Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	1543
Gene name	Cytochrome P450 family 1 subfamily A member 1
Gene symbol	CYP1A1
Synonyms (NCBI Gene)	AHHAHRRCP11CYP1CYPIA1P1-450P450-CP450DX
Chromosome	15
Chromosome location	15q24.1
Summary	This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This prot

Show/Hide all (86)

miRTarBase ID	miRNA	Experiments	Reference
MIRT038448	hsa-miR-296-3p	CLASH	23622248
MIRT497727	hsa-miR-8084	PAR-CLIP	22291592
MIRT497728	hsa-miR-200b-3p	PAR-CLIP	22291592
MIRT497726	hsa-miR-200c-3p	PAR-CLIP	22291592
MIRT497725	hsa-miR-429	PAR-CLIP	22291592
MIRT497724	hsa-miR-452-5p	PAR-CLIP	22291592
MIRT497723	hsa-miR-4676-3p	PAR-CLIP	22291592
MIRT497722	hsa-miR-892c-3p	PAR-CLIP	22291592
MIRT497721	hsa-miR-3120-5p	PAR-CLIP	22291592
MIRT497720	hsa-miR-374c-5p	PAR-CLIP	22291592
MIRT497719	hsa-miR-655-3p	PAR-CLIP	22291592
MIRT497718	hsa-miR-155-5p	PAR-CLIP	22291592
MIRT497716	hsa-miR-6888-3p	PAR-CLIP	22291592
MIRT497717	hsa-miR-4288	PAR-CLIP	22291592
MIRT497715	hsa-miR-632	PAR-CLIP	22291592
MIRT497714	hsa-miR-1231	PAR-CLIP	22291592
MIRT489679	hsa-miR-3664-5p	PAR-CLIP	23592263
MIRT489678	hsa-miR-4677-3p	PAR-CLIP	23592263
MIRT489677	hsa-miR-4679	PAR-CLIP	23592263
MIRT489676	hsa-miR-4680-5p	PAR-CLIP	23592263
MIRT489675	hsa-miR-4294	PAR-CLIP	23592263
MIRT489674	hsa-miR-3191-5p	PAR-CLIP	23592263
MIRT489673	hsa-miR-4768-5p	PAR-CLIP	23592263
MIRT489672	hsa-miR-6833-3p	PAR-CLIP	23592263
MIRT489671	hsa-miR-6809-3p	PAR-CLIP	23592263
MIRT497727	hsa-miR-8084	PAR-CLIP	22291592
MIRT497728	hsa-miR-200b-3p	PAR-CLIP	22291592
MIRT497726	hsa-miR-200c-3p	PAR-CLIP	22291592
MIRT497725	hsa-miR-429	PAR-CLIP	22291592
MIRT497724	hsa-miR-452-5p	PAR-CLIP	22291592
MIRT497723	hsa-miR-4676-3p	PAR-CLIP	22291592
MIRT497722	hsa-miR-892c-3p	PAR-CLIP	22291592
MIRT497721	hsa-miR-3120-5p	PAR-CLIP	22291592
MIRT497720	hsa-miR-374c-5p	PAR-CLIP	22291592
MIRT497719	hsa-miR-655-3p	PAR-CLIP	22291592
