Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	1555
Gene name	Cytochrome P450 family 2 subfamily B member 6
Gene symbol	CYP2B6
Synonyms (NCBI Gene)	CPB6CYP2BCYP2B7CYP2B7PCYPIIB6EFVMIIB1P450
Chromosome	19
Chromosome location	19q13.2
Summary	This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This prot

Show/Hide all (12)

SNP ID	Visualize variation	Clinical significance	Consequence
rs2279343	A>G	Drug-response, benign	Coding sequence variant, missense variant
rs2279345	T>A,C,G	Drug-response	Intron variant
rs3745274	G>A,T	Drug-response	Synonymous variant, coding sequence variant, missense variant
rs4803419	C>T	Drug-response	Intron variant
rs28399499	T>C	Drug-response	Coding sequence variant, missense variant
rs34097093	C>T	Drug-response	Stop gained, coding sequence variant
rs36079186	T>C	Drug-response	Coding sequence variant, missense variant
rs139801276	T>C	Drug-response	Missense variant, coding sequence variant
rs186335453	G>C,T	Drug-response	Missense variant, coding sequence variant
rs281864907	T>A	Drug-response	Coding sequence variant, stop gained
rs371424910	T>C	Drug-response	Missense variant, coding sequence variant
rs373489637	T>G	Drug-response	Missense variant, coding sequence variant

412

Show/Hide all (412)

