ZMAT2 (zinc finger matrin-type 2)

Gene

• Entrez ID: 153527
• Gene name: Zinc finger matrin-type 2
• Gene symbol: ZMAT2
• Synonyms (NCBI Gene): Ptg-12, Snu23
• Chromosome: 5
• Chromosome location: 5q31.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT045065	hsa-miR-186-5p	CLASH	23622248
MIRT630918	hsa-miR-6895-5p	HITS-CLIP	23824327
MIRT630917	hsa-miR-764	HITS-CLIP	23824327
MIRT630916	hsa-miR-5693	HITS-CLIP	23824327
MIRT630915	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT630914	hsa-miR-4284	HITS-CLIP	23824327
MIRT630913	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT630912	hsa-miR-4640-5p	HITS-CLIP	23824327
MIRT630911	hsa-miR-4726-5p	HITS-CLIP	23824327
MIRT630910	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT630909	hsa-miR-7977	HITS-CLIP	23824327
MIRT630918	hsa-miR-6895-5p	HITS-CLIP	23824327
MIRT630917	hsa-miR-764	HITS-CLIP	23824327
MIRT630916	hsa-miR-5693	HITS-CLIP	23824327
MIRT630915	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT630914	hsa-miR-4284	HITS-CLIP	23824327
MIRT630913	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT630912	hsa-miR-4640-5p	HITS-CLIP	23824327
MIRT630911	hsa-miR-4726-5p	HITS-CLIP	23824327
MIRT630910	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT630909	hsa-miR-7977	HITS-CLIP	23824327
MIRT630918	hsa-miR-6895-5p	HITS-CLIP	23824327
MIRT630917	hsa-miR-764	HITS-CLIP	23824327
MIRT630916	hsa-miR-5693	HITS-CLIP	23824327
MIRT630915	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT630914	hsa-miR-4284	HITS-CLIP	23824327
MIRT630913	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT630912	hsa-miR-4640-5p	HITS-CLIP	23824327
MIRT630911	hsa-miR-4726-5p	HITS-CLIP	23824327
MIRT630910	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT630909	hsa-miR-7977	HITS-CLIP	23824327
MIRT630918	hsa-miR-6895-5p	HITS-CLIP	23824327
MIRT630917	hsa-miR-764	HITS-CLIP	23824327
MIRT630916	hsa-miR-5693	HITS-CLIP	23824327
MIRT630915	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT630914	hsa-miR-4284	HITS-CLIP	23824327
MIRT630913	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT630912	hsa-miR-4640-5p	HITS-CLIP	23824327
MIRT630911	hsa-miR-4726-5p	HITS-CLIP	23824327
MIRT630910	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT630909	hsa-miR-7977	HITS-CLIP	23824327
MIRT1514089	hsa-miR-1207-5p	CLIP-seq
MIRT1514090	hsa-miR-125a-3p	CLIP-seq
MIRT1514091	hsa-miR-1267	CLIP-seq
MIRT1514092	hsa-miR-1286	CLIP-seq
MIRT1514093	hsa-miR-1290	CLIP-seq
MIRT1514094	hsa-miR-1292	CLIP-seq
MIRT1514095	hsa-miR-129-5p	CLIP-seq
MIRT1514096	hsa-miR-134	CLIP-seq
MIRT1514097	hsa-miR-1825	CLIP-seq
MIRT1514098	hsa-miR-1914	CLIP-seq
MIRT1514099	hsa-miR-1972	CLIP-seq
MIRT1514100	hsa-miR-199a-5p	CLIP-seq
MIRT1514101	hsa-miR-199b-5p	CLIP-seq
