Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
159963
Gene name Gene Name - the full gene name approved by the HGNC.
Solute carrier family 5 member 12
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SLC5A12
Synonyms (NCBI Gene) Gene synonyms aliases
SMCT2
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11p14.2
Summary Summary of gene provided in NCBI Entrez Gene.
Normal blood lactate is maintained at about 1.5 mM, and little filtered lactate is excreted in urine. Reabsorption of lactate is mediated by the low-affinity Na(+)-coupled lactate transporter SLC5A12 in the initial part of the proximal tubule and by the h
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT721584 hsa-miR-6890-3p HITS-CLIP 19536157
MIRT721583 hsa-miR-205-5p HITS-CLIP 19536157
MIRT721582 hsa-miR-4268 HITS-CLIP 19536157
MIRT721581 hsa-miR-4448 HITS-CLIP 19536157
MIRT721580 hsa-miR-505-3p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005343 Function Organic acid:sodium symporter activity TAS
GO:0005654 Component Nucleoplasm IDA
GO:0005886 Component Plasma membrane IDA
GO:0005886 Component Plasma membrane IEA
GO:0005886 Component Plasma membrane TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
612455 28750 ENSG00000148942
Protein
UniProt ID Q1EHB4
Protein name Sodium-coupled monocarboxylate transporter 2 (Electroneutral sodium monocarboxylate cotransporter) (Low-affinity sodium-lactate cotransporter) (Solute carrier family 5 member 12)
Protein function Acts as an electroneutral and low-affinity sodium (Na(+))-dependent sodium-coupled solute transporter (PubMed:17692818). Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionat
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00474 SSF 41 445 Sodium:solute symporter family Family
Sequence
Sequence length 618
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Multifunctional anion exchangers
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Erectile Dysfunction Erectile dysfunction N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Squamous Cell Carcinoma of Head and Neck Associate 33628816