Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	1607
Gene name Gene Name - the full gene name approved by the HGNC.	Diacylglycerol kinase beta
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	DGKB
Synonyms (NCBI Gene) Gene synonyms aliases	DAGK2, DGK, DGK-BETA
Chromosome Chromosome number	7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	7p21.2
Summary Summary of gene provided in NCBI Entrez Gene.	Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes.

Show/Hide all(193)

miRTarBase ID	miRNA	Experiments
MIRT933832	hsa-miR-122	CLIP-seq
MIRT933833	hsa-miR-149	CLIP-seq
MIRT933834	hsa-miR-24	CLIP-seq
MIRT933835	hsa-miR-3064-5p	CLIP-seq
MIRT933836	hsa-miR-3065-5p	CLIP-seq
MIRT933837	hsa-miR-3135b	CLIP-seq
MIRT933838	hsa-miR-3153	CLIP-seq
MIRT933839	hsa-miR-3160-5p	CLIP-seq
MIRT933840	hsa-miR-3185	CLIP-seq
MIRT933841	hsa-miR-3650	CLIP-seq
MIRT933842	hsa-miR-3652	CLIP-seq
MIRT933843	hsa-miR-383	CLIP-seq
MIRT933844	hsa-miR-4261	CLIP-seq
MIRT933845	hsa-miR-4284	CLIP-seq
MIRT933846	hsa-miR-4310	CLIP-seq
MIRT933847	hsa-miR-4424	CLIP-seq
MIRT933848	hsa-miR-4426	CLIP-seq
MIRT933849	hsa-miR-4427	CLIP-seq
MIRT933850	hsa-miR-4430	CLIP-seq
MIRT933851	hsa-miR-4647	CLIP-seq
MIRT933852	hsa-miR-4659a-3p	CLIP-seq
MIRT933853	hsa-miR-4659b-3p	CLIP-seq
MIRT933854	hsa-miR-4662b	CLIP-seq
MIRT933855	hsa-miR-4668-5p	CLIP-seq
MIRT933856	hsa-miR-4680-3p	CLIP-seq
MIRT933857	hsa-miR-4701-5p	CLIP-seq
MIRT933858	hsa-miR-4709-3p	CLIP-seq
MIRT933859	hsa-miR-4772-5p	CLIP-seq
MIRT933860	hsa-miR-4794	CLIP-seq
MIRT933861	hsa-miR-495	CLIP-seq
MIRT933862	hsa-miR-541	CLIP-seq
MIRT933863	hsa-miR-548ac	CLIP-seq
MIRT933864	hsa-miR-548ae	CLIP-seq
MIRT933865	hsa-miR-548aj	CLIP-seq
MIRT933866	hsa-miR-548am	CLIP-seq
MIRT933867	hsa-miR-548d-3p	CLIP-seq
MIRT933868	hsa-miR-548p	CLIP-seq
MIRT933869	hsa-miR-548x	CLIP-seq
MIRT933870	hsa-miR-548z	CLIP-seq
MIRT933871	hsa-miR-588	CLIP-seq
MIRT933872	hsa-miR-653	CLIP-seq
MIRT933873	hsa-miR-654-5p	CLIP-seq
MIRT933874	hsa-miR-760	CLIP-seq
MIRT933875	hsa-miR-9	CLIP-seq
MIRT933832	hsa-miR-122	CLIP-seq
MIRT1976483	hsa-miR-1279	CLIP-seq
MIRT933833	hsa-miR-149	CLIP-seq
MIRT1976484	hsa-miR-203	CLIP-seq
MIRT933834	hsa-miR-24	CLIP-seq
MIRT933837	hsa-miR-3135b	CLIP-seq
MIRT1976485	hsa-miR-3187-3p	CLIP-seq
MIRT1976486	hsa-miR-34b	CLIP-seq
MIRT1976487	hsa-miR-3545-3p	CLIP-seq
MIRT1976488	hsa-miR-3614-5p	CLIP-seq
MIRT933841	hsa-miR-3650	CLIP-seq
MIRT933842	hsa-miR-3652	CLIP-seq
MIRT1976489	hsa-miR-3663-5p	CLIP-seq
MIRT1976490	hsa-miR-3908	CLIP-seq
MIRT1976491	hsa-miR-3942-5p	CLIP-seq
MIRT933845	hsa-miR-4284	CLIP-seq
MIRT933850	hsa-miR-4430	CLIP-seq
MIRT1976492	hsa-miR-4435	CLIP-seq
MIRT1976493	hsa-miR-4635	CLIP-seq
MIRT933852	hsa-miR-4659a-3p	CLIP-seq
MIRT933853	hsa-miR-4659b-3p	CLIP-seq
MIRT1976494	hsa-miR-4680-5p	CLIP-seq
MIRT933857	hsa-miR-4701-5p	CLIP-seq
MIRT1976495	hsa-miR-4703-5p	CLIP-seq
MIRT1976496	hsa-miR-4717-3p	CLIP-seq
MIRT1976497	hsa-miR-4740-3p	CLIP-seq
MIRT1976498	hsa-miR-4755-3p	CLIP-seq
MIRT1976499	hsa-miR-4763-5p	CLIP-seq
MIRT1976500	hsa-miR-4766-3p	CLIP-seq
MIRT1976501	hsa-miR-4772-3p	CLIP-seq
MIRT1976502	hsa-miR-4775	CLIP-seq
MIRT933860	hsa-miR-4794	CLIP-seq
MIRT1976503	hsa-miR-5095	CLIP-seq
MIRT1976504	hsa-miR-548s	CLIP-seq
MIRT933871	hsa-miR-588	CLIP-seq
MIRT933832	hsa-miR-122	CLIP-seq
MIRT2211876	hsa-miR-1254	CLIP-seq
MIRT1976483	hsa-miR-1279	CLIP-seq
MIRT933833	hsa-miR-149	CLIP-seq
MIRT933834	hsa-miR-24	CLIP-seq
MIRT933835	hsa-miR-3064-5p	CLIP-seq
MIRT2211877	hsa-miR-3116	CLIP-seq
MIRT933837	hsa-miR-3135b	CLIP-seq
MIRT2211878	hsa-miR-3149	CLIP-seq
MIRT2211879	hsa-miR-3180-5p	CLIP-seq
