Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
155
Gene name Gene Name - the full gene name approved by the HGNC.
Adrenoceptor beta 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ADRB3
Synonyms (NCBI Gene) Gene synonyms aliases
BETA3AR
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8p11.23
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involve
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs4994 A>G Risk-factor Missense variant, coding sequence variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT610941 hsa-miR-8485 HITS-CLIP 23313552
MIRT610940 hsa-miR-329-3p HITS-CLIP 23313552
MIRT610939 hsa-miR-362-3p HITS-CLIP 23313552
MIRT610938 hsa-miR-124-3p HITS-CLIP 23313552
MIRT610943 hsa-miR-3714 HITS-CLIP 23313552
Transcription factors
Transcription factor Regulation Reference
SP1 Unknown 11316759
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0002024 Process Diet induced thermogenesis IEA
GO:0002025 Process Norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IBA
GO:0002025 Process Norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IEA
GO:0004930 Function G protein-coupled receptor activity IEA
GO:0004935 Function Adrenergic receptor activity IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
109691 288 ENSG00000188778
Protein
UniProt ID P13945
Protein name Beta-3 adrenergic receptor (Beta-3 adrenoreceptor) (Beta-3 adrenoceptor)
Protein function Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.
PDB 9IJD , 9IJE
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 54 346 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Expressed mainly in adipose tissues.
Sequence
Sequence length 408
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Hormone signaling
Thermogenesis
Regulation of lipolysis in adipocytes
Renin secretion
Salivary secretion
Chemical carcinogenesis - receptor activation
  Adrenoceptors
G alpha (s) signalling events
ADORA2B mediated anti-inflammatory cytokines production
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Obesity obesity N/A N/A ClinVar
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Alzheimer Disease Associate 19271249
Atherosclerosis Associate 10395234
Body Weight Associate 29587766
Breast Neoplasms Associate 11434877, 17264845, 18611262
Cholelithiasis Associate 23577061, 24556804
Connective Tissue Diseases Associate 29606859, 32090130
Diabetes Gestational Associate 30618040, 31651836
Diabetes Mellitus Associate 10395234, 21992420, 24972470, 29464546, 34347822, 7609751
Diabetes Mellitus Type 2 Associate 17825092, 17852419, 18335327, 19133996, 19576569, 21992420, 24972470, 29361938, 30618040, 34072007, 7609750, 7609751, 9313101
Dyslipidemias Associate 17087055, 29083445, 29361938, 29606859, 30954083