DAPK1 (death associated protein kinase 1)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 1612
Gene name Death associated protein kinase 1
Gene symbol DAPK1
Synonyms (NCBI Gene)
DAPKROCO3
Chromosome 9
Chromosome location 9q21.33
Summary Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consen
miRNA miRNA information provided by mirtarbase database.
93
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (93)
miRTarBase ID miRNA Experiments Reference
MIRT004738 hsa-miR-214-3p MicroarrayqRT-PCR 19435428
MIRT004738 hsa-miR-214-3p MicroarrayqRT-PCR 19435428
MIRT006690 hsa-miR-103a-3p Luciferase reporter assayWestern blot 22593189
MIRT006690 hsa-miR-103a-3p Luciferase reporter assayWestern blot 22593189
MIRT006691 hsa-miR-107 Luciferase reporter assayWestern blot 22593189
Transcription factors Transcription factors information provided by TRRUST V2 database.
3
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (3)
Transcription factor Regulation Reference
CEBPB Unknown 19521987
HOXB7 Repression 17540169
MBD2 Unknown 21693597
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
63
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0002357 Process Defense response to tumor cell IMP 30429596
GO:0002834 Process Regulation of response to tumor cell IDA 11573098
GO:0004672 Function Protein kinase activity IDA 7828849, 12730201
GO:0004672 Function Protein kinase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
600831 2674 ENSG00000196730
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P53355
Protein name Death-associated protein kinase 1 (DAP kinase 1) (EC 2.7.11.1)
Protein function Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on t
PDB 1IG1 , 1JKK , 1JKL , 1JKS , 1JKT , 1P4F , 1WVW , 1WVX , 1WVY , 1YR5 , 2W4J , 2W4K , 2X0G , 2XUU , 2XZS , 2Y0A , 2Y4P , 2Y4V , 2YAK , 3DFC , 3DGK , 3EH9 , 3EHA , 3F5G , 3F5U , 3GU4 , 3GU5 , 3GU6 , 3GU7 , 3GU8 , 3GUB , 3ZXT , 4B4L , 4PF4 , 4TL0 , 4TXC , 4UV0 , 4YO4 , 4YPD , 5AUT , 5AUU , 5AUV , 5AUW , 5AUX , 5AUY , 5AUZ , 5AV0 , 5AV1 , 5AV2 , 5AV3 , 5AV4
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 13 → 275 Protein kinase domain Domain
PF00023 Ank 444 → 476 Ankyrin repeat Repeat
PF00023 Ank 477 → 509 Ankyrin repeat Repeat
PF00023 Ank 510 → 542 Ankyrin repeat Repeat
PF00023 Ank 576 → 608 Ankyrin repeat Repeat
PF00023 Ank 609 → 641 Ankyrin repeat Repeat
PF00531 Death 1310 → 1396 Death domain Domain
Tissue specificity TISSUE SPECIFICITY: Isoform 2 is expressed in normal intestinal tissue as well as in colorectal carcinomas. {ECO:0000269|PubMed:18422656}.
Sequence 
MTVFRQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSRED
IEREVSILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFL
KQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGT
PEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEY
FSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSRKASAVNMEKFKKFA
ARKKWKQSVRLISLCQRLSRSFLSRSNMSVARSDDTLDEEDSFVMKAIIHAINDDNVPGL
QHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAA
RHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEET
PLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNAC
DKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEAN
CNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAG
LLARLRKDTHRGLFIQQLRPTQNLQPRIKLKLFGHSGSGKTTLVESLKCGLLRSFFRRRR
PRLSSTNSSRFPPSPLASKPTVSVSINNLYPGCENVSVRSRSMMFEPGLTKGMLEVFVAP
THHPHCSADDQSTKAIDIQNAYLNGVGDFSVWEFSGNPVYFCCYDYFAANDPTSIHVVVF
SLEEPYEIQLNQVIFWLSFLKSLVPVEEPIAFGGKLKNPLQVVLVATHADIMNVPRPAGG
EFGYDKDTSLLKEIRNRFGNDLHISNKLFVLDAGASGSKDMKVLRNHLQEIRSQIVSVCP
PMTHLCEKIISTLPSWRKLNGPNQLMSLQQFVYDVQDQLNPLASEEDLRRIAQQLHSTGE
INIMQSETVQDVLLLDPRWLCTNVLGKLLSVETPRALHHYRGRYTVEDIQRLVPDSDVEE
LLQILDAMDICARDLSSGTMVDVPALIKTDNLHRSWADEEDEVMVYGGVRIVPVEHLTPF
PCGIFHKVQVNLCRWIHQQSTEGDADIRLWVNGCKLANRGAELLVLLVNHGQGIEVQVRG
LETEKIKCCLLLDSVCSTIENVMATTLPGLLTVKHYLSPQQLREHHEPVMIYQPRDFFRA
QTLKETSLTNTMGGYKESFSSIMCFGCHDVYSQASLGMDIHASDLNLLTRRKLSRLLDPP
DPLGKDWCLLAMNLGLPDLVAKYNTSNGAPKDFLPSPLHALLREWTTYPESTVGTLMSKL
RELGRRDAADFLLKASSVFKINLDGNGQEAYASSCNSGTSYNSISSVVSR
Sequence length 1430
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG 
  Autophagy - animal
Pathways in cancer
Bladder cancer 		 
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (12)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Acute myeloid leukemia Benign rs200670633, rs76063532 RCV005904374
RCV005903585
Cervical cancer Benign rs76063532 RCV005903587
Cholangiocarcinoma Likely benign rs201908003 RCV005904394
Familial cancer of breast Benign; Likely benign rs200670633, rs201908003 RCV005904373
RCV005904392
Show/Hide Text Mining Associations (124)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Inhibit 17401463
Adenocarcinoma Associate 32998713, 33510126
Adenocarcinoma of Lung Associate 26722491
Adenoma Pleomorphic Associate 23510689
Agnosia Associate 25065733
Alcoholism Inhibit 29790687
Alzheimer Disease Associate 18336955, 18830724, 31279627, 31978714, 35887339
Anemia Refractory with Excess of Blasts Inhibit 25679997
Angina Stable Associate 22420243
Asthma Associate 31924195