MIRT2211880	hsa-miR-3182	CLIP-seq
MIRT2211881	hsa-miR-338-3p	CLIP-seq
MIRT2211882	hsa-miR-3647-3p	CLIP-seq
MIRT933841	hsa-miR-3650	CLIP-seq
MIRT933842	hsa-miR-3652	CLIP-seq
MIRT933845	hsa-miR-4284	CLIP-seq
MIRT933846	hsa-miR-4310	CLIP-seq
MIRT933850	hsa-miR-4430	CLIP-seq
MIRT2211883	hsa-miR-4438	CLIP-seq
MIRT2211884	hsa-miR-4530	CLIP-seq
MIRT933852	hsa-miR-4659a-3p	CLIP-seq
MIRT933853	hsa-miR-4659b-3p	CLIP-seq
MIRT2211885	hsa-miR-4727-5p	CLIP-seq
MIRT2211886	hsa-miR-4735-5p	CLIP-seq
MIRT1976497	hsa-miR-4740-3p	CLIP-seq
MIRT1976502	hsa-miR-4775	CLIP-seq
MIRT933860	hsa-miR-4794	CLIP-seq
MIRT2211887	hsa-miR-498	CLIP-seq
MIRT2211888	hsa-miR-499-3p	CLIP-seq
MIRT2211889	hsa-miR-499a-3p	CLIP-seq
MIRT1976503	hsa-miR-5095	CLIP-seq
MIRT2211890	hsa-miR-590-3p	CLIP-seq
MIRT2211891	hsa-miR-661	CLIP-seq
MIRT933874	hsa-miR-760	CLIP-seq
MIRT2386866	hsa-miR-452	CLIP-seq
MIRT2386867	hsa-miR-4676-3p	CLIP-seq
MIRT2211876	hsa-miR-1254	CLIP-seq
MIRT2448187	hsa-miR-2110	CLIP-seq
MIRT2211877	hsa-miR-3116	CLIP-seq
MIRT2211878	hsa-miR-3149	CLIP-seq
MIRT2448188	hsa-miR-3150a-3p	CLIP-seq
MIRT2448189	hsa-miR-411	CLIP-seq
MIRT2448190	hsa-miR-4271	CLIP-seq
MIRT2448191	hsa-miR-4715-3p	CLIP-seq
MIRT2448192	hsa-miR-4725-3p	CLIP-seq
MIRT2211886	hsa-miR-4735-5p	CLIP-seq
MIRT1976502	hsa-miR-4775	CLIP-seq
MIRT933860	hsa-miR-4794	CLIP-seq
MIRT2211890	hsa-miR-590-3p	CLIP-seq
MIRT2211891	hsa-miR-661	CLIP-seq
MIRT2211876	hsa-miR-1254	CLIP-seq
MIRT2448187	hsa-miR-2110	CLIP-seq
MIRT2211877	hsa-miR-3116	CLIP-seq
MIRT2211878	hsa-miR-3149	CLIP-seq
MIRT2448188	hsa-miR-3150a-3p	CLIP-seq
MIRT2448189	hsa-miR-411	CLIP-seq
MIRT2448190	hsa-miR-4271	CLIP-seq
MIRT2448191	hsa-miR-4715-3p	CLIP-seq
MIRT2448192	hsa-miR-4725-3p	CLIP-seq
MIRT2211886	hsa-miR-4735-5p	CLIP-seq
MIRT1976502	hsa-miR-4775	CLIP-seq
MIRT933860	hsa-miR-4794	CLIP-seq
MIRT2211890	hsa-miR-590-3p	CLIP-seq
MIRT2211891	hsa-miR-661	CLIP-seq
MIRT933832	hsa-miR-122	CLIP-seq
MIRT2515652	hsa-miR-1227	CLIP-seq
MIRT2211876	hsa-miR-1254	CLIP-seq
MIRT1976483	hsa-miR-1279	CLIP-seq
MIRT2515653	hsa-miR-197	CLIP-seq
MIRT933834	hsa-miR-24	CLIP-seq
MIRT2211877	hsa-miR-3116	CLIP-seq
MIRT933837	hsa-miR-3135b	CLIP-seq
MIRT2211878	hsa-miR-3149	CLIP-seq
MIRT933841	hsa-miR-3650	CLIP-seq
MIRT933842	hsa-miR-3652	CLIP-seq
MIRT2448189	hsa-miR-411	CLIP-seq
MIRT933845	hsa-miR-4284	CLIP-seq
MIRT933850	hsa-miR-4430	CLIP-seq
MIRT2211883	hsa-miR-4438	CLIP-seq
MIRT2515654	hsa-miR-455-5p	CLIP-seq
MIRT2448191	hsa-miR-4715-3p	CLIP-seq
MIRT2211886	hsa-miR-4735-5p	CLIP-seq
MIRT1976501	hsa-miR-4772-3p	CLIP-seq
MIRT1976502	hsa-miR-4775	CLIP-seq
MIRT933860	hsa-miR-4794	CLIP-seq
MIRT1976503	hsa-miR-5095	CLIP-seq
MIRT2515655	hsa-miR-5096	CLIP-seq
MIRT2211890	hsa-miR-590-3p	CLIP-seq
MIRT2211891	hsa-miR-661	CLIP-seq
MIRT933832	hsa-miR-122	CLIP-seq
MIRT2515652	hsa-miR-1227	CLIP-seq
MIRT2211876	hsa-miR-1254	CLIP-seq
MIRT1976483	hsa-miR-1279	CLIP-seq
MIRT2515653	hsa-miR-197	CLIP-seq
MIRT933834	hsa-miR-24	CLIP-seq
MIRT2211877	hsa-miR-3116	CLIP-seq
MIRT933837	hsa-miR-3135b	CLIP-seq
MIRT2211878	hsa-miR-3149	CLIP-seq
MIRT933841	hsa-miR-3650	CLIP-seq
MIRT933842	hsa-miR-3652	CLIP-seq
MIRT2448189	hsa-miR-411	CLIP-seq
MIRT933845	hsa-miR-4284	CLIP-seq
MIRT933850	hsa-miR-4430	CLIP-seq
MIRT2211883	hsa-miR-4438	CLIP-seq
MIRT2515654	hsa-miR-455-5p	CLIP-seq
MIRT2448191	hsa-miR-4715-3p	CLIP-seq
MIRT2211886	hsa-miR-4735-5p	CLIP-seq
MIRT1976501	hsa-miR-4772-3p	CLIP-seq
MIRT1976502	hsa-miR-4775	CLIP-seq
MIRT933860	hsa-miR-4794	CLIP-seq
MIRT1976503	hsa-miR-5095	CLIP-seq
MIRT2515655	hsa-miR-5096	CLIP-seq
MIRT2211890	hsa-miR-590-3p	CLIP-seq
MIRT2211891	hsa-miR-661	CLIP-seq