miRTarBase ID	miRNA	Experiments	Reference
MIRT051706	hsa-let-7e-5p	CLASH	23622248
MIRT647556	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT647555	hsa-miR-1470	HITS-CLIP	23824327
MIRT647554	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT647553	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT647552	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT647551	hsa-miR-4287	HITS-CLIP	23824327
MIRT647550	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT647549	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT647548	hsa-miR-20a-3p	HITS-CLIP	23824327
MIRT647547	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT647546	hsa-miR-498	HITS-CLIP	23824327
MIRT626340	hsa-miR-188-5p	HITS-CLIP	23824327
MIRT626339	hsa-miR-6866-3p	HITS-CLIP	23824327
MIRT626338	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT626336	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT626335	hsa-miR-5193	HITS-CLIP	23824327
MIRT626334	hsa-miR-3692-3p	HITS-CLIP	23824327
MIRT626333	hsa-miR-587	HITS-CLIP	23824327
MIRT626340	hsa-miR-188-5p	HITS-CLIP	23824327
MIRT626339	hsa-miR-6866-3p	HITS-CLIP	23824327
MIRT626338	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT626337	hsa-miR-1247-5p	HITS-CLIP	23824327
MIRT626336	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT626335	hsa-miR-5193	HITS-CLIP	23824327
MIRT626334	hsa-miR-3692-3p	HITS-CLIP	23824327
MIRT626333	hsa-miR-587	HITS-CLIP	23824327
MIRT458552	hsa-miR-4707-5p	PAR-CLIP	23592263
MIRT458551	hsa-miR-5587-3p	PAR-CLIP	23592263
MIRT458550	hsa-miR-4532	PAR-CLIP	23592263
MIRT458549	hsa-miR-4787-5p	PAR-CLIP	23592263
MIRT458548	hsa-miR-4537	PAR-CLIP	23592263
MIRT458547	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT458546	hsa-miR-6086	PAR-CLIP	23592263
MIRT458545	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT458544	hsa-miR-3689d	PAR-CLIP	23592263
MIRT458543	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT458542	hsa-miR-6752-5p	PAR-CLIP	23592263
MIRT458541	hsa-miR-6842-5p	PAR-CLIP	23592263
MIRT458540	hsa-miR-7110-5p	PAR-CLIP	23592263
MIRT458539	hsa-miR-4651	PAR-CLIP	23592263
MIRT458538	hsa-miR-608	PAR-CLIP	23592263
MIRT458537	hsa-miR-363-5p	PAR-CLIP	23592263
MIRT458536	hsa-miR-6745	PAR-CLIP	23592263
MIRT458535	hsa-miR-6880-5p	PAR-CLIP	23592263
MIRT458534	hsa-miR-7847-3p	PAR-CLIP	23592263
MIRT458533	hsa-miR-6763-3p	PAR-CLIP	23592263
MIRT458532	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT458531	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT734347	hsa-miR-605-3p	Luciferase reporter assayqRT-PCRWestern blotting	31766967
MIRT736659	hsa-miR-4254	RNA-seq	32772362
MIRT736660	hsa-miR-6867-5p	RNA-seq	32772362
MIRT647556	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT647555	hsa-miR-1470	HITS-CLIP	23824327
MIRT647554	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT647553	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT647552	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT647551	hsa-miR-4287	HITS-CLIP	23824327
MIRT647550	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT647549	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT647548	hsa-miR-20a-3p	HITS-CLIP	23824327
MIRT647547	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT647546	hsa-miR-498	HITS-CLIP	23824327
MIRT626340	hsa-miR-188-5p	HITS-CLIP	23824327
MIRT626339	hsa-miR-6866-3p	HITS-CLIP	23824327
MIRT626338	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT626336	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT626335	hsa-miR-5193	HITS-CLIP	23824327
MIRT626334	hsa-miR-3692-3p	HITS-CLIP	23824327
MIRT626333	hsa-miR-587	HITS-CLIP	23824327
MIRT626340	hsa-miR-188-5p	HITS-CLIP	23824327
MIRT626339	hsa-miR-6866-3p	HITS-CLIP	23824327
MIRT626338	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT626337	hsa-miR-1247-5p	HITS-CLIP	23824327
MIRT626336	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT626335	hsa-miR-5193	HITS-CLIP	23824327
MIRT626334	hsa-miR-3692-3p	HITS-CLIP	23824327