MIRT497718	hsa-miR-155-5p	PAR-CLIP	22291592
MIRT497716	hsa-miR-6888-3p	PAR-CLIP	22291592
MIRT497717	hsa-miR-4288	PAR-CLIP	22291592
MIRT497715	hsa-miR-632	PAR-CLIP	22291592
MIRT497714	hsa-miR-1231	PAR-CLIP	22291592
MIRT489679	hsa-miR-3664-5p	PAR-CLIP	23592263
MIRT489678	hsa-miR-4677-3p	PAR-CLIP	23592263
MIRT489677	hsa-miR-4679	PAR-CLIP	23592263
MIRT489676	hsa-miR-4680-5p	PAR-CLIP	23592263
MIRT489675	hsa-miR-4294	PAR-CLIP	23592263
MIRT489674	hsa-miR-3191-5p	PAR-CLIP	23592263
MIRT489673	hsa-miR-4768-5p	PAR-CLIP	23592263
MIRT489672	hsa-miR-6833-3p	PAR-CLIP	23592263
MIRT489671	hsa-miR-6809-3p	PAR-CLIP	23592263
MIRT920537	hsa-miR-1205	CLIP-seq
MIRT920538	hsa-miR-1286	CLIP-seq
MIRT920539	hsa-miR-3074-5p	CLIP-seq
MIRT920540	hsa-miR-3202	CLIP-seq
MIRT920541	hsa-miR-375	CLIP-seq
MIRT920542	hsa-miR-4257	CLIP-seq
MIRT920543	hsa-miR-4326	CLIP-seq
MIRT920544	hsa-miR-4330	CLIP-seq
MIRT920545	hsa-miR-4436b-3p	CLIP-seq
MIRT920546	hsa-miR-4476	CLIP-seq
MIRT920547	hsa-miR-4520a-3p	CLIP-seq
MIRT920548	hsa-miR-4520b-3p	CLIP-seq
MIRT920549	hsa-miR-4521	CLIP-seq
MIRT920550	hsa-miR-4722-3p	CLIP-seq
MIRT920551	hsa-miR-4722-5p	CLIP-seq
MIRT920552	hsa-miR-4763-5p	CLIP-seq
MIRT1972780	hsa-miR-3120-3p	CLIP-seq
MIRT1972781	hsa-miR-3942-5p	CLIP-seq
MIRT1972782	hsa-miR-4436a	CLIP-seq
MIRT1972783	hsa-miR-4703-5p	CLIP-seq
MIRT1972784	hsa-miR-4749-3p	CLIP-seq
MIRT1972785	hsa-miR-665	CLIP-seq
MIRT2208443	hsa-miR-203	CLIP-seq
MIRT2208444	hsa-miR-3154	CLIP-seq
MIRT2208445	hsa-miR-4310	CLIP-seq
MIRT1972782	hsa-miR-4436a	CLIP-seq
MIRT2208446	hsa-miR-4514	CLIP-seq
MIRT2208447	hsa-miR-4685-5p	CLIP-seq
MIRT2208448	hsa-miR-4688	CLIP-seq
MIRT2208449	hsa-miR-4692	CLIP-seq
MIRT2208450	hsa-miR-4747-5p	CLIP-seq
MIRT1972784	hsa-miR-4749-3p	CLIP-seq
MIRT2208451	hsa-miR-486-3p	CLIP-seq
MIRT2208452	hsa-miR-548ag	CLIP-seq
MIRT2208453	hsa-miR-548ai	CLIP-seq
MIRT1972785	hsa-miR-665	CLIP-seq
MIRT2208454	hsa-miR-940	CLIP-seq

