EML5 (EMAP like 5)

Gene

• Entrez ID: 161436
• Gene name: EMAP like 5
• Gene symbol: EML5
• Synonyms (NCBI Gene): EMAP-2, EMAP-5, FAP16
• Chromosome: 14
• Chromosome location: 14q31.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT036960	hsa-miR-877-3p	CLASH	23622248
MIRT962197	hsa-miR-1200	CLIP-seq
MIRT962198	hsa-miR-1323	CLIP-seq
MIRT962199	hsa-miR-29a	CLIP-seq
MIRT962200	hsa-miR-29b	CLIP-seq
MIRT962201	hsa-miR-29c	CLIP-seq
MIRT962202	hsa-miR-3140-5p	CLIP-seq
MIRT962203	hsa-miR-3940-5p	CLIP-seq
MIRT962204	hsa-miR-4326	CLIP-seq
MIRT962205	hsa-miR-4452	CLIP-seq
MIRT962206	hsa-miR-4507	CLIP-seq
MIRT962207	hsa-miR-4680-3p	CLIP-seq
MIRT962208	hsa-miR-548o	CLIP-seq
MIRT962209	hsa-miR-591	CLIP-seq
MIRT962210	hsa-miR-606	CLIP-seq
MIRT962211	hsa-miR-635	CLIP-seq
MIRT1985168	hsa-miR-1256	CLIP-seq
MIRT1985169	hsa-miR-1285	CLIP-seq
MIRT1985170	hsa-miR-1909	CLIP-seq
MIRT1985171	hsa-miR-203	CLIP-seq
MIRT1985172	hsa-miR-296-3p	CLIP-seq
MIRT962199	hsa-miR-29a	CLIP-seq
MIRT962200	hsa-miR-29b	CLIP-seq
MIRT962201	hsa-miR-29c	CLIP-seq
MIRT1985173	hsa-miR-3126-3p	CLIP-seq
MIRT1985174	hsa-miR-3163	CLIP-seq
MIRT1985175	hsa-miR-3187-5p	CLIP-seq
MIRT1985176	hsa-miR-339-5p	CLIP-seq
MIRT1985177	hsa-miR-378g	CLIP-seq
MIRT962203	hsa-miR-3940-5p	CLIP-seq
MIRT1985178	hsa-miR-3945	CLIP-seq
MIRT1985179	hsa-miR-4253	CLIP-seq
MIRT1985180	hsa-miR-4287	CLIP-seq
MIRT1985181	hsa-miR-4314	CLIP-seq
MIRT1985182	hsa-miR-4469	CLIP-seq
MIRT1985183	hsa-miR-4486	CLIP-seq
MIRT962206	hsa-miR-4507	CLIP-seq
MIRT1985184	hsa-miR-4539	CLIP-seq
MIRT1985185	hsa-miR-4642	CLIP-seq
MIRT1985186	hsa-miR-4659a-3p	CLIP-seq
MIRT1985187	hsa-miR-4659b-3p	CLIP-seq
MIRT1985188	hsa-miR-4685-3p	CLIP-seq
MIRT1985189	hsa-miR-4713-5p	CLIP-seq
MIRT1985190	hsa-miR-4803	CLIP-seq
MIRT1985191	hsa-miR-548g	CLIP-seq
MIRT1985192	hsa-miR-582-5p	CLIP-seq
MIRT962209	hsa-miR-591	CLIP-seq
MIRT1985193	hsa-miR-612	CLIP-seq
MIRT1985194	hsa-miR-629	CLIP-seq
MIRT962211	hsa-miR-635	CLIP-seq
MIRT1985174	hsa-miR-3163	CLIP-seq
MIRT2448809	hsa-miR-4282	CLIP-seq
MIRT2448810	hsa-miR-4446-5p	CLIP-seq
MIRT2448811	hsa-miR-4765	CLIP-seq
MIRT2448812	hsa-miR-548c-3p	CLIP-seq
MIRT2448813	hsa-miR-590-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003674	Function	Molecular_function	ND
GO:0003824	Function	Catalytic activity	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005874	Component	Microtubule	IEA
GO:0008017	Function	Microtubule binding	IBA	21873635
GO:0008150	Process	Biological_process	ND
GO:0070062	Component	Extracellular exosome	HDA	19056867