MIRT626333	hsa-miR-587	HITS-CLIP	23824327
MIRT458552	hsa-miR-4707-5p	PAR-CLIP	23592263
MIRT458551	hsa-miR-5587-3p	PAR-CLIP	23592263
MIRT458550	hsa-miR-4532	PAR-CLIP	23592263
MIRT458549	hsa-miR-4787-5p	PAR-CLIP	23592263
MIRT458548	hsa-miR-4537	PAR-CLIP	23592263
MIRT458547	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT458546	hsa-miR-6086	PAR-CLIP	23592263
MIRT458545	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT458544	hsa-miR-3689d	PAR-CLIP	23592263
MIRT458543	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT458542	hsa-miR-6752-5p	PAR-CLIP	23592263
MIRT458541	hsa-miR-6842-5p	PAR-CLIP	23592263
MIRT458540	hsa-miR-7110-5p	PAR-CLIP	23592263
MIRT458539	hsa-miR-4651	PAR-CLIP	23592263
MIRT458538	hsa-miR-608	PAR-CLIP	23592263
MIRT458537	hsa-miR-363-5p	PAR-CLIP	23592263
MIRT458536	hsa-miR-6745	PAR-CLIP	23592263
MIRT458535	hsa-miR-6880-5p	PAR-CLIP	23592263
MIRT458534	hsa-miR-7847-3p	PAR-CLIP	23592263
MIRT458533	hsa-miR-6763-3p	PAR-CLIP	23592263
MIRT458532	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT458531	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT921288	hsa-miR-1262	CLIP-seq
MIRT921289	hsa-miR-1265	CLIP-seq
MIRT921290	hsa-miR-1273e	CLIP-seq
MIRT921291	hsa-miR-130a	CLIP-seq
MIRT921292	hsa-miR-130b	CLIP-seq
MIRT921293	hsa-miR-1321	CLIP-seq
MIRT921294	hsa-miR-1827	CLIP-seq
MIRT921295	hsa-miR-18a	CLIP-seq
MIRT921296	hsa-miR-18b	CLIP-seq
MIRT921297	hsa-miR-297	CLIP-seq
MIRT921298	hsa-miR-301a	CLIP-seq
MIRT921299	hsa-miR-301b	CLIP-seq
MIRT921300	hsa-miR-3115	CLIP-seq
MIRT921301	hsa-miR-3122	CLIP-seq
MIRT921302	hsa-miR-3138	CLIP-seq
MIRT921303	hsa-miR-3149	CLIP-seq
MIRT921304	hsa-miR-3153	CLIP-seq
MIRT921305	hsa-miR-3162-5p	CLIP-seq
MIRT921306	hsa-miR-34b	CLIP-seq
MIRT921307	hsa-miR-3613-3p	CLIP-seq
MIRT921308	hsa-miR-3614-5p	CLIP-seq
MIRT921309	hsa-miR-3666	CLIP-seq
MIRT921310	hsa-miR-3671	CLIP-seq
MIRT921311	hsa-miR-3689a-3p	CLIP-seq
MIRT921312	hsa-miR-3689c	CLIP-seq
MIRT921313	hsa-miR-371-5p	CLIP-seq
MIRT921314	hsa-miR-371b-5p	CLIP-seq
MIRT921315	hsa-miR-374a	CLIP-seq
MIRT921316	hsa-miR-374b	CLIP-seq
MIRT921317	hsa-miR-3913-5p	CLIP-seq
MIRT921318	hsa-miR-3929	CLIP-seq
MIRT921319	hsa-miR-3975	CLIP-seq
MIRT921320	hsa-miR-4295	CLIP-seq
MIRT921321	hsa-miR-4419b	CLIP-seq
MIRT921322	hsa-miR-4433	CLIP-seq
MIRT921323	hsa-miR-4459	CLIP-seq
MIRT921324	hsa-miR-4478	CLIP-seq
MIRT921325	hsa-miR-4491	CLIP-seq
MIRT921326	hsa-miR-4504	CLIP-seq
MIRT921327	hsa-miR-4520a-3p	CLIP-seq
MIRT921328	hsa-miR-454	CLIP-seq
MIRT921329	hsa-miR-4649-3p	CLIP-seq
MIRT921330	hsa-miR-4652-3p	CLIP-seq
MIRT921331	hsa-miR-4657	CLIP-seq
MIRT921332	hsa-miR-4668-5p	CLIP-seq
MIRT921333	hsa-miR-4671-3p	CLIP-seq
MIRT921334	hsa-miR-4701-3p	CLIP-seq
MIRT921335	hsa-miR-4722-5p	CLIP-seq
MIRT921336	hsa-miR-4728-5p	CLIP-seq
MIRT921337	hsa-miR-4735-3p	CLIP-seq
MIRT921338	hsa-miR-4739	CLIP-seq
MIRT921339	hsa-miR-4756-5p	CLIP-seq
MIRT921340	hsa-miR-4764-5p	CLIP-seq
MIRT921341	hsa-miR-4768-3p	CLIP-seq
MIRT921342	hsa-miR-4775	CLIP-seq
MIRT921343	hsa-miR-4778-5p	CLIP-seq
MIRT921344	hsa-miR-485-5p	CLIP-seq
MIRT921345	hsa-miR-548c-3p	CLIP-seq
MIRT921346	hsa-miR-568	CLIP-seq
MIRT921347	hsa-miR-590-3p	CLIP-seq
MIRT921348	hsa-miR-640	CLIP-seq
MIRT921349	hsa-miR-656	CLIP-seq
MIRT921350	hsa-miR-940	CLIP-seq
MIRT1972981	hsa-miR-1285	CLIP-seq
MIRT1972982	hsa-miR-1293	CLIP-seq
MIRT921295	hsa-miR-18a	CLIP-seq
MIRT921296	hsa-miR-18b	CLIP-seq
MIRT921301	hsa-miR-3122	CLIP-seq
MIRT1972983	hsa-miR-3187-5p	CLIP-seq
MIRT1972984	hsa-miR-3652	CLIP-seq
MIRT921311	hsa-miR-3689a-3p	CLIP-seq
MIRT921312	hsa-miR-3689c	CLIP-seq
MIRT921317	hsa-miR-3913-5p	CLIP-seq
MIRT921319	hsa-miR-3975	CLIP-seq
MIRT1972985	hsa-miR-4430	CLIP-seq
MIRT1972986	hsa-miR-4483	CLIP-seq
MIRT1972987	hsa-miR-4505	CLIP-seq
MIRT921329	hsa-miR-4649-3p	CLIP-seq
MIRT921336	hsa-miR-4728-5p	CLIP-seq
MIRT921337	hsa-miR-4735-3p	CLIP-seq
MIRT1972988	hsa-miR-4793-3p	CLIP-seq
MIRT1972989	hsa-miR-4802-3p	CLIP-seq
MIRT1972990	hsa-miR-564	CLIP-seq