MIRT1514102	hsa-miR-2052	CLIP-seq
MIRT1514103	hsa-miR-2110	CLIP-seq
MIRT1514104	hsa-miR-3118	CLIP-seq
MIRT1514105	hsa-miR-3123	CLIP-seq
MIRT1514106	hsa-miR-3150a-3p	CLIP-seq
MIRT1514107	hsa-miR-3164	CLIP-seq
MIRT1514108	hsa-miR-3182	CLIP-seq
MIRT1514109	hsa-miR-329	CLIP-seq
MIRT1514110	hsa-miR-338-3p	CLIP-seq
MIRT1514111	hsa-miR-362-3p	CLIP-seq
MIRT1514112	hsa-miR-3649	CLIP-seq
MIRT1514113	hsa-miR-3667-5p	CLIP-seq
MIRT1514114	hsa-miR-3925-3p	CLIP-seq
MIRT1514115	hsa-miR-3925-5p	CLIP-seq
MIRT1514116	hsa-miR-3926	CLIP-seq
MIRT1514117	hsa-miR-3934	CLIP-seq
MIRT1514118	hsa-miR-3941	CLIP-seq
MIRT1514119	hsa-miR-4260	CLIP-seq
MIRT1514120	hsa-miR-4263	CLIP-seq
MIRT1514121	hsa-miR-4450	CLIP-seq
MIRT1514122	hsa-miR-4471	CLIP-seq
MIRT1514123	hsa-miR-450b-5p	CLIP-seq
MIRT1514124	hsa-miR-4530	CLIP-seq
MIRT1514125	hsa-miR-4640-3p	CLIP-seq
MIRT1514126	hsa-miR-4650-5p	CLIP-seq
MIRT1514127	hsa-miR-4652-3p	CLIP-seq
MIRT1514128	hsa-miR-4654	CLIP-seq
MIRT1514129	hsa-miR-4684-3p	CLIP-seq
MIRT1514130	hsa-miR-4711-5p	CLIP-seq
MIRT1514131	hsa-miR-4717-5p	CLIP-seq
MIRT1514132	hsa-miR-4722-5p	CLIP-seq
MIRT1514133	hsa-miR-4763-3p	CLIP-seq
MIRT1514134	hsa-miR-4769-5p	CLIP-seq
MIRT1514135	hsa-miR-507	CLIP-seq
MIRT1514136	hsa-miR-508-5p	CLIP-seq
MIRT1514137	hsa-miR-510	CLIP-seq
MIRT1514138	hsa-miR-541	CLIP-seq
MIRT1514139	hsa-miR-548m	CLIP-seq
MIRT1514140	hsa-miR-557	CLIP-seq
MIRT1514141	hsa-miR-579	CLIP-seq
MIRT1514142	hsa-miR-603	CLIP-seq
MIRT1514143	hsa-miR-654-5p	CLIP-seq
MIRT1514089	hsa-miR-1207-5p	CLIP-seq
MIRT1514091	hsa-miR-1267	CLIP-seq
MIRT1514092	hsa-miR-1286	CLIP-seq
MIRT1514095	hsa-miR-129-5p	CLIP-seq
MIRT2155062	hsa-miR-1324	CLIP-seq
MIRT1514096	hsa-miR-134	CLIP-seq
MIRT1514097	hsa-miR-1825	CLIP-seq
MIRT1514098	hsa-miR-1914	CLIP-seq
MIRT1514100	hsa-miR-199a-5p	CLIP-seq
MIRT1514101	hsa-miR-199b-5p	CLIP-seq
MIRT1514102	hsa-miR-2052	CLIP-seq
MIRT1514104	hsa-miR-3118	CLIP-seq
MIRT1514105	hsa-miR-3123	CLIP-seq
MIRT1514107	hsa-miR-3164	CLIP-seq
MIRT1514108	hsa-miR-3182	CLIP-seq
MIRT1514112	hsa-miR-3649	CLIP-seq
MIRT1514113	hsa-miR-3667-5p	CLIP-seq
MIRT1514114	hsa-miR-3925-3p	CLIP-seq
MIRT1514115	hsa-miR-3925-5p	CLIP-seq
MIRT1514120	hsa-miR-4263	CLIP-seq
MIRT1514123	hsa-miR-450b-5p	CLIP-seq
MIRT2155063	hsa-miR-4649-3p	CLIP-seq
MIRT1514127	hsa-miR-4652-3p	CLIP-seq
MIRT1514128	hsa-miR-4654	CLIP-seq
MIRT2155064	hsa-miR-4666-5p	CLIP-seq
MIRT1514129	hsa-miR-4684-3p	CLIP-seq
MIRT1514132	hsa-miR-4722-5p	CLIP-seq
MIRT1514133	hsa-miR-4763-3p	CLIP-seq
MIRT1514134	hsa-miR-4769-5p	CLIP-seq
MIRT2155065	hsa-miR-4789-5p	CLIP-seq
MIRT2155066	hsa-miR-4795-3p	CLIP-seq
MIRT1514135	hsa-miR-507	CLIP-seq
MIRT1514136	hsa-miR-508-5p	CLIP-seq
MIRT1514138	hsa-miR-541	CLIP-seq
MIRT1514140	hsa-miR-557	CLIP-seq
MIRT1514143	hsa-miR-654-5p	CLIP-seq
