IRX2 (iroquois homeobox 2)

Gene

• Entrez ID: 153572
• Gene name: Iroquois homeobox 2
• Gene symbol: IRX2
• Synonyms (NCBI Gene): IRXA2
• Chromosome: 5
• Chromosome location: 5p15.33
• Summary: IRX2 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.[supplied by OMIM, Apr 2004]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017070	hsa-miR-335-5p	Microarray	18185580
MIRT635297	hsa-miR-330-3p	HITS-CLIP	23824327
MIRT635296	hsa-miR-4504	HITS-CLIP	23824327
MIRT635295	hsa-miR-542-3p	HITS-CLIP	23824327
MIRT635294	hsa-miR-6808-3p	HITS-CLIP	23824327
MIRT635293	hsa-miR-607	HITS-CLIP	23824327
MIRT635292	hsa-miR-758-3p	HITS-CLIP	23824327
MIRT635291	hsa-miR-1305	HITS-CLIP	23824327
MIRT635290	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT635291	hsa-miR-1305	HITS-CLIP	27418678
MIRT635291	hsa-miR-1305	HITS-CLIP	27418678
MIRT635291	hsa-miR-1305	HITS-CLIP	27418678
MIRT635297	hsa-miR-330-3p	HITS-CLIP	27418678
MIRT635297	hsa-miR-330-3p	HITS-CLIP	27418678
MIRT635297	hsa-miR-330-3p	HITS-CLIP	27418678
MIRT635290	hsa-miR-335-3p	HITS-CLIP	27418678
MIRT635290	hsa-miR-335-3p	HITS-CLIP	27418678
MIRT635290	hsa-miR-335-3p	HITS-CLIP	27418678
MIRT635293	hsa-miR-607	HITS-CLIP	27418678
MIRT635293	hsa-miR-607	HITS-CLIP	27418678
MIRT635293	hsa-miR-607	HITS-CLIP	27418678
MIRT635297	hsa-miR-330-3p	HITS-CLIP	23824327
MIRT635296	hsa-miR-4504	HITS-CLIP	23824327
MIRT635295	hsa-miR-542-3p	HITS-CLIP	23824327
MIRT635294	hsa-miR-6808-3p	HITS-CLIP	23824327
MIRT635293	hsa-miR-607	HITS-CLIP	23824327
MIRT635292	hsa-miR-758-3p	HITS-CLIP	23824327
MIRT635291	hsa-miR-1305	HITS-CLIP	23824327
MIRT635290	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT1072259	hsa-miR-101	CLIP-seq
MIRT1072260	hsa-miR-1200	CLIP-seq
MIRT1072261	hsa-miR-1228	CLIP-seq
MIRT1072262	hsa-miR-1245	CLIP-seq
MIRT1072263	hsa-miR-1290	CLIP-seq
MIRT1072264	hsa-miR-144	CLIP-seq
MIRT1072265	hsa-miR-153	CLIP-seq
MIRT1072266	hsa-miR-224	CLIP-seq
MIRT1072267	hsa-miR-28-3p	CLIP-seq
MIRT1072268	hsa-miR-3065-5p	CLIP-seq
MIRT1072269	hsa-miR-3074-3p	CLIP-seq
MIRT1072270	hsa-miR-3163	CLIP-seq
MIRT1072271	hsa-miR-3167	CLIP-seq
MIRT1072272	hsa-miR-3177-5p	CLIP-seq
MIRT1072273	hsa-miR-340	CLIP-seq
MIRT1072274	hsa-miR-3616-5p	CLIP-seq
MIRT1072275	hsa-miR-3647-5p	CLIP-seq
MIRT1072276	hsa-miR-3658	CLIP-seq
MIRT1072277	hsa-miR-3674	CLIP-seq
MIRT1072278	hsa-miR-3688-5p	CLIP-seq
MIRT1072279	hsa-miR-377	CLIP-seq
MIRT1072280	hsa-miR-3908	CLIP-seq
MIRT1072281	hsa-miR-4251	CLIP-seq
MIRT1072282	hsa-miR-4318	CLIP-seq
MIRT1072283	hsa-miR-4324	CLIP-seq
MIRT1072284	hsa-miR-4445	CLIP-seq
MIRT1072285	hsa-miR-448	CLIP-seq
MIRT1072286	hsa-miR-4514	CLIP-seq
MIRT1072287	hsa-miR-4527	CLIP-seq
MIRT1072288	hsa-miR-4528	CLIP-seq