MIRT1972991	hsa-miR-612	CLIP-seq
MIRT921349	hsa-miR-656	CLIP-seq
MIRT921288	hsa-miR-1262	CLIP-seq
MIRT921289	hsa-miR-1265	CLIP-seq
MIRT2208593	hsa-miR-128	CLIP-seq
MIRT1972981	hsa-miR-1285	CLIP-seq
MIRT921291	hsa-miR-130a	CLIP-seq
MIRT921292	hsa-miR-130b	CLIP-seq
MIRT921293	hsa-miR-1321	CLIP-seq
MIRT921295	hsa-miR-18a	CLIP-seq
MIRT921296	hsa-miR-18b	CLIP-seq
MIRT921298	hsa-miR-301a	CLIP-seq
MIRT921299	hsa-miR-301b	CLIP-seq
MIRT921301	hsa-miR-3122	CLIP-seq
MIRT921302	hsa-miR-3138	CLIP-seq
MIRT921305	hsa-miR-3162-5p	CLIP-seq
MIRT2208594	hsa-miR-3176	CLIP-seq
MIRT1972983	hsa-miR-3187-5p	CLIP-seq
MIRT921306	hsa-miR-34b	CLIP-seq
MIRT921308	hsa-miR-3614-5p	CLIP-seq
MIRT921309	hsa-miR-3666	CLIP-seq
MIRT921311	hsa-miR-3689a-3p	CLIP-seq
MIRT921312	hsa-miR-3689c	CLIP-seq
MIRT921317	hsa-miR-3913-5p	CLIP-seq
MIRT2208595	hsa-miR-3922-3p	CLIP-seq
MIRT921318	hsa-miR-3929	CLIP-seq
MIRT921319	hsa-miR-3975	CLIP-seq
MIRT2208596	hsa-miR-4252	CLIP-seq
MIRT921320	hsa-miR-4295	CLIP-seq
MIRT2208597	hsa-miR-4302	CLIP-seq
MIRT921321	hsa-miR-4419b	CLIP-seq
MIRT921322	hsa-miR-4433	CLIP-seq
MIRT921323	hsa-miR-4459	CLIP-seq
MIRT921324	hsa-miR-4478	CLIP-seq
MIRT921325	hsa-miR-4491	CLIP-seq
MIRT2208598	hsa-miR-4501	CLIP-seq
MIRT921327	hsa-miR-4520a-3p	CLIP-seq
MIRT921328	hsa-miR-454	CLIP-seq
MIRT921331	hsa-miR-4657	CLIP-seq
MIRT921333	hsa-miR-4671-3p	CLIP-seq
MIRT2208599	hsa-miR-4672	CLIP-seq
MIRT921334	hsa-miR-4701-3p	CLIP-seq
MIRT2208600	hsa-miR-4709-5p	CLIP-seq
MIRT921336	hsa-miR-4728-5p	CLIP-seq
MIRT921337	hsa-miR-4735-3p	CLIP-seq
MIRT921338	hsa-miR-4739	CLIP-seq
MIRT921339	hsa-miR-4756-5p	CLIP-seq
MIRT921340	hsa-miR-4764-5p	CLIP-seq
MIRT921341	hsa-miR-4768-3p	CLIP-seq
MIRT1972988	hsa-miR-4793-3p	CLIP-seq
MIRT2208601	hsa-miR-4798-3p	CLIP-seq
MIRT921344	hsa-miR-485-5p	CLIP-seq
MIRT2208602	hsa-miR-508-5p	CLIP-seq
MIRT1972990	hsa-miR-564	CLIP-seq
MIRT921347	hsa-miR-590-3p	CLIP-seq
MIRT1972991	hsa-miR-612	CLIP-seq
MIRT921349	hsa-miR-656	CLIP-seq
MIRT2208603	hsa-miR-661	CLIP-seq
MIRT2208604	hsa-miR-766	CLIP-seq
MIRT1972981	hsa-miR-1285	CLIP-seq
MIRT1972983	hsa-miR-3187-5p	CLIP-seq
MIRT921306	hsa-miR-34b	CLIP-seq
MIRT921308	hsa-miR-3614-5p	CLIP-seq
MIRT2386661	hsa-miR-3672	CLIP-seq
MIRT2208596	hsa-miR-4252	CLIP-seq
MIRT2208597	hsa-miR-4302	CLIP-seq
MIRT921322	hsa-miR-4433	CLIP-seq
MIRT921323	hsa-miR-4459	CLIP-seq
MIRT2208600	hsa-miR-4709-5p	CLIP-seq
MIRT921341	hsa-miR-4768-3p	CLIP-seq
MIRT1972988	hsa-miR-4793-3p	CLIP-seq
MIRT2208602	hsa-miR-508-5p	CLIP-seq
MIRT1972991	hsa-miR-612	CLIP-seq
MIRT2208603	hsa-miR-661	CLIP-seq
MIRT2208604	hsa-miR-766	CLIP-seq
MIRT921288	hsa-miR-1262	CLIP-seq
MIRT921291	hsa-miR-130a	CLIP-seq
MIRT921292	hsa-miR-130b	CLIP-seq
MIRT921293	hsa-miR-1321	CLIP-seq
MIRT921294	hsa-miR-1827	CLIP-seq
MIRT921295	hsa-miR-18a	CLIP-seq
MIRT921296	hsa-miR-18b	CLIP-seq
MIRT921298	hsa-miR-301a	CLIP-seq
MIRT921299	hsa-miR-301b	CLIP-seq
MIRT921301	hsa-miR-3122	CLIP-seq
MIRT921305	hsa-miR-3162-5p	CLIP-seq
MIRT921309	hsa-miR-3666	CLIP-seq
MIRT2447916	hsa-miR-3675-3p	CLIP-seq
MIRT921311	hsa-miR-3689a-3p	CLIP-seq
MIRT921312	hsa-miR-3689c	CLIP-seq
MIRT921317	hsa-miR-3913-5p	CLIP-seq
MIRT921318	hsa-miR-3929	CLIP-seq
MIRT921319	hsa-miR-3975	CLIP-seq
MIRT921320	hsa-miR-4295	CLIP-seq
MIRT921321	hsa-miR-4419b	CLIP-seq
MIRT921324	hsa-miR-4478	CLIP-seq
MIRT921328	hsa-miR-454	CLIP-seq
MIRT921329	hsa-miR-4649-3p	CLIP-seq
MIRT2447917	hsa-miR-4662a-5p	CLIP-seq
MIRT921333	hsa-miR-4671-3p	CLIP-seq
MIRT2447918	hsa-miR-4684-5p	CLIP-seq
MIRT921334	hsa-miR-4701-3p	CLIP-seq
MIRT921336	hsa-miR-4728-5p	CLIP-seq
MIRT921337	hsa-miR-4735-3p	CLIP-seq
MIRT921338	hsa-miR-4739	CLIP-seq
MIRT921339	hsa-miR-4756-5p	CLIP-seq
MIRT921344	hsa-miR-485-5p	CLIP-seq
MIRT921345	hsa-miR-548c-3p	CLIP-seq
MIRT921350	hsa-miR-940	CLIP-seq
MIRT921291	hsa-miR-130a	CLIP-seq
MIRT921292	hsa-miR-130b	CLIP-seq
MIRT921293	hsa-miR-1321	CLIP-seq
MIRT921294	hsa-miR-1827	CLIP-seq
MIRT921295	hsa-miR-18a	CLIP-seq
MIRT921296	hsa-miR-18b	CLIP-seq