MIRT1514091	hsa-miR-1267	CLIP-seq
MIRT1514092	hsa-miR-1286	CLIP-seq
MIRT2375002	hsa-miR-1915	CLIP-seq
MIRT1514099	hsa-miR-1972	CLIP-seq
MIRT1514105	hsa-miR-3123	CLIP-seq
MIRT2375003	hsa-miR-3159	CLIP-seq
MIRT1514108	hsa-miR-3182	CLIP-seq
MIRT1514109	hsa-miR-329	CLIP-seq
MIRT1514111	hsa-miR-362-3p	CLIP-seq
MIRT1514112	hsa-miR-3649	CLIP-seq
MIRT2375004	hsa-miR-3653	CLIP-seq
MIRT2375005	hsa-miR-3658	CLIP-seq
MIRT2375006	hsa-miR-3714	CLIP-seq
MIRT2375007	hsa-miR-3908	CLIP-seq
MIRT2375008	hsa-miR-3917	CLIP-seq
MIRT1514115	hsa-miR-3925-5p	CLIP-seq
MIRT1514118	hsa-miR-3941	CLIP-seq
MIRT2375009	hsa-miR-425	CLIP-seq
MIRT2375010	hsa-miR-4267	CLIP-seq
MIRT2375011	hsa-miR-4424	CLIP-seq
MIRT2375012	hsa-miR-4436b-3p	CLIP-seq
MIRT2375013	hsa-miR-4511	CLIP-seq
MIRT2375014	hsa-miR-4514	CLIP-seq
MIRT1514125	hsa-miR-4640-3p	CLIP-seq
MIRT2375015	hsa-miR-4643	CLIP-seq
MIRT2375016	hsa-miR-4645-5p	CLIP-seq
MIRT1514126	hsa-miR-4650-5p	CLIP-seq
MIRT1514127	hsa-miR-4652-3p	CLIP-seq
MIRT2375017	hsa-miR-466	CLIP-seq
MIRT2375018	hsa-miR-4673	CLIP-seq
MIRT1514129	hsa-miR-4684-3p	CLIP-seq
MIRT2375019	hsa-miR-4685-5p	CLIP-seq
MIRT2375020	hsa-miR-4692	CLIP-seq
MIRT1514132	hsa-miR-4722-5p	CLIP-seq
MIRT2375021	hsa-miR-4789-3p	CLIP-seq
MIRT2375022	hsa-miR-548an	CLIP-seq
MIRT2375023	hsa-miR-548b-3p	CLIP-seq
MIRT2375024	hsa-miR-552	CLIP-seq
MIRT2375025	hsa-miR-596	CLIP-seq
MIRT1514142	hsa-miR-603	CLIP-seq
MIRT2375026	hsa-miR-885-5p	CLIP-seq
MIRT2667487	hsa-miR-1225-3p	CLIP-seq
MIRT2667488	hsa-miR-1233	CLIP-seq
MIRT1514091	hsa-miR-1267	CLIP-seq
MIRT1514092	hsa-miR-1286	CLIP-seq
MIRT2667489	hsa-miR-1470	CLIP-seq
MIRT2667490	hsa-miR-150	CLIP-seq
MIRT2667491	hsa-miR-188-5p	CLIP-seq
MIRT1514099	hsa-miR-1972	CLIP-seq
MIRT2667492	hsa-miR-2276	CLIP-seq
MIRT2667493	hsa-miR-3064-3p	CLIP-seq
MIRT2667494	hsa-miR-3117-5p	CLIP-seq
MIRT1514105	hsa-miR-3123	CLIP-seq
MIRT1514108	hsa-miR-3182	CLIP-seq
MIRT1514109	hsa-miR-329	CLIP-seq
MIRT1514110	hsa-miR-338-3p	CLIP-seq
MIRT1514111	hsa-miR-362-3p	CLIP-seq
MIRT1514112	hsa-miR-3649	CLIP-seq
MIRT2375004	hsa-miR-3653	CLIP-seq
MIRT2375005	hsa-miR-3658	CLIP-seq
MIRT1514115	hsa-miR-3925-5p	CLIP-seq
MIRT1514116	hsa-miR-3926	CLIP-seq
MIRT1514118	hsa-miR-3941	CLIP-seq
MIRT2667495	hsa-miR-3943	CLIP-seq
MIRT2667496	hsa-miR-3973	CLIP-seq
MIRT2667497	hsa-miR-4282	CLIP-seq
MIRT2667498	hsa-miR-4290	CLIP-seq
MIRT2667499	hsa-miR-4310	CLIP-seq
MIRT2375011	hsa-miR-4424	CLIP-seq
MIRT2375013	hsa-miR-4511	CLIP-seq
MIRT2375014	hsa-miR-4514	CLIP-seq
MIRT1514124	hsa-miR-4530	CLIP-seq
MIRT1514125	hsa-miR-4640-3p	CLIP-seq
MIRT2375016	hsa-miR-4645-5p	CLIP-seq
MIRT1514126	hsa-miR-4650-5p	CLIP-seq
MIRT1514127	hsa-miR-4652-3p	CLIP-seq
MIRT2667500	hsa-miR-4667-3p	CLIP-seq
MIRT2375018	hsa-miR-4673	CLIP-seq
MIRT1514129	hsa-miR-4684-3p	CLIP-seq
