Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	1608
Gene name	Diacylglycerol kinase gamma
Gene symbol	DGKG
Synonyms (NCBI Gene)	DAGK3DGK-GAMMA
Chromosome	3
Chromosome location	3q27.2-q27.3
Summary	This gene encodes an enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid secon

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Show/Hide all (207)

miRTarBase ID	miRNA	Experiments	Reference
MIRT615036	hsa-miR-8485	HITS-CLIP	19536157
MIRT504730	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT504729	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT504727	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT504728	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT504726	hsa-miR-6083	HITS-CLIP	21572407
MIRT504730	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT504731	hsa-miR-1295b-3p	HITS-CLIP	23313552
MIRT504729	hsa-miR-410-3p	HITS-CLIP	23313552
MIRT504727	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT504728	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT504726	hsa-miR-6083	HITS-CLIP	23313552
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT633045	hsa-miR-208a-3p	HITS-CLIP	23824327
MIRT633044	hsa-miR-208b-3p	HITS-CLIP	23824327
MIRT633043	hsa-miR-499a-5p	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT504730	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT504727	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT611885	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT504728	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT633045	hsa-miR-208a-3p	HITS-CLIP	23824327
MIRT633044	hsa-miR-208b-3p	HITS-CLIP	23824327
MIRT633043	hsa-miR-499a-5p	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT611885	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT611885	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT504730	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT504731	hsa-miR-1295b-3p	PAR-CLIP	20371350
MIRT504729	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT504727	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT504728	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT504726	hsa-miR-6083	PAR-CLIP	20371350
MIRT504730	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT504731	hsa-miR-1295b-3p	PAR-CLIP	20371350
MIRT504729	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT504727	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT504728	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT504726	hsa-miR-6083	PAR-CLIP	20371350
MIRT504730	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT504731	hsa-miR-1295b-3p	PAR-CLIP	21572407
MIRT504729	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT504727	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT504728	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT504726	hsa-miR-6083	PAR-CLIP	21572407
MIRT504730	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT504731	hsa-miR-1295b-3p	PAR-CLIP	23446348
MIRT504729	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT504727	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT504728	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504726	hsa-miR-6083	PAR-CLIP	23446348
MIRT504730	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT504731	hsa-miR-1295b-3p	PAR-CLIP	23446348
MIRT504729	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT504727	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT504728	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504726	hsa-miR-6083	PAR-CLIP	23446348
MIRT504730	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT504731	hsa-miR-1295b-3p	PAR-CLIP	23446348
MIRT504729	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT504727	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT504728	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504726	hsa-miR-6083	PAR-CLIP	23446348
MIRT615036	hsa-miR-8485	HITS-CLIP	19536157
MIRT504730	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT504729	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT504727	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT504728	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT504726	hsa-miR-6083	HITS-CLIP	21572407
MIRT504730	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT504731	hsa-miR-1295b-3p	HITS-CLIP	23313552
MIRT504729	hsa-miR-410-3p	HITS-CLIP	23313552
MIRT504727	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT504728	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT504726	hsa-miR-6083	HITS-CLIP	23313552