MIRT921298	hsa-miR-301a	CLIP-seq
MIRT921299	hsa-miR-301b	CLIP-seq
MIRT921301	hsa-miR-3122	CLIP-seq
MIRT921305	hsa-miR-3162-5p	CLIP-seq
MIRT921309	hsa-miR-3666	CLIP-seq
MIRT921311	hsa-miR-3689a-3p	CLIP-seq
MIRT921312	hsa-miR-3689c	CLIP-seq
MIRT921317	hsa-miR-3913-5p	CLIP-seq
MIRT921318	hsa-miR-3929	CLIP-seq
MIRT921319	hsa-miR-3975	CLIP-seq
MIRT921320	hsa-miR-4295	CLIP-seq
MIRT921321	hsa-miR-4419b	CLIP-seq
MIRT921324	hsa-miR-4478	CLIP-seq
MIRT921328	hsa-miR-454	CLIP-seq
MIRT921329	hsa-miR-4649-3p	CLIP-seq
MIRT921333	hsa-miR-4671-3p	CLIP-seq
MIRT921335	hsa-miR-4722-5p	CLIP-seq
MIRT921336	hsa-miR-4728-5p	CLIP-seq
MIRT921337	hsa-miR-4735-3p	CLIP-seq
MIRT921338	hsa-miR-4739	CLIP-seq
MIRT921339	hsa-miR-4756-5p	CLIP-seq
MIRT921341	hsa-miR-4768-3p	CLIP-seq
MIRT921344	hsa-miR-485-5p	CLIP-seq
MIRT921350	hsa-miR-940	CLIP-seq
MIRT921288	hsa-miR-1262	CLIP-seq
MIRT2208593	hsa-miR-128	CLIP-seq
MIRT921291	hsa-miR-130a	CLIP-seq
MIRT921292	hsa-miR-130b	CLIP-seq
MIRT921293	hsa-miR-1321	CLIP-seq
MIRT921294	hsa-miR-1827	CLIP-seq
MIRT921295	hsa-miR-18a	CLIP-seq
MIRT921296	hsa-miR-18b	CLIP-seq
MIRT921298	hsa-miR-301a	CLIP-seq
MIRT921299	hsa-miR-301b	CLIP-seq
MIRT2512468	hsa-miR-3120-5p	CLIP-seq
MIRT921301	hsa-miR-3122	CLIP-seq
MIRT921305	hsa-miR-3162-5p	CLIP-seq
MIRT921307	hsa-miR-3613-3p	CLIP-seq
MIRT2512469	hsa-miR-3664-5p	CLIP-seq
MIRT921309	hsa-miR-3666	CLIP-seq
MIRT2386661	hsa-miR-3672	CLIP-seq
MIRT2447916	hsa-miR-3675-3p	CLIP-seq
MIRT921311	hsa-miR-3689a-3p	CLIP-seq
MIRT921312	hsa-miR-3689c	CLIP-seq
MIRT921313	hsa-miR-371-5p	CLIP-seq
MIRT921314	hsa-miR-371b-5p	CLIP-seq
MIRT921317	hsa-miR-3913-5p	CLIP-seq
MIRT921318	hsa-miR-3929	CLIP-seq
MIRT921319	hsa-miR-3975	CLIP-seq
MIRT921320	hsa-miR-4295	CLIP-seq
MIRT2512470	hsa-miR-4330	CLIP-seq
MIRT921321	hsa-miR-4419b	CLIP-seq
MIRT921324	hsa-miR-4478	CLIP-seq
MIRT2512471	hsa-miR-4522	CLIP-seq
MIRT2512472	hsa-miR-4536	CLIP-seq
MIRT921328	hsa-miR-454	CLIP-seq
MIRT921329	hsa-miR-4649-3p	CLIP-seq
MIRT2447917	hsa-miR-4662a-5p	CLIP-seq
MIRT921333	hsa-miR-4671-3p	CLIP-seq
MIRT2208599	hsa-miR-4672	CLIP-seq
MIRT2447918	hsa-miR-4684-5p	CLIP-seq
MIRT921334	hsa-miR-4701-3p	CLIP-seq
MIRT921335	hsa-miR-4722-5p	CLIP-seq
MIRT921336	hsa-miR-4728-5p	CLIP-seq
MIRT921337	hsa-miR-4735-3p	CLIP-seq
MIRT921338	hsa-miR-4739	CLIP-seq
MIRT921339	hsa-miR-4756-5p	CLIP-seq
MIRT921341	hsa-miR-4768-3p	CLIP-seq
MIRT2512473	hsa-miR-4797-5p	CLIP-seq
MIRT921344	hsa-miR-485-5p	CLIP-seq
MIRT921345	hsa-miR-548c-3p	CLIP-seq
MIRT2512474	hsa-miR-759	CLIP-seq
MIRT921350	hsa-miR-940	CLIP-seq
MIRT921288	hsa-miR-1262	CLIP-seq
MIRT2208593	hsa-miR-128	CLIP-seq
MIRT921291	hsa-miR-130a	CLIP-seq
MIRT921292	hsa-miR-130b	CLIP-seq
MIRT921293	hsa-miR-1321	CLIP-seq
MIRT921294	hsa-miR-1827	CLIP-seq
MIRT921295	hsa-miR-18a	CLIP-seq
MIRT921296	hsa-miR-18b	CLIP-seq
MIRT921298	hsa-miR-301a	CLIP-seq
MIRT921299	hsa-miR-301b	CLIP-seq
MIRT921301	hsa-miR-3122	CLIP-seq
MIRT921305	hsa-miR-3162-5p	CLIP-seq
MIRT921309	hsa-miR-3666	CLIP-seq
MIRT2386661	hsa-miR-3672	CLIP-seq
MIRT2447916	hsa-miR-3675-3p	CLIP-seq
MIRT921311	hsa-miR-3689a-3p	CLIP-seq
MIRT921312	hsa-miR-3689c	CLIP-seq
MIRT921317	hsa-miR-3913-5p	CLIP-seq
MIRT921318	hsa-miR-3929	CLIP-seq
MIRT921319	hsa-miR-3975	CLIP-seq
MIRT921320	hsa-miR-4295	CLIP-seq
MIRT2512470	hsa-miR-4330	CLIP-seq
MIRT921321	hsa-miR-4419b	CLIP-seq
MIRT921324	hsa-miR-4478	CLIP-seq
MIRT2512472	hsa-miR-4536	CLIP-seq
MIRT921328	hsa-miR-454	CLIP-seq
MIRT921329	hsa-miR-4649-3p	CLIP-seq
MIRT2447917	hsa-miR-4662a-5p	CLIP-seq
MIRT921333	hsa-miR-4671-3p	CLIP-seq
MIRT2208599	hsa-miR-4672	CLIP-seq
MIRT2447918	hsa-miR-4684-5p	CLIP-seq
MIRT921334	hsa-miR-4701-3p	CLIP-seq
MIRT921335	hsa-miR-4722-5p	CLIP-seq
MIRT921336	hsa-miR-4728-5p	CLIP-seq
MIRT921337	hsa-miR-4735-3p	CLIP-seq
MIRT921338	hsa-miR-4739	CLIP-seq
MIRT921339	hsa-miR-4756-5p	CLIP-seq
MIRT921341	hsa-miR-4768-3p	CLIP-seq
MIRT921344	hsa-miR-485-5p	CLIP-seq
MIRT921345	hsa-miR-548c-3p	CLIP-seq
MIRT921350	hsa-miR-940	CLIP-seq