MIRT2375020	hsa-miR-4692	CLIP-seq
MIRT2667501	hsa-miR-4713-5p	CLIP-seq
MIRT1514131	hsa-miR-4717-5p	CLIP-seq
MIRT1514132	hsa-miR-4722-5p	CLIP-seq
MIRT2667502	hsa-miR-4772-3p	CLIP-seq
MIRT2667503	hsa-miR-4777-3p	CLIP-seq
MIRT2667504	hsa-miR-532-3p	CLIP-seq
MIRT2375023	hsa-miR-548b-3p	CLIP-seq
MIRT1514142	hsa-miR-603	CLIP-seq
MIRT2375026	hsa-miR-885-5p	CLIP-seq
MIRT2667487	hsa-miR-1225-3p	CLIP-seq
MIRT2667488	hsa-miR-1233	CLIP-seq
MIRT1514091	hsa-miR-1267	CLIP-seq
MIRT1514092	hsa-miR-1286	CLIP-seq
MIRT2667489	hsa-miR-1470	CLIP-seq
MIRT2667490	hsa-miR-150	CLIP-seq
MIRT2667491	hsa-miR-188-5p	CLIP-seq
MIRT1514099	hsa-miR-1972	CLIP-seq
MIRT2667492	hsa-miR-2276	CLIP-seq
MIRT2667493	hsa-miR-3064-3p	CLIP-seq
MIRT2667494	hsa-miR-3117-5p	CLIP-seq
MIRT1514105	hsa-miR-3123	CLIP-seq
MIRT1514108	hsa-miR-3182	CLIP-seq
MIRT1514109	hsa-miR-329	CLIP-seq
MIRT1514110	hsa-miR-338-3p	CLIP-seq
MIRT1514111	hsa-miR-362-3p	CLIP-seq
MIRT1514112	hsa-miR-3649	CLIP-seq
MIRT2375004	hsa-miR-3653	CLIP-seq
MIRT2375005	hsa-miR-3658	CLIP-seq
MIRT1514115	hsa-miR-3925-5p	CLIP-seq
MIRT1514116	hsa-miR-3926	CLIP-seq
MIRT1514118	hsa-miR-3941	CLIP-seq
MIRT2667495	hsa-miR-3943	CLIP-seq
MIRT2667496	hsa-miR-3973	CLIP-seq
MIRT2667497	hsa-miR-4282	CLIP-seq
MIRT2667498	hsa-miR-4290	CLIP-seq
MIRT2667499	hsa-miR-4310	CLIP-seq
MIRT2375011	hsa-miR-4424	CLIP-seq
MIRT2375013	hsa-miR-4511	CLIP-seq
MIRT2375014	hsa-miR-4514	CLIP-seq
MIRT1514124	hsa-miR-4530	CLIP-seq
MIRT1514125	hsa-miR-4640-3p	CLIP-seq
MIRT2375016	hsa-miR-4645-5p	CLIP-seq
MIRT1514126	hsa-miR-4650-5p	CLIP-seq
MIRT1514127	hsa-miR-4652-3p	CLIP-seq
MIRT2667500	hsa-miR-4667-3p	CLIP-seq
MIRT2375018	hsa-miR-4673	CLIP-seq
MIRT1514129	hsa-miR-4684-3p	CLIP-seq
MIRT2375020	hsa-miR-4692	CLIP-seq
MIRT2667501	hsa-miR-4713-5p	CLIP-seq
MIRT1514131	hsa-miR-4717-5p	CLIP-seq
MIRT1514132	hsa-miR-4722-5p	CLIP-seq
MIRT2667502	hsa-miR-4772-3p	CLIP-seq
MIRT2667503	hsa-miR-4777-3p	CLIP-seq
MIRT2667504	hsa-miR-532-3p	CLIP-seq
MIRT2375023	hsa-miR-548b-3p	CLIP-seq
MIRT1514142	hsa-miR-603	CLIP-seq
MIRT2375026	hsa-miR-885-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000398	Process	MRNA splicing, via spliceosome	IBA
GO:0000398	Process	MRNA splicing, via spliceosome	IDA	28781166
GO:0000398	Process	MRNA splicing, via spliceosome	IEA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	20195357, 23275563, 25416956, 31515488, 32296183, 32814053
GO:0005634	Component	Nucleus	IDA	28781166
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IEA
GO:0006397	Process	MRNA processing	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0046540	Component	U4/U6 x U5 tri-snRNP complex	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0071005	Component	U2-type precatalytic spliceosome	IDA	28781166

