Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	1557
Gene name Gene Name - the full gene name approved by the HGNC.	Cytochrome P450 family 2 subfamily C member 19
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CYP2C19
Synonyms (NCBI Gene) Gene synonyms aliases	CPCJ, CYP2C, CYPIIC17, CYPIIC19, P450C2C, P450IIC19
Chromosome Chromosome number	10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	10q23.33
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein local

Show/Hide all(37)

SNP ID	Visualize variation	Clinical significance	Consequence
rs4244285	G>A,C	Other, drug-response, likely-benign	Coding sequence variant, synonymous variant
rs4986893	G>A	Other, drug-response	Coding sequence variant, stop gained
rs6413438	C>T	Drug-response	Coding sequence variant, missense variant
rs7902257	G>A	Drug-response	Upstream transcript variant
rs12248560	C>A,T	Other, drug-response, benign	Upstream transcript variant
rs12769205	A>G	Drug-response	Intron variant
rs17878739	T>C	Drug-response	Upstream transcript variant
rs17879685	C>G,T	Drug-response	Missense variant, coding sequence variant
rs17882687	A>C	Drug-response, benign	Missense variant, coding sequence variant
rs17884712	G>A,C	Drug-response	Missense variant, coding sequence variant
rs28399504	A>G,T	Drug-response, other, likely-benign	Missense variant, initiator codon variant
rs41291556	T>C	Drug-response, other	Missense variant, coding sequence variant
rs55640102	A>C,T	Drug-response	Stop lost, terminator codon variant
rs55752064	T>A,C	Drug-response	Missense variant, coding sequence variant
rs56337013	C>T	Drug-response, other	Missense variant, coding sequence variant
rs58973490	G>A	Drug-response	Missense variant, coding sequence variant
rs72552267	G>A	Drug-response	Missense variant, coding sequence variant
rs72558186	T>A,C	Drug-response	Splice donor variant
rs111490789	C>A	Drug-response	Upstream transcript variant
rs113934938	G>A	Drug-response	Missense variant, coding sequence variant
rs118203756	G>C	Drug-response	Missense variant, coding sequence variant
rs118203757	G>A	Drug-response	Missense variant, coding sequence variant
rs118203759	C>A,G	Drug-response	Missense variant, coding sequence variant
rs138142612	G>A	Drug-response	Missense variant, coding sequence variant
rs140278421	G>A,C,T	Drug-response	Missense variant, coding sequence variant
rs145328984	C>A,T	Drug-response	Missense variant, coding sequence variant
rs192154563	C>G,T	Drug-response	Coding sequence variant, missense variant
rs367543001	G>A	Drug-response	5 prime UTR variant
rs367543002	C>T	Drug-response	Coding sequence variant, missense variant
rs367543003	T>C	Drug-response	Coding sequence variant, missense variant
rs370803989	G>A	Drug-response	Coding sequence variant, missense variant
rs375781227	G>A,C	Drug-response	Coding sequence variant, missense variant
rs377184510	A>G	Drug-response	Coding sequence variant, synonymous variant
rs1288601658	A>G,T	Drug-response	Coding sequence variant, missense variant
rs1564656981	A>T	Drug-response	Missense variant, coding sequence variant
rs1564657013	A>G	Drug-response	Missense variant, coding sequence variant
rs1564660997	C>T	Drug-response	Missense variant, coding sequence variant

