Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	161198
Gene name	C-type lectin domain containing 14A
Gene symbol	CLEC14A
Synonyms (NCBI Gene)	C14orf27CEG1EGFR-5
Chromosome	14
Chromosome location	14q21.1
Summary	This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles

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Show/Hide all (166)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018973	hsa-miR-335-5p	Microarray	18185580
MIRT607877	hsa-miR-8485	HITS-CLIP	22927820
MIRT607876	hsa-miR-329-3p	HITS-CLIP	22927820
MIRT607875	hsa-miR-362-3p	HITS-CLIP	22927820
MIRT607874	hsa-miR-603	HITS-CLIP	22927820
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	22927820
MIRT607871	hsa-miR-3941	HITS-CLIP	22927820
MIRT607870	hsa-miR-4789-5p	HITS-CLIP	22927820
MIRT607877	hsa-miR-8485	HITS-CLIP	23313552
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23313552
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT607876	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT607875	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT607874	hsa-miR-603	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607871	hsa-miR-3941	HITS-CLIP	23824327
MIRT607870	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT607876	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT607875	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT607874	hsa-miR-603	HITS-CLIP	23824327
MIRT607871	hsa-miR-3941	HITS-CLIP	23824327
MIRT607870	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT670441	hsa-miR-3924	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT607876	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT607875	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT607874	hsa-miR-603	HITS-CLIP	23824327
MIRT607871	hsa-miR-3941	HITS-CLIP	23824327
MIRT607870	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT670441	hsa-miR-3924	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT639520	hsa-miR-577	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT639520	hsa-miR-577	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	24906430
MIRT607876	hsa-miR-329-3p	HITS-CLIP	24906430
MIRT607875	hsa-miR-362-3p	HITS-CLIP	24906430
MIRT607874	hsa-miR-603	HITS-CLIP	24906430
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	24906430
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	24906430
MIRT607871	hsa-miR-3941	HITS-CLIP	24906430
MIRT607870	hsa-miR-4789-5p	HITS-CLIP	24906430
MIRT607876	hsa-miR-329-3p	HITS-CLIP	27418678
MIRT607876	hsa-miR-329-3p	HITS-CLIP	27418678
MIRT607876	hsa-miR-329-3p	HITS-CLIP	27418678
MIRT607876	hsa-miR-329-3p	HITS-CLIP	27418678
MIRT607876	hsa-miR-329-3p	HITS-CLIP	27418678
MIRT607875	hsa-miR-362-3p	HITS-CLIP	27418678
MIRT607875	hsa-miR-362-3p	HITS-CLIP	27418678
MIRT607875	hsa-miR-362-3p	HITS-CLIP	27418678
MIRT607875	hsa-miR-362-3p	HITS-CLIP	27418678
MIRT607875	hsa-miR-362-3p	HITS-CLIP	27418678
MIRT670441	hsa-miR-3924	HITS-CLIP	27418678
MIRT670441	hsa-miR-3924	HITS-CLIP	27418678
MIRT670441	hsa-miR-3924	HITS-CLIP	27418678
MIRT670441	hsa-miR-3924	HITS-CLIP	27418678
MIRT670441	hsa-miR-3924	HITS-CLIP	27418678
MIRT607871	hsa-miR-3941	HITS-CLIP	27418678
MIRT607871	hsa-miR-3941	HITS-CLIP	27418678
MIRT607871	hsa-miR-3941	HITS-CLIP	27418678
MIRT607871	hsa-miR-3941	HITS-CLIP	27418678
MIRT607871	hsa-miR-3941	HITS-CLIP	27418678
MIRT607870	hsa-miR-4789-5p	HITS-CLIP	27418678
MIRT607870	hsa-miR-4789-5p	HITS-CLIP	27418678
MIRT607870	hsa-miR-4789-5p	HITS-CLIP	27418678
MIRT607870	hsa-miR-4789-5p	HITS-CLIP	27418678
MIRT607870	hsa-miR-4789-5p	HITS-CLIP	27418678
MIRT607874	hsa-miR-603	HITS-CLIP	27418678
MIRT607874	hsa-miR-603	HITS-CLIP	27418678
MIRT607874	hsa-miR-603	HITS-CLIP	27418678
MIRT607874	hsa-miR-603	HITS-CLIP	27418678
MIRT607874	hsa-miR-603	HITS-CLIP	27418678
MIRT607877	hsa-miR-8485	HITS-CLIP	27418678
MIRT607877	hsa-miR-8485	HITS-CLIP	27418678
MIRT607877	hsa-miR-8485	HITS-CLIP	27418678
MIRT607877	hsa-miR-8485	HITS-CLIP	27418678
MIRT607877	hsa-miR-8485	HITS-CLIP	27418678
MIRT607877	hsa-miR-8485	HITS-CLIP	22927820
MIRT607876	hsa-miR-329-3p	HITS-CLIP	22927820
MIRT607875	hsa-miR-362-3p	HITS-CLIP	22927820
MIRT607874	hsa-miR-603	HITS-CLIP	22927820
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	22927820
MIRT607871	hsa-miR-3941	HITS-CLIP	22927820
MIRT607870	hsa-miR-4789-5p	HITS-CLIP	22927820
MIRT607877	hsa-miR-8485	HITS-CLIP	23313552
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23313552
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT607876	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT607875	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT607874	hsa-miR-603	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607871	hsa-miR-3941	HITS-CLIP	23824327
MIRT607870	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT607876	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT607875	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT607874	hsa-miR-603	HITS-CLIP	23824327
MIRT607871	hsa-miR-3941	HITS-CLIP	23824327
MIRT607870	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT670441	hsa-miR-3924	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT607876	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT607875	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT607874	hsa-miR-603	HITS-CLIP	23824327
MIRT607871	hsa-miR-3941	HITS-CLIP	23824327
MIRT607870	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT670441	hsa-miR-3924	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT639520	hsa-miR-577	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT639520	hsa-miR-577	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT2678258	hsa-miR-3675-3p	CLIP-seq
MIRT2678259	hsa-miR-4803	CLIP-seq

Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001946	Process	Lymphangiogenesis	IEA
GO:0002040	Process	Sprouting angiogenesis	IEA
GO:0002042	Process	Cell migration involved in sprouting angiogenesis	IEA
GO:0005515	Function	Protein binding	IPI	27991863, 32296183
GO:0009897	Component	External side of plasma membrane	IBA
GO:0009897	Component	External side of plasma membrane	IDA	25745997
GO:0016020	Component	Membrane	IEA
GO:0016477	Process	Cell migration	IBA
GO:0030246	Function	Carbohydrate binding	IEA
GO:0031012	Component	Extracellular matrix	HDA	23979707
GO:0036324	Process	Vascular endothelial growth factor receptor-2 signaling pathway	IEA
GO:0036324	Process	Vascular endothelial growth factor receptor-2 signaling pathway	IEA
GO:0036324	Process	Vascular endothelial growth factor receptor-2 signaling pathway	IMP	27991863
GO:0036325	Process	Vascular endothelial growth factor receptor-3 signaling pathway	IEA
GO:0036325	Process	Vascular endothelial growth factor receptor-3 signaling pathway	IEA
GO:0036325	Process	Vascular endothelial growth factor receptor-3 signaling pathway	IMP	27991863
GO:0050840	Function	Extracellular matrix binding	IBA
GO:1990430	Function	Extracellular matrix protein binding	IBA
GO:1990430	Function	Extracellular matrix protein binding	IDA	25745997

MIM	HGNC	e!Ensembl
616845	19832	ENSG00000176435

Q86T13

Protein name

C-type lectin domain family 14 member A (Epidermal growth factor receptor 5) (EGFR-5)

Family and domains

Sequence

MRPAFALCLLWQALWPGPGGGEHPTADRAGCSASGACYSLHHATMKRQAAEEACILRGGA
LSTVRAGAELRAVLALLRAGPGPGGGSKDLLFWVALERRRSHCTLENEPLRGFSWLSSDP
GGLESDTLQWVEEPQRSCTARRCAVLQATGGVEPAGWKEMRCHLRANGYLCKYQFEVLCP
APRPGAASNLSYRAPFQLHSAALDFSPPGTEVSALCRGQLPISVTCIADEIGARWDKLSG
DVLCPCPGRYLRAGKCAELPNCLDDLGGFACECATGFELGKDGRSCVTSGEGQPTLGGTG
VPTRRPPATATSPVPQRTWPIRVDEKLGETPLVPEQDNSVTSIPEIPRWGSQSTMSTLQM
SLQAESKATITPSGSVISKFNSTTSSATPQAFDSSSAVVFIFVSTAVVVLVILTMTVLGL
VKLCFHESPSSQPRKESMGPPGLESDPEPAALGSSSAHCTNNGVKVGDCDLRDRAEGALL
AESPLGSSDA

Sequence length

490

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (8)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY VASOSPASM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (9)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Brain Diseases	Associate	35641310	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Associate	18446232	★★★★★ ★☆☆☆☆ Found in Text Mining only
CADASIL	Associate	35641310	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Associate	35576868	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Associate	33761933	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinosarcoma	Associate	28088687	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	28088687, 28878328, 35576868	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Associate	21694441	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stroke	Associate	35641310	★★★★★ ★☆☆☆☆ Found in Text Mining only

CLEC14A (C-type lectin domain containing 14A)