Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	161
Gene name Gene Name - the full gene name approved by the HGNC.	Adaptor related protein complex 2 subunit alpha 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	AP2A2
Synonyms (NCBI Gene) Gene synonyms aliases	ADTAB, CLAPA2, HIP-9, HIP9, HYPJ
Chromosome Chromosome number	11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	11p15.5
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a subunit of the AP-2 adaptor protein complex, which is involved in linking lipid and protein membrane components with the clathrin lattice. This interaction supports the formation of clathrin-coated vesicles, and the e

Show/Hide all(126)

miRTarBase ID	miRNA	Experiments	Reference
MIRT025343	hsa-miR-34a-5p	Proteomics	21566225
MIRT025343	hsa-miR-34a-5p	Proteomics	21566225
MIRT025343	hsa-miR-34a-5p	Proteomics	21566225
MIRT025343	hsa-miR-34a-5p	Proteomics	21566225
MIRT048756	hsa-miR-93-5p	CLASH	23622248
MIRT043335	hsa-miR-331-3p	CLASH	23622248
MIRT040723	hsa-miR-92b-3p	CLASH	23622248
MIRT037420	hsa-miR-744-5p	CLASH	23622248
MIRT036876	hsa-miR-877-3p	CLASH	23622248
MIRT441215	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT441215	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT787565	hsa-miR-10a	CLIP-seq
MIRT787566	hsa-miR-10b	CLIP-seq
MIRT787567	hsa-miR-1200	CLIP-seq
MIRT787568	hsa-miR-1228	CLIP-seq
MIRT787569	hsa-miR-1238	CLIP-seq
MIRT787570	hsa-miR-1289	CLIP-seq
MIRT787571	hsa-miR-1291	CLIP-seq
MIRT787572	hsa-miR-1343	CLIP-seq
MIRT787573	hsa-miR-3173-5p	CLIP-seq
MIRT787574	hsa-miR-3198	CLIP-seq
MIRT787575	hsa-miR-3921	CLIP-seq
MIRT787576	hsa-miR-4254	CLIP-seq
MIRT787577	hsa-miR-4294	CLIP-seq
MIRT787578	hsa-miR-4308	CLIP-seq
MIRT787579	hsa-miR-4309	CLIP-seq
MIRT787580	hsa-miR-431	CLIP-seq
MIRT787581	hsa-miR-4324	CLIP-seq
MIRT787582	hsa-miR-4488	CLIP-seq
MIRT787583	hsa-miR-4653-5p	CLIP-seq
MIRT787584	hsa-miR-4663	CLIP-seq
MIRT787585	hsa-miR-4682	CLIP-seq
MIRT787586	hsa-miR-4691-5p	CLIP-seq
MIRT787587	hsa-miR-4697-5p	CLIP-seq
MIRT787588	hsa-miR-4701-5p	CLIP-seq
MIRT787589	hsa-miR-4734	CLIP-seq
MIRT787590	hsa-miR-544b	CLIP-seq
MIRT787591	hsa-miR-588	CLIP-seq
MIRT787592	hsa-miR-627	CLIP-seq
MIRT787593	hsa-miR-637	CLIP-seq
MIRT787594	hsa-miR-663b	CLIP-seq
MIRT787595	hsa-miR-924	CLIP-seq
MIRT787567	hsa-miR-1200	CLIP-seq
MIRT787569	hsa-miR-1238	CLIP-seq
MIRT787581	hsa-miR-4324	CLIP-seq
MIRT787586	hsa-miR-4691-5p	CLIP-seq
MIRT787590	hsa-miR-544b	CLIP-seq
MIRT787567	hsa-miR-1200	CLIP-seq
MIRT787569	hsa-miR-1238	CLIP-seq
MIRT2172611	hsa-miR-1470	CLIP-seq
MIRT787581	hsa-miR-4324	CLIP-seq
MIRT787584	hsa-miR-4663	CLIP-seq
MIRT2172612	hsa-miR-4667-3p	CLIP-seq
MIRT787586	hsa-miR-4691-5p	CLIP-seq
MIRT787590	hsa-miR-544b	CLIP-seq
MIRT787567	hsa-miR-1200	CLIP-seq
MIRT787569	hsa-miR-1238	CLIP-seq
MIRT2384272	hsa-miR-3153	CLIP-seq
MIRT787581	hsa-miR-4324	CLIP-seq
MIRT2384273	hsa-miR-4646-5p	CLIP-seq
MIRT787584	hsa-miR-4663	CLIP-seq
MIRT2384274	hsa-miR-4668-5p	CLIP-seq
MIRT787586	hsa-miR-4691-5p	CLIP-seq
MIRT787590	hsa-miR-544b	CLIP-seq
MIRT787567	hsa-miR-1200	CLIP-seq
MIRT787569	hsa-miR-1238	CLIP-seq
MIRT2475596	hsa-miR-1247	CLIP-seq
MIRT2475597	hsa-miR-1908	CLIP-seq
MIRT2475598	hsa-miR-3064-3p	CLIP-seq
MIRT2475599	hsa-miR-3151	CLIP-seq
MIRT2475600	hsa-miR-3175	CLIP-seq
MIRT2475601	hsa-miR-3180	CLIP-seq
MIRT2475602	hsa-miR-3180-3p	CLIP-seq
MIRT2475603	hsa-miR-3196	CLIP-seq
MIRT2475604	hsa-miR-3197	CLIP-seq
MIRT2475605	hsa-miR-3929	CLIP-seq
MIRT2475606	hsa-miR-3960	CLIP-seq
MIRT787581	hsa-miR-4324	CLIP-seq
MIRT2475607	hsa-miR-4419b	CLIP-seq
MIRT2475608	hsa-miR-4447	CLIP-seq
MIRT2475609	hsa-miR-4467	CLIP-seq
MIRT2475610	hsa-miR-4472	CLIP-seq
MIRT2475611	hsa-miR-4478	CLIP-seq
MIRT2475612	hsa-miR-455-3p	CLIP-seq
MIRT2475613	hsa-miR-4645-5p	CLIP-seq
MIRT787584	hsa-miR-4663	CLIP-seq
MIRT2475614	hsa-miR-4673	CLIP-seq
MIRT2475615	hsa-miR-4690-3p	CLIP-seq
MIRT787586	hsa-miR-4691-5p	CLIP-seq
MIRT2475616	hsa-miR-4706	CLIP-seq
MIRT2475617	hsa-miR-4749-5p	CLIP-seq
MIRT2475618	hsa-miR-491-5p	CLIP-seq
MIRT787590	hsa-miR-544b	CLIP-seq
MIRT2475619	hsa-miR-663	CLIP-seq
MIRT2475620	hsa-miR-744	CLIP-seq
MIRT787567	hsa-miR-1200	CLIP-seq
MIRT787569	hsa-miR-1238	CLIP-seq
MIRT2475596	hsa-miR-1247	CLIP-seq
MIRT2475597	hsa-miR-1908	CLIP-seq
MIRT2475598	hsa-miR-3064-3p	CLIP-seq
MIRT2475599	hsa-miR-3151	CLIP-seq
MIRT2475600	hsa-miR-3175	CLIP-seq
MIRT2475601	hsa-miR-3180	CLIP-seq
MIRT2475602	hsa-miR-3180-3p	CLIP-seq
MIRT2475603	hsa-miR-3196	CLIP-seq
MIRT2475604	hsa-miR-3197	CLIP-seq
MIRT2475605	hsa-miR-3929	CLIP-seq
MIRT2475606	hsa-miR-3960	CLIP-seq
MIRT787581	hsa-miR-4324	CLIP-seq
MIRT2475607	hsa-miR-4419b	CLIP-seq
MIRT2475608	hsa-miR-4447	CLIP-seq
MIRT2475609	hsa-miR-4467	CLIP-seq
MIRT2475610	hsa-miR-4472	CLIP-seq
MIRT2475611	hsa-miR-4478	CLIP-seq
MIRT2475612	hsa-miR-455-3p	CLIP-seq
MIRT2475613	hsa-miR-4645-5p	CLIP-seq
MIRT787584	hsa-miR-4663	CLIP-seq
MIRT2475614	hsa-miR-4673	CLIP-seq
MIRT2475615	hsa-miR-4690-3p	CLIP-seq
MIRT787586	hsa-miR-4691-5p	CLIP-seq
MIRT2475616	hsa-miR-4706	CLIP-seq
MIRT2475617	hsa-miR-4749-5p	CLIP-seq
MIRT2475618	hsa-miR-491-5p	CLIP-seq
MIRT787590	hsa-miR-544b	CLIP-seq
MIRT2475619	hsa-miR-663	CLIP-seq
MIRT2475620	hsa-miR-744	CLIP-seq