Show/Hide all (8)

Transcription factor	Regulation	Reference
AHR	Unknown	19928584
ATF5	Activation	18332083
EGR1	Activation	18303024
HNF4A	Unknown	18666237
NR1I2	Unknown	18096673;19928584
NR1I3	Activation	19702527
NR1I3	Unknown	19928584
NR5A1	Unknown	7789992

Show/Hide all (40)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004497	Function	Monooxygenase activity	IDA	19651758
GO:0004497	Function	Monooxygenase activity	IEA
GO:0004497	Function	Monooxygenase activity	TAS
GO:0005506	Function	Iron ion binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006805	Process	Xenobiotic metabolic process	IBA
GO:0006805	Process	Xenobiotic metabolic process	IDA	19651758, 20061448
GO:0006805	Process	Xenobiotic metabolic process	IMP	18356043
GO:0006805	Process	Xenobiotic metabolic process	TAS
GO:0008202	Process	Steroid metabolic process	IMP	18356043
GO:0008390	Function	Testosterone 16-alpha-hydroxylase activity	IDA	21289075
GO:0008390	Function	Testosterone 16-alpha-hydroxylase activity	IEA
GO:0008392	Function	Arachidonate epoxygenase activity	IBA
GO:0016020	Component	Membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016705	Function	Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA
GO:0016712	Function	Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA
GO:0016712	Function	Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IEA
GO:0019373	Process	Epoxygenase P450 pathway	IBA
GO:0020037	Function	Heme binding	IBA
GO:0020037	Function	Heme binding	IDA	20061448
GO:0020037	Function	Heme binding	IEA
GO:0042178	Process	Xenobiotic catabolic process	IDA	19029318
GO:0042180	Process	Ketone metabolic process	IDA	19651758
GO:0043231	Component	Intracellular membrane-bounded organelle	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0062184	Function	Testosterone 16-beta-hydroxylase activity	IDA	21289075
GO:0062184	Function	Testosterone 16-beta-hydroxylase activity	IEA
GO:0062187	Function	Anandamide 8,9 epoxidase activity	IDA	21289075
GO:0062187	Function	Anandamide 8,9 epoxidase activity	IEA
GO:0062188	Function	Anandamide 11,12 epoxidase activity	IDA	21289075
GO:0062188	Function	Anandamide 11,12 epoxidase activity	IEA
GO:0062189	Function	Anandamide 14,15 epoxidase activity	IDA	21289075
GO:0062189	Function	Anandamide 14,15 epoxidase activity	IEA
GO:0101021	Function	Estrogen 2-hydroxylase activity	IDA	12865317
GO:0101021	Function	Estrogen 2-hydroxylase activity	IEA