Show/Hide all(39)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004143	Function	ATP-dependent diacylglycerol kinase activity	IBA
GO:0004143	Function	ATP-dependent diacylglycerol kinase activity	IDA	11719522, 22627129
GO:0004143	Function	ATP-dependent diacylglycerol kinase activity	IEA
GO:0004143	Function	ATP-dependent diacylglycerol kinase activity	TAS
GO:0005509	Function	Calcium ion binding	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IDA	11719522
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	11719522
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	11719522
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006654	Process	Phosphatidic acid biosynthetic process	IBA
GO:0006654	Process	Phosphatidic acid biosynthetic process	ISS
GO:0007165	Process	Signal transduction	IEA
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0008289	Function	Lipid binding	IDA	22627129
GO:0008289	Function	Lipid binding	IEA
GO:0016020	Component	Membrane	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016607	Component	Nuclear speck	IDA
GO:0016740	Function	Transferase activity	IEA
GO:0030168	Process	Platelet activation	IEA
GO:0030168	Process	Platelet activation	TAS
GO:0035556	Process	Intracellular signal transduction	IBA
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0046339	Process	Diacylglycerol metabolic process	IBA
GO:0046339	Process	Diacylglycerol metabolic process	ISS
GO:0046486	Process	Glycerolipid metabolic process	IDA	22627129
GO:0046486	Process	Glycerolipid metabolic process	IEA
GO:0046834	Process	Lipid phosphorylation	IDA	11719522, 22627129
GO:0046834	Process	Lipid phosphorylation	IEA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
604070	2850	ENSG00000136267

