DGKH (diacylglycerol kinase eta)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
160851
Gene name Gene Name - the full gene name approved by the HGNC.
Diacylglycerol kinase eta
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
DGKH
Synonyms (NCBI Gene) Gene synonyms aliases
DGKeta
Chromosome Chromosome number
13
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
13q14.11
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the diacylglycerol kinase (DGK) enzyme family. Members of this family are involved in regulating intracellular concentrations of diacylglycerol and phosphatidic acid. Variation in this gene has been associated with bipolar di
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(188)
miRTarBase ID miRNA Experiments Reference
MIRT023493 hsa-miR-1-3p Microarray 18668037
MIRT711623 hsa-miR-6873-5p HITS-CLIP 19536157
MIRT711622 hsa-miR-3614-3p HITS-CLIP 19536157
MIRT711620 hsa-miR-4457 HITS-CLIP 19536157
MIRT711621 hsa-miR-125b-2-3p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(23)
GO ID Ontology Definition Evidence Reference
GO:0003951 Function NAD+ kinase activity IEA
GO:0004143 Function Diacylglycerol kinase activity IBA 21873635
GO:0004143 Function Diacylglycerol kinase activity IDA 23949095
GO:0004143 Function Diacylglycerol kinase activity IMP 12810723
GO:0004143 Function Diacylglycerol kinase activity ISS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
604071 2854 ENSG00000102780
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q86XP1
Protein name Diacylglycerol kinase eta (DAG kinase eta) (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta)
Protein function Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12810723, PubMed:23949095). Thereby, acts as a central switch between the si
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00169 PH 66 → 158 PH domain Domain
PF00130 C1_1 176 → 228 Phorbol esters/diacylglycerol binding domain (C1 domain) Domain
PF00130 C1_1 248 → 301 Phorbol esters/diacylglycerol binding domain (C1 domain) Domain
PF00781 DAGK_cat 332 → 454 Diacylglycerol kinase catalytic domain Family
PF00609 DAGK_acc 770 → 927 Diacylglycerol kinase accessory domain Family
PF07647 SAM_2 1148 → 1211 SAM domain (Sterile alpha motif) Domain
Tissue specificity TISSUE SPECIFICITY: [Isoform 1]: Expressed only in testis, kidney and colon. {ECO:0000269|PubMed:12810723}.; TISSUE SPECIFICITY: [Isoform 2]: Ubiquitously expressed. {ECO:0000269|PubMed:12810723}.
Sequence 
MAGAGGQHHPPGAAGGAAAGAGAAVTSAAASAGPGEDSSDSEAEQEGPQKLIRKVSTSGQ
IRTKTSIKEGQLLKQTSSFQRWKKRYFKLRGRTLYYAKDSKSLIFDEVDLSDASVAEAST
KNANNSFTIITPFRRLMLCAENRKEMEDWISSLKSVQTREPYEVAQFNVEHFSGMHNWYA
CSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIED
EDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDLYHPICPL
GQCKVSIIPPIALNSTDSDGFCRATFSFCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPA
QVFDLMNGGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLNKQCQLGVLPLGTG
NDLARVLGWGGSYDDDTQLPQILEKLERASTKMLDRWSIMTYELKLPPKASLLPGPPEAS
EEFYMTIYEDSVATHLTKILNSDEHAVVISSAKTLCETVKDFVAKVEKTYDKTLENAVVA
DAVASKCSVLNEKLEQLLQALHTDSQAAPVLPGLSPLIVEEDAVESSSEESLGESKEQLG
DDVTKPSSQKAVKPREIMLRANSLKKAVRQVIEEAGKVMDDPTVHPCEPANQSSDYDSTE
TDESKEEAKDDGAKESITVKTAPRSPDARASYGHSQTDSVPGPAVAASKENLPVLNTRII
CPGLRAGLAASIAGSSIINKMLLANIDPFGATPFIDPDLDSVDGYSEKCVMNNYFGIGLD
AKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQLECDGQYIPLP
SLQGIAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAIFDSMQMAVSRVIKLQH
HRIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQMLTRDRAFESTLKSWE
DKQKCDSGKPVLRTHLYIHHAIDLATEEVSQMQLCSQAAEELITRICDAATIHCLLEQEL
AHAVNACSHALNKANPRCPESLTRDTATEIAINVKALYNETESLLVGRVPLQLESPHEER
VSNALHSVEVELQKLTEIPWLYYILHPNEDEEPPMDCTKRNNRSTVFRIVPKFKKEKVQK
QKTSSQPVQKWGTEEVAAWLDLLNLGEYKDIFIRHDIRGAELLHLERRDLKDLGIPKVGH
VKRILQGIKELGRSTPQSEV
Sequence length 1220
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Glycerolipid metabolism
Glycerophospholipid metabolism
Metabolic pathways
Phosphatidylinositol signaling system
Phospholipase D signaling pathway
Choline metabolism in cancer 		  Effects of PIP2 hydrolysis
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Esophagus neoplasm Esophageal Neoplasms rs28934578, rs121918714, rs1567556006, rs1575166666 22960999
Show/Hide Unknown Diseases (9)
Unknown
Disease term Disease name Evidence References Source
Asthma Asthma 25221879 ClinVar
Mental depression Unipolar Depression 21654738 ClinVar
Bipolar Disorder Bipolar Disorder GWAS
Nephrolithiasis Nephrolithiasis GWAS
Show/Hide Text Mining Associations (9)
Associations from Text Mining
Disease Name Relationship Type References
Attention Deficit Disorder with Hyperactivity Associate 21654738
Bipolar Disorder Associate 17486107, 21654738, 21771265, 22048461, 22892719, 30266033
Central Nervous System Vascular Malformations Associate 35627254
Depressive Disorder Associate 21654738
Diabetic Nephropathies Associate 36482994
Mood Disorders Associate 21654738, 24944871
Nephrolithiasis Associate 22396660, 28361944
Nephrolithiasis Calcium Oxalate Associate 35741705
Urolithiasis Associate 28361944