Show/Hide all(168)

miRTarBase ID	miRNA	Experiments	Reference
MIRT528537	hsa-miR-10b-3p	PAR-CLIP	20371350
MIRT528536	hsa-miR-6780b-3p	PAR-CLIP	20371350
MIRT528535	hsa-miR-938	PAR-CLIP	20371350
MIRT528534	hsa-miR-6886-3p	PAR-CLIP	20371350
MIRT528533	hsa-miR-145-5p	PAR-CLIP	20371350
MIRT528532	hsa-miR-5195-3p	PAR-CLIP	20371350
MIRT528531	hsa-miR-3157-3p	PAR-CLIP	20371350
MIRT528530	hsa-miR-874-3p	PAR-CLIP	20371350
MIRT528529	hsa-miR-3912-5p	PAR-CLIP	20371350
MIRT528528	hsa-miR-3180-5p	PAR-CLIP	20371350
MIRT528537	hsa-miR-10b-3p	PAR-CLIP	20371350
MIRT528536	hsa-miR-6780b-3p	PAR-CLIP	20371350
MIRT528535	hsa-miR-938	PAR-CLIP	20371350
MIRT528534	hsa-miR-6886-3p	PAR-CLIP	20371350
MIRT528533	hsa-miR-145-5p	PAR-CLIP	20371350
MIRT528532	hsa-miR-5195-3p	PAR-CLIP	20371350
MIRT528531	hsa-miR-3157-3p	PAR-CLIP	20371350
MIRT528530	hsa-miR-874-3p	PAR-CLIP	20371350
MIRT528529	hsa-miR-3912-5p	PAR-CLIP	20371350
MIRT528528	hsa-miR-3180-5p	PAR-CLIP	20371350
MIRT528537	hsa-miR-10b-3p	PAR-CLIP	20371350
MIRT528536	hsa-miR-6780b-3p	PAR-CLIP	20371350
MIRT528535	hsa-miR-938	PAR-CLIP	20371350
MIRT528534	hsa-miR-6886-3p	PAR-CLIP	20371350
MIRT528533	hsa-miR-145-5p	PAR-CLIP	20371350
MIRT528532	hsa-miR-5195-3p	PAR-CLIP	20371350
MIRT528531	hsa-miR-3157-3p	PAR-CLIP	20371350
MIRT528530	hsa-miR-874-3p	PAR-CLIP	20371350
MIRT528529	hsa-miR-3912-5p	PAR-CLIP	20371350
MIRT528528	hsa-miR-3180-5p	PAR-CLIP	20371350
MIRT528537	hsa-miR-10b-3p	PAR-CLIP	22012620
MIRT528536	hsa-miR-6780b-3p	PAR-CLIP	22012620
MIRT528535	hsa-miR-938	PAR-CLIP	22012620
MIRT528534	hsa-miR-6886-3p	PAR-CLIP	22012620
MIRT528533	hsa-miR-145-5p	PAR-CLIP	22012620
MIRT528532	hsa-miR-5195-3p	PAR-CLIP	22012620
MIRT528531	hsa-miR-3157-3p	PAR-CLIP	22012620
MIRT528530	hsa-miR-874-3p	PAR-CLIP	22012620
MIRT528529	hsa-miR-3912-5p	PAR-CLIP	22012620
MIRT528528	hsa-miR-3180-5p	PAR-CLIP	22012620
MIRT456013	hsa-miR-25-3p	PAR-CLIP	23592263
MIRT456012	hsa-miR-32-5p	PAR-CLIP	23592263
MIRT456011	hsa-miR-363-3p	PAR-CLIP	23592263
MIRT456010	hsa-miR-367-3p	PAR-CLIP	23592263
MIRT456009	hsa-miR-92a-3p	PAR-CLIP	23592263
MIRT456008	hsa-miR-92b-3p	PAR-CLIP	23592263
MIRT456007	hsa-miR-4459	PAR-CLIP	23592263
MIRT456006	hsa-miR-665	PAR-CLIP	23592263
MIRT456005	hsa-miR-5186	PAR-CLIP	23592263
MIRT456004	hsa-miR-4537	PAR-CLIP	23592263
MIRT456003	hsa-miR-6134	PAR-CLIP	23592263
MIRT456002	hsa-miR-767-5p	PAR-CLIP	23592263
MIRT456001	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT456000	hsa-miR-4683	PAR-CLIP	23592263
MIRT455999	hsa-miR-3689d	PAR-CLIP	23592263
MIRT455998	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT455997	hsa-miR-6880-5p	PAR-CLIP	23592263