Other IDs

• MIM: 619930
• HGNC: 26433
• e!Ensembl: ENSG00000146007

Protein

• UniProt ID: Q96NC0
• Protein name: Zinc finger matrin-type protein 2
• Protein function: Involved in pre-mRNA splicing as a component of the spliceosome.
• PDB: 5O9Z, 6AHD, 7AAV, 7ABF, 7ABG, 7ABI, 8H6K, 8Q7N, 8QO9, 8QPE, 8QZS
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12171	zf-C2H2_jaz	79 → 105	Zinc-finger double-stranded RNA-binding	Family

• Sequence:

  MASGSGTKNLDFRRKWDKDEYEKLAEKRLTEEREKKDGKPVQPVKRELLRHRDYKVDLES
  KLGKTIVITKTTPQSEMGGYYCNVCDCVVKDSINFLDHINGKKHQRNLGMSMRVERSTLD
  QVKKRFEVNKKKMEEKQKDYDFEERMKELREEEEKAKAYKKEKQKEKKRRAEEDLTFEED
  DEMAAVMGFSGFGSTKKSY

• Sequence length: 199

Pathways

KEGG:

Spliceosome

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CONGENITAL RADIOULNAR SYNOSTOSIS	—	GenCC	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Depressive Disorder	Associate	34021117	★☆☆☆☆ Found in Text Mining only