Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	157
Gene name Gene Name - the full gene name approved by the HGNC.	G protein-coupled receptor kinase 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GRK3
Synonyms (NCBI Gene) Gene synonyms aliases	ADRBK2, BARK2
Chromosome Chromosome number	22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	22q12.1
Summary Summary of gene provided in NCBI Entrez Gene.	The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic rec

Show/Hide all(262)

miRTarBase ID	miRNA	Experiments	Reference
MIRT613352	hsa-miR-8485	HITS-CLIP	22927820
MIRT613351	hsa-miR-602	HITS-CLIP	22927820
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	22927820
MIRT613349	hsa-miR-609	HITS-CLIP	22927820
MIRT613348	hsa-miR-2052	HITS-CLIP	22927820
MIRT613347	hsa-miR-19a-5p	HITS-CLIP	22927820
MIRT613346	hsa-miR-19b-1-5p	HITS-CLIP	22927820
MIRT613345	hsa-miR-19b-2-5p	HITS-CLIP	22927820
MIRT636736	hsa-miR-4709-5p	HITS-CLIP	22927820
MIRT628479	hsa-miR-574-5p	HITS-CLIP	22927820
MIRT660878	hsa-miR-122-5p	HITS-CLIP	22927820
MIRT628485	hsa-miR-6867-5p	HITS-CLIP	22927820
MIRT628484	hsa-miR-7159-5p	HITS-CLIP	22927820
MIRT628483	hsa-miR-505-3p	HITS-CLIP	22927820
MIRT628482	hsa-miR-421	HITS-CLIP	22927820
MIRT628481	hsa-miR-1305	HITS-CLIP	22927820
MIRT628480	hsa-miR-4455	HITS-CLIP	22927820
MIRT613351	hsa-miR-602	HITS-CLIP	23313552
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23313552
MIRT613349	hsa-miR-609	HITS-CLIP	23313552
MIRT613348	hsa-miR-2052	HITS-CLIP	23313552
MIRT613347	hsa-miR-19a-5p	HITS-CLIP	23313552
MIRT613346	hsa-miR-19b-1-5p	HITS-CLIP	23313552
MIRT613345	hsa-miR-19b-2-5p	HITS-CLIP	23313552
MIRT400048	hsa-miR-106a-5p	HITS-CLIP	23824327
MIRT400049	hsa-miR-106b-5p	HITS-CLIP	23824327
MIRT400045	hsa-miR-17-5p	HITS-CLIP	23824327
MIRT400046	hsa-miR-20a-5p	HITS-CLIP	23824327
MIRT400050	hsa-miR-20b-5p	HITS-CLIP	23824327
MIRT400052	hsa-miR-519d-3p	HITS-CLIP	23824327
MIRT400051	hsa-miR-526b-3p	HITS-CLIP	23824327
MIRT400047	hsa-miR-93-5p	HITS-CLIP	23824327
MIRT680137	hsa-miR-519a-3p	HITS-CLIP	23824327
MIRT680136	hsa-miR-519b-3p	HITS-CLIP	23824327
MIRT680135	hsa-miR-519c-3p	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT680134	hsa-miR-520g-3p	HITS-CLIP	23824327
MIRT680133	hsa-miR-520h	HITS-CLIP	23824327
MIRT680132	hsa-miR-8064	HITS-CLIP	23824327
MIRT680131	hsa-miR-6829-5p	HITS-CLIP	23824327
MIRT680130	hsa-miR-185-3p	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT680129	hsa-miR-518a-5p	HITS-CLIP	23824327
MIRT680128	hsa-miR-527	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613348	hsa-miR-2052	HITS-CLIP	23824327
MIRT613347	hsa-miR-19a-5p	HITS-CLIP	23824327
MIRT613346	hsa-miR-19b-1-5p	HITS-CLIP	23824327
MIRT613345	hsa-miR-19b-2-5p	HITS-CLIP	23824327
MIRT613344	hsa-miR-7850-5p	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613348	hsa-miR-2052	HITS-CLIP	23824327
MIRT613347	hsa-miR-19a-5p	HITS-CLIP	23824327
MIRT613346	hsa-miR-19b-1-5p	HITS-CLIP	23824327
MIRT613345	hsa-miR-19b-2-5p	HITS-CLIP	23824327
MIRT673535	hsa-miR-6796-3p	HITS-CLIP	23824327
MIRT673534	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT673533	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT673532	hsa-miR-4532	HITS-CLIP	23824327
MIRT673531	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT673530	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT673529	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT673528	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT673527	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT673526	hsa-miR-1976	HITS-CLIP	23824327
MIRT673525	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT673524	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT673523	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT673522	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT673521	hsa-miR-3194-3p	HITS-CLIP	23824327
MIRT673520	hsa-miR-1206	HITS-CLIP	23824327
MIRT673519	hsa-miR-4279	HITS-CLIP	23824327
MIRT673518	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT673517	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613348	hsa-miR-2052	HITS-CLIP	23824327
MIRT613347	hsa-miR-19a-5p	HITS-CLIP	23824327
MIRT613346	hsa-miR-19b-1-5p	HITS-CLIP	23824327
MIRT613345	hsa-miR-19b-2-5p	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT628485	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT628484	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT628483	hsa-miR-505-3p	HITS-CLIP	23824327
MIRT628482	hsa-miR-421	HITS-CLIP	23824327
MIRT628481	hsa-miR-1305	HITS-CLIP	23824327
MIRT628480	hsa-miR-4455	HITS-CLIP	23824327