MIRT455996	hsa-miR-7703	PAR-CLIP	23592263
MIRT455995	hsa-miR-4325	PAR-CLIP	23592263
MIRT455994	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT455993	hsa-miR-1270	PAR-CLIP	23592263
MIRT455992	hsa-miR-620	PAR-CLIP	23592263
MIRT455991	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT731396	hsa-miR-29a-3p	EMSA, Luciferase reporter assay, qRT-PCR, Western blot	26296572
MIRT731396	hsa-miR-29a-3p	EMSA, Luciferase reporter assay, qRT-PCR, Western blot	26296572
MIRT528537	hsa-miR-10b-3p	PAR-CLIP	26701625
MIRT528537	hsa-miR-10b-3p	PAR-CLIP	26701625
MIRT528533	hsa-miR-145-5p	PAR-CLIP	26701625
MIRT528533	hsa-miR-145-5p	PAR-CLIP	26701625
MIRT528531	hsa-miR-3157-3p	PAR-CLIP	26701625
MIRT528531	hsa-miR-3157-3p	PAR-CLIP	26701625
MIRT528528	hsa-miR-3180-5p	PAR-CLIP	26701625
MIRT528528	hsa-miR-3180-5p	PAR-CLIP	26701625
MIRT528529	hsa-miR-3912-5p	PAR-CLIP	26701625
MIRT528529	hsa-miR-3912-5p	PAR-CLIP	26701625
MIRT528532	hsa-miR-5195-3p	PAR-CLIP	26701625
MIRT528532	hsa-miR-5195-3p	PAR-CLIP	26701625
MIRT528536	hsa-miR-6780b-3p	PAR-CLIP	26701625
MIRT528536	hsa-miR-6780b-3p	PAR-CLIP	26701625
MIRT528534	hsa-miR-6886-3p	PAR-CLIP	26701625
MIRT528534	hsa-miR-6886-3p	PAR-CLIP	26701625
MIRT528530	hsa-miR-874-3p	PAR-CLIP	26701625
MIRT528530	hsa-miR-874-3p	PAR-CLIP	26701625
MIRT528535	hsa-miR-938	PAR-CLIP	26701625
MIRT528535	hsa-miR-938	PAR-CLIP	26701625
MIRT528537	hsa-miR-10b-3p	PAR-CLIP	27292025
MIRT528537	hsa-miR-10b-3p	PAR-CLIP	27292025
MIRT528533	hsa-miR-145-5p	PAR-CLIP	27292025
MIRT528533	hsa-miR-145-5p	PAR-CLIP	27292025
MIRT528531	hsa-miR-3157-3p	PAR-CLIP	27292025
MIRT528531	hsa-miR-3157-3p	PAR-CLIP	27292025
MIRT528528	hsa-miR-3180-5p	PAR-CLIP	27292025
MIRT528528	hsa-miR-3180-5p	PAR-CLIP	27292025
MIRT528529	hsa-miR-3912-5p	PAR-CLIP	27292025
MIRT528529	hsa-miR-3912-5p	PAR-CLIP	27292025
MIRT528532	hsa-miR-5195-3p	PAR-CLIP	27292025
MIRT528532	hsa-miR-5195-3p	PAR-CLIP	27292025
MIRT528536	hsa-miR-6780b-3p	PAR-CLIP	27292025
MIRT528536	hsa-miR-6780b-3p	PAR-CLIP	27292025
MIRT528534	hsa-miR-6886-3p	PAR-CLIP	27292025
MIRT528534	hsa-miR-6886-3p	PAR-CLIP	27292025
MIRT528530	hsa-miR-874-3p	PAR-CLIP	27292025
MIRT528530	hsa-miR-874-3p	PAR-CLIP	27292025
MIRT528535	hsa-miR-938	PAR-CLIP	27292025
MIRT528535	hsa-miR-938	PAR-CLIP	27292025
MIRT528537	hsa-miR-10b-3p	PAR-CLIP	20371350
MIRT528536	hsa-miR-6780b-3p	PAR-CLIP	20371350
MIRT528535	hsa-miR-938	PAR-CLIP	20371350
MIRT528534	hsa-miR-6886-3p	PAR-CLIP	20371350
MIRT528533	hsa-miR-145-5p	PAR-CLIP	20371350
MIRT528532	hsa-miR-5195-3p	PAR-CLIP	20371350