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Transcription factor	Regulation	Reference
AHR	Activation	12213390;9865727
AHR	Repression	17012224
AHR	Unknown	10359656;12376470;15325265;19376845;21357676;24639079;8631128;9698073
ARNT	Activation	22387692
ARNT	Unknown	12376470;19255421;19376845;8631128
BRCA1	Unknown	16567799
ESR1	Repression	15837795
KLF4	Unknown	9651398
NFIC	Repression	10490621
NFKB1	Unknown	19928584
PPARA	Activation	15521013
RARA	Unknown	15325265
RELA	Unknown	19928584
USF1	Repression	9388470
VDR	Unknown	22837390

104

Show/Hide all (104)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001666	Process	Response to hypoxia	IEA
GO:0001676	Process	Long-chain fatty acid metabolic process	IDA	18577768
GO:0001889	Process	Liver development	IEA
GO:0002933	Process	Lipid hydroxylation	IDA	14559847
GO:0003824	Function	Catalytic activity	IEA
GO:0004497	Function	Monooxygenase activity	IEA
GO:0004497	Function	Monooxygenase activity	TAS
GO:0005506	Function	Iron ion binding	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 25910212
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	ISS
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006631	Process	Fatty acid metabolic process	IDA	15041462
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0006694	Process	Steroid biosynthetic process	IEA
GO:0006706	Process	Steroid catabolic process	IBA
GO:0006778	Process	Porphyrin-containing compound metabolic process	IEA
GO:0006805	Process	Xenobiotic metabolic process	IDA	19219744
GO:0008202	Process	Steroid metabolic process	IDA	14559847
GO:0008202	Process	Steroid metabolic process	IEA
GO:0008210	Process	Estrogen metabolic process	IBA
GO:0008210	Process	Estrogen metabolic process	IDA	11555828, 12865317, 14559847
GO:0008391	Function	Arachidonate monooxygenase activity	IDA	15041462
GO:0008395	Function	Steroid hydroxylase activity	IBA
GO:0008395	Function	Steroid hydroxylase activity	IEA
GO:0009308	Process	Amine metabolic process	IEA
GO:0009404	Process	Toxin metabolic process	IBA
GO:0009404	Process	Toxin metabolic process	IEA
GO:0009410	Process	Response to xenobiotic stimulus	IEA
GO:0009624	Process	Response to nematode	IEA
GO:0009635	Process	Response to herbicide	IEA
GO:0009636	Process	Response to toxic substance	IEA
GO:0009692	Process	Ethylene metabolic process	TAS
GO:0009804	Process	Coumarin metabolic process	IEA
GO:0009812	Process	Flavonoid metabolic process	IEA
GO:0010041	Process	Response to iron(III) ion	IEA
GO:0016020	Component	Membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IDA	19219744
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016679	Function	Oxidoreductase activity, acting on diphenols and related substances as donors	IEA
GO:0016705	Function	Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA
GO:0016711	Function	Flavonoid 3'-monooxygenase activity	IEA
GO:0016712	Function	Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA
GO:0016712	Function	Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IEA
GO:0016829	Function	Lyase activity	IEA
GO:0017143	Process	Insecticide metabolic process	IEA
GO:0018894	Process	Dibenzo-p-dioxin metabolic process	IEA
GO:0018958	Process	Phenol-containing compound metabolic process	IEA
GO:0019341	Process	Dibenzo-p-dioxin catabolic process	IEA
GO:0019373	Process	Epoxygenase P450 pathway	TAS
GO:0019825	Function	Oxygen binding	TAS	1691986
GO:0019899	Function	Enzyme binding	IEA
GO:0020037	Function	Heme binding	IEA
GO:0030544	Function	Hsp70 protein binding	IEA
GO:0030544	Function	Hsp70 protein binding	ISS
GO:0032094	Process	Response to food	IEA
GO:0032451	Function	Demethylase activity	IEA
GO:0032496	Process	Response to lipopolysaccharide	IEA
GO:0033189	Process	Response to vitamin A	IEA
GO:0033595	Process	Response to genistein	IEA
GO:0035902	Process	Response to immobilization stress	IEA
GO:0042178	Process	Xenobiotic catabolic process	IBA
GO:0042359	Process	Vitamin D metabolic process	IDA	15546903
GO:0042445	Process	Hormone metabolic process	IEA
GO:0042572	Process	Retinol metabolic process	IDA	10681376
GO:0042572	Process	Retinol metabolic process	IEA
GO:0042759	Process	Long-chain fatty acid biosynthetic process	TAS
GO:0042904	Process	9-cis-retinoic acid biosynthetic process	IEA
GO:0043010	Process	Camera-type eye development	IEA
GO:0046209	Process	Nitric oxide metabolic process	IEA
GO:0046685	Process	Response to arsenic-containing substance	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0048565	Process	Digestive tract development	IEA
GO:0048771	Process	Tissue remodeling	IEA
GO:0050665	Process	Hydrogen peroxide biosynthetic process	IEA
GO:0051879	Function	Hsp90 protein binding	IEA
GO:0051879	Function	Hsp90 protein binding	ISS
GO:0055093	Process	Response to hyperoxia	IEA
GO:0060137	Process	Maternal process involved in parturition	IEA
GO:0070365	Process	Hepatocyte differentiation	IEA
GO:0070576	Function	Vitamin D 24-hydroxylase activity	IDA	15546903
GO:0071280	Process	Cellular response to copper ion	IEA
GO:0097267	Process	Omega-hydroxylase P450 pathway	TAS
GO:0101020	Function	Estrogen 16-alpha-hydroxylase activity	IDA	11555828, 14559847
GO:0101020	Function	Estrogen 16-alpha-hydroxylase activity	IEA
GO:0101021	Function	Estrogen 2-hydroxylase activity	IDA	11555828, 12865317
GO:0101021	Function	Estrogen 2-hydroxylase activity	IEA
GO:0102033	Function	Long-chain fatty acid omega-hydroxylase activity	IDA	18577768
GO:0106256	Function	Hydroperoxy icosatetraenoate dehydratase activity	IEA
GO:0120254	Process	Olefinic compound metabolic process	IEA
GO:0120319	Function	Long-chain fatty acid omega-1 hydroxylase activity	IDA	18577768
GO:1900087	Process	Positive regulation of G1/S transition of mitotic cell cycle	IEA
GO:1901497	Process	Response to diphenyl ether	IEA
GO:1904010	Process	Response to Aroclor 1254	IEA
GO:1904612	Process	Response to 2,3,7,8-tetrachlorodibenzodioxine	IEA
GO:1904681	Process	Response to 3-methylcholanthrene	IEA