MIRT628479	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613348	hsa-miR-2052	HITS-CLIP	23824327
MIRT613347	hsa-miR-19a-5p	HITS-CLIP	23824327
MIRT613346	hsa-miR-19b-1-5p	HITS-CLIP	23824327
MIRT613345	hsa-miR-19b-2-5p	HITS-CLIP	23824327
MIRT613344	hsa-miR-7850-5p	HITS-CLIP	23824327
MIRT628479	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT660878	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT628485	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT628484	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT628483	hsa-miR-505-3p	HITS-CLIP	23824327
MIRT628482	hsa-miR-421	HITS-CLIP	23824327
MIRT628481	hsa-miR-1305	HITS-CLIP	23824327
MIRT628480	hsa-miR-4455	HITS-CLIP	23824327
MIRT660877	hsa-miR-483-5p	HITS-CLIP	23824327
MIRT660872	hsa-miR-411-5p	HITS-CLIP	23824327
MIRT660876	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT660875	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT660874	hsa-miR-193b-5p	HITS-CLIP	23824327
MIRT660873	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT660872	hsa-miR-411-5p	HITS-CLIP	23824327
MIRT660871	hsa-miR-6794-3p	HITS-CLIP	23824327
MIRT660870	hsa-miR-1303	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613348	hsa-miR-2052	HITS-CLIP	23824327
MIRT613347	hsa-miR-19a-5p	HITS-CLIP	23824327
MIRT613346	hsa-miR-19b-1-5p	HITS-CLIP	23824327
MIRT613345	hsa-miR-19b-2-5p	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613348	hsa-miR-2052	HITS-CLIP	23824327
MIRT613347	hsa-miR-19a-5p	HITS-CLIP	23824327
MIRT613346	hsa-miR-19b-1-5p	HITS-CLIP	23824327
MIRT613345	hsa-miR-19b-2-5p	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613348	hsa-miR-2052	HITS-CLIP	23824327
MIRT613347	hsa-miR-19a-5p	HITS-CLIP	23824327
MIRT613346	hsa-miR-19b-1-5p	HITS-CLIP	23824327
MIRT613345	hsa-miR-19b-2-5p	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613348	hsa-miR-2052	HITS-CLIP	23824327
MIRT613347	hsa-miR-19a-5p	HITS-CLIP	23824327
MIRT613346	hsa-miR-19b-1-5p	HITS-CLIP	23824327
MIRT613345	hsa-miR-19b-2-5p	HITS-CLIP	23824327
MIRT636736	hsa-miR-4709-5p	HITS-CLIP	23824327
MIRT628485	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT628484	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT628483	hsa-miR-505-3p	HITS-CLIP	23824327
MIRT628482	hsa-miR-421	HITS-CLIP	23824327
MIRT628481	hsa-miR-1305	HITS-CLIP	23824327
MIRT628480	hsa-miR-4455	HITS-CLIP	23824327
MIRT628479	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT636735	hsa-miR-4683	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613348	hsa-miR-2052	HITS-CLIP	23824327
MIRT613347	hsa-miR-19a-5p	HITS-CLIP	23824327
MIRT613346	hsa-miR-19b-1-5p	HITS-CLIP	23824327
MIRT613345	hsa-miR-19b-2-5p	HITS-CLIP	23824327
MIRT636734	hsa-miR-4531	HITS-CLIP	23824327
MIRT636733	hsa-miR-1270	HITS-CLIP	23824327
MIRT636732	hsa-miR-620	HITS-CLIP	23824327
MIRT613344	hsa-miR-7850-5p	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613348	hsa-miR-2052	HITS-CLIP	23824327
MIRT613347	hsa-miR-19a-5p	HITS-CLIP	23824327
MIRT613346	hsa-miR-19b-1-5p	HITS-CLIP	23824327
MIRT613345	hsa-miR-19b-2-5p	HITS-CLIP	23824327
MIRT613344	hsa-miR-7850-5p	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613348	hsa-miR-2052	HITS-CLIP	23824327
MIRT613347	hsa-miR-19a-5p	HITS-CLIP	23824327
MIRT613346	hsa-miR-19b-1-5p	HITS-CLIP	23824327
MIRT613345	hsa-miR-19b-2-5p	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613348	hsa-miR-2052	HITS-CLIP	23824327
MIRT613347	hsa-miR-19a-5p	HITS-CLIP	23824327
MIRT613346	hsa-miR-19b-1-5p	HITS-CLIP	23824327
MIRT613345	hsa-miR-19b-2-5p	HITS-CLIP	23824327
MIRT613344	hsa-miR-7850-5p	HITS-CLIP	23824327
MIRT628485	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT628484	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT628483	hsa-miR-505-3p	HITS-CLIP	23824327
MIRT628482	hsa-miR-421	HITS-CLIP	23824327
MIRT628481	hsa-miR-1305	HITS-CLIP	23824327
MIRT628480	hsa-miR-4455	HITS-CLIP	23824327
MIRT628479	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613348	hsa-miR-2052	HITS-CLIP	23824327
MIRT613347	hsa-miR-19a-5p	HITS-CLIP	23824327
MIRT613346	hsa-miR-19b-1-5p	HITS-CLIP	23824327
MIRT613345	hsa-miR-19b-2-5p	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613348	hsa-miR-2052	HITS-CLIP	23824327
MIRT613347	hsa-miR-19a-5p	HITS-CLIP	23824327
MIRT613346	hsa-miR-19b-1-5p	HITS-CLIP	23824327
MIRT613345	hsa-miR-19b-2-5p	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613348	hsa-miR-2052	HITS-CLIP	23824327
MIRT613347	hsa-miR-19a-5p	HITS-CLIP	23824327
MIRT613346	hsa-miR-19b-1-5p	HITS-CLIP	23824327
MIRT613345	hsa-miR-19b-2-5p	HITS-CLIP	23824327
MIRT613344	hsa-miR-7850-5p	HITS-CLIP	23824327