MIRT528531	hsa-miR-3157-3p	PAR-CLIP	20371350
MIRT528530	hsa-miR-874-3p	PAR-CLIP	20371350
MIRT528529	hsa-miR-3912-5p	PAR-CLIP	20371350
MIRT528528	hsa-miR-3180-5p	PAR-CLIP	20371350
MIRT528537	hsa-miR-10b-3p	PAR-CLIP	20371350
MIRT528536	hsa-miR-6780b-3p	PAR-CLIP	20371350
MIRT528535	hsa-miR-938	PAR-CLIP	20371350
MIRT528534	hsa-miR-6886-3p	PAR-CLIP	20371350
MIRT528533	hsa-miR-145-5p	PAR-CLIP	20371350
MIRT528532	hsa-miR-5195-3p	PAR-CLIP	20371350
MIRT528531	hsa-miR-3157-3p	PAR-CLIP	20371350
MIRT528530	hsa-miR-874-3p	PAR-CLIP	20371350
MIRT528529	hsa-miR-3912-5p	PAR-CLIP	20371350
MIRT528528	hsa-miR-3180-5p	PAR-CLIP	20371350
MIRT528537	hsa-miR-10b-3p	PAR-CLIP	20371350
MIRT528536	hsa-miR-6780b-3p	PAR-CLIP	20371350
MIRT528535	hsa-miR-938	PAR-CLIP	20371350
MIRT528534	hsa-miR-6886-3p	PAR-CLIP	20371350
MIRT528533	hsa-miR-145-5p	PAR-CLIP	20371350
MIRT528532	hsa-miR-5195-3p	PAR-CLIP	20371350
MIRT528531	hsa-miR-3157-3p	PAR-CLIP	20371350
MIRT528530	hsa-miR-874-3p	PAR-CLIP	20371350
MIRT528529	hsa-miR-3912-5p	PAR-CLIP	20371350
MIRT528528	hsa-miR-3180-5p	PAR-CLIP	20371350
MIRT528537	hsa-miR-10b-3p	PAR-CLIP	22012620
MIRT528536	hsa-miR-6780b-3p	PAR-CLIP	22012620
MIRT528535	hsa-miR-938	PAR-CLIP	22012620
MIRT528534	hsa-miR-6886-3p	PAR-CLIP	22012620
MIRT528533	hsa-miR-145-5p	PAR-CLIP	22012620
MIRT528532	hsa-miR-5195-3p	PAR-CLIP	22012620
MIRT528531	hsa-miR-3157-3p	PAR-CLIP	22012620
MIRT528530	hsa-miR-874-3p	PAR-CLIP	22012620
MIRT528529	hsa-miR-3912-5p	PAR-CLIP	22012620
MIRT528528	hsa-miR-3180-5p	PAR-CLIP	22012620
MIRT456013	hsa-miR-25-3p	PAR-CLIP	23592263
MIRT456012	hsa-miR-32-5p	PAR-CLIP	23592263
MIRT456011	hsa-miR-363-3p	PAR-CLIP	23592263
MIRT456010	hsa-miR-367-3p	PAR-CLIP	23592263
MIRT456009	hsa-miR-92a-3p	PAR-CLIP	23592263
MIRT456008	hsa-miR-92b-3p	PAR-CLIP	23592263
MIRT456007	hsa-miR-4459	PAR-CLIP	23592263
MIRT456006	hsa-miR-665	PAR-CLIP	23592263
MIRT456005	hsa-miR-5186	PAR-CLIP	23592263
MIRT456004	hsa-miR-4537	PAR-CLIP	23592263
MIRT456003	hsa-miR-6134	PAR-CLIP	23592263
MIRT456002	hsa-miR-767-5p	PAR-CLIP	23592263
MIRT456001	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT456000	hsa-miR-4683	PAR-CLIP	23592263
MIRT455999	hsa-miR-3689d	PAR-CLIP	23592263
MIRT455998	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT455997	hsa-miR-6880-5p	PAR-CLIP	23592263
MIRT455996	hsa-miR-7703	PAR-CLIP	23592263
MIRT455995	hsa-miR-4325	PAR-CLIP	23592263
MIRT455994	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT455993	hsa-miR-1270	PAR-CLIP	23592263
MIRT455992	hsa-miR-620	PAR-CLIP	23592263
MIRT455991	hsa-miR-6516-5p	PAR-CLIP	23592263