MIM	HGNC	e!Ensembl
108330	2595	ENSG00000140465

P04798

Protein name

Cytochrome P450 1A1 (CYPIA1) (EC 1.14.14.1) (Cytochrome P450 form 6) (Cytochrome P450-C) (Cytochrome P450-P1) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152)

Protein function

A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:14559847, PubMed:15041462, PubMed:158053

PDB

4I8V , 6DWM , 6DWN , 6O5Y , 6UDL , 6UDM

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00067	p450	40 → 501	Cytochrome P450	Domain

Tissue specificity

TISSUE SPECIFICITY: Lung, lymphocytes and placenta.

Sequence

MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPH
LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS
MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG
PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL
RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANV
QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS
DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL
WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF
SVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS

Sequence length

512

Interactions

View interactions

	KEGG		Reactome
	Steroid hormone biosynthesis Tryptophan metabolism Retinol metabolism Metabolism of xenobiotics by cytochrome P450 Metabolic pathways Ovarian steroidogenesis Chemical carcinogenesis - DNA adducts Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Lipid and atherosclerosis		PPARA activates gene expression Xenobiotics Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Biosynthesis of protectins

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
CYP1A1-related disorder	Benign; Likely benign	rs28399429, rs150427960, rs4646422, rs1048943, rs1349977436, rs561096394, rs578251068, rs745879982, rs56240201, rs1799814, rs45528935, rs145198866, rs45460597, rs147033233, rs41279188	RCV003897243 RCV003964628 RCV003979497 RCV003984578 RCV003942053 RCV003952173 RCV003907350 RCV003936786 RCV003957250 RCV003972309 RCV003972207 RCV003915964 RCV003905909 RCV003926270 RCV003975623

