CYP51A1 (cytochrome P450 family 51 subfamily A member 1)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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1595 |
Gene name
Gene Name - the full gene name approved by the HGNC.
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Cytochrome P450 family 51 subfamily A member 1 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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CYP51A1 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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CP51, CYP51, CYPL1, LDM, P450-14DM, P450L1 |
Chromosome
Chromosome number
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7 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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7q21.2 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic r |
miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein | |||||||||||
UniProt ID | Q16850 | ||||||||||
Protein name | Lanosterol 14-alpha demethylase (LDM) (EC 1.14.14.154) (CYPLI) (Cytochrome P450 51A1) (CYP51A1) (Cytochrome P450-14DM) (Cytochrome P45014DM) (Cytochrome P450LI) (Sterol 14-alpha demethylase) | ||||||||||
Protein function | Sterol 14alpha-demethylase that plays a critical role in the cholesterol biosynthesis pathway, being cholesterol the major sterol component in mammalian membranes as well as a precursor for bile acid and steroid hormone synthesis (PubMed:2014979 | ||||||||||
PDB | 3JUS , 3JUV , 3LD6 , 4UHI , 4UHL , 6Q2T , 6UEZ , 8SBI , 8SS0 | ||||||||||
Family and domains |
Pfam
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Tissue specificity | TISSUE SPECIFICITY: Ubiquitously expressed with highest levels in testis, ovary, adrenal, prostate, liver, kidney and lung. {ECO:0000269|PubMed:8619637}. | ||||||||||
Sequence | |||||||||||
Sequence length | 503 | ||||||||||
Interactions | View interactions |
Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease information provided by ClinVar, GenCC, and GWAS databases.
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