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
ESR1	Repression	20675569

Show/Hide all(30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004497	Function	Monooxygenase activity	IDA	19651758
GO:0005506	Function	Iron ion binding	IEA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006082	Process	Organic acid metabolic process	IBA	21873635
GO:0006805	Process	Xenobiotic metabolic process	IBA	21873635
GO:0006805	Process	Xenobiotic metabolic process	TAS
GO:0008202	Process	Steroid metabolic process	IMP	18356043
GO:0008392	Function	Arachidonic acid epoxygenase activity	IBA	21873635
GO:0008395	Function	Steroid hydroxylase activity	IBA	21873635
GO:0008395	Function	Steroid hydroxylase activity	IMP	18356043
GO:0016098	Process	Monoterpenoid metabolic process	IDA	16401082
GO:0016491	Function	Oxidoreductase activity	IDA	16401082, 19219744
GO:0016712	Function	Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA	21873635
GO:0017144	Process	Drug metabolic process	IDA	19219744, 19651758
GO:0018675	Function	(S)-limonene 6-monooxygenase activity	IEA
GO:0018676	Function	(S)-limonene 7-monooxygenase activity	IEA
GO:0019373	Process	Epoxygenase P450 pathway	IBA	21873635
GO:0019373	Process	Epoxygenase P450 pathway	TAS
GO:0019825	Function	Oxygen binding	TAS	3442670
GO:0019899	Function	Enzyme binding	IPI	15680923
GO:0020037	Function	Heme binding	IBA	21873635
GO:0020037	Function	Heme binding	IDA	23118231
GO:0042738	Process	Exogenous drug catabolic process	IBA	21873635
GO:0042738	Process	Exogenous drug catabolic process	IDA	19029318
GO:0043231	Component	Intracellular membrane-bounded organelle	IBA	21873635
GO:0046483	Process	Heterocycle metabolic process	IDA	19651758
GO:0052741	Function	(R)-limonene 6-monooxygenase activity	IEA
GO:0070330	Function	Aromatase activity	IEA
GO:0097267	Process	Omega-hydroxylase P450 pathway	TAS

MIM	HGNC	e!Ensembl
124020	2621	ENSG00000165841

Protein

UniProt ID

P33261

Protein name

Cytochrome P450 2C19 (EC 1.14.14.1) ((R)-limonene 6-monooxygenase) (EC 1.14.14.53) ((S)-limonene 6-monooxygenase) (EC 1.14.14.51) ((S)-limonene 7-monooxygenase) (EC 1.14.14.52) (CYPIIC17) (CYPIIC19) (Cytochrome P450-11A) (Cytochrome P450-254C) (Fenbendazo

Protein function

A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) (PubMed:18577768, PubMed:19965576, PubMed:20972997). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing

PDB

4GQS

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00067	p450	30 → 487	Cytochrome P450	Domain

Sequence

MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKI
YGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRW
KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS
IIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFM
ESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTE
TTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYID
LIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFK
KSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVP
PFYQLCFIPV

