CYP3A7 (cytochrome P450 family 3 subfamily A member 7)

Gene

• Entrez ID: 1551
• Gene name: Cytochrome P450 family 3 subfamily A member 7
• Gene symbol: CYP3A7
• Synonyms (NCBI Gene): CP37, CYPIIIA7, P-450(HFL33), P-450111A7, P450-HFLA, P450HLp2
• Chromosome: 7
• Chromosome location: 7q22.1
• Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes, which participate in drug metabolism and the synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT921557	hsa-miR-103a	CLIP-seq
MIRT921558	hsa-miR-107	CLIP-seq
MIRT921559	hsa-miR-1208	CLIP-seq
MIRT921560	hsa-miR-1255a	CLIP-seq
MIRT921561	hsa-miR-1255b	CLIP-seq
MIRT921562	hsa-miR-1304	CLIP-seq
MIRT921563	hsa-miR-326	CLIP-seq
MIRT921564	hsa-miR-330-5p	CLIP-seq
MIRT921565	hsa-miR-4299	CLIP-seq
MIRT921566	hsa-miR-4456	CLIP-seq
MIRT921567	hsa-miR-4694-5p	CLIP-seq
MIRT921568	hsa-miR-491-3p	CLIP-seq
MIRT921569	hsa-miR-548a-5p	CLIP-seq
MIRT921570	hsa-miR-548ab	CLIP-seq
MIRT921571	hsa-miR-548ak	CLIP-seq
MIRT921572	hsa-miR-548b-5p	CLIP-seq
MIRT921573	hsa-miR-548c-5p	CLIP-seq
MIRT921574	hsa-miR-548d-5p	CLIP-seq
MIRT921575	hsa-miR-548h	CLIP-seq
MIRT921576	hsa-miR-548i	CLIP-seq
MIRT921577	hsa-miR-548j	CLIP-seq
MIRT921578	hsa-miR-548k	CLIP-seq
MIRT921579	hsa-miR-548l	CLIP-seq
MIRT921580	hsa-miR-548q	CLIP-seq
MIRT921581	hsa-miR-548w	CLIP-seq
MIRT921582	hsa-miR-548y	CLIP-seq
MIRT921583	hsa-miR-559	CLIP-seq
MIRT921584	hsa-miR-593	CLIP-seq
MIRT921585	hsa-miR-668	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
FOXA3	Unknown	19706729
NFAT5	Unknown	17600221
NFKB1	Unknown	19928584
RELA	Unknown	19928584
SP1	Unknown	11495920
SP3	Unknown	11495920
VDR	Unknown	15358113

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002933	Process	Lipid hydroxylation	IDA	14559847
GO:0004497	Function	Monooxygenase activity	IEA
GO:0004497	Function	Monooxygenase activity	ISS
GO:0004497	Function	Monooxygenase activity	TAS
GO:0005506	Function	Iron ion binding	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006694	Process	Steroid biosynthetic process	IEA
GO:0006805	Process	Xenobiotic metabolic process	TAS
GO:0008202	Process	Steroid metabolic process	IBA
GO:0008202	Process	Steroid metabolic process	IDA	14559847
GO:0008210	Process	Estrogen metabolic process	IDA	12865317, 14559847
GO:0008395	Function	Steroid hydroxylase activity	IDA	14559847
GO:0008401	Function	Retinoic acid 4-hydroxylase activity	IDA	11093772
GO:0016020	Component	Membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016705	Function	Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA
GO:0016712	Function	Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IEA
GO:0019825	Function	Oxygen binding	TAS	2722762
GO:0020037	Function	Heme binding	IEA
GO:0042572	Process	Retinol metabolic process	IEA
GO:0042573	Process	Retinoic acid metabolic process	IDA	11093772
GO:0046872	Function	Metal ion binding	IEA
GO:0050649	Function	Testosterone 6-beta-hydroxylase activity	IBA
GO:0050649	Function	Testosterone 6-beta-hydroxylase activity	IEA
GO:0062183	Function	All-trans retinoic acid 18-hydroxylase activity	IEA
GO:0070989	Process	Oxidative demethylation	IBA
GO:0101020	Function	Estrogen 16-alpha-hydroxylase activity	IBA
GO:0101020	Function	Estrogen 16-alpha-hydroxylase activity	IDA	14559847
GO:0101020	Function	Estrogen 16-alpha-hydroxylase activity	IEA
GO:0101021	Function	Estrogen 2-hydroxylase activity	IDA	12865317
GO:0101021	Function	Estrogen 2-hydroxylase activity	IEA

Other IDs

• MIM: 605340
• HGNC: 2640
• e!Ensembl: ENSG00000160870

Interactions View interactions

Pathways

KEGG:

Steroid hormone biosynthesis
Retinol metabolism
Metabolic pathways
Chemical carcinogenesis - DNA adducts

Reactome:

Xenobiotics

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
AUTISM SPECTRUM DISORDER	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Adrenal Gland Neoplasms	Associate	18445661	★☆☆☆☆ Found in Text Mining only
Anencephaly	Associate	15845858	★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Associate	26964624, 33495599	★☆☆☆☆ Found in Text Mining only
Calcinosis Cutis	Inhibit	22971343	★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Associate	40026294	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Associate	25024626, 25101946	★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Associate	32789468	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Associate	23036011	★☆☆☆☆ Found in Text Mining only
Congenital adrenal hyperplasia due to 21 hydroxylase deficiency	Associate	21915484	★☆☆☆☆ Found in Text Mining only
Drug Related Side Effects and Adverse Reactions	Associate	26964624	★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Associate	23358850	★☆☆☆☆ Found in Text Mining only
Hypertension	Associate	23036011	★☆☆☆☆ Found in Text Mining only
Insulin Resistance	Associate	23036011	★☆☆☆☆ Found in Text Mining only
Laron Syndrome	Associate	33495599	★☆☆☆☆ Found in Text Mining only
Leukemia Lymphocytic Chronic B Cell	Associate	26964624	★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Associate	26964624	★☆☆☆☆ Found in Text Mining only
Malnutrition	Associate	23036011	★☆☆☆☆ Found in Text Mining only
Melanosis	Associate	26238215	★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	26964624, 40026294	★☆☆☆☆ Found in Text Mining only
Polycystic Ovary Syndrome	Associate	18445661	★☆☆☆☆ Found in Text Mining only
Respiratory Distress Syndrome	Associate	22445700	★☆☆☆☆ Found in Text Mining only
Respiratory Distress Syndrome Newborn	Associate	22445700	★☆☆☆☆ Found in Text Mining only
Sarcoma Ewing	Associate	25670065	★☆☆☆☆ Found in Text Mining only
Virilism	Associate	18445661	★☆☆☆☆ Found in Text Mining only