Show/Hide Text Mining Associations (136)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	18990008, 27396354
Adenocarcinoma of Lung	Associate	39257908
Adenoma	Associate	23840148
Arrest of spermatogenesis	Associate	18980759
Arthritis Rheumatoid	Stimulate	28535889
Ataxia	Associate	9077484
Barrett Esophagus	Associate	10933049
Bile Duct Neoplasms	Associate	19168589
Bone Resorption	Associate	15647817
Brain Neoplasms	Associate	16598069, 16968971, 23661361, 24460273
Breast Neoplasms	Associate	10468307, 11062177, 15217514, 15237001, 15241822, 15642161, 15856430, 18059023, 18454852, 18628428, 18842620, 19679043, 2029891, 20878621, 22292665 View all (19 more)
Breast Neoplasms	Inhibit	22901117
Bronchopulmonary Dysplasia	Associate	18824009
Carcinogenesis	Associate	17695473, 20051482, 24358191, 30010986, 36518267, 7908263
Carcinoma Basal Cell	Associate	16582078, 9077484
Carcinoma Bronchogenic	Associate	1707592
Carcinoma Hepatocellular	Associate	10408872, 10490621, 20051482, 27113703, 35692498
Carcinoma Non Small Cell Lung	Associate	19174490, 19608585, 22111840, 26782595, 27090234, 28425245
Carcinoma Renal Cell	Associate	22296350
Carcinoma Squamous Cell	Associate	10732758, 21870186, 27396354, 9231161
Cardiomegaly	Associate	28498411
Cardiomyopathies	Associate	28498411
Cerebral Infarction	Associate	33046100
Choroidal Neovascularization	Associate	33050031
Chromosome 7 monosomy	Associate	12468438
Chromosome Aberrations	Associate	12468438
Cirrhosis Familial	Associate	33978213
Colonic Neoplasms	Stimulate	24358191
Colorectal Neoplasms	Associate	17695473, 18159984, 18409146, 18768509, 20886582, 21407259, 23886179, 24939416, 26782431, 28018104, 28273931, 31201936, 31608899, 33906313, 35485310, 36148682 View all (1 more)
Colorectal Neoplasms	Inhibit	20937634
Colorectal Neoplasms Hereditary Nonpolyposis	Associate	18768509, 21407259
Communication Disorders	Associate	23411129
Coronary Artery Disease	Associate	25189712, 28415751, 28513235
Cough	Associate	18447907
Death	Associate	28425245, 35996502
Dermatitis Exfoliative	Associate	33491359
Drug Related Side Effects and Adverse Reactions	Inhibit	18824009
Drug Related Side Effects and Adverse Reactions	Associate	20171976, 24998545, 27113703, 29368655, 33938965
Endometrial Hyperplasia	Associate	16803538
Endometrial Neoplasms	Associate	14675315, 16803538, 18318428, 24957043, 9155064
Endometriosis	Associate	11730751, 12620480, 27323100, 27706624
Esophageal Neoplasms	Associate	12854128, 24377558, 25169514, 26782562, 36070107, 36881057
Esophageal Neoplasms	Stimulate	30758105
Esophageal Squamous Cell Carcinoma	Associate	12189551, 12854128, 24504680, 36070107, 36881057
Essential Hypertension	Associate	27977510, 32555714
Eye Diseases	Associate	18447907
Eye Neoplasms	Associate	18447907
Femoral Fractures	Associate	34299011
Fibroadenoma	Associate	15241822
Fibrocystic Breast Disease	Associate	22292665
Gallbladder Diseases	Associate	19168589
Gallbladder Neoplasms	Associate	18990008, 19168589, 20544687, 24535777, 24863943, 31870105
Gastrointestinal Neoplasms	Associate	38554324
Genetic Diseases Inborn	Associate	22994769
Genital Neoplasms Female	Associate	14675315
Glioma	Associate	16968971
Head and Neck Neoplasms	Inhibit	21545198
Head and Neck Neoplasms	Associate	22918668, 38099560
Healthcare Associated Pneumonia	Associate	23411129
Heart Failure	Associate	28498411
Hepatitis B Chronic	Associate	10408872
Hepatolenticular Degeneration	Associate	34117631
Hyperandrogenism	Associate	36368943
Hyperoxia	Stimulate	18824009
Hypospadias	Associate	29080015, 30858503
Hypoxia	Inhibit	20228066
Infertility	Associate	27706624
Infertility Male	Associate	18774560, 27220890, 34806654