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT633045	hsa-miR-208a-3p	HITS-CLIP	23824327
MIRT633044	hsa-miR-208b-3p	HITS-CLIP	23824327
MIRT633043	hsa-miR-499a-5p	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT504730	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT504727	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT611885	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT504728	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT633045	hsa-miR-208a-3p	HITS-CLIP	23824327
MIRT633044	hsa-miR-208b-3p	HITS-CLIP	23824327
MIRT633043	hsa-miR-499a-5p	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT611885	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT611885	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT504730	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT504731	hsa-miR-1295b-3p	PAR-CLIP	20371350
MIRT504729	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT504727	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT504728	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT504726	hsa-miR-6083	PAR-CLIP	20371350
MIRT504730	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT504731	hsa-miR-1295b-3p	PAR-CLIP	20371350
MIRT504729	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT504727	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT504728	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT504726	hsa-miR-6083	PAR-CLIP	20371350
MIRT504730	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT504731	hsa-miR-1295b-3p	PAR-CLIP	21572407
MIRT504729	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT504727	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT504728	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT504726	hsa-miR-6083	PAR-CLIP	21572407
MIRT504730	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT504731	hsa-miR-1295b-3p	PAR-CLIP	23446348
MIRT504729	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT504727	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT504728	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504726	hsa-miR-6083	PAR-CLIP	23446348
MIRT504730	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT504731	hsa-miR-1295b-3p	PAR-CLIP	23446348
MIRT504729	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT504727	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT504728	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504726	hsa-miR-6083	PAR-CLIP	23446348
MIRT504730	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT504731	hsa-miR-1295b-3p	PAR-CLIP	23446348
MIRT504729	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT504727	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT504728	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504726	hsa-miR-6083	PAR-CLIP	23446348
MIRT934199	hsa-miR-425	CLIP-seq
MIRT934200	hsa-miR-1225-3p	CLIP-seq
MIRT934201	hsa-miR-1233	CLIP-seq
MIRT934202	hsa-miR-190	CLIP-seq
MIRT934203	hsa-miR-190b	CLIP-seq
MIRT934204	hsa-miR-216a	CLIP-seq
MIRT934205	hsa-miR-3173-5p	CLIP-seq
MIRT934206	hsa-miR-3201	CLIP-seq
MIRT934207	hsa-miR-3653	CLIP-seq
MIRT934208	hsa-miR-370	CLIP-seq
MIRT934209	hsa-miR-3919	CLIP-seq
MIRT934210	hsa-miR-4330	CLIP-seq
MIRT934211	hsa-miR-450b-3p	CLIP-seq
MIRT934212	hsa-miR-4534	CLIP-seq
MIRT934213	hsa-miR-4663	CLIP-seq
MIRT934214	hsa-miR-4722-3p	CLIP-seq
MIRT934215	hsa-miR-4756-3p	CLIP-seq
MIRT934216	hsa-miR-4791	CLIP-seq
MIRT934217	hsa-miR-4802-5p	CLIP-seq
MIRT934218	hsa-miR-769-3p	CLIP-seq
MIRT1976549	hsa-miR-204	CLIP-seq
MIRT1976550	hsa-miR-211	CLIP-seq
MIRT1976551	hsa-miR-4755-5p	CLIP-seq
MIRT1976552	hsa-miR-298	CLIP-seq
MIRT1976553	hsa-miR-3064-5p	CLIP-seq
MIRT1976554	hsa-miR-34a	CLIP-seq
MIRT1976555	hsa-miR-34c-5p	CLIP-seq
MIRT1976556	hsa-miR-3652	CLIP-seq
MIRT1976557	hsa-miR-3678-3p	CLIP-seq
MIRT1976558	hsa-miR-4430	CLIP-seq
MIRT1976559	hsa-miR-449a	CLIP-seq
MIRT1976560	hsa-miR-449b	CLIP-seq
MIRT1976561	hsa-miR-4505	CLIP-seq
MIRT2211931	hsa-miR-1258	CLIP-seq
MIRT2211932	hsa-miR-1271	CLIP-seq
MIRT2211933	hsa-miR-149	CLIP-seq
MIRT2211934	hsa-miR-205	CLIP-seq
MIRT2211935	hsa-miR-4278	CLIP-seq
MIRT2211936	hsa-miR-760	CLIP-seq
MIRT2211937	hsa-miR-892b	CLIP-seq
MIRT2211938	hsa-miR-96	CLIP-seq
MIRT2515662	hsa-miR-3194-3p	CLIP-seq
MIRT2515663	hsa-miR-3670	CLIP-seq
MIRT2515664	hsa-miR-4329	CLIP-seq
MIRT934213	hsa-miR-4663	CLIP-seq
MIRT2515665	hsa-miR-4786-5p	CLIP-seq
MIRT2515666	hsa-miR-769-5p	CLIP-seq

