Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	159296
Gene name Gene Name - the full gene name approved by the HGNC.	NK2 homeobox 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	NKX2-3
Synonyms (NCBI Gene) Gene synonyms aliases	CSX3, NK2.3, NKX2.3, NKX2C, NKX4-3
Chromosome Chromosome number	10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	10q24.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a homeodomain-containing transcription factor. The encoded protein is a member of the NKX family of homeodomain transcription factors. Studies of similar proteins in mouse and rat have indicated a potential role in cellular differentiati

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miRTarBase ID	miRNA	Experiments	Reference
MIRT637413	hsa-miR-4707-5p	HITS-CLIP	23824327
MIRT637414	hsa-miR-5587-3p	HITS-CLIP	23824327
MIRT637412	hsa-miR-5090	HITS-CLIP	23824327
MIRT637411	hsa-miR-6775-5p	HITS-CLIP	23824327
MIRT637410	hsa-miR-4508	HITS-CLIP	23824327
MIRT667204	hsa-miR-6854-3p	HITS-CLIP	23824327
MIRT637409	hsa-miR-4529-5p	HITS-CLIP	23824327
MIRT637408	hsa-miR-6789-3p	HITS-CLIP	23824327
MIRT637407	hsa-miR-6508-3p	HITS-CLIP	23824327
MIRT637406	hsa-miR-6762-5p	HITS-CLIP	23824327
MIRT637405	hsa-miR-6845-5p	HITS-CLIP	23824327
MIRT637404	hsa-miR-6763-3p	HITS-CLIP	23824327
MIRT637403	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT637402	hsa-miR-6727-5p	HITS-CLIP	23824327
MIRT667203	hsa-miR-4727-5p	HITS-CLIP	23824327
MIRT667202	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT667201	hsa-miR-544a	HITS-CLIP	23824327
MIRT667200	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT637413	hsa-miR-4707-5p	HITS-CLIP	23824327
MIRT637414	hsa-miR-5587-3p	HITS-CLIP	23824327
MIRT637412	hsa-miR-5090	HITS-CLIP	23824327
MIRT637411	hsa-miR-6775-5p	HITS-CLIP	23824327
MIRT637410	hsa-miR-4508	HITS-CLIP	23824327
MIRT637409	hsa-miR-4529-5p	HITS-CLIP	23824327
MIRT637408	hsa-miR-6789-3p	HITS-CLIP	23824327
MIRT637407	hsa-miR-6508-3p	HITS-CLIP	23824327
MIRT637406	hsa-miR-6762-5p	HITS-CLIP	23824327
MIRT637405	hsa-miR-6845-5p	HITS-CLIP	23824327
MIRT637404	hsa-miR-6763-3p	HITS-CLIP	23824327
MIRT637403	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT637402	hsa-miR-6727-5p	HITS-CLIP	23824327
MIRT637413	hsa-miR-4707-5p	HITS-CLIP	23824327
MIRT637414	hsa-miR-5587-3p	HITS-CLIP	23824327
MIRT637412	hsa-miR-5090	HITS-CLIP	23824327
MIRT637411	hsa-miR-6775-5p	HITS-CLIP	23824327
MIRT637410	hsa-miR-4508	HITS-CLIP	23824327
MIRT667204	hsa-miR-6854-3p	HITS-CLIP	23824327
MIRT637409	hsa-miR-4529-5p	HITS-CLIP	23824327
MIRT637408	hsa-miR-6789-3p	HITS-CLIP	23824327
MIRT637407	hsa-miR-6508-3p	HITS-CLIP	23824327
MIRT637406	hsa-miR-6762-5p	HITS-CLIP	23824327
MIRT637405	hsa-miR-6845-5p	HITS-CLIP	23824327
MIRT637404	hsa-miR-6763-3p	HITS-CLIP	23824327
MIRT637403	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT637402	hsa-miR-6727-5p	HITS-CLIP	23824327
MIRT667203	hsa-miR-4727-5p	HITS-CLIP	23824327
MIRT667202	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT667201	hsa-miR-544a	HITS-CLIP	23824327
MIRT667200	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT637413	hsa-miR-4707-5p	HITS-CLIP	23824327
MIRT637414	hsa-miR-5587-3p	HITS-CLIP	23824327
MIRT637412	hsa-miR-5090	HITS-CLIP	23824327
MIRT637411	hsa-miR-6775-5p	HITS-CLIP	23824327
MIRT637410	hsa-miR-4508	HITS-CLIP	23824327
MIRT637409	hsa-miR-4529-5p	HITS-CLIP	23824327
MIRT637408	hsa-miR-6789-3p	HITS-CLIP	23824327
MIRT637407	hsa-miR-6508-3p	HITS-CLIP	23824327
MIRT637406	hsa-miR-6762-5p	HITS-CLIP	23824327
MIRT637405	hsa-miR-6845-5p	HITS-CLIP	23824327
MIRT637404	hsa-miR-6763-3p	HITS-CLIP	23824327
MIRT637403	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT637402	hsa-miR-6727-5p	HITS-CLIP	23824327
MIRT1186541	hsa-miR-1254	CLIP-seq
MIRT1186542	hsa-miR-2861	CLIP-seq
MIRT1186543	hsa-miR-3116	CLIP-seq
MIRT1186544	hsa-miR-4512	CLIP-seq
MIRT1186545	hsa-miR-513c	CLIP-seq
MIRT1186546	hsa-miR-514b-5p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001776	Process	Leukocyte homeostasis	IEA
GO:0002317	Process	Plasma cell differentiation	IEA
GO:0005575	Component	Cellular_component	ND
GO:0005634	Component	Nucleus	IBA	21873635
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0006641	Process	Triglyceride metabolic process	IEA
GO:0008150	Process	Biological_process	ND
GO:0022612	Process	Gland morphogenesis	IEA
GO:0030154	Process	Cell differentiation	IBA	21873635
GO:0030225	Process	Macrophage differentiation	IEA
GO:0042127	Process	Regulation of cell population proliferation	IEA
GO:0042475	Process	Odontogenesis of dentin-containing tooth	IEA
GO:0043367	Process	CD4-positive, alpha-beta T cell differentiation	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0048535	Process	Lymph node development	IEA
GO:0048536	Process	Spleen development	IEA
GO:0048541	Process	Peyer's patch development	IEA
GO:0048621	Process	Post-embryonic digestive tract morphogenesis	IEA
GO:0050900	Process	Leukocyte migration	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
606727	7836	ENSG00000119919

