CLIP	19536157
MIRT711107	hsa-miR-199a-5p	HITS-CLIP	19536157
MIRT711106	hsa-miR-199b-5p	HITS-CLIP	19536157
MIRT711105	hsa-miR-3925-3p	HITS-CLIP	19536157
MIRT711104	hsa-miR-4469	HITS-CLIP	19536157
MIRT711111	hsa-miR-508-5p	HITS-CLIP	19536157
MIRT711110	hsa-miR-371b-3p	HITS-CLIP	19536157
MIRT711109	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT711108	hsa-miR-1825	HITS-CLIP	19536157
MIRT711107	hsa-miR-199a-5p	HITS-CLIP	19536157
MIRT711106	hsa-miR-199b-5p	HITS-CLIP	19536157
MIRT711105	hsa-miR-3925-3p	HITS-CLIP	19536157
MIRT711104	hsa-miR-4469	HITS-CLIP	19536157
MIRT711111	hsa-miR-508-5p	HITS-CLIP	19536157
MIRT711110	hsa-miR-371b-3p	HITS-CLIP	19536157
MIRT711109	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT711108	hsa-miR-1825	HITS-CLIP	19536157
MIRT711107	hsa-miR-199a-5p	HITS-CLIP	19536157
MIRT711106	hsa-miR-199b-5p	HITS-CLIP	19536157
MIRT711105	hsa-miR-3925-3p	HITS-CLIP	19536157
MIRT711104	hsa-miR-4469	HITS-CLIP	19536157
MIRT711111	hsa-miR-508-5p	HITS-CLIP	19536157
MIRT711110	hsa-miR-371b-3p	HITS-CLIP	19536157
MIRT711109	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT711108	hsa-miR-1825	HITS-CLIP	19536157
MIRT711107	hsa-miR-199a-5p	HITS-CLIP	19536157
MIRT711106	hsa-miR-199b-5p	HITS-CLIP	19536157
MIRT711105	hsa-miR-3925-3p	HITS-CLIP	19536157
MIRT711104	hsa-miR-4469	HITS-CLIP	19536157
MIRT711111	hsa-miR-508-5p	HITS-CLIP	19536157
MIRT711110	hsa-miR-371b-3p	HITS-CLIP	19536157
MIRT711109	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT711108	hsa-miR-1825	HITS-CLIP	19536157
MIRT711107	hsa-miR-199a-5p	HITS-CLIP	19536157
MIRT711106	hsa-miR-199b-5p	HITS-CLIP	19536157
MIRT711105	hsa-miR-3925-3p	HITS-CLIP	19536157
MIRT711104	hsa-miR-4469	HITS-CLIP	19536157
MIRT711111	hsa-miR-508-5p	HITS-CLIP	19536157
MIRT711110	hsa-miR-371b-3p	HITS-CLIP	19536157
MIRT711109	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT711108	hsa-miR-1825	HITS-CLIP	19536157
MIRT711107	hsa-miR-199a-5p	HITS-CLIP	19536157
MIRT711106	hsa-miR-199b-5p	HITS-CLIP	19536157
MIRT711105	hsa-miR-3925-3p	HITS-CLIP	19536157
MIRT711104	hsa-miR-4469	HITS-CLIP	19536157
MIRT711111	hsa-miR-508-5p	HITS-CLIP	19536157
MIRT711110	hsa-miR-371b-3p	HITS-CLIP	19536157
MIRT711109	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT711108	hsa-miR-1825	HITS-CLIP	19536157
MIRT711107	hsa-miR-199a-5p	HITS-CLIP	19536157
MIRT711106	hsa-miR-199b-5p	HITS-CLIP	19536157
MIRT711105	hsa-miR-3925-3p	HITS-CLIP	19536157
MIRT711104	hsa-miR-4469	HITS-CLIP	19536157
MIRT711111	hsa-miR-508-5p	HITS-CLIP	19536157
MIRT711110	hsa-miR-371b-3p	HITS-CLIP	19536157
MIRT711109	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT711108	hsa-miR-1825	HITS-CLIP	19536157
MIRT711107	hsa-miR-199a-5p	HITS-CLIP	19536157
MIRT711106	hsa-miR-199b-5p	HITS-CLIP	19536157
MIRT711105	hsa-miR-3925-3p	HITS-CLIP	19536157
MIRT711104	hsa-miR-4469	HITS-CLIP	19536157