Sequence length

490

Interactions

View interactions

	KEGG		Reactome
	Arachidonic acid metabolism Linoleic acid metabolism Drug metabolism - cytochrome P450 Metabolic pathways Serotonergic synapse Chemical carcinogenesis - DNA adducts		Xenobiotics CYP2E1 reactions Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)

Show/Hide Causal Diseases (3)

Disease term	Disease name	dbSNP ID	References
Causal
Atrial fibrillation	Atrial Fibrillation	rs120074192, rs121908590, rs121908593, rs121434558, rs587776851, rs387906612, rs387906613, rs387906614, rs387906615, rs199472687, rs199472705, rs199473324, rs587777336, rs587777339, rs587777557 View all (6 more)	27356304
Premature ovarian failure	Hypergonadotropic Ovarian Failure, X-Linked, Premature Ovarian Failure 1	rs587776535, rs71647804, rs137853320, rs606231206, rs121918655, rs121918656, rs606231207, rs606231208, rs80359775, rs397507719, rs200503569, rs587777267, rs730880018, rs587777268, rs587777269 View all (40 more)	15248218
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	21716162

Show/Hide Unknown Diseases (2)

Disease term	Disease name	References	Source
Unknown
Mental depression	Mental Depression, Depressive disorder, Unipolar Depression, Major Depressive Disorder	21192344, 11412815, 16812949, 21926427, 8835703, 23081704, 17667959, 24014145, 21861666	ClinVar
Paroxysmal atrial fibrillation	Paroxysmal atrial fibrillation	27356304	ClinVar

Show/Hide Text Mining Associations (141)

