Gene Gene information from NCBI Gene database.
Entrez ID 1544
Gene name Cytochrome P450 family 1 subfamily A member 2
Gene symbol CYP1A2
Synonyms (NCBI Gene)
CP12CYPIA2P3-450P450(PA)
Chromosome 15
Chromosome location 15q24.1
Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encode
miRNA miRNA information provided by mirtarbase database.
440
miRTarBase ID miRNA Experiments Reference
MIRT052168 hsa-let-7b-5p CLASH 23622248
MIRT619678 hsa-miR-508-5p HITS-CLIP 23824327
MIRT619677 hsa-miR-1273g-3p HITS-CLIP 23824327
MIRT619676 hsa-miR-6849-3p HITS-CLIP 23824327
MIRT619675 hsa-miR-221-5p HITS-CLIP 23824327
Transcription factors Transcription factors information provided by TRRUST V2 database.
4
Transcription factor Regulation Reference
AHR Unknown 21357676
FOS Unknown 12135113
HNF1A Unknown 7723729
JUN Unknown 12135113
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
70
GO ID Ontology Definition Evidence Reference
GO:0004497 Function Monooxygenase activity IDA 15327587, 19651758
GO:0004497 Function Monooxygenase activity IEA
GO:0004497 Function Monooxygenase activity TAS
GO:0005506 Function Iron ion binding IEA
GO:0005515 Function Protein binding IPI 26988023, 32296183
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
124060 2596 ENSG00000140505
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P05177
Protein name Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) (Cholesterol 25-hydroxylase) (Cytochrome P(3)450) (Cytochrome P450 4) (Cytochrome P450-P3) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152)
Protein function A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:19965576, PubMed:9435160). Mechanistical
PDB 2HI4
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00067 p450 42 505 Cytochrome P450 Domain
Tissue specificity TISSUE SPECIFICITY: Liver.
Sequence
Sequence length 516
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Steroid hormone biosynthesis
Caffeine metabolism
Tryptophan metabolism
Linoleic acid metabolism
Retinol metabolism
Metabolism of xenobiotics by cytochrome P450
Drug metabolism - cytochrome P450
Metabolic pathways
Chemical carcinogenesis - DNA adducts
Chemical carcinogenesis - receptor activation
Chemical carcinogenesis - reactive oxygen species
  Methylation
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
Aflatoxin activation and detoxification
Biosynthesis of protectins
Biosynthesis of maresin-like SPMs