Protein

UniProt ID

Q9Y6T7

Protein name

Diacylglycerol kinase beta (DAG kinase beta) (EC 2.7.1.107) (90 kDa diacylglycerol kinase) (Diglyceride kinase beta) (DGK-beta)

Protein function

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:11719522). Thereby, acts as a central switch between the signaling pathways

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF14513	DAG_kinase_N	6 → 149	Diacylglycerol kinase N-terminus	Domain
PF13499	EF-hand_7	151 → 222	EF-hand domain pair	Domain
PF00130	C1_1	245 → 297	Phorbol esters/diacylglycerol binding domain (C1 domain)	Domain
PF00130	C1_1	310 → 361	Phorbol esters/diacylglycerol binding domain (C1 domain)	Domain
PF00781	DAGK_cat	438 → 559	Diacylglycerol kinase catalytic domain	Family
PF00609	DAGK_acc	582 → 762	Diacylglycerol kinase accessory domain	Family

Tissue specificity

TISSUE SPECIFICITY: [Isoform 1]: Specifically expressed in brain but also detected in uterus (PubMed:11719522). In adult brain, expressed in the amygdala, caudate nucleus, and hippocampus (PubMed:11719522). {ECO:0000269|PubMed:11719522}.; TISSUE SPECIFICI

Sequence

MTNQEKWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDF
EGFKLFMKTFLEAELPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPR
TTSPANTCSPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIISQ
MMHVAEYLEWDVTELNPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENNVK
DDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVK
SKRNTDVMHHYWVEGNCPTKCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDC
GPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKMQRANS
VTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGL
NFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGYE
GENLMKILKDIENSTEIMLDRWKFEVIPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFH
IMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLEGIA
ILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGL
EGAMEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPCTIKITHKNQAPM
LMGPPPKTGLFCSLVKRTRNRSKE

Sequence length

804

Interactions

View interactions

	KEGG		Reactome
	Glycerolipid metabolism Glycerophospholipid metabolism Metabolic pathways Phosphatidylinositol signaling system Phospholipase D signaling pathway Choline metabolism in cancer		Effects of PIP2 hydrolysis

Show/Hide Unknown Diseases (9)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Atrial Fibrillation	Atrial fibrillation	N/A	N/A	GWAS
Diabetes	Type 2 diabetes	N/A	N/A	GWAS
Glioblastoma	Glioblastoma	N/A	N/A	GWAS
Hypogonadism	Hypogonadism	N/A	N/A	GWAS
Insomnia	Insomnia	N/A	N/A	GWAS
Mental Depression	Major depressive disorder	N/A	N/A	GWAS
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS
Neuroblastoma	Neuroblastoma	N/A	N/A	GWAS
Oligodendroglioma	Oligodendroglioma	N/A	N/A	GWAS

Show/Hide Text Mining Associations (22)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Alzheimer Disease	Associate	21059989
Anxiety	Associate	36652249
Arthritis Rheumatoid	Associate	34201265
Asthma	Associate	34278583
Cardiovascular Diseases	Associate	34201265
Colorectal Neoplasms	Associate	28446149
Diabetes Mellitus Noninsulin Dependent 2	Associate	27896979
Diabetes Mellitus Type 2	Associate	20081858, 27896979
Endometriosis	Associate	36652249
Feeding and Eating Disorders	Associate	36652249
Glioblastoma	Associate	36603576
Glioma	Associate	28912153
Hyperglycemia	Associate	20185807
Hyperinsulinism	Associate	20185807
Kidney Calculi	Associate	40372791
Mitochondrial Diseases	Inhibit	36603576
Neoplasms	Associate	28446149, 30307468, 35885996
Obesity	Associate	27377425
Osteoporosis	Associate	34201265
Prostatic Neoplasms	Associate	30307468
Psychomotor Disorders	Associate	23860044
Urinary Bladder Neoplasms	Associate	35958598

DGKB (diacylglycerol kinase beta)