MIRT1072289	hsa-miR-4645-5p	CLIP-seq
MIRT1072290	hsa-miR-4673	CLIP-seq
MIRT1072291	hsa-miR-4692	CLIP-seq
MIRT1072292	hsa-miR-4693-5p	CLIP-seq
MIRT1072293	hsa-miR-4699-3p	CLIP-seq
MIRT1072294	hsa-miR-4760-5p	CLIP-seq
MIRT1072295	hsa-miR-4782-5p	CLIP-seq
MIRT1072296	hsa-miR-4789-3p	CLIP-seq
MIRT1072297	hsa-miR-4795-5p	CLIP-seq
MIRT1072298	hsa-miR-508-3p	CLIP-seq
MIRT1072299	hsa-miR-520d-5p	CLIP-seq
MIRT1072300	hsa-miR-524-5p	CLIP-seq
MIRT1072301	hsa-miR-539	CLIP-seq
MIRT1072302	hsa-miR-542-5p	CLIP-seq
MIRT1072303	hsa-miR-544b	CLIP-seq
MIRT1072304	hsa-miR-548aa	CLIP-seq
MIRT1072305	hsa-miR-548ac	CLIP-seq
MIRT1072306	hsa-miR-548ae	CLIP-seq
MIRT1072307	hsa-miR-548aj	CLIP-seq
MIRT1072308	hsa-miR-548am	CLIP-seq
MIRT1072309	hsa-miR-548c-3p	CLIP-seq
MIRT1072310	hsa-miR-548d-3p	CLIP-seq
MIRT1072311	hsa-miR-548x	CLIP-seq
MIRT1072312	hsa-miR-548z	CLIP-seq
MIRT1072313	hsa-miR-561	CLIP-seq
MIRT1072314	hsa-miR-568	CLIP-seq
MIRT1072315	hsa-miR-573	CLIP-seq
MIRT1072316	hsa-miR-576-3p	CLIP-seq
MIRT1072317	hsa-miR-582-5p	CLIP-seq
MIRT1072318	hsa-miR-605	CLIP-seq
MIRT1072319	hsa-miR-634	CLIP-seq
MIRT1072320	hsa-miR-876-5p	CLIP-seq
MIRT1072321	hsa-miR-888	CLIP-seq
MIRT1072322	hsa-miR-892a	CLIP-seq
MIRT1072265	hsa-miR-153	CLIP-seq
MIRT1072266	hsa-miR-224	CLIP-seq
MIRT2017850	hsa-miR-23a	CLIP-seq
MIRT2017851	hsa-miR-23b	CLIP-seq
MIRT2017852	hsa-miR-23c	CLIP-seq
MIRT1072267	hsa-miR-28-3p	CLIP-seq
MIRT1072268	hsa-miR-3065-5p	CLIP-seq
MIRT2017853	hsa-miR-3607-3p	CLIP-seq
MIRT2017854	hsa-miR-3692	CLIP-seq
MIRT1072279	hsa-miR-377	CLIP-seq
MIRT2017855	hsa-miR-4436b-5p	CLIP-seq
MIRT1072284	hsa-miR-4445	CLIP-seq
MIRT1072285	hsa-miR-448	CLIP-seq
MIRT1072293	hsa-miR-4699-3p	CLIP-seq
MIRT1072294	hsa-miR-4760-5p	CLIP-seq
MIRT1072296	hsa-miR-4789-3p	CLIP-seq
MIRT2017856	hsa-miR-513a-3p	CLIP-seq
MIRT1072302	hsa-miR-542-5p	CLIP-seq
MIRT1072313	hsa-miR-561	CLIP-seq
MIRT1072321	hsa-miR-888	CLIP-seq
MIRT1072259	hsa-miR-101	CLIP-seq
MIRT1072260	hsa-miR-1200	CLIP-seq
MIRT1072261	hsa-miR-1228	CLIP-seq
MIRT1072262	hsa-miR-1245	CLIP-seq
MIRT1072263	hsa-miR-1290	CLIP-seq
MIRT1072264	hsa-miR-144	CLIP-seq
MIRT1072266	hsa-miR-224	CLIP-seq
MIRT2017850	hsa-miR-23a	CLIP-seq
MIRT2017851	hsa-miR-23b	CLIP-seq
MIRT2017852	hsa-miR-23c	CLIP-seq
MIRT1072267	hsa-miR-28-3p	CLIP-seq
MIRT1072268	hsa-miR-3065-5p	CLIP-seq
MIRT1072269	hsa-miR-3074-3p	CLIP-seq
MIRT1072271	hsa-miR-3167	CLIP-seq
MIRT1072272	hsa-miR-3177-5p	CLIP-seq
MIRT2249657	hsa-miR-3613-5p	CLIP-seq
MIRT1072274	hsa-miR-3616-5p	CLIP-seq
MIRT1072275	hsa-miR-3647-5p	CLIP-seq
MIRT1072278	hsa-miR-3688-5p	CLIP-seq
MIRT2017854	hsa-miR-3692	CLIP-seq
MIRT1072279	hsa-miR-377	CLIP-seq
MIRT1072281	hsa-miR-4251	CLIP-seq
