ADRB2 (adrenoceptor beta 2)

Gene
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
154
Gene name Gene Name - the full gene name approved by the HGNC.
Adrenoceptor beta 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ADRB2
Synonyms (NCBI Gene) Gene synonyms aliases
ADRB2R, ADRBR, ARB2, B2AR, BAR, BETA2AR
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q32
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel compl
SNPs SNP information provided by dbSNP.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(2)
SNP ID Visualize variation Clinical significance Consequence
rs1042713 G>A,C Risk-factor, benign, drug-response Coding sequence variant, missense variant
rs1800888 C>T Drug-response Coding sequence variant, missense variant
miRNA miRNA information provided by mirtarbase database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(25)
miRTarBase ID miRNA Experiments Reference
MIRT734423 hsa-miR-16-5p Luciferase reporter assay, qRT-PCR, Western blotting 33920233
MIRT1921855 hsa-miR-127-5p CLIP-seq
MIRT1921856 hsa-miR-4268 CLIP-seq
MIRT1921857 hsa-miR-4448 CLIP-seq
MIRT1921858 hsa-miR-4762-5p CLIP-seq
Transcription factors
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
Transcription factor Regulation Reference
EZH2 Repression 17996646
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(83)
GO ID Ontology Definition Evidence Reference
GO:0001540 Function Amyloid-beta binding IDA 20395454
GO:0001993 Process Regulation of systemic arterial blood pressure by norepinephrine-epinephrine IEA
GO:0002024 Process Diet induced thermogenesis IEA
GO:0002025 Process Norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IBA
GO:0002025 Process Norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
109690 286 ENSG00000169252
Protein
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P07550
Protein name Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor)
Protein function Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepineph
PDB 1GQ4 , 2R4R , 2R4S , 2RH1 , 3D4S , 3KJ6 , 3NY8 , 3NY9 , 3NYA , 3P0G , 3PDS , 3SN6 , 4GBR , 4LDE , 4LDL , 4LDO , 4QKX , 5D5A , 5D5B , 5D6L , 5JQH , 5X7D , 6E67 , 6KR8 , 6MXT , 6N48 , 6NI3 , 6OBA , 6PRZ , 6PS0 , 6PS1 , 6PS2 , 6PS3 , 6PS4 , 6PS5 , 6PS6 , 7BZ2 , 7DHI , 7DHR , 7XK9 , 7XKA , 8GDZ , 8GE1 , 8GE2 , 8GE3 , 8GE4 , 8GE5 , 8GE6 , 8GE7 , 8GE8 , 8GE9
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 50 → 326 7 transmembrane receptor (rhodopsin family) Family
Sequence
Sequence length 413
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Hormone signaling
Adrenergic signaling in cardiomyocytes
Regulation of lipolysis in adipocytes
Renin secretion
Salivary secretion
Chemical carcinogenesis - receptor activation 		  Adrenoceptors
G alpha (s) signalling events
Ub-specific processing proteases
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
ADORA2B mediated anti-inflammatory cytokines production
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (6)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Colorectal Cancer Metastasis in stage I-III microsatellite instability low/stable colorectal cancer (time to event) N/A N/A GWAS
Insomnia Insomnia N/A N/A GWAS
Metabolic Syndrome Metabolic syndrome N/A N/A GWAS
Pancreatitis Acute pancreatitis N/A N/A GWAS
Show/Hide Text Mining Associations (213)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Abdominal Pain Associate 33546600
Acute Coronary Syndrome Associate 28235084
Acute Disease Associate 18159608
Adenocarcinoma of Lung Associate 23111975, 33979320, 35571564, 35812244, 35833114
Adenocarcinoma of Lung Inhibit 36163241
Adenomyosis Associate 33602248
Airway Obstruction Associate 19293197
Alcohol Related Disorders Associate 21488193
Anemia Sickle Cell Associate 18324973
Anxiety Associate 37142998