Show/Hide all(25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001669	Component	Acrosomal vesicle	IEA
GO:0003779	Function	Actin binding	IEA
GO:0005096	Function	GTPase activator activity	IBA
GO:0005096	Function	GTPase activator activity	IDA	28067790
GO:0005096	Function	GTPase activator activity	IEA
GO:0005515	Function	Protein binding	IPI	28067790, 32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0007283	Process	Spermatogenesis	ISS
GO:0007288	Process	Sperm axoneme assembly	IEA
GO:0007288	Process	Sperm axoneme assembly	ISS
GO:0030154	Process	Cell differentiation	IEA
GO:0030317	Process	Flagellated sperm motility	IEA
GO:0030317	Process	Flagellated sperm motility	ISS
GO:0031267	Function	Small GTPase binding	IMP	16923123
GO:0031410	Component	Cytoplasmic vesicle	IBA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0048227	Process	Plasma membrane to endosome transport	IBA
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0097225	Component	Sperm midpiece	IEA
GO:0097225	Component	Sperm midpiece	ISS
GO:0120317	Process	Sperm mitochondrial sheath assembly	IEA
GO:0120317	Process	Sperm mitochondrial sheath assembly	ISS
GO:1902017	Process	Regulation of cilium assembly	IMP	17646400

MIM	HGNC	e!Ensembl
620387	28536	ENSG00000167139

Protein

UniProt ID

Q8IYX1

Protein name

TBC1 domain family member 21 (Male germ cell Rab GTPase-activating protein)

Protein function

Acts as a GTPase-activating protein for Rab family protein(s) (PubMed:19077034, PubMed:28067790). Essential for the establishment of male fertility, and is required for both the production of normal sperm number and sperm function (By similarity

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00566	RabGAP-TBC	60 → 287	Rab-GTPase-TBC domain	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in round and elongated spermatids (at protein level). Expressed specifically in adult testis and very weakly in fetal brain. {ECO:0000269|PubMed:21128978, ECO:0000269|PubMed:33536340}.

Sequence

MTTLSPENSLSARQSASFILVKRKPPIDKTEWDSFFDESGHLAKSRDFICVNILERGLHP
FVRTEAWKFLTGYFSWQSSQDERLTVDSMRRKNYKALCQMYEKIQPLLENLHRNFTETRN
NIARDIQKIYDKDPLGNVLIDKKRLEKILLLSYVCNTQAEYQQGFHEMMMLFQLMVEHDH
ETFWLFQFFLQKTEHSCVINIGVAKNLDMLSTLITFLDPVFAEHLKGKGAGAVQSLFPWF
CFCFQRAFKSFDDVWRLWEVLLTGKPCRNFQVLVAYSMLQMVREQVLQESMGGDDILLAC
NNLIDLDADELISAACVVYAELIQKDVPQTLKDFFL

Sequence length

336

Interactions

View interactions

Show/Hide Unknown Diseases (6)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Bipolar Disorder	Bipolar I disorder	N/A	N/A	GWAS
Diabetes	End-stage renal disease in type 2 diabetes, Diabetic kidney disease in type 2 diabetes (ESRD vs. no ESRD)	N/A	N/A	GWAS
Insomnia	Insomnia	N/A	N/A	GWAS
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS
Neuroticism	Neuroticism	N/A	N/A	GWAS
Oligodendroglioma	Oligodendroglioma	N/A	N/A	GWAS

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Exfoliation Syndrome	Associate	24938310

TBC1D21 (TBC1 domain family member 21)