MIRT1072282	hsa-miR-4318	CLIP-seq
MIRT1072283	hsa-miR-4324	CLIP-seq
MIRT2017855	hsa-miR-4436b-5p	CLIP-seq
MIRT1072284	hsa-miR-4445	CLIP-seq
MIRT1072287	hsa-miR-4527	CLIP-seq
MIRT1072288	hsa-miR-4528	CLIP-seq
MIRT1072292	hsa-miR-4693-5p	CLIP-seq
MIRT1072293	hsa-miR-4699-3p	CLIP-seq
MIRT1072294	hsa-miR-4760-5p	CLIP-seq
MIRT1072295	hsa-miR-4782-5p	CLIP-seq
MIRT1072296	hsa-miR-4789-3p	CLIP-seq
MIRT1072297	hsa-miR-4795-5p	CLIP-seq
MIRT1072299	hsa-miR-520d-5p	CLIP-seq
MIRT1072300	hsa-miR-524-5p	CLIP-seq
MIRT1072301	hsa-miR-539	CLIP-seq
MIRT1072302	hsa-miR-542-5p	CLIP-seq
MIRT1072303	hsa-miR-544b	CLIP-seq
MIRT1072313	hsa-miR-561	CLIP-seq
MIRT1072315	hsa-miR-573	CLIP-seq
MIRT1072316	hsa-miR-576-3p	CLIP-seq
MIRT1072317	hsa-miR-582-5p	CLIP-seq
MIRT1072318	hsa-miR-605	CLIP-seq
MIRT1072320	hsa-miR-876-5p	CLIP-seq
MIRT1072321	hsa-miR-888	CLIP-seq
MIRT1072322	hsa-miR-892a	CLIP-seq
MIRT2553125	hsa-miR-1237	CLIP-seq
MIRT2553126	hsa-miR-1248	CLIP-seq
MIRT2553127	hsa-miR-147	CLIP-seq
MIRT2553128	hsa-miR-3691-5p	CLIP-seq
MIRT2553129	hsa-miR-3911	CLIP-seq
MIRT2553130	hsa-miR-4645-3p	CLIP-seq
MIRT2553131	hsa-miR-4752	CLIP-seq
MIRT2553132	hsa-miR-4753-3p	CLIP-seq
MIRT2553133	hsa-miR-512-3p	CLIP-seq
MIRT1072316	hsa-miR-576-3p	CLIP-seq
MIRT1072317	hsa-miR-582-5p	CLIP-seq
MIRT2553134	hsa-miR-644	CLIP-seq
MIRT2553135	hsa-miR-942	CLIP-seq
MIRT2553125	hsa-miR-1237	CLIP-seq
MIRT2553126	hsa-miR-1248	CLIP-seq
MIRT1072263	hsa-miR-1290	CLIP-seq
MIRT2553127	hsa-miR-147	CLIP-seq
MIRT1072271	hsa-miR-3167	CLIP-seq
MIRT2017853	hsa-miR-3607-3p	CLIP-seq
MIRT2249657	hsa-miR-3613-5p	CLIP-seq
MIRT2682916	hsa-miR-3686	CLIP-seq
MIRT2553128	hsa-miR-3691-5p	CLIP-seq
MIRT2553129	hsa-miR-3911	CLIP-seq
MIRT1072287	hsa-miR-4527	CLIP-seq
MIRT2553130	hsa-miR-4645-3p	CLIP-seq
MIRT2553131	hsa-miR-4752	CLIP-seq
MIRT2553132	hsa-miR-4753-3p	CLIP-seq
MIRT1072295	hsa-miR-4782-5p	CLIP-seq
MIRT2553133	hsa-miR-512-3p	CLIP-seq
MIRT2017856	hsa-miR-513a-3p	CLIP-seq
MIRT2682917	hsa-miR-556-5p	CLIP-seq
MIRT1072316	hsa-miR-576-3p	CLIP-seq
MIRT1072317	hsa-miR-582-5p	CLIP-seq
MIRT2553134	hsa-miR-644	CLIP-seq
MIRT1072320	hsa-miR-876-5p	CLIP-seq
MIRT2553135	hsa-miR-942	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	26560478
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	26560478
GO:0001656	Process	Metanephros development	IEA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0030182	Process	Neuron differentiation	IBA
GO:0043565	Function	Sequence-specific DNA binding	IDA	23332764
GO:0048468	Process	Cell development	IBA
GO:0072086	Process	Specification of loop of Henle identity	IEA
GO:0072272	Process	Proximal/distal pattern formation involved in metanephric nephron development	IEA

