Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
154043
Gene name Gene Name - the full gene name approved by the HGNC.
CNKSR family member 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CNKSR3
Synonyms (NCBI Gene) Gene synonyms aliases
CNK3, CNK3/IPCEF1, MAGI1
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6q25.2
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT022563 hsa-miR-124-3p Microarray 18668037
MIRT704529 hsa-miR-3169 HITS-CLIP 23313552
MIRT704528 hsa-miR-518c-5p HITS-CLIP 23313552
MIRT704527 hsa-miR-6764-3p HITS-CLIP 23313552
MIRT704526 hsa-miR-6824-3p HITS-CLIP 23313552
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 22085542, 25416956, 32296183
GO:0005737 Component Cytoplasm IEA
GO:0010765 Process Positive regulation of sodium ion transport ISS
GO:0016324 Component Apical plasma membrane IEA
GO:0033137 Process Negative regulation of peptidyl-serine phosphorylation ISS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
617476 23034 ENSG00000153721
Protein
UniProt ID Q6P9H4
Protein name Connector enhancer of kinase suppressor of ras 3 (Connector enhancer of KSR 3) (CNK homolog protein 3) (CNK3) (CNKSR family member 3) (Maguin-like protein)
Protein function Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly o
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00536 SAM_1 5 69 SAM domain (Sterile alpha motif) Domain
PF10534 CRIC_ras_sig 80 172 Connector enhancer of kinase suppressor of ras Domain
PF00595 PDZ 211 290 PDZ domain Domain
PF06663 DUF1170 332 545 Protein of unknown function (DUF1170) Family
Sequence
Sequence length 555
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Parkinson disease Parkinson Disease rs33939927, rs35801418, rs34805604, rs35870237, rs34995376, rs74315355, rs28940284, rs74315356, rs74315357, rs28940285, rs730880302, rs750664040, rs74315359, rs74315360, rs45539432
View all (84 more)
22451204
Associations from Text Mining
Disease Name Relationship Type References
Diabetes Mellitus Type 2 Associate 28401168
Diabetic Nephropathies Associate 28401168
Diabetic Retinopathy Associate 28401168
Duane Retraction Syndrome Associate 28401168
Monosomy Associate 23357503
Uveal melanoma Associate 23357503