Protein

UniProt ID

Q8TAU0

Protein name

Homeobox protein Nkx-2.3 (Homeobox protein NK-2 homolog C)

Protein function

Transcription factor.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00046	Homeodomain	149 → 205	Homeodomain	Domain

Sequence

MMLPSPVTSTPFSVKDILNLEQQHQHFHGAHLQADLEHHFHSAPCMLAAAEGTQFSDGGE
EDEEDEGEKLSYLNSLAAADGHGDSGLCPQGYVHTVLRDSCSEPKEHEEEPEVVRDRSQK
SCQLKKSLETAGDCKAAEESERPKPRSRRKPRVLFSQAQVFELERRFKQQRYLSAPEREH
LASSLKLTSTQVKIWFQNRRYKCKRQRQDKSLELGAHAPPPPPRRVAVPVLVRDGKPCVT
PSAQAYGAPYSVGASAYSYNSFPAYGYGNSAAAAAAAAAAAAAAAAYSSSYGCAYPAGGG
GGGGGTSAATTAMQPACSAAGGGPFVNVSNLGGFGSGGSAQPLHQGTAAGAACAQGTLQG
IRAW

Sequence length

364

Interactions

View interactions

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Crohn disease	Crohn Disease, Regional enteritis		17554261, 18438406, 18438405	ClinVar

NKX2-3 (NK2 homeobox 3)