Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	157855
Gene name Gene Name - the full gene name approved by the HGNC.	Potassium calcium-activated channel subfamily U member 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	KCNU1
Synonyms (NCBI Gene) Gene synonyms aliases	KCNMC1, KCa5, KCa5.1, Kcnma3, SPGF79, Slo3
Chromosome Chromosome number	8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	8p11.23
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the potassium channel family of proteins. The encoded voltage-gated ion channel allows the outward flow of potassium ions during plasma membrane hyperpolarization in sperm. Opening of this channel may be regulated by calcium

Show/Hide all(3)

miRTarBase ID	miRNA	Experiments
MIRT1082516	hsa-miR-3908	CLIP-seq
MIRT1082516	hsa-miR-3908	CLIP-seq
MIRT1082516	hsa-miR-3908	CLIP-seq

Show/Hide all(23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005216	Function	Monoatomic ion channel activity	IEA
GO:0005267	Function	Potassium channel activity	IBA
GO:0005267	Function	Potassium channel activity	IEA
GO:0005267	Function	Potassium channel activity	IMP	34980136, 35551387
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS
GO:0005929	Component	Cilium	IEA
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006813	Process	Potassium ion transport	IEA
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0022414	Process	Reproductive process	IMP	34980136, 35551387
GO:0031514	Component	Motile cilium	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0034702	Component	Monoatomic ion channel complex	IEA
GO:0036126	Component	Sperm flagellum	IDA	24670955
GO:0042995	Component	Cell projection	IEA
GO:0055085	Process	Transmembrane transport	IEA
GO:0060072	Function	Large conductance calcium-activated potassium channel activity	IBA
GO:0071805	Process	Potassium ion transmembrane transport	IBA
GO:0071805	Process	Potassium ion transmembrane transport	IDA	23129643
GO:0071805	Process	Potassium ion transmembrane transport	IEA

MIM	HGNC	e!Ensembl
615215	18867	ENSG00000215262

Protein

UniProt ID

A8MYU2

Protein name

Potassium channel subfamily U member 1 (Calcium-activated potassium channel subunit alpha-3) (Calcium-activated potassium channel, subfamily M subunit alpha-3) (KCa5) (Slowpoke homolog 3)

Protein function

Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+) (PubMed:23129643, PubMed:24670955, PubMed:36649421, PubMed:38267364, PubMed:9452476). Represents the primary spermatozoan K(+)

PDB

4HPF

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00520	Ion_trans	98 → 323	Ion transport protein	Family
PF03493	BK_channel_a	462 → 557	Calcium-activated BK potassium channel alpha subunit	Family

Tissue specificity

TISSUE SPECIFICITY: Testis-specific. {ECO:0000269|PubMed:34980136, ECO:0000269|PubMed:35551387, ECO:0000269|PubMed:9452476}.

Sequence

MFQTKLRNETWEDLPKMSCTTEIQAAFILSSFVTFFSGLIILLIFRLIWRSVKKWQIIKG
TGIILELFTSGTIARSHVRSLHFQGQFRDHIEMLLSAQTFVGQVLVILVFVLSIGSLIIY
FINSADPVGSCSSYEDKTIPIDLVFNAFFSFYFGLRFMAADDKIKFWLEMNSIVDIFTIP
PTFISYYLKSNWLGLRFLRALRLLELPQILQILRAIKTSNSVKFSKLLSIILSTWFTAAG
FIHLVENSGDPWLKGRNSQNISYFESIYLVMATTSTVGFGDVVAKTSLGRTFIMFFTLGS
LILFANYIPEMVELFANKRKYTSSYEALKGKKFIVVCGNITVDSVTAFLRNFLRDKSGEI
NTEIVFLGETPPSLELETIFKCYLAYTTFISGSAMKWEDLRRVAVESAEACLIIANPLCS
DSHAEDISNIMRVLSIKNYDSTTRIIIQILQSHNKVYLPKIPSWNWDTGDNIICFAELKL
GFIAQGCLVPGLCTFLTSLFVEQNKKVMPKQTWKKHFLNSMKNKILTQRLSDDFAGMSFP
EVARLCFLKMHLLLIAIEYKSLFTDGFCGLILNPPPQVRIRKNTLGFFIAETPKDVRRAL
FYCSVCHDDVFIPELITNCGCKSRSRQHITVPSVKRMKKCLKGISSRISGQDSPPRVSAS
TSSISNFTTRTLQHDVEQDSDQLDSSGMFHWCKPTSLDKVTLKRTGKSKYKFRNHIVACV
FGDAHSAPMGLRNFVMPLRASNYTRKELKDIVFIGSLDYLQREWRFLWNFPQIYILPGCA
LYSGDLHAANIEQCSMCAVLSPPPQPSSNQTLVDTEAIMATLTIGSLQIDSSSDPSPSVS
EETPGYTNGHNEKSNCRKVPILTELKNPSNIHFIEQLGGLEGSLQETNLHLSTAFSTGTV
FSGSFLDSLLATAFYNYHVLELLQMLVTGGVSSQLEQHLDKDKVYGVADSCTSLLSGRNR
CKLGLLSLHETILSDVNPRNTFGQLFCGSLDLFGILCVGLYRIIDEEELNPENKRFVITR
PANEFKLLPSDLVFCAIPFSTACYKRNEEFSLQKSYEIVNKASQTTETHSDTNCPPTIDS
VTETLYSPVYSYQPRTNSLSFPKQIAWNQSRTNSIISSQIPLGDNAKENERKTSDEVYDE
DPFAYSEPL

Sequence length

1149

Interactions

View interactions

	KEGG		Reactome
	cGMP-PKG signaling pathway Vascular smooth muscle contraction Insulin secretion		Sperm Motility And Taxes

Show/Hide Unknown Diseases (5)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Bipolar Disorder	Bipolar disorder	N/A	N/A	GWAS
Breast cancer	Breast cancer	N/A	N/A	GWAS
Breast Cancer	Breast cancer (estrogen-receptor negative)	N/A	N/A	GWAS
Diabetes	Type 2 diabetes (PheCode 250.2), Type 2 diabetes	N/A	N/A	GWAS
Spermatogenic Failure	spermatogenic failure 79	N/A	N/A	GenCC

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Asthenozoospermia	Associate	34980136
Congenital Abnormalities	Associate	34980136
Infertility Male	Associate	34980136, 36649421
Mitochondrial Diseases	Associate	34980136

KCNU1 (potassium calcium-activated channel subfamily U member 1)