Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
154141
Gene name Gene Name - the full gene name approved by the HGNC.
Membrane bound glycerophospholipid O-acyltransferase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MBOAT1
Synonyms (NCBI Gene) Gene synonyms aliases
LPEAT1, LPLAT, LPLAT 1, LPLAT14, LPSAT, OACT1, dJ434O11.1
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6p22.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene belongs to the membrane-bound O-acetyltransferase superfamily. The encoded transmembrane protein is an enzyme that transfers organic compounds, preferably from oleoyl-CoA, to hydroxyl groups of protein targets in membranes. A translocation disru
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT636843 hsa-miR-6850-3p HITS-CLIP 23313552
MIRT636842 hsa-miR-6499-5p HITS-CLIP 23313552
MIRT636841 hsa-miR-4284 HITS-CLIP 23313552
MIRT636840 hsa-miR-24-3p HITS-CLIP 23313552
MIRT636839 hsa-miR-3178 HITS-CLIP 23313552
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003841 Function 1-acylglycerol-3-phosphate O-acyltransferase activity TAS
GO:0005783 Component Endoplasmic reticulum IEA
GO:0005789 Component Endoplasmic reticulum membrane IEA
GO:0005789 Component Endoplasmic reticulum membrane ISS
GO:0005789 Component Endoplasmic reticulum membrane TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
611732 21579 ENSG00000172197
Protein
UniProt ID Q6ZNC8
Protein name Membrane-bound glycerophospholipid O-acyltransferase 1 (EC 2.3.1.-) (1-acylglycerophosphocholine O-acyltransferase) (EC 2.3.1.23) (1-acylglycerophosphoethanolamine O-acyltransferase) (EC 2.3.1.n7) (1-acylglycerophosphoserine O-acyltransferase) (EC 2.3.1.n
Protein function Acyltransferase which catalyzes the transfer of an acyl group from an acyl-CoA towards a lysophospholipid producing a phospholipid and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (Pub
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03062 MBOAT 33 439 MBOAT, membrane-bound O-acyltransferase family Family
Tissue specificity TISSUE SPECIFICITY: Expressed in neutrophils. {ECO:0000269|PubMed:18772128}.
Sequence
Sequence length 495
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Glycerolipid metabolism
Glycerophospholipid metabolism
Metabolic pathways
  Acyl chain remodelling of PS
Acyl chain remodelling of PE
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Diabetes Type 2 diabetes N/A N/A GWAS
Myocardial Infarction Myocardial infarction N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Alzheimer Disease Associate 32699331