Disease Name	Relationship Type	References
Associations from Text Mining
Acrocephalosyndactylia	Associate	29347970
Acute Coronary Syndrome	Associate	22377481, 22742403, 22971905, 23137413, 23257377, 23872648, 23886632, 24581091, 25156215, 26108379, 26147597, 26265611, 26521100, 27323099, 27977637 View all (15 more)
Acute Disease	Associate	32759249
Acute Kidney Injury	Associate	34730282
Adjustment Disorders	Associate	32139218
Adrenal Hyperplasia Congenital	Associate	18957504
Adrenocortical Carcinoma	Associate	32607875
Alcohol Related Disorders	Associate	15447734
Anemia Sickle Cell	Associate	27551817
Angina Pectoris	Associate	26147597
Angina Stable	Associate	25156215
Angina Unstable	Associate	20492467
Anxiety	Inhibit	34523245
Anxiety Disorders	Associate	38493365
Arthritis Psoriatic	Associate	12713578
Asthma	Associate	21160212, 25844821
Atherosclerosis	Associate	32644829
Behcet Syndrome	Associate	27875029
Bipolar Disorder	Associate	36698099, 38377518
Blood Platelet Disorders	Associate	18482659, 18577829, 19706858, 22007612, 23971745, 25008027, 25329996, 26147597, 26521100, 26961113, 27072325, 27977637, 30098132, 31643039, 35418564, 35929455, 38083918 View all (2 more)
Brain Ischemia	Associate	24877854, 26265611, 26338921, 26916483, 27137706, 31128980, 32840598, 35144415, 35176816, 35699175, 36792180, 38387302
Breast Neoplasms	Associate	18423013, 20102361, 22180071, 23781139, 25466287, 26799162, 29479969, 33432065, 37688505
Bronchial Diseases	Associate	21160212
Carcinoma Hepatocellular	Associate	24906606, 25024626, 25288013, 25921128, 27203676, 29479826, 34863035, 39193514
Carcinoma Non Small Cell Lung	Associate	25227813
Cardiovascular Diseases	Associate	19106084, 19706858, 20492467, 22390861, 23074110, 23981380, 25381554, 26147597, 26521100, 26993229, 27368038, 27663770, 29397568, 29936693, 32216088 View all (6 more)
Carotid Artery Thrombosis	Associate	33745326
Carotid Stenosis	Associate	33611730, 40670064
Cerebral Infarction	Associate	24330577, 25207801, 27133299, 27137706, 27233747, 27637911, 28064328, 31006731, 31134829, 32176040, 32644829, 32759249, 33121452, 33246208, 33611730 View all (7 more)
Cerebrovascular Disorders	Associate	21786436, 35144415
Chronic Limb Threatening Ischemia	Associate	38092392
Constriction Pathologic	Associate	33121452
Coronary Aneurysm	Associate	26993229
Coronary Artery Disease	Associate	19429918, 20460345, 21786436, 22118006, 24581091, 25008027, 25156215, 32702814, 32764090, 32840598, 35929455, 37070954, 40295977
Coronary Disease	Associate	21168310, 23981380, 26958179, 27488401, 27663770, 28783717, 33327349, 38286794
Coronary Restenosis	Associate	24330577, 24877854, 32109992
COVID 19	Associate	34473836
Death	Associate	19706858, 26587656, 27637911, 28597175, 29352151, 29479826, 33707344
Depressive Disorder	Associate	33048453, 34435592, 34523245
Depressive Disorder Major	Associate	36333412, 36698099
Diabetes Mellitus	Associate	20510210, 22385219, 27661054, 39472784
Diabetes Mellitus Type 2	Associate	29439084, 34656068, 39436079
Diabetes Mellitus Type 2	Inhibit	36734157
Diarrhea	Associate	28817838
Disease	Associate	25605208
Drug Hypersensitivity	Associate	20546557
Drug Metabolism Poor CYP2C19 Related	Associate	27233747
Drug Related Side Effects and Adverse Reactions	Associate	24016178, 25227813, 32216088, 37807195, 37915145
Drug Resistant Epilepsy	Associate	21985811
Dyspepsia	Associate	31030500
Encephalitis Herpes Simplex	Associate	33952670
End Stage Liver Disease	Associate	25024626
Endometriosis	Associate	19499406, 24796765, 25403437
Epilepsy	Associate	32868386
Epilepsy Tonic Clonic	Associate	26019129
Esophageal Motility Disorders	Associate	28373773
Esophageal Neoplasms	Associate	15222046
Esophageal Squamous Cell Carcinoma	Associate	22984423, 25927305
Esophagitis	Associate	28373773, 33048453
Essential Hypertension	Associate	23074110, 28513222
Fibrosis	Associate	20457439
Gastritis	Associate	25605208, 26730167, 33048453, 36284359
Gastritis Atrophic	Associate	23801863
Gastroesophageal Reflux	Associate	24366288, 27782887, 28373773
Gastrointestinal Diseases	Associate	26456622
Gastrointestinal Hemorrhage	Associate	37143396
Gastrointestinal Neoplasms	Associate	40022682