Show/Hide all(34)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003674	Function	Molecular_function	ND
GO:0005515	Function	Protein binding	IPI	15598649, 16902404, 22262466, 22323290, 23676497, 32296183
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0006886	Process	Intracellular protein transport	IEA
GO:0006898	Process	Receptor-mediated endocytosis	IBA	21873635
GO:0008289	Function	Lipid binding	IEA
GO:0019886	Process	Antigen processing and presentation of exogenous peptide antigen via MHC class II	TAS
GO:0019901	Function	Protein kinase binding	ISS
GO:0030122	Component	AP-2 adaptor complex	IBA	21873635
GO:0030122	Component	AP-2 adaptor complex	IDA	23676497
GO:0030122	Component	AP-2 adaptor complex	TAS	12121421
GO:0030666	Component	Endocytic vesicle membrane	TAS
GO:0030667	Component	Secretory granule membrane	TAS
GO:0030669	Component	Clathrin-coated endocytic vesicle membrane	TAS
GO:0031410	Component	Cytoplasmic vesicle	ISS
GO:0032802	Process	Low-density lipoprotein particle receptor catabolic process	TAS
GO:0034383	Process	Low-density lipoprotein particle clearance	TAS
GO:0035615	Function	Clathrin adaptor activity	IBA	21873635
GO:0035615	Function	Clathrin adaptor activity	TAS	12121421
GO:0036020	Component	Endolysosome membrane	TAS
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0045334	Component	Clathrin-coated endocytic vesicle	NAS	25898166
GO:0048013	Process	Ephrin receptor signaling pathway	TAS
GO:0050690	Process	Regulation of defense response to virus by virus	TAS
GO:0060071	Process	Wnt signaling pathway, planar cell polarity pathway	TAS
GO:0061024	Process	Membrane organization	TAS
GO:0072583	Process	Clathrin-dependent endocytosis	IBA	21873635
GO:0072583	Process	Clathrin-dependent endocytosis	IDA	23676497
GO:0072583	Process	Clathrin-dependent endocytosis	IMP	22262466
GO:0072583	Process	Clathrin-dependent endocytosis	TAS	12121421
GO:0097718	Function	Disordered domain specific binding	IEA
GO:0101003	Component	Ficolin-1-rich granule membrane	TAS
GO:0140312	Function	Cargo adaptor activity	IBA	21873635