MIM	HGNC	e!Ensembl
123930	2615	ENSG00000197408

P20813

Protein name

Cytochrome P450 2B6 (EC 1.14.13.-) (1,4-cineole 2-exo-monooxygenase) (CYPIIB6) (Cytochrome P450 IIB1)

Protein function

A cytochrome P450 monooxygenase involved in the metabolism of endocannabinoids and steroids (PubMed:12865317, PubMed:21289075). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a wat

PDB

3IBD , 3QOA , 3QU8 , 3UA5 , 4I91 , 4RQL , 4RRT , 4ZV8 , 5UAP , 5UDA , 5UEC , 5UFG , 5WBG

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00067	p450	31 → 488	Cytochrome P450	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in liver, lung and heart right ventricle. {ECO:0000269|PubMed:10768437}.

Sequence

MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFRE
KYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNR
WKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIIC
SIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQE
INAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGT
ETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFS
DLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGAL
KKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKI
PPTYQIRFLPR

Sequence length

491

Interactions

View interactions

	KEGG		Reactome
	Arachidonic acid metabolism Retinol metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 Metabolic pathways Chemical carcinogenesis - receptor activation Lipid and atherosclerosis		Fatty acids Xenobiotics CYP2E1 reactions

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
CYP2B6-related disorder	Benign; drug response; Likely benign	rs2279343, rs28399499, rs12721655, rs34477445, rs376359134, rs368531402, rs189970623, rs34883432, rs35349987, rs200334437, rs45482602, rs150742423, rs146956370, rs143488417, rs3745274	RCV003974998 RCV003927895 RCV003911401 RCV003933978 RCV003919553 RCV003951611 RCV003951853 RCV003932303 RCV003951365 RCV003959166 RCV003926884 RCV003956855 RCV003963842 RCV003961986 RCV003974851
Efavirenz response	Benign; drug response	rs2279343, rs186335453, rs139801276, rs373489637, rs371424910, rs281864907, rs34097093, rs36079186, rs3745274	RCV000106294 RCV000106295 RCV000106296 RCV000106297 RCV000106298 RCV000133445 RCV000133446 RCV000133447 RCV000022520
efavirenz response - Metabolism/PK	drug response	rs3745274	RCV001787330
efavirenz response - Toxicity	drug response	rs3745274	RCV001787331
Familial cancer of breast	drug response	rs186335453, rs3745274	RCV005887818 RCV005888646
nevirapine response - Metabolism/PK	drug response	rs3745274	RCV001787332
nevirapine response - Toxicity	drug response	rs28399499	RCV001787338