Graft vs Host Disease	Associate	36211438
Heart Diseases	Associate	10886124, 38083918
Helicobacter Infections	Associate	20457439, 25605208, 28577017, 31030500, 33399167
Hemorrhage	Associate	22260716, 23257377, 24762860, 26521100, 29701129, 29936693, 30742211, 31128980, 34506827, 35172619, 36503270, 36697242, 36792180, 36890711
Hepatitis B	Associate	25921128
Hepatitis B Chronic	Associate	25921128
HIV Infections	Associate	19890215
Hypertension	Associate	20460345, 21332417, 27663770, 35016407, 37024851, 39472784
Hyperuricemia	Associate	27661054
Infections	Associate	30341969, 31699831
Inflammation	Inhibit	20460345
Intestinal Diseases	Associate	23801863
Intracranial Aneurysm	Associate	29382029
Intracranial Arteriosclerosis	Associate	26587656, 33246208
Ischemic Attack Transient	Associate	26587656, 29901608, 30742211, 31171523, 33065552, 33246208, 33411687, 33727661, 33795788, 35727586, 36535779, 36697242, 37279000, 37429630, 37795861, 40701985 View all (1 more)
Ischemic Stroke	Associate	40670064
Kidney Diseases	Associate	27661054
Kidney Failure Chronic	Associate	15248218
Laryngeal Neoplasms	Associate	22183943
Leukemia Myeloid Acute	Associate	26233624
Leukopenia	Associate	26456622
Liver Cirrhosis Alcoholic	Inhibit	25024626
Liver Diseases	Associate	10930962, 34863035
Lung Neoplasms	Associate	15222046, 24510350
Lupus Erythematosus Systemic	Associate	26456622
Lupus Nephritis	Associate	37915145
Malaria Cerebral	Associate	34730282
Mental Disorders	Associate	36257936, 38493365
Metabolic Diseases	Associate	26521100
Metabolic Syndrome	Associate	27681143
Microvascular Angina	Associate	27663770
Migraine Disorders	Inhibit	34649359
Multiple Myeloma	Associate	17666363
Muscular Dystrophy Congenital with Rapid Progression	Associate	36890711
Myocardial Infarction	Associate	18482659, 19106083, 20492467, 21511217, 21511218, 22971905, 25001880, 25207801, 26108379, 26147597, 26365936, 26556524, 27072325, 29743380, 32139220 View all (5 more)
Myocardial Ischemia	Associate	37202608
Neoplasm Residual	Associate	18482659
Neoplasms	Associate	10792207, 11501173, 15222046, 18854824, 22180071, 22183943, 25288013, 25526449, 26125444, 29479826, 29479969, 40022682
Nephrosis	Associate	27661054
Neurologic Manifestations	Associate	32345264
Neuromyelitis Optica	Associate	34217665
No Reflow Phenomenon	Associate	33641235
Non alcoholic Fatty Liver Disease	Associate	19651758, 28986475
Obesity	Associate	23400848
Obsessive Compulsive Disorder	Associate	33048453
Optic Neuropathy Ischemic	Associate	34903548
Pancreatic Neoplasms	Associate	25752914
Peptic Ulcer	Associate	20457439, 25605208, 33399167
Peripheral Arterial Disease	Associate	24877854, 35988587, 38387302
Peripheral Vascular Diseases	Associate	25851472, 34661267
Pharyngitis	Associate	23623526
Porphyria Acute Intermittent	Associate	30808393
Post Infectious Disorders	Associate	25001880
Primary Ovarian Insufficiency	Inhibit	15248218
Psoriasis	Associate	12713578
Pulmonary Disease Chronic Obstructive	Stimulate	29850024
Pulmonary Disease Chronic Obstructive	Associate	32757668
Renal Artery Obstruction	Associate	33121452, 33727661
Renal Insufficiency Chronic	Associate	38308569
Respiratory Insufficiency	Associate	23623526
Respiratory Tract Infections	Associate	23623526
Retinal Dysplasia	Associate	23801863
Smoke Inhalation Injury	Associate	20460345, 24510350, 27072325
ST Elevation Myocardial Infarction	Associate	32139220, 33641235, 34506827
Stomach Neoplasms	Associate	15222046, 25605208
Stomach Ulcer	Associate	20457439
Stroke	Associate	20492467, 24330577, 25030528, 25207801, 26019129, 26108379, 26587656, 26699760, 29901608, 30742211, 31171523, 32176040, 32568642, 32759249, 33121452 View all (12 more)
Thalassemia Beta+ Silent Allele	Associate	35727586
Thiopurine S methyltranferase deficiency	Associate	26521100
Thromboembolism	Associate	34217665
Thrombosis	Associate	19106084, 21099121, 22118006, 22723959, 23555019, 24581091, 25744629, 26108379, 26147597, 29352151, 29382029, 32139218, 32623598, 33745326, 37045504
Triple Negative Breast Neoplasms	Associate	25466287
Urinary Bladder Neoplasms	Associate	15222046
Uterine Cervical Neoplasms	Associate	38376298

CYP2C19 (cytochrome P450 family 2 subfamily C member 19)