Other IDs

• MIM: 618119
• HGNC: 18197
• e!Ensembl: ENSG00000165521

Protein

• UniProt ID: Q05BV3
• Protein name: Echinoderm microtubule-associated protein-like 5 (EMAP-5)
• Protein function: May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03451	HELP	2 → 48	HELP motif	Family
  PF00400	WD40	51 → 91	WD domain, G-beta repeat	Repeat
  PF00400	WD40	314 → 353	WD domain, G-beta repeat	Repeat
  PF12894	ANAPC4_WD40	376 → 462	Anaphase-promoting complex subunit 4 WD40 domain	Repeat
  PF00400	WD40	553 → 592	WD domain, G-beta repeat	Repeat
  PF03451	HELP	656 → 715	HELP motif	Family
  PF00400	WD40	717 → 757	WD domain, G-beta repeat	Repeat
  PF00400	WD40	761 → 802	WD domain, G-beta repeat	Repeat
  PF00400	WD40	988 → 1026	WD domain, G-beta repeat	Repeat
  PF03451	HELP	1332 → 1402	HELP motif	Family
  PF00400	WD40	1684 → 1722	WD domain, G-beta repeat	Repeat
  PF12894	ANAPC4_WD40	1741 → 1873	Anaphase-promoting complex subunit 4 WD40 domain	Repeat
  PF00400	WD40	1925 → 1963	WD domain, G-beta repeat	Repeat

• Sequence:

  MAARSAPSCHLRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVYSPREHRQKFYRGH
  SDDIISLALHPERVLVATGQVGKEPYICIWDSYTVQTISVLKDVHTHGIACLAFDLDGQR
  LVSVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIFDISWDLYQPNKLVSCGVKHIKFWSLC
  GNALTPKRGVFGKTGDLQTILCLACARDELTYSGALNGDIYVWKGINLIRTIQGAHAAGI
  FSMNACEEGFATGGRDGCIRLWDLTFKPITVIDLRETDQGYKGLSVRSVCWRGDHILVGT
  QDSEIFEIVVQERNKPFLIMQGHCEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALI
  ARCNMEEPIRCAAVNADGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDG
  TYLAVGCNDSSVDIYGVAQRYKKVGECLGSLSFITHLDWSSDSRYLQTNDGNGKRLFYRM
  PGGKEVTSTEEIKGVHWASWTCVSGLEVNGIWPKYSDINDINSVDGNYIGQVLVTADDYG
  IIKLFRYPCLRKGAKFRKYIGHSAHVTNVRWSHDYQWVISIGGADHSVFQWKFIPERKLK
  DAVHIAPQESLADSHSDESDSDLSDVPELDSEIEQETQLTYRRQVYKEDLPQLKEQCKEK
  QKSATSKRRERAPGNSIRLHFVHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNRQQNTQ
  RFYLGHDDDILCLTIHPLKDYVATGQVGRDPSIHIWDTETIKPLSILKGHHQYGVSAVDF
  SADGKRLASVGIDDSHTVVLWDWKKGEKLSIARGSKDKIFVVKMNPYVPDKLITAGIKHM
  KFWRKAGGGLIGRKGYIGTLGKNDTMMCAVYGWTEEMAFSGTSTGDVCIWRDIFLVKTVK
  AHDGPVFSMHALEKGFVTGGKDGIVALWDDSFERCLKTYAIKRAALAPGSKGLLLEDNPS
  IRAISLGHGHILVGTKNGEILEVDKSGPITLLVQGHMEGEVWGLATHPYLPICATVSDDK
  TLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADTLEDLVSFHH
  RKDMISDIRFSPGSGKYLAVASHDSFIDIYNVMSSKRVGICKGATSYITHIDWDIRGKLL
  QVNTGAKEQLFFEAPRGKKQTIPSVEVEKIAWASWTSVLGLCCEGIWPVIGEVTDVTASC
  LTSDKMVLATGDDLGFVKLFRYPTKGKFGKFKRYVAHSTHVTNVRWTYDDSMLVTLGGTD
  MSLMVWTNEMEGYREKRPCDSEESDIDSEEDGGYDSDVTRENEISYTIRALSTNIRPMLG
  IKPHLQQKEPSIDERPPVSRAPPQPEKLQTNNVGKKKRPIEDLVLELIFGYRGRDCRNNV
  HYLNDGDDIIYHTASVGILHNVATGSQSFYQEHNDDILCLTVNQHPKFINIVATGQVGDS
  ADMSATAPSIHIWDAMNKQTLSILRCYHSKGVCSVSFSATGKLLLSVGLDPEHTITIWRW
  QEGAKIASRAGHNQRIFVAEFRPDSDTQFVSVGVKHVKFWTLAGRALLSKKGLLSTLEDA
  RMQTMLAIAFGANNLTFTGTISGDVCVWKDHILCRIVARAHNGPVFAMYTTLRDGLIVTG
  GKERPSKEGGAVKLWDQELRRCRAFRLETGQATDCVRSVCRGKGKILVGTRNAEIIEVGE
  KNAACNILVNGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVNLGHAART
  VCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRYLAVGSSENS
  VDFYDLTLGPTLNRISYCKDIPSFVIQMDFSADSSYLQVSSGCYKRHVYEVPSGKHLMDH
  AAIDRITWATWTSILGDEVLGIWSRHAEKADVNCACVSHSGISLVTGDDFGMVKLFDFPC
  PEKFAKHKRFLGHSPHVTNIRFTSGDRHVVSAGGDDCSLFVWKCVHTPH

• Sequence length: 1969

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	19571809, 21752600