NKAIN2 (sodium/potassium transporting ATPase interacting 2)

Gene

• Entrez ID: 154215
• Gene name: Sodium/potassium transporting ATPase interacting 2
• Gene symbol: NKAIN2
• Synonyms (NCBI Gene): FAM77B, NKAIP2, TCBA, TCBA1
• Chromosome: 6
• Chromosome location: 6q22.31
• Summary: This gene encodes a transmembrane protein that interacts with the beta subunit of a sodium/potassium-transporting ATPase. A chromosomal translocation involving this gene is a cause of lymphoma. Alternative splicing results in multiple transcript variants

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017569	hsa-miR-335-5p	Microarray	18185580
MIRT1186022	hsa-miR-1224-3p	CLIP-seq
MIRT1186023	hsa-miR-1260	CLIP-seq
MIRT1186024	hsa-miR-1260b	CLIP-seq
MIRT1186025	hsa-miR-1280	CLIP-seq
MIRT1186026	hsa-miR-3171	CLIP-seq
MIRT1186027	hsa-miR-3907	CLIP-seq
MIRT1186028	hsa-miR-4802-5p	CLIP-seq
MIRT1186029	hsa-miR-626	CLIP-seq
MIRT1186030	hsa-miR-1244	CLIP-seq
MIRT1186031	hsa-miR-297	CLIP-seq
MIRT1186032	hsa-miR-3064-3p	CLIP-seq
MIRT1186033	hsa-miR-3674	CLIP-seq
MIRT1186034	hsa-miR-369-3p	CLIP-seq
MIRT1186035	hsa-miR-374c	CLIP-seq
MIRT1186036	hsa-miR-3924	CLIP-seq
MIRT1186037	hsa-miR-3935	CLIP-seq
MIRT1186038	hsa-miR-4328	CLIP-seq
MIRT1186039	hsa-miR-4666-5p	CLIP-seq
MIRT1186040	hsa-miR-4727-5p	CLIP-seq
MIRT1186041	hsa-miR-4769-3p	CLIP-seq
MIRT1186042	hsa-miR-544	CLIP-seq
MIRT1186043	hsa-miR-567	CLIP-seq
MIRT1186044	hsa-miR-606	CLIP-seq
MIRT1186045	hsa-miR-655	CLIP-seq
MIRT2283105	hsa-miR-140-3p	CLIP-seq
MIRT2283106	hsa-miR-3117-3p	CLIP-seq
MIRT2283107	hsa-miR-3156-5p	CLIP-seq
MIRT2283108	hsa-miR-3169	CLIP-seq
MIRT2283109	hsa-miR-4695-3p	CLIP-seq
MIRT2283110	hsa-miR-4759	CLIP-seq
MIRT2283111	hsa-miR-651	CLIP-seq
MIRT2283112	hsa-miR-888	CLIP-seq
MIRT2283106	hsa-miR-3117-3p	CLIP-seq
MIRT2283108	hsa-miR-3169	CLIP-seq
MIRT2283110	hsa-miR-4759	CLIP-seq
MIRT2283111	hsa-miR-651	CLIP-seq
MIRT2581362	hsa-miR-145	CLIP-seq
MIRT2581363	hsa-miR-2115	CLIP-seq
MIRT2581364	hsa-miR-3160-5p	CLIP-seq
MIRT2581365	hsa-miR-4712-5p	CLIP-seq
MIRT2581366	hsa-miR-516a-3p	CLIP-seq
MIRT1186042	hsa-miR-544	CLIP-seq
MIRT2581367	hsa-miR-770-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002028	Process	Regulation of sodium ion transport	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0016020	Component	Membrane	IEA

Other IDs

• MIM: 609758
• HGNC: 16443
• e!Ensembl: ENSG00000188580

Protein

• UniProt ID: Q5VXU1
• Protein name: Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2 (Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 2) (Protein FAM77B) (T-cell lymphoma breakpoint-associated target protein 1)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05640	NKAIN	1 → 207	Na,K-Atpase Interacting protein	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in fetal brain. Weakly expressed in adult brain and thymus. Not expressed in any other normal tissue examined. {ECO:0000269|PubMed:11979551}.
• Sequence:

  MGYCSGRCTLIFICGMQLVCVLERQIFDFLGYQWAPILANFVHIIIVILGLFGTIQYRPR
  YITGYAVWLVLWVTWNVFVICFYLEAGDLSKETDLILTFNISMHRSWWMENGPGCTVTSV
  TPAPDWAPEDHRYITVSGCLLEYQYIEVAHSSLQIVLALAGFIYACYVVKCITEEEDSFD
  FIGGFDSYGYQGPQKTSHLQLQPMYMSK

• Sequence length: 208

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Associated diseases

Unknown
Disease merge term	Disease name	Evidence	References	Source
Biliary Atresia	Biliary atresia	N/A	N/A	GWAS
Celiac disease	Celiac disease	N/A	N/A	GWAS
Insomnia	Insomnia	N/A	N/A	GWAS
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS
Neuroticism	Neuroticism	N/A	N/A	GWAS
Oligodendroglioma	Oligodendroglioma	N/A	N/A	GWAS
Schizophrenia	Schizophrenia	N/A	N/A	GWAS
Tremor	Essential tremor	N/A	N/A	GWAS
Uterine Fibroids	Uterine fibroids	N/A	N/A	GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Neoplasms	Inhibit	27588475
Neuroblastoma	Associate	24205241
Pancreatic Neoplasms	Associate	28381166
Prostatic Neoplasms	Inhibit	27588475
Schizophrenia	Associate	34099189