Other IDs

• MIM: 606198
• HGNC: 14359
• e!Ensembl: ENSG00000170561

Protein

• UniProt ID: Q9BZI1
• Protein name: Iroquois-class homeodomain protein IRX-2 (Homeodomain protein IRXA2) (Iroquois homeobox protein 2)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05920	Homeobox_KN	132 → 171	Homeobox KN domain	Family

• Sequence:

  MSYPQGYLYQAPGSLALYSCPAYGASALAAPRSEELARSASGSAFSPYPGSAAFTAQAAT
  GFGSPLQYSADAAAAAAGFPSYMGAPYDAHTTGMTGAISYHPYGSAAYPYQLNDPAYRKN
  ATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTW
  APRNKSEDEDEDEGDATRSKDESPDKAQEGTETSAEDEGISLHVDSLTDHSCSAESDGEK
  LPCRAGDPLCESGSECKDKYDDLEDDEDDDEEGERGLAPPKPVTSSPLTGLEAPLLSPPP
  EAAPRGGRKTPQGSRTSPGAPPPASKPKLWSLAEIATSDLKQPSLGPGCGPPGLPAAAAP
  ASTGAPPGGSPYPASPLLGRPLYYTSPFYGNYTNYGNLNAALQGQGLLRYNSAAAAPGEA
  LHTAPKAASDAGKAGAHPLESHYRSPGGGYEPKKDASEGCTVVGGGVQPYL

• Sequence length: 471