Inflammation	Associate	30010986
Intervertebral Disc Degeneration	Associate	36817437
Ischemia	Stimulate	30649309
Keshan disease	Associate	28498411
Kidney Calculi	Associate	19168589
Kidney Neoplasms	Associate	22296350
Leukemia	Associate	17496311
Leukemia Lymphocytic Chronic B Cell	Associate	18061941, 18224491
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	18224491, 35527244
Leukemia Myeloid Acute	Associate	12468438, 17367411
Leukoplakia	Associate	23396292
Lung Injury	Associate	18824009
Lung Neoplasms	Associate	10102576, 10732758, 1362539, 17174438, 18161011, 19276377, 19479063, 19608585, 20054510, 20804547, 21882217, 22111840, 23803127, 25040976, 26782595 View all (6 more)
Lung Neoplasms	Stimulate	27090234
Lymphatic Metastasis	Associate	23870476
Lymphoma Non Hodgkin	Associate	18061941, 19899130
Lymphoma Non Hodgkin	Stimulate	19899130
Macular Degeneration	Associate	33050031
Melanoma	Associate	36533319, 37506884
Meningioma	Stimulate	33099292
Metabolic Diseases	Associate	30342560
Mouth Diseases	Associate	22660220
Mouth Neoplasms	Associate	17461521, 21545219, 22660220, 23681307, 25735346, 26919242, 30803192, 32887903, 35751315
Myelodysplastic Syndromes	Associate	17367411
Neoplasm Metastasis	Associate	27509995, 35409669
Neoplasms	Associate	11501173, 12189551, 15647817, 17548691, 18161011, 18409146, 18454852, 19168589, 20094781, 21990318, 22292665, 22660220, 22876118, 23873331, 24096584 View all (15 more)
Neoplasms	Stimulate	11953897
Neoplasms	Inhibit	22901117
Neoplasms Germ Cell and Embryonal	Associate	19627379
Neoplasms Squamous Cell	Associate	1707592, 22072123, 27396354
Neoplastic Syndromes Hereditary	Associate	30947698
Non alcoholic Fatty Liver Disease	Associate	29738693, 35062050, 37861538
Obesity	Associate	19265796
Obesity Abdominal	Associate	30348034
Oral Submucous Fibrosis	Associate	27509973
Osteoporosis	Associate	15647817, 28300467, 34299011
Ovarian Neoplasms	Associate	14675315, 22395499
Papillomavirus Infections	Associate	25281494
Periodontitis	Associate	33491359
Pituitary Neoplasms	Associate	30321868
Pneumonia	Associate	28403117
Polycystic Ovary Syndrome	Associate	30348034
Precancerous Conditions	Associate	10408872, 1362539, 19376845, 19608585, 24358191, 31870105, 37499768, 9439147
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	10029576
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	37642051
Premature Birth	Associate	18320229
Prostatic Neoplasms	Associate	16625286, 17192049, 19022961, 22549291, 23381648, 29165164, 31870130, 31929142
Pterygium	Associate	20596254, 20700368, 22876118
Pulmonary Disease Chronic Obstructive	Associate	24841653, 34820703, 36475041
Rectal Neoplasms	Associate	28273931
Respiratory Distress Syndrome	Associate	27220890
Respiratory Sounds	Associate	18447907
Retinal Dysplasia	Associate	21897271
Small Cell Lung Carcinoma	Associate	20804547
Smoke Inhalation Injury	Associate	15217514, 18320229, 19537956, 20886582, 26782595, 27754415
Squamous Cell Carcinoma of Head and Neck	Associate	17461521, 21870186, 22660220
Stomach Neoplasms	Associate	15929164, 16270381, 17646057, 30266078
Stroke	Associate	33046100
Stroke Lacunar	Associate	33046100
Thrombophilia	Associate	15237001
Thyroid Cancer Papillary	Associate	18601742
Thyroid Neoplasms	Associate	18601742, 27509995
Thyroid Nodule	Associate	21086258
Urinary Bladder Neoplasms	Inhibit	21990318
Urinary Bladder Neoplasms	Associate	23886208, 28348449
Urinary Bladder Neoplasms	Stimulate	24358191
Uterine Cervical Dysplasia	Associate	21897271
Uterine Cervical Neoplasms	Associate	21897271, 24626963, 25281494, 26782546, 26798414, 27265845, 31983191, 34784845, 35996502, 38376298

CYP1A1 (cytochrome P450 family 1 subfamily A member 1)