Show/Hide all (2)

Transcription factor	Regulation	Reference
CREB5	Activation	21132541
CREB5	Repression	21132541

Show/Hide all (40)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004143	Function	ATP-dependent diacylglycerol kinase activity	IBA
GO:0004143	Function	ATP-dependent diacylglycerol kinase activity	IDA	8034597, 22627129
GO:0004143	Function	ATP-dependent diacylglycerol kinase activity	IEA
GO:0004143	Function	ATP-dependent diacylglycerol kinase activity	TAS
GO:0005509	Function	Calcium ion binding	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	8034597
GO:0005829	Component	Cytosol	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006654	Process	Phosphatidic acid biosynthetic process	IBA
GO:0006654	Process	Phosphatidic acid biosynthetic process	IDA	8034597
GO:0006654	Process	Phosphatidic acid biosynthetic process	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0008289	Function	Lipid binding	IDA	22627129
GO:0008289	Function	Lipid binding	IEA
GO:0016020	Component	Membrane	IDA	8034597
GO:0016020	Component	Membrane	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030168	Process	Platelet activation	IEA
GO:0030168	Process	Platelet activation	TAS
GO:0035556	Process	Intracellular signal transduction	IBA
GO:0046339	Process	Diacylglycerol metabolic process	IBA
GO:0046339	Process	Diacylglycerol metabolic process	IDA	8034597
GO:0046339	Process	Diacylglycerol metabolic process	IEA
GO:0046486	Process	Glycerolipid metabolic process	IDA	22627129
GO:0046486	Process	Glycerolipid metabolic process	IEA
GO:0046834	Process	Lipid phosphorylation	IDA	8034597, 22627129
GO:0046834	Process	Lipid phosphorylation	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0050773	Process	Regulation of dendrite development	IEA
GO:0160195	Process	Negative regulation of phospholipase C/protein kinase C signal transduction	IEA
GO:0160195	Process	Negative regulation of phospholipase C/protein kinase C signal transduction	ISS

MIM	HGNC	e!Ensembl
601854	2853	ENSG00000058866

P49619

Protein name

Diacylglycerol kinase gamma (DAG kinase gamma) (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma)

Protein function

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:8034597). Thereby, acts as a central switch between the signaling pathways a

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF14513	DAG_kinase_N	5 → 175	Diacylglycerol kinase N-terminus	Domain
PF00130	C1_1	272 → 324	Phorbol esters/diacylglycerol binding domain (C1 domain)	Domain
PF00781	DAGK_cat	434 → 554	Diacylglycerol kinase catalytic domain	Family
PF00609	DAGK_acc	578 → 752	Diacylglycerol kinase accessory domain	Family

Tissue specificity

TISSUE SPECIFICITY: Predominantly expressed in retina and in a much lesser extent in the brain. Other tissues contain extremely low levels of DGK-gamma.

Sequence

MGEERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDPHEPISYDVFKLFMR
AYLEVDLPQPLSTHLFLAFSQKPRHETSDHPTEGASNSEANSADTNIQNADNATKADEAC
APDTESNMAEKQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGRPQDKL
EFMFRLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYDRDGFV
SLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGVRKQGL
CCTYCKYTVHERCVSRNIPGCVKTYSKAKRSGEVMQHAWVEGNSSVKCDRCHKSIKCYQS
VTARHCVWCRMTFHRKCELSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSAKGEL
VMQYKIIPTPGTHPLLVLVNPKSGGRQGERILRKFHYLLNPKQVFNLDNGGPTPGLNFFR
DTPDFRVLACGGDGTVGWILDCIDKANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGSL
TKILKDIEQSPLVMLDRWHLEVIPREEVENGDQVPYSIMNNYFSIGVDASIAHRFHVMRE
KHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVGVDLSNIFLEGIAILNI
PSMYGGTNLWGENKKNRAVIRESRKGVTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIY
TGLKSAGRRLAQCASVTIRTNKLLPMQVDGEPWMQPCCTIKITHKNQAPMMMGPPQKSSF
FSLRRKSRSKD

Sequence length

791

Interactions

View interactions

	KEGG		Reactome
	Glycerolipid metabolism Glycerophospholipid metabolism Metabolic pathways Phosphatidylinositol signaling system Phospholipase D signaling pathway Choline metabolism in cancer		Effects of PIP2 hydrolysis

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Benign	rs61752077	RCV005905865
Clear cell carcinoma of kidney	Benign	rs61752080, rs61752077	RCV005908282 RCV005905866
Sarcoma	Benign	rs61752077	RCV005905867
Thymoma	Benign	rs61752077	RCV005905868

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Asthma	Associate	20816195
Epilepsy	Associate	35421845
Hemangioblastoma	Associate	33446752
Neuroendocrine Tumors	Associate	39217365

DGKG (diacylglycerol kinase gamma)