Show/Hide Text Mining Associations (85)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Acquired Immunodeficiency Syndrome	Associate	20662624, 23080225
Adrenocortical Carcinoma	Associate	28073588
Alcoholism	Associate	35404482
Alzheimer Disease	Associate	27056331
Breast Neoplasms	Associate	15084249, 20079471, 20179710, 23824676, 25526449, 26602960, 27858847, 28178648
Carcinogenesis	Associate	23591849
Carcinoma Basal Cell	Associate	16582078
Carcinoma Hepatocellular	Associate	19041150, 25024626, 31570105
Cardiovascular Diseases	Associate	21505298, 29847509
Central Nervous System Diseases	Associate	20639527, 28145050, 28492729, 29855606, 31006110, 35512066
Chemical and Drug Induced Liver Injury	Associate	22808112, 35512066
Chromosome Aberrations	Associate	24586425
Cleft Palate	Associate	1869518
Colitis Ulcerative	Associate	33686088
Congenital adrenal hyperplasia due to 21 hydroxylase deficiency	Associate	1869518
COVID 19	Associate	34473836
Death	Associate	26602960
Depressive Disorder	Associate	29973058
Diabetes Mellitus Type 2	Associate	29439084
Diabetes Mellitus Type 2	Inhibit	36734157
Drug Hypersensitivity	Associate	25147095
Drug Related Side Effects and Adverse Reactions	Associate	17465455, 19486190, 22798551, 29559695, 30320358, 36320932, 37915145
Exanthema	Associate	35235559
Fatty Liver	Associate	35062050
Gastrointestinal Diseases	Associate	26456622
Gastrointestinal Neoplasms	Associate	38554324
Glioblastoma	Associate	36477472
Glomerulonephritis Membranous	Associate	36277605
Graft vs Host Disease	Associate	36211438
Hallucinations	Associate	23734829
Head and Neck Neoplasms	Associate	35404482
Hepatitis Viral Human	Associate	37512019
Heroin Dependence	Associate	17465455
Hirschsprung Disease	Associate	25424204, 34752660
HIV Infections	Associate	17352764, 17391322, 18281305, 18728241, 18784455, 19124658, 19371316, 19486190, 19779319, 20696882, 21150552, 22297601, 22462748, 22471906, 22927450 View all (22 more)
Hyperaldosteronism	Associate	20066577
Hypercholesterolemia	Associate	40532247
Hypoxia	Inhibit	30320358
Infertility	Associate	19342032
Inflammation	Associate	17576808, 18206661, 29715548
Jaw Cysts	Associate	16582078
Kidney Diseases	Associate	17335546
Kidney Failure Chronic	Associate	15248218
Leukemia Lymphocytic Chronic B Cell	Associate	24128861, 37706370
Leukemia Myeloid Acute	Associate	24586425, 26107207, 32119768, 34397877
Leukopenia	Associate	26456622
Liver Failure	Stimulate	25798860
Liver Failure	Associate	26602960, 37479763, 37512019
Long QT Syndrome	Associate	27333947
Lung Neoplasms	Associate	23591849
Lupus Erythematosus Systemic	Associate	26456622
Lupus Nephritis	Associate	22380717, 37915145
Lymphoma	Associate	25677220
Lymphoma B Cell	Associate	26773420
Lymphopenia	Associate	37479763
Malaria	Associate	29559695, 30818046
Malaria Falciparum	Associate	30818046
Mastocytosis Cutaneous	Associate	32752121
Medulloblastoma	Associate	30320358
Meniere Disease	Associate	35741759
Mouth Neoplasms	Associate	35404482
Myelodysplastic Syndromes	Associate	23684483
Neoplasm Metastasis	Associate	26602960
Neoplasms	Associate	23382387, 28321040, 34592995
Neutropenia	Associate	27858847
Non alcoholic Fatty Liver Disease	Associate	19651758, 35062050
Obesity	Associate	35491971
Oropharyngeal Neoplasms	Associate	35404482
Polycystic Ovary Syndrome	Associate	19342032
Precancerous Conditions	Associate	1521541
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	34397877
Pulmonary Disease Chronic Obstructive	Associate	29767774, 31564857
Rectal Neoplasms	Associate	32224706
Renal Insufficiency	Associate	28481785
Rhabdomyosarcoma	Associate	27388155
Sleep Initiation and Maintenance Disorders	Associate	23734829
Spasms Infantile	Associate	17391322
Squamous Cell Carcinoma of Head and Neck	Associate	35404482
Stevens Johnson Syndrome	Associate	25147095
Taste Disorders	Associate	1869518
Thrombocytopenia	Associate	37479763
Triple Negative Breast Neoplasms	Associate	35579950
Tuberculosis	Associate	24551111, 30818046
Tuberculosis Meningeal	Associate	30239753, 30818046
Weight Gain	Associate	32829410, 32960272, 37910437

CYP2B6 (cytochrome P450 family 2 subfamily B member 6)