MIM	HGNC	e!Ensembl
607242	562	ENSG00000183020

Protein

UniProt ID

O94973

Protein name

AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain)

Protein function

Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be invo

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01602	Adaptin_N	29 → 590	Adaptin N terminal region	Family
PF02883	Alpha_adaptinC2	713 → 821	Adaptin C-terminal domain	Domain
PF02296	Alpha_adaptin_C	826 → 934	Alpha adaptin AP2, C-terminal domain	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in the brain (at protein level). {ECO:0000269|PubMed:23676497}.

Sequence

MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVC
KLLFIFLLGHDIDFGHMEAVNLLSSNRYTEKQIGYLFISVLVNSNSELIRLINNAIKNDL
ASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLGVVTAATSLITTLAQKNPEEFKTSVSLAVSRLSRIVTSA
STDLQDYTYYFVPAPWLSVKLLRLLQCYPPPDPAVRGRLTECLETILNKAQEPPKSKKVQ
HSNAKNAVLFEAISLIIHHDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEF
SHEAVKTHIETVINALKTERDVSVRQRAVDLLYAMCDRSNAPQIVAEMLSYLETADYSIR
EEIVLKVAILAEKYAVDYTWYVDTILNLIRIAGDYVSEEVWYRVIQIVINRDDVQGYAAK
TVFEALQAPACHENLVKVGGYILGEFGNLIAGDPRSSPLIQFHLLHSKFHLCSVPTRALL
LSTYIKFVNLFPEVKPTIQDVLRSDSQLRNADVELQQRAVEYLRLSTVASTDILATVLEE
MPPFPERESSILAKLKKKKGPSTVTDLEDTKRDRSVDVNGGPEPAPASTSAVSTPSPSAD
LLGLGAAPPAPAGPPPSSGGSGLLVDVFSDSASVVAPLAPGSEDNFARFVCKNNGVLFEN
QLLQIGLKSEFRQNLGRMFIFYGNKTSTQFLNFTPTLICSDDLQPNLNLQTKPVDPTVEG
GAQVQQVVNIECVSDFTEAPVLNIQFRYGGTFQNVSVQLPITLNKFFQPTEMASQDFFQR
WKQLSNPQQEVQNIFKAKHPMDTEVTKAKIIGFGSALLEEVDPNPANFVGAGIIHTKTTQ
IGCLLRLEPNLQAQMYRLTLRTSKEAVSQRLCELLSAQF

Sequence length

939

Interactions

View interactions

	KEGG		Reactome
	Endocytosis Synaptic vesicle cycle Endocrine and other factor-regulated calcium reabsorption Huntington disease		Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Trafficking of GluR2-containing AMPA receptors Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Neutrophil degranulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Alzheimer disease	Alzheimer`s Disease	rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039 View all (65 more)	24162737

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Asthma	Asthma		27611488	ClinVar, GWAS

Show/Hide Text Mining Associations (9)

Disease Name	Relationship Type	References
Associations from Text Mining
Alzheimer Disease	Associate	28800327, 30086706, 31748784
Asthma	Associate	36946148
Atherosclerosis	Associate	29685964
Atrial Fibrillation	Associate	32478689
Coronary Artery Disease	Associate	30086706
Dementia	Associate	35299244
Diabetes Mellitus Type 2	Associate	30086706
Diffuse Neurofibrillary Tangles with Calcification	Associate	31748784
Proteostasis Deficiencies	Associate	31748784

AP2A2 (adaptor related protein complex 2 subunit alpha 2)