Show/Hide all(11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004672	Function	Protein kinase activity	TAS	8427589
GO:0004703	Function	G protein-coupled receptor kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	23455922, 28514442
GO:0005524	Function	ATP binding	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0006468	Process	Protein phosphorylation	IEA
GO:0007165	Process	Signal transduction	TAS	8427589
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0031623	Process	Receptor internalization	IDA	20074556
GO:0047696	Function	Beta-adrenergic receptor kinase activity	TAS

MIM	HGNC	e!Ensembl
109636	290	ENSG00000100077

Protein

UniProt ID

P35626

Protein name

G protein-coupled receptor kinase 3 (EC 2.7.11.15) (Beta-adrenergic receptor kinase 2) (Beta-ARK-2)

Protein function

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00615	RGS	54 → 174	Regulator of G protein signaling domain	Domain
PF00069	Pkinase	191 → 453	Protein kinase domain	Domain
PF00169	PH	559 → 652	PH domain	Domain

Sequence

MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFN
QKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSC
SHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNV
ELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER
IMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATE
IILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASVGTHGYMAPE
VLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPE
LKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAA
DAFDIGSFDEEDTKGIKLLDCDQELYKNFPLVISERWQQEVTETVYEAVNADTDKIEARK
RAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQNL
LTMEQILSVEETQIKDKKCILFRIKGGKQFVLQCESDPEFVQWKKELNETFKEAQRLLRR
APKFLNKPRSGTVELPKPSLCHRNSNGL

Sequence length

688

Interactions

View interactions

	KEGG		Reactome
	Chemokine signaling pathway Endocytosis Hedgehog signaling pathway Glutamatergic synapse Olfactory transduction Morphine addiction		G alpha (s) signalling events Cargo recognition for clathrin-mediated endocytosis

GRK3 